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All Journal Medula E-Dimas: Jurnal Pengabdian kepada Masyarakat Jurnal Penelitian Pendidikan IPA (JPPIPA) Manuju : Malahayati Nursing Journal JURNAL PENELITIAN PERAWAT PROFESIONAL JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Kesehatan Tambusai Bioscientist : Jurnal Ilmiah Biologi Jurnal Abmas Negeri (JAGRI) Dharma: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Sosial Indonesia JOURNAL OF Mental Health Concerns Jurnal Pengabdian Masyarakat Jurnal Pengabdian Multidisiplin Indonesia Jurnal Kesehatan Qamarul Huda JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Suryadi Islami
Fakultas Kedokteran, Universitas Lampung
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Faktor Risiko dan Komplikasi Hipertensi Tidak Terkontrol di Indonesia: Literature Review Puspitasari, Nabila; Yonata, Ade; Islami, Suryadi
Medula Vol 16 No 3 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i3.1822

Abstract

Uncontrolled hypertension is one of the major public health problems in Indonesia and contributes substantially to increased morbidity and mortality related to cardiovascular disease and target organ damage. This condition occurs when blood pressure remains above the recommended target despite the use of antihypertensive therapy. This article aims to review and analyze risk factors and complications associated with uncontrolled hypertension in the Indonesian population. The study applied a literature review design with article searches conducted through the Google Scholar and Garuda databases in accordance with the PRISMA 2020 guidelines. Following the selection process, twelve articles met the inclusion criteria and were analyzed descriptively. The review results indicate that the dominant risk factors for uncontrolled hypertension include older age, obesity, diabetes mellitus, dyslipidemia, employment status, low educational level, poor medication adherence, excessive salt intake, physical inactivity, smoking, and psychological stress. The most frequently reported complications were stroke, chronic kidney disease, heart failure, myocardial infarction, and hypertensive retinopathy. These findings demonstrate that uncontrolled hypertension in Indonesia remains a serious challenge that requires integrated control strategies through early detection, optimization of therapy, improvement of patient adherence, and strengthening of promotive and preventive interventions based on primary health care services and community involvement.
Eksplorasi In Silico Senyawa Fitokimia untuk Penghambatan Protein STAT3 dalam Mengatasi Resistensi Obat pada Kanker Payudara Triple Negatif Dewi Hambar Sari; Sri Suciati Ningsih; Suryadi Islami
Jurnal Penelitian Pendidikan IPA Vol 10 No 12 (2024): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i12.9174

Abstract

Breast cancer is the most common cancer among women and a major cause of cancer-related death worldwide, including Indonesia. Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer, characterized by high mortality and resistance to standard treatments. Cancer stem cells (CSCs) is known to be a key factor of drug resistance in TNBC, mediated by the signal tranducer and activator of transcription factor 3 (STAT3). This study aims to explore the bioactive compounds from Indonesian’s natural product which potentially target CSCs by inhibiting STAT3. We used in silico methods, consist of literature review, followed by selection of promising compounds, ADMET analysis and selection using Lipinski’s rules, and molecular docking simulation. Our results found curcumin, quercetin, α-mangostin, gingerol, and rocalglamide as the bioactive candidates which target CSCs. ADMET testing showed that only curcumin, quercetin, and gingerol meet the Lipinski’s criteria. The molecular docking results showed that quercetin exhibited the strongest binding affinity (-8.3 kcal/mol) compared to curcumin (-6.9 kcal/mol) and gingerol (-5.9 kcal/mol). The results indicate that quercetin binds effectively at the active site of STAT3. The findings suggest that quercetin has potential as a STAT3 inhibitor. Further research is needed to determine the significant efficacy and potential as an anticancer.
Faktor-Faktor yang Berhubungan dengan Kecemasan pada Petani: Tinjauan Review Nabylly Aghna Bachtiar; Fitria Saftarina; Ratri Mauluti Larasati; Suryadi Islami
Malahayati Nursing Journal Vol 7, No 7 (2025): Volume 7 Nomor 7 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v7i7.18744

