Claim Missing Document
Check
Articles

In vitro study: thymoquinone inhibits the proliferation and migration of keloid fibroblasts and increases their apoptosis Hadi, Restu Syamsul; Juniarti, Juniarti
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.23975

Abstract

Background: No treatment can eliminate keloids. Thymoquinone (TQ) is hypothesized to play a pivotal role in treating keloids by modulating cellular processes such as proliferation, migration, and apoptosis. However, the existing studies investigating its effects on these mechanisms in keloid fibroblasts are limited and require further exploration.Objective: This study aims to investigate the effects of TQ on the proliferation, migration, and apoptosis of keloid fibroblasts in vitro.Methods: This experimental study was conducted using keloid fibroblast cultured in vitro. Cells were seeded in a 96-well plate at a density of about 5x103 cells per well with 100 μl of culture medium, and cells were cultured for 24, 48, and 72 hr for each concentration of TQ. Cell proliferation was assessed using a CCK-8 Kit, measuring optical density with a microplate reader. Apoptosis was measured using the TUNEL assay. Cell migration following TQ treatment was evaluated using the Scratch assay. The statistical test used a one-way analysis of variance (ANOVA) followed by the least significant difference (LSD) test. Results: TQ inhibited the proliferation of keloid fibroblasts at a dose of 5 µM after 48 hours of incubation and 10 µM after 24 hours of incubation. The inhibitory effect of TQ on fibroblast proliferation increased in a dose- and time-dependent manner. Treatment at 5 and 10 µM doses increased apoptosis in keloid fibroblast cultures. The TQ5 µM group achieved 60% closure, while the 10 µM group showed 55% closure. Migration was significantly inhibited in the 25 µM and 50 µM groups, with only 30% and 10% closure, respectively, at 72 hours.Conclusion: Thymoquinone inhibits the proliferation and migration of keloid fibroblast cells while promoting apoptosis. These properties suggest that TQ could be developed as a potential treatment for keloid-related skin issues.
Perbedaan Prokrastinasi Akademik Siswa SMA Ditinjau Dari Jenis Sekolah Ferdiansyah, Muhammad Aldy; Kurniawati, Rika; Jannah, Anisa Raudhatul; Sari, Puspa; Dwita, Adel Karen; Juniarti, Juniarti; Hartono, Yusuf; Lubis, Khadijah
Guidance : Jurnal Bimbingan dan Konseling Vol 22 No 1 (2025): Guidance: Jurnal Bimbingan dan Konseling
Publisher : Prodi Bimbingan dan Konseling Fakultas Keguruan dan Ilmu Pendidikan | Universitas Islam As-Syafi'iyah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34005/guidance.v22i1.4662

Abstract

Penelitian ini bertujuan menguji perbedaan tingkat prokrastinasi akademik berdasarkan jenis sekolah, karena kecenderungan siswa dalam menunda tugas diduga dipengaruhi oleh karakteristik lingkungan pendidikan masing-masing. Penelitian menggunakan pendekatan kuantitatif dengan metode komparatif tipe ex-post facto. Sampel berjumlah 120 siswa dipilih melalui teknik simple random sampling dari ketiga jenis sekolah (SMA Negeri, SMA Swasta, dan SMA Islam). Data dikumpulkan menggunakan angket prokrastinasi akademik dan dianalisis dengan uji One-Way ANOVA serta dilanjutkan uji Post Hoc. Hasil menunjukkan nilai Sig. 0,000, membuktikan adanya perbedaan signifikan antar jenis sekolah. Tingkat prokrastinasi tertinggi terdapat pada siswa SMA Islam, disusul SMA Negeri, dan terendah SMA Swasta. Perbedaan signifikan ditemukan antara SMA Islam dengan dua sekolah lainnya (Sig. 0,001), sementara antara SMA Negeri dan SMA Swasta tidak terdapat perbedaan signifikan (Sig. 1,000).
In Vivo Study of Telang Cream on Interleukin (IL)-6, Epidermal Growth Factor (EGF), and Wound Reepithelialization Pratiwi, Nike; Irwandi, Nurmayani; Hadi, Restu Syamsul; Thamrin, Nabila Pyrenina; Damayanti, Ndaru Andri; Juniarti, Juniarti; Rahmah, Nunung Ainur
Jurnal Kesehatan Vokasional Vol 10, No 2 (2025): May
Publisher : Sekolah Vokasi Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkesvo.106084

