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All Journal Medula E-Dimas: Jurnal Pengabdian kepada Masyarakat Jurnal Penelitian Pendidikan IPA (JPPIPA) Manuju : Malahayati Nursing Journal Jurnal Pembelajaran dan Biologi Nukleus JURNAL PENELITIAN PERAWAT PROFESIONAL JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Kesehatan Tambusai Bioscientist : Jurnal Ilmiah Biologi Jurnal Abmas Negeri (JAGRI) Dharma: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Sosial Indonesia Jurnal Pengabdian Masyarakat Jurnal Pengabdian Multidisiplin Indonesia Jurnal Kesehatan Qamarul Huda JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Suryadi Islami
Fakultas Kedokteran, Universitas Lampung
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Education on Sedentary Lifestyle, Nutritional Status, and Metabolic Syndrome Among Students Prasetyo, Muhammad Purwono; Wardhana, Carbela Zahra; Lestari, Dharma Lina; Putri, Nandini Amerta; Hening, Putik Titian Citra; Islami, Suryadi
Jurnal Abmas Negeri (JAGRI) Vol. 6 No. 2 (2025): Volume 6 Nomor 2 Desember 2025
Publisher : Sarana Ilmu Indonesia (salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jagri.v6i2.1798

Abstract

Sedentary lifestyle and imbalanced nutritional status are major risk factors for metabolic syndrome, including among adolescents. Currently, many adolescents experience a lack of physical activity due to various factors, including excessive use of gadgets, prolonged sitting during study, and unhealthy eating habits. This community service activity aimed to educate students of Ar-Raihan Boarding School, Lampung, regarding sedentary lifestyle, nutritional status, and the prevention of metabolic syndrome. The methods included health promotion through interactive counseling, simple nutritional status assessment using Body Mass Index (BMI) measurement, blood pressure examination, and random blood glucose examination, as well as group discussions. The health education activities were successfully implemented and received positive responses from students. Screening results showed variations in nutritional status and health conditions that served as the basis for providing educational feedback. After the intervention, students demonstrated increased understanding of sedentary lifestyle risk factors and the importance of adopting a healthy lifestyle to prevent metabolic syndrome. This health education program is expected to be implemented sustainably to support the development of healthy behaviors from adolescence.
Faktor Risiko dan Komplikasi Hipertensi Tidak Terkontrol di Indonesia: Literature Review Puspitasari, Nabila; Yonata, Ade; Islami, Suryadi
Medula Vol 16 No 3 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i3.1822

Abstract

Uncontrolled hypertension is one of the major public health problems in Indonesia and contributes substantially to increased morbidity and mortality related to cardiovascular disease and target organ damage. This condition occurs when blood pressure remains above the recommended target despite the use of antihypertensive therapy. This article aims to review and analyze risk factors and complications associated with uncontrolled hypertension in the Indonesian population. The study applied a literature review design with article searches conducted through the Google Scholar and Garuda databases in accordance with the PRISMA 2020 guidelines. Following the selection process, twelve articles met the inclusion criteria and were analyzed descriptively. The review results indicate that the dominant risk factors for uncontrolled hypertension include older age, obesity, diabetes mellitus, dyslipidemia, employment status, low educational level, poor medication adherence, excessive salt intake, physical inactivity, smoking, and psychological stress. The most frequently reported complications were stroke, chronic kidney disease, heart failure, myocardial infarction, and hypertensive retinopathy. These findings demonstrate that uncontrolled hypertension in Indonesia remains a serious challenge that requires integrated control strategies through early detection, optimization of therapy, improvement of patient adherence, and strengthening of promotive and preventive interventions based on primary health care services and community involvement.
Eksplorasi In Silico Senyawa Fitokimia untuk Penghambatan Protein STAT3 dalam Mengatasi Resistensi Obat pada Kanker Payudara Triple Negatif Dewi Hambar Sari; Sri Suciati Ningsih; Suryadi Islami
Jurnal Penelitian Pendidikan IPA Vol 10 No 12 (2024): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i12.9174

Abstract

Breast cancer is the most common cancer among women and a major cause of cancer-related death worldwide, including Indonesia. Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer, characterized by high mortality and resistance to standard treatments. Cancer stem cells (CSCs) is known to be a key factor of drug resistance in TNBC, mediated by the signal tranducer and activator of transcription factor 3 (STAT3). This study aims to explore the bioactive compounds from Indonesian’s natural product which potentially target CSCs by inhibiting STAT3. We used in silico methods, consist of literature review, followed by selection of promising compounds, ADMET analysis and selection using Lipinski’s rules, and molecular docking simulation. Our results found curcumin, quercetin, α-mangostin, gingerol, and rocalglamide as the bioactive candidates which target CSCs. ADMET testing showed that only curcumin, quercetin, and gingerol meet the Lipinski’s criteria. The molecular docking results showed that quercetin exhibited the strongest binding affinity (-8.3 kcal/mol) compared to curcumin (-6.9 kcal/mol) and gingerol (-5.9 kcal/mol). The results indicate that quercetin binds effectively at the active site of STAT3. The findings suggest that quercetin has potential as a STAT3 inhibitor. Further research is needed to determine the significant efficacy and potential as an anticancer.
Phytochemical Profiling and Granule Formulation of Green Betel Leaf (Piper betle L.) Extract for Potential Bio-Larvicidal Application Mahardianti, Meita; Nurani, Puspa Rini Cahaya; Tresnaningtyas, Sekar Asri; Islami, Suryadi
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 11, No 4: Jurnal Pembelajaran Dan Biologi Nukleus December 2025
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v11i4.8448