Abstract

ABSTRACT Anxiety is an unpleasant feeling of worry or fear accompanied by certain physical symptoms. The prevalence of anxiety has been increasing globally in the last three decades. Farmers are generally faced with a number of working conditions that are considered unfavorable, such as long working hours, monotonous tasks, and dangerous physical work environments. Therefore, farmers are at high risk of experiencing mental health problems that are rarely discussed in scientific publications, especially specifically anxiety. To conclude the factors associated with anxiety in farmers. The literature review method was used in the preparation to conclude the factors that trigger anxiety in farmers, where the literature was obtained from the PubMed, ScienceDirect, DOAJ, Cochrane, and Garuda databases, which are available online. It was found that anxiety in farmers is related to various aspects, both those originating from the work environment such as pesticide use, climate change, land ownership, and isolated work environments as well as those originating from individual factors such as gender, financial condition, and interpersonal relationships. Anxiety in farmers is influenced by individual, occupational, and environmental factors. Factors such as gender, social support, financial condition, pesticide use, land ownership, climate change, and the impact of the COVID-19 pandemic contribute significantly. Understanding and addressing these factors is important to support farmers' mental well-being. Keywords: Farmers, Anxiety, Mental Health  ABSTRAK Kecemasan adalah perasaan khawatir atau takut yang tidak menyenangkan yang disertai dengan gejala-gejala tubuh tertentu. Prevalensi kecemasan secara global terus meningkat dalam tiga dekade terakhir. Petani umumnya dihadapkan pada sejumlah kondisi kerja yang dianggap tidak menguntungkan, seperti jam kerja yang panjang, tugas yang monoton, dan lingkungan kerja fisik yang berbahaya. Oleh karena itu petani berisiko tinggi mengalami masalah kesehatan mental yang jarang sekali dibahas dalam publikasi ilmiah terutama secara spesifik pada kecemasan. Tujuanuntuk menyimpulkan faktor-faktor yang berhubungan dengan kecemasan pada petani. Metode tinjauan literatur digunakan dalam penyusunan untuk menyimpulkan faktor yang memicu kecemasan pada petani, dimana literatur diperoleh dari database PubMed, ScienceDirect, DOAJ, Cochrane, dan Garuda yang tersedia secara online. Didapatkan bahwa kecemasan pada petani berhubungan dengan berbagai aspek, baik yang berasal dari lingkungan pekerjaan seperti penggunaan pestisida, perubahan iklim, kepemilikan lahan, dan lingkungan kerja terisolasi maupun yang berasal dari faktor individu seperti jenis kelamin, kondisi finansial dan hubungan interpersonal. Kecemasan pada petani dipengaruhi oleh faktor individu, pekerjaan, dan lingkungan. Faktor seperti jenis kelamin, dukungan sosial, kondisi finansial, penggunaan pestisida, kepemilikan lahan, perubahan iklim, dan dampak pandemi COVID-19 berkontribusi signifikan. Pemahaman dan penanganan faktor-faktor ini penting untuk mendukung kesejahteraan mental petani. Kata Kunci: Petani, Kecemasan, Kesehatan Mental
Medication adherence and relapse in patients with schizophrenia: A literature review Rahmanda Putri, Venna; Carolia, Novita; Islami, Suryadi; Septa, Tendry
JOURNAL OF Mental Health Concerns Vol. 5 No. 1 (2026): April Edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Unit Penelitian dan Pengabdian Kep Akademi Keperawatan Baitul Hikmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/mhc.v5i1.2736