Abstract

Background: Povidone iodine is widely used in wound healing, but it can cause irritation and cellular toxicity. Clitoria ternatea L. has the potential to contain compounds such as rutin, quercetin 3-O-rhamnoside, ternatin, and anthocyanins as natural alternatives in wound healing. In this study, the extract used contains anthocyanins.Objective: The study aimed to evaluate the effects of Clitoria ternatea L. extract cream on the expression of Interleukin-6, Epidermal Growth Factor, and re-epithelialization in Sprague Dawley rat incision wounds.Methods: An in-vivo study with a post-test only control design was conducted on five treatment groups, including a control group without wounds (healthy), povidone iodine, and Clitoria ternatea L. extract cream (5%, 10%, 15%). IL-6 and EGF were analyzed using immunohistochemistry, while re-epithelialization was assessed using hematoxylin-eosin staining.Results: Clitoria ternatea L. extract increased IL-6 and EGF expression, with the highest expression at a 10% concentration. Re-epithelialization was faster in the treatment groups compared to both the positive and negative controls.Conclusion: The 10% Clitoria ternatea L. extract cream demonstrated efficacy comparable to povidone iodine in incision wound healing.
Kreatif dan Inovatif Melalui Pelatihan Membuat Buket Snack Sebagai Alternatif Buah Tangan Bagi Santri Hukama, La Diadhan; Simon, Zainal Zawir; Juniarti, Juniarti; Zain, Efendi
Journal of Dedicators Community Vol 6, No 3 (2022)
Publisher : Universitas Islam Nahdlatul Ulama Jepara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34001/jdc.v6i3.3130

Abstract

The tradition of giving gifts is something that is common and common to individuals from various circles of society. Snack bouquets can be used as an alternative gift that can be given to others, such as when there is a grade increase or graduation celebration. Snack bouquet is a series of snacks (snacks) that are arranged, arranged, arranged like a bouquet of flowers. This activity aims to increase the capacity and skills of students through training in making snack bouquets for students at the Daarul Uluum I Islamic Boarding School in Bogor City. One of the alternative steps to increase the creativity and innovation of students, in this community service activity, uses the ABCD (Asset Based Community Development) approach. Meanwhile, in the practice of making a snack bouquet, the Peer Assisted Learning model is used. As a result of this community service activity, participants were able to make a snack bouquet. In addition, the participants were very enthusiastic about participating in the training from start to finish.
Nd Evaluation And Suitability of Land For Development of Sorghum (Sorghum bicholor L.) on Peat Land in West Sumatera, Indonesia Juniarti, Juniarti; N, Sandi.; A, Sari.; A , Agustar.; D.P, Sari.
Agrium Vol 22 No 2 (2025)
Publisher : Faculty of Agriculture, Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/agrium.v22i2.22811

Abstract

Sorghum is a perennial food crop that has great potential for development in Indonesia. The development of sorghum will increase land productivity, supporting the development of sustainable agriculture and enhancing Indonesian food production. The research findings establish sorghum as an ideal choice for enhancing the productivity of arid, acidic, or otherwise unproductive lands, including former mining areas reclaimed. Through the assessment of land characteristics suitable for sorghum development as biomass energy crop in West Sumatra, Indonesia, this research endeavors to facilitate the sustainable growth of sorghum cultivation within the region. This research aims to evaluate the suitability of land for sorghum in West Sumatra, Indonesia. Regency uses purposive sampling and survey methods. The results showed that peatland in West Sumatera, Indonesia has potential for the development of sorghum plants with average temperature characteristics 25-27 º C, rainfall <200 mm, air humidity <75%, good drainage, soil depth of peatland > 60 cm, pH 4.4 - 5.1 but low N, P and K nutrient availability. Key words: land evaluation, perennial crop, marginal land
Analysis Of Work Stress, Work Conflict And Organizational Commitment To Employee Performance At The Office Of The Baerah Revenue Agency (Bapenda) Of North Sumatra Province Lubis, Ira Handayani; Juniarti, Juniarti; Waruwu , Ahmad Aswan
Journal of Management, Economic, and Accounting Vol. 4 No. 2 (2025): Juli-Desember
Publisher : Universitas Dehasen Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37676/jmea.v4i2.841

