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Retno Sari
Department Of Pharmaceutics, Faculty Of Pharmacy, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Science and Technology Indonesia

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Enhancing Chitosan-Carboxymethyl Chitosan Composite Film Properties by Silver Nanoparticles Grafting for Acne vulgaris Dwi Mulyana, Septian; Agus Syamsur Rijal, Muh.; Sari, Retno
Science and Technology Indonesia Vol. 11 No. 2 (2026): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.2.559-568

Abstract

Silver nanoparticles (AgNPs) have been widely used in developing antibacterial preparations. AgNPs are used in film preparation to enhance the film’s antibacterial properties. The combination of natural polymers is an effective strategy to enhance mechanical properties, prolong degradation time, preserve gas and vapor permeability, and maintain biocompatibility. This research aims to develop an AgNP-chitosan-carboxymethyl chitosan (CMChi) nanocomposite film that exhibits desirable physical properties and enhances antibacterial activity by incorporating AgNPs. Chitosan-CMChi composite films were prepared using the solvent casting method. Characterization and antibacterial tests using Propionibacterium acnes (P. acnes) were carried out for AgNO3 and AgNP-chitosan-CMChi nanocomposite films. The results showed that a 1 mM AgNO3 solution with 1% lime powder at pH 9 was the optimal formulation for AgNP formation, exhibiting an absorbance of 4.631 at 408.1 nm, a particle size of 68.4 nm, and antibacterial activity. To optimize the chitosan-CMChi composite film, a formula of 1.5% chitosan and 1.5% CMChi was selected, yielding a tensile strength value of 0.514 MPa. The AgNP solution was then added. In the AgNP-chitosan-CMChi nanocomposite film, it was observed that increasing the AgNP volume affected the mechanical strength of the film. The antibacterial activity of the AgNP-chitosan-CMChi nanocomposite film increased with the AgNP concentration. Combining AgNPs with the chitosan-CMChi polymer yields nanocomposite films with good physical properties and enhanced antibacterial activity against P. acnes compared with films without AgNPs.
Co-Authors , Idha Kusumawati Abd Hakim Laenggeng, Abd Hakim Abhimata Paramanandana Adhitiawarman, Adhitiawarman Adjat Sudradjat Agus Syamsur Rijal, Muh. Agustin Agustin Alam, Gust Rizki Samudra Noor Andang Miatmoko Andi Saifah Andi Saryoko Andre Andre, Andre Anggai, Rifka Anggraini Annisa Maulidia Rahayyu Ardiputra, Muh Akbar Arief Cahyo Wibowo Asri Pirade Paserang Bambang Sardi Bastoni Semendawai Devi Bunga Pagalla Dewanthy, Kyrana Sekar Dewi Isadiartuti Dewi Isadiartuti Dhurriah Zain Dicky Kurniawan, Muhammad Dinda Monika Nusantara Ratri Dini Retnowati Dini Retnowati Diyah, Nuzul Wahyuning dwi hartanto Dwi Mulyana, Septian Dwi Setyawan Eryka A. Novarinandha Esti Hendradi Fadjar Mulya Fauzia, Alfi Nur Febrianti, Clara Firmansyah, Mochamad Lutfi Firmansyah, Mochammad Lutfi Fitrallisan Fitrallisan Guli, Musjaya Hardini, Erza Shafiah Zahraani Pravita Hasan, Wafiqah Latuapo Hidayad, Khavid Ida Ayu Putu Sri Widnyani Idha Kusumawati Ilma Amalina Imam Sujadi Intan Nurul Rizki Irma Purnamasari, Ade Junadhi, Junadhi Juni Ekowati Kresna Ramanda Laksono Trisnantoro Lemako, Gideon Sulivan Lumbantoruan, Daniel M. Agus Syamsur Rijal M. Agus Syamsur Rijal M. Irfan Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Marlina Marlina Miatmoko, Andang Mirza Ardella Saputra Mochammad Hatta Moh Iqbal Muchammad Farchan Chanif Muchammad Farchan Hanif Mufariha, Mufariha Muh Agus S Rijal Muhammad Aditya Bryan Rahadi Muhammad Agus Syamsur Rijal Muhammad Fahrizal Himawan Muhammad Ilyas Mulya, Fadjar Mulyana, Septian Dwi Mustafid Rasyiid Nasution, Ramadhani Syafitri Noorma Rosita Nugroho, Dito Pradita Nur Rahmiati, Nur Nurman Nurman Patigu, Rosy Feraningsih Pawahid Pawahid Pohwain, Berkhat Agung Prastika Krisma Jiwanti Prawiro, Sumarno Reto Raden Joko Kuncoroningrat Susilo Rahayyu, Annisa Maulidia Rahma Rahma Rahmah, Mufti Hatur Rahmawati, Nurul Dina Rahmiati Rahmiati Ramadanil Pitopang Ramadhan, Wahyu Satria Ramadhani, Firmansyah Ardian Ramlah Ramlah Rani Naomi Panjaitan Ratih Yulia Hayuningtyas Ridwansyah Ridwansyah Rifka Anggraini Anggai Rijal, Agus Syamsur Rijal, M. Agus Syamsur Rinaldi Dikanda, Arif Rohana, Melissa Rosyda, Susy Sartini Sartini Septian Nafiatul Khasanah Siammita, Dhea Anansya Siti Nurhasanah Nugraha Sugiyartono Sugiyartono Sugiyartono, Sugiyartono Suhailah Hayaza Sukardiman Sulistyowati, Melanny Ika sultan, firdaus SUZANA, SUZANA Tahta Amrillah Theo, Deli Tri Atmojo Kusmayadi Tristiana Erawati Tutiek Purwanti Tutik Sri Wahyuni Wahyu Harso Widji Soeratri Yeremia Budi Cristian