Abstract

Background: Schizophrenia is a chronic psychiatric disorder with high relapse rates that significantly affect social functioning, quality of life, and healthcare burden. Medication adherence to antipsychotic treatment plays a critical role in maintaining clinical stability and preventing relapse; however, it remains a major challenge in clinical practice. Purpose: To examine the relationship between medication adherence and relapse among patients with schizophrenia through a narrative review approach. Method: Literature searches were conducted in Google Scholar, PubMed, NCBI, ScienceDirect, and Elsevier between January and February 2024 using keywords related to medication adherence, schizophrenia, and relapse. Of the 85 identified articles, 8 studies met the inclusion criteria and were analyzed narratively. Results: The review findings consistently demonstrated that non-adherence to antipsychotic medication was associated with a significantly higher risk of relapse, rehospitalization, and poorer long-term prognosis. Additionally, considerable variability was observed in the definitions and assessment methods of adherence and relapse across studies. Conclusion: Medication adherence is a key determinant in relapse prevention among patients with schizophrenia and should be a primary focus of long-term clinical management. Keywords: Medication Adherence; Relapse; Schizophrenia.
Co-Authors Ade Yonata, Ade Adelia Farisa Adisti, Fransiska aflika, terza Afriyani Afriyani Afriyani, Afriyani Afriyani, Afriyani ani Ambarwati, Endah Andika S.D.R. Andrifianie, Femmy Arafah, Aisyah Putri arby tamaila Arianto, Nayla Nadhifa Asep Sukohar Centya Cheirini Damayanti, Ervina Daudea Kirana Sari Dita Noviyanda Saerulloh Djamilu, Berneta Rendiana Dwi, Farah Ergidona Nurizqi Ervina Damayanti Ervina Damayanti Ervina Damayanti Ety Apriliana Ety Apriliana Evy Afriyani Farhana, Lubna Febriana, Triana Femmy Andrifianie Fitria Saftarina Habib, Farid Alif Hafizh, Ahmad Fauzan Hanna Mutiara, Hanna Haq, Rais Amaral Hardiansyah, Ridwan Hatimi, Fahmi Ilham Hening, Putik Titian Citra Idris, Mohamad Ihsanti Dwi Rahayu Indri Windarti Irma Nur Humaida Januaristy, Gracia Rescuefa Jhons Fatriyadi Suwandi Khairun Nisa Kirana, Shela Sandra Laksana, Bayu Lestari, Dharma Lina Linda Septiani Luhut Uji Arto Naenggolan M. Rifqi Efendi Magistra, Muhammad Akbar Marcellia, Selvi Mesa Sukmadani Rusdi Mighuel A.S.N. Muhammad Fitra Wardhana Sayoeti Muhammad Maulana Muhammad Ricky Ramadhian Nabylly Aghna Bachtiar Natasya Karren Zeta Nisa Karima Novita Carolia Nugraha, Dian Sastra Oktafany, Oktafany Pardilawati, Citra Yuliyanda Prasetyo, Muhammad Purwono Prayogi, Norbertus Marcell Puspitasari, Nabila Putri Handayani Putri, Eka Meilinda Putri, Nandini Amerta Putri, Reny Arienta Qonita, Adzrok Rahmanda Putri, Venna Ramadhina, Farrasyifa Ramdini, Dwi Aulia Ratri Mauluti Larasati Rika Lisiswanti Rizki Hanriko Rizki Nisfi Ramdhini Rosa, Emantis Rossa, Putri Emylia Rudiyanto, Waluyo Sabina, Diana Larisa Sari, Dewi Hambar Selvi Marcellia Septa, Tendry Septiani, Linda Sitanggang, Grety Thessalonica Sofyan Musyabiq Wijaya Sri Suciati Ningsih Suci Nurhaliza Suri, Nurma Susianti Susianti Syahrani, Fitri Aulia Syazili Mustofa Syiffatulhaya Syiffatulhaya Temun, Jedo Muchamad Tias Triavina Khairunisa Vanadis, Zifa Aisha Vestinaliyou, Nanda Vidini Caya, Tazkia Wardhana, Carbela Zahra Wijaya, Ardia Syifa Winda Winda Yustina Yustina