Abstract

This study was conducted to determine the effect of work stress, work conflict, and organizational commitment on employee performance at the Regional Revenue Agency (Bapenda) of North Sumatra Province. The research approach used was quantitative with a descriptive quantitative research design involving numerical data and statistical analysis using SPSS Version 26. The study population consisted of all civil servants working at the Regional Revenue Agency (Bapenda) of North Sumatra Province, totaling 181 employees. The sampling technique employed was probability sampling using random sampling with the Slovin formula, with a margin of error of 10%, resulting in a sample size of 64 employees. The results of this study indicate that work stress has a positive and significant partial effect on employee performance with a tvalue > ttable (31.613 > 2.00030) and work conflict has a positive and significant partial effect on employee performance with a tvalue > ttable (19.004 > 2.00030), and organizational commitment has a positive and significant partial effect on employee performance with a tvalue > ttable (12.048 > 2.00030). Simultaneously, work stress, work conflict, and organizational commitment have a positive and significant effect on employee performance at the Regional Revenue Agency (Bapenda) of North Sumatra Province, with the calculated Fvalue > Ftable (1224.415 > 2.76). The results of this study indicate that H1 is accepted and H0 is rejected, both partially and simultaneously. The coefficient of determination obtained is 98.3%, with the remaining 1.7% explained by other independent variables not examined in this study.
The Influence Of Work Ability, Work Compensation, And Work Supervision On Employee Performance At PT. Pembangunan Prasarana Sumatera Utara Nadya, Dea; Wulandari, Niken; Juniarti, Juniarti
Jurnal Fokus Manajemen Vol 5 No 3 (2025): Agustus
Publisher : LPPJPHKI Universitas Dehasen Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37676/jfm.v5i3.9059

Abstract

This study ains to analyze how much influence work ability, work compensation, and work supervision have on employee performance at PT. Pembangunan Prasarana Sumatera Utara. Quantitative methods based on an associative approach were used in this investigation. All 55 workers of PT. Pembangunan Prasarana Sumatera Utara made up the population in this research. Multiple linear regression was utilized for data analysis, and saturation sampling was employed to choose the sample. It is evident from the estimated t value < t table (1.519 < 2.006) and a significant level of 0.135 > 0.05 that work ability does not impact performance, according to the findings of this research. According to the study's indicate that work compensation effects performance, this can be seen from the calculated t value> t table (5.321 < 2.006) and a significance level of 0.000 < 0.05, job remuneration does not effect performance. As the computed t value > t table (3.182 < 2.006) and a significant level of 0.002 < 0.05 show, the study's findings suggest that job supervision influences performance. Based on the estimated f value (54.637 > 2.78), a significant level of 0.000 < 0.05, and the fact that work ability, work compensation, and work supervision all impact employee performance at the same time, it is clear that these factors influence performance in this research.
How Osteoporosis Looks Like in CT Scan Images: An Alternative Osteoporosis Assessment Genisa, Maya; Abdullah, Johari Yap; MD Yusoff, Bazli Bin; Aryenti, Aryenti; Juniarti, Juniarti
Journal of Health and Nutrition Research Vol. 4 No. 2 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i2.393

