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Retno Sari
Department Of Pharmaceutics, Faculty Of Pharmacy, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Health Notions

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Preparation and Characterization of BSA-loaded Chitosan Microspheres Hendradi, Esti; Sari, Retno; Anggai, Rifka Anggraini
Health Notions Vol 2 No 9 (2018): September 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

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Preparation and characterization of BSA-loaded Chitosan Microspheres Esti Hendradi; Retno Sari; Rifka Anggraini Anggai
Health Notions Vol 2, No 9 (2018): September
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (255.339 KB) | DOI: 10.33846/hn.v2i9.317

Abstract

Proteins are unstable molecules because of their complex structure and easily degraded by enzymatic systems. Biodegradable microspheres have been used in protein delivery system. Bovine serum albumin was chosen as a model protein. Chitosan/tripolyphosphate microparticles have already been used to encapsulated BSA. The aim of this work was to microencapsulate these protein-CS/TPP by ionic gelation and freeze-drying. The morphology, particle size, and encapsulation efficiency of the prepared microspheres were investigated. The results revealed that the microspheres exhibited good sphericity with ranged in size from 2.25 to 2.73 µm. The study found that the moisture content of microspheres was 2.8%, the encapsulation efficiency of BSA in CS-TPP microspheres ranged from 88.14 to 96.25%. The results suggested that iontoropic gelation method will be an effective method for fabricating chitosan microspheres for delivery of protein.. Keywords: Microspheres, BSA, Ionic Gelation
Co-Authors Abd Hakim Laenggeng, Abd Hakim Abhimata Paramanandana Adhitiawarman, Adhitiawarman Adjat Sudradjat Agustin Agustin Alam, Gust Rizki Samudra Noor Andi Saifah Andi Saryoko Andre Andre, Andre Anggai, Rifka Anggraini Annisa Maulidia Rahayyu Ardiputra, Muh Akbar Arief Cahyo Wibowo Asri Pirade Paserang Bambang Sardi Bastoni Semendawai Budi Santoso, Satrio Dewanthy, Kyrana Sekar Dewi Isadiartuti Dewi Isadiartuti Dhurriah Zain Dicky Kurniawan, Muhammad Dinda Monika Nusantara Ratri Dini Retnowati Dini Retnowati Diyah, Nuzul Wahyuning dwi hartanto Dwi Setyawan Eka Saputra, Bagas Eryka A. Novarinandha Esti Hendradi Fadjar Mulya Fauzia, Alfi Nur Febrianti, Clara Firmansyah, Mochamad Lutfi Firmansyah, Mochammad Lutfi Fitrallisan Fitrallisan Guli, Musjaya Hardini, Erza Shafiah Zahraani Pravita Hasan, Wafiqah Latuapo Hidayad, Khavid Ida Ayu Putu Sri Widnyani Idha Kusumawati Ilma Amalina Imam Sujadi Intan Nurul Rizki Iqbal, Moh Irma Purnamasari, Ade Junadhi, Junadhi Juni Ekowati Kresna Ramanda Laksono Trisnantoro Lemako, Gideon Sulivan Lumbantoruan, Daniel M. Agus Syamsur Rijal Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Marlina Marlina Miatmoko, Andang Mirza Ardella Saputra Mochammad Hatta Muchammad Farchan Chanif Muchammad Farchan Hanif Mufariha, Mufariha Muh Agus S Rijal Muhammad Aditya Bryan Rahadi Muhammad Agus Syamsur Rijal Muhammad Fahrizal Himawan Muhammad Ilyas Mulya, Fadjar Mulyana, Septian Dwi Mustafid Rasyiid Muzakki Ramadhan, Naufal Nasution, Ramadhani Syafitri Nugroho, Anggi Nugroho, Dito Pradita Nur Rahmiati, Nur Patigu, Rosy Feraningsih Pawahid Pawahid Pohwain, Berkhat Agung Prastika Krisma Jiwanti Prawiro, Sumarno Reto Putra, Arizal Eka Raden Joko Kuncoroningrat Susilo Rahayyu, Annisa Maulidia Rahma Rahma Rahmawati, Nurul Dina Rahmiati Rahmiati Ramadanil Pitopang Ramadhan, Wahyu Satria Ramadhani, Firmansyah Ardian Rani Naomi Panjaitan Ratih Yulia Hayuningtyas Ridwansyah Ridwansyah Rifka Anggraini Anggai Rijal, Agus Syamsur Rijal, M. Agus Syamsur Rinaldi Dikanda, Arif Rohana, Melissa Rosyda, Susy Sartini Sartini Seimahuira, Syarah Septian Nafiatul Khasanah Siammita, Dhea Anansya Siti Nurhasanah Nugraha Sugiyartono Sugiyartono Sugiyartono, Sugiyartono Suhailah Hayaza Sukardiman Sulistyowati, Melanny Ika sultan, firdaus SUZANA, SUZANA Tahta Amrillah Taopik Hidayat Theo, Deli Tri Atmojo Kusmayadi Tristiana Erawati Tutiek Purwanti Tutik Sri Wahyuni Wahyu Harso Widji Soeratri Yeremia Budi Cristian