Abstract

Background: The increasing spread of Aedes aegypti as a vector of dengue disease has encouraged the exploration of safer, plant-based larvicidal materials. This study aimed to identify the phytochemical constituents of green betel leaf (Piper betle L.) extract and to develop a bio-larvicidal granule formulation as a modified dosage form. Phytochemical screening was conducted to identify bioactive compounds potentially associated with larvicidal activity. Methodology: Granules were prepared using the wet granulation method, employing polyvinylpyrrolidone (PVP) as a binder and lactose as a filler. The formulated granules were further evaluated through physical characterization tests, including flow rate, angle of repose, and dispersion time, to assess their suitability as a granular dosage form. Findings: The results demonstrated that all formulations exhibited acceptable flow properties, appropriate angles of repose, and rapid dispersion in water, indicating favorable handling and application characteristics. The flow rate test results showed that granules with concentration variations of 25%, 50%, 75%, and 100% exhibited flow rates of 71.4 g/s, 62.5 g/s, 50 g/s, and 45.5 g/s, respectively. Physical evaluation demonstrated that the granules had acceptable angles of repose (31°–36°) and dispersion time (20–25 seconds). Contribution: This study was conducted as a step toward developing an environmentally safe, natural-material-based biolarvicide
Co-Authors Ade Yonata, Ade Adelia Farisa Adisti, Fransiska aflika, terza Afriyani Afriyani Afriyani, Afriyani Afriyani, Afriyani ani Ambarwati, Endah Andika S.D.R. Andrifianie, Femmy Arafah, Aisyah Putri arby tamaila Arianto, Nayla Nadhifa Asep Sukohar Bachtiar, Nabylly Aghna Centya Cheirini Damayanti, Ervina Daudea Kirana Sari Dita Noviyanda Saerulloh Djamilu, Berneta Rendiana Dwi, Farah Ergidona Nurizqi Ervina Damayanti Ervina Damayanti Ervina Damayanti Ety Apriliana Ety Apriliana Evy Afriyani Farhana, Lubna Febriana, Triana Femmy Andrifianie Fitria Saftarina Habib, Farid Alif Hafizh, Ahmad Fauzan Hanna Mutiara, Hanna Haq, Rais Amaral Hardiansyah, Ridwan Hatimi, Fahmi Ilham Hening, Putik Titian Citra Idris, Mohamad Ihsanti Dwi Rahayu Indri Windarti Irma Nur Humaida Januaristy, Gracia Rescuefa Jhons Fatriyadi Suwandi Khairun Nisa Kirana, Shela Sandra Laksana, Bayu Larasati, Ratri Mauluti Lestari, Dharma Lina Linda Septiani Luhut Uji Arto Naenggolan M. Rifqi Efendi Magistra, Muhammad Akbar Mahardianti, Meita Marcellia, Selvi Mesa Sukmadani Rusdi Mighuel A.S.N. Muhammad Fitra Wardhana Sayoeti Muhammad Maulana Muhammad Ricky Ramadhian Natasya Karren Zeta Nisa Karima Nugraha, Dian Sastra Nurani, Puspa Rini Cahaya Oktafany, Oktafany Pardilawati, Citra Yuliyanda Prasetyo, Muhammad Purwono Prayogi, Norbertus Marcell Puspitasari, Nabila Putri Handayani Putri, Eka Meilinda Putri, Nandini Amerta Putri, Reny Arienta Qonita, Adzrok Ramadhina, Farrasyifa Ramdini, Dwi Aulia Rika Lisiswanti Rizki Hanriko Rizki Nisfi Ramdhini Rosa, Emantis Rossa, Putri Emylia Rudiyanto, Waluyo Sabina, Diana Larisa Sari, Dewi Hambar Selvi Marcellia Septiani, Linda Sitanggang, Grety Thessalonica Sofyan Musyabiq Wijaya Sri Suciati Ningsih Suci Nurhaliza Suri, Nurma Susianti Susianti, Susianti Syahrani, Fitri Aulia Syazili Mustofa Syiffatulhaya Syiffatulhaya Temun, Jedo Muchamad Tias Tresnaningtyas, Sekar Asri Triavina Khairunisa Vanadis, Zifa Aisha Vestinaliyou, Nanda Vidini Caya, Tazkia Wardhana, Carbela Zahra Wijaya, Ardia Syifa Winda Winda Yustina Yustina