Abstract

Osteoporosis is a silent degenerative disease that commonly affects the elderly, leading to decreased bone density and increased risk of fractures. Dual-Energy X-ray Absorptiometry (DEXA) is the standard tool for assessing Bone Mineral Density (BMD), but its limited availability and high cost in many healthcare facilities, especially in developing countries like Indonesia, necessitate alternative diagnostic methods. This study aims to assess the potential use of Computed Tomography (CT) scan images as a substitute for DEXA in detecting osteoporosis. The objective is to analyze bone texture attributes from CT images to differentiate between normal and osteoporotic bone structures. The method involved collecting CT scan data from patients at Hospital Universiti Sains Malaysia (HUSM). The vertebrae regions were segmented from the abdominal CT images using image processing techniques to isolate bone tissue. Four image-derived texture attributes—Roughness, Contrast, Greyscale, and Phase—were then extracted using MATLAB-based analysis. The results showed that osteoporotic bones had higher values in Roughness and Contrast, and lower values in Greyscale and Phase compared to normal bones. Among these, Roughness was identified as the most sensitive attribute in detecting changes associated with osteoporosis. These findings indicate that CT scan images, when analyzed through proper segmentation and texture evaluation, have the potential to serve as a viable alternative for osteoporosis screening, particularly in settings where DEXA is unavailable.
Financial Report Quality: The Role of Accrual-Based Government Accounting Standards and H.R. Competency Juniarti, Juniarti; Noersanti, Lina; Gladys, Asthya
Taxation and Public Finance Vol. 1 No. 1 (2023): DESEMBER 2023
Publisher : Santoso Academy Network

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58777/tpf.v1i1.157

Abstract

This study aims to analyze and obtain empirical evidence about the effect of accrual-based government accounting standards and human resource competencies on the quality of government financial reports. Respondents in this study were employees of the financial division of offices in DKI Jakarta. The financial employee research sample is 100 respondents. The analysis technique uses PLS-SEM with the SmartPLS 3.0 program. The results of this study indicate that the competence of human resources influences the application of P.P. No. 71 of 2010 based on accruals and the quality of financial reports. Meanwhile, the application of accrual-based government accounting standards has no effect on the quality of financial reports. The results of this research can be useful for the government as input and consideration in determining policies, especially related to improving the quality of local government financial reporting information and increasing human resource competence, as well as financial accountability.
Analisis Harga Pokok Produksi pada UMKM Ayam Geprek Hanania Kitchen Apandi, Aden; Noersanti, Lina; Juniarti, Juniarti
Jurnal Pendidikan Tambusai Vol. 8 No. 2 (2024)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai, Riau, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Penelitian ini bertujuan untuk menjelaskan perhitungan biaya produksi UMKM yang digunakan saat ini, menghitung serta menyediakan dasar perhitungan harga pokok produksi dengan metode full costing, serta membandingkan perhitungan metode UMKM saat ini dan metode full costing lalu menentukan metode yang tepat. Penelitian ini diharapkan dapat memberikan berbagai manfaat. Manfaat praktis dari penelitian ini adalah dapat digunakan UMKM untuk mengevaluasi hasil perhitungan harga pokok produksi sekaligus sebagai dasar dalam menentukan harga jual, mengefisiensi biaya, dapat bersaing di pasar dan menyusun strategi pemasaran. Penelitian ini bersifat deskriptif kualitatif, data yang digunakan berupa data primer berupa wawancara. Hasil penelitian ini menunjukkan bahwa UMKM Ayam Geprek Hanania Kitchen masih melakukan perhitungan yang sederhana tanpa mengelompokkan biaya-biaya terkait proses produksi.
Co-Authors . Reflinaldon A , Agustar. A M, Hendra A, Sari. Abdul Kahar Abdullah, Johari Yap Adrian Budiman Afdhal Muttaqin Afrima Sari Agil Syah Putra Agnes Andriyani Sentosa Agustian Agustian Akhmadi, Ali Alex Darmawan, Alex Almurni, Siti Amelinda Rosita Aminuyati Amrizal Saidi Anastasia Audina Candra Anastasya Debbie Aliantho Andi Sadapotto Angelina Evelyn Apandi, Aden Aries Novita Putri Aryenti, Aryenti Asdi Agustar Auzar Syarif Awang Al Hamdi Azhari, Rudi Azwar Rasyidin Bramanta, Giraldi Sapta Carolina Limantoro Caroline Janet Sukamto Christina Christina Christina Corolina Corolina Crystalita Crystalita Crystalita Damayanti, Ndaru Andri Devina Andriani Tandiono Devina Mustikarina Natanagara Dian Fiantis Doni Hariandi Dwita, Adel Karen DYAH PUSPITA SARI Dyah Puspita Sari Elisabeth Kartika Y.W Evelina Kurniawan Evelyn Stacia Evelyn Sutejo Evelyne Evelyne Evita Vianita Sari Fadil Hukama Hamdi Fajri, Riyadhul Fathan, Muhammad Fatma Andria Wahyuni Febriyani, Ellsa Indah Ferbiana Helena Ferdiansyah, Muhammad Aldy Ferry Aditya Fhigo, Lucky Fidelia Fidelia Fidelia Finda Yovita Finy Amelia Firdaus Hi Jahja Kunoli FITRI, RUHIL Florencia Irena Chandra Florensia Agatha Francisca Ivana Frans Sanjaya Fransisca Elsa Monica Frency Yunita Gabriela Natalia Lay Gladys, Asthya Gunadi Gunadi Gunadi Gunadi Gunadi Gunadi Gusnidar, G Hanani, Hulfiatun Hans William Santoso Harianti, Mimien Hasmiandy Hamid Hastin, Abiyyah Helena, Ferbiana Hendro, Junaidi Hermansah Hermansah, Hermansah Hermeria, Noveriza Hijri, Nurul Hikmawati Hikmawati Hukama, La Diadhan Ilham Wibowo Indra Dwipa Ineke Oktaviani Irfan Suliansyah Irwandi, Nurmayani Ivanovich, Vasenev Ivan Jannah, Anisa Raudhatul Jessica Kartika Halim Karina Novitasari Kathrin Angelin Hardy Khairati, Nurul Komalasari, Ulvi Intan Kurniati, Fimetha Riva Liana Dewi Lilyani Kartika Sinatra Lina Noersanti Lince, Lince Listiyani Chandra Lubis, Ira Handayani Lubis, Khadijah Margaret Carolina Maria Yunita Maya Genisa MD Yusoff, Bazli Bin Meisilva Erona Sitepu Monica Hendrik Monica Oktavia Musliar Kasim Mustika, Maya N, Sandi N, Sandi. Nabilah Nabilah Nadila Aulia Ardi Nadra, Nadra Nadya, Dea Nandita Samaralya Tori Nasution, Sarifa Ulfa Nathania Nathania Nelly Kawijaya Niken Wulandari Noferita, Jelsi Trisna Nofrita Sandi Novi Dwi Vivian Thejakusuma Novitasari, Karina Nunung Ainur Rahmah Nur Afni Nurfina Yenti Okianna Okianna Olgawati Hudoyo Ong Yuliana Pannya Pannya Pannya Pohan, Syahrial Hasanuddin Pratiwi, Nike Preztika Ayu Ardheta Puspa Sari, Puspa Ranti Novia Restu Syamsul Hadi Rika Kurniawati Risnah, Risnah Rizwan, Mohamad Rido Rosmilan Pulungan Ryan Budi Setiawan Sam Hermansyah Septaria, Vera Shinta Mulyana Simon Eric Hanjoyo Siska Effendi Siti Rahmah Stefany Sicilia Ahliawan Stephanie Loyanaputra Stephanie Natalie Tanzil Stephen Hadi Wibowo Sudewi Isminingsih Surya - Wibowo Sylvia Adriani T N, Novidra Thamrin, Nabila Pyrenina Tjamdinata, Wenny Vania Allan Sutanto Vera Septaria Veronica Wijaya Vincent Valentino Vivian Jacob Vonny Vinisia Wahyuni, Fatma Andria Waruwu , Ahmad Aswan Waruwu, Ahmad Aswan Wenny Tjamdinata Y Yuzirwan Yaherwandi Yuliana Yuliana Yulmira Yanti Yulnafatmawita Yulnafatmawita Yusuf Hartono Z, Naspendra Zain, Efendi Zainal Zawir Simon Zuldadan Naspendra