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All Journal Jurnal Ilmiah Farmasi JURNAL GIZI INDONESIA Syntax Literate: Jurnal Ilmiah Indonesia Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Window of Health : Jurnal Kesehatan Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Science Midwifery Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan) Jurnal Farmasi Jurnal Farmasi dan Sains Indonesia (JFSI) JOURNAL LA MEDIHEALTICO Indonesian Journal of Multidisciplinary Science Medical Sains : Jurnal Ilmiah Kefarmasian Praeparandi : Jurnal Farmasi dan Sains Jurnal Farmasi Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian
Siti Pandanwangi TW
Pharmacy Study Program, STF YPIB Cirebon, West Java, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Science Midwifery

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The role of honey, curcuma, and black cumin supplements in overcoming stunting on the adaptive immune system Sabarudin, Cecep; Hasimun, Patonah; Kusriani, Herni; Zuniarto, Ahmad Azrul; Pandanwangi, Siti; Fatmawati, Eva; Afief, Arief R.; Sodik, Jajang Japar
Science Midwifery Vol 13 No 5 (2025): Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i5.2185

Abstract

Stunting is strongly associated with impaired immune function, as chronically malnourished children tend to have weaker immunity and are more vulnerable to infection. This study aimed to examine the effect of temulawak–black cumin herbal honey on the adaptive immune system in stunted children. A quasi-experimental one-group pre-test and post-test design was used. The findings showed that the intervention significantly increased height-for-age (TB/U) in the treatment group compared to the control group (p = 0.014). Weight-for-age (BB/U) also rose significantly within the treatment group (p = 0.013), but no significant difference was found relative to the control group (p = 0.192). The supplement significantly elevated IgM levels in the treatment group (p = 0.001), though again without a significant difference from the control (p = 0.546). CD4 concentration decreased in the treatment group (p = 0.003), but the change was not significantly different from the control (p = 0.682). In conclusion, temulawak–black cumin herbal honey can improve nutritional status and enhance adaptive immunity by increasing IgM levels, although it does not raise CD4 levels and instead slows CD4 decline. However, its effectiveness in increasing IgM and CD4 concentrations compared to controls is not significant.
The role of honey, curcuma, and black cumin supplements in overcoming stunting on the adaptive immune system Sabarudin, Cecep; Hasimun, Patonah; Kusriani, Herni; Zuniarto, Ahmad Azrul; Pandanwangi, Siti; Fatmawati, Eva; Afief, Arief R.; Sodik, Jajang Japar
Science Midwifery Vol 13 No 5 (2025): December: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i5.2185

Abstract

Stunting is strongly associated with impaired immune function, as chronically malnourished children tend to have weaker immunity and are more vulnerable to infection. This study aimed to examine the effect of temulawak–black cumin herbal honey on the adaptive immune system in stunted children. A quasi-experimental one-group pre-test and post-test design was used. The findings showed that the intervention significantly increased height-for-age (TB/U) in the treatment group compared to the control group (p = 0.014). Weight-for-age (BB/U) also rose significantly within the treatment group (p = 0.013), but no significant difference was found relative to the control group (p = 0.192). The supplement significantly elevated IgM levels in the treatment group (p = 0.001), though again without a significant difference from the control (p = 0.546). CD4 concentration decreased in the treatment group (p = 0.003), but the change was not significantly different from the control (p = 0.682). In conclusion, temulawak–black cumin herbal honey can improve nutritional status and enhance adaptive immunity by increasing IgM levels, although it does not raise CD4 levels and instead slows CD4 decline. However, its effectiveness in increasing IgM and CD4 concentrations compared to controls is not significant.
Co-Authors , stf1 ., Amirudin Afief, Arief R. Akrom, Akrom Aldhi Bayu Ali, Taufik Amirudin . Andriswana, Dwi Meiria Anjastika, Luky Septiansyah Anna Pradiningsih Aribowo Aribowo ARIS ARIS, ARIS ASEP SUPARMAN Ayuditiawati, Meita Azrul Zuniarto, Ahmad Bachtiar, Arsyad Deni Firmansyah Dewi, Komala Diana Agustina Didi Rohadi Dzulhijjah, Hawa Eka Putri Wulandari, Eka Putri Farhan Alfawwaz, Azriel Fatmawati, Eva Fauzia, Rizki Rahmah Febriawan, Toyyib Viat Fitri Zakiah Haerunnisa, Tita HARYATI, ETI Hasimun, Patonah Husni Mubarok IIN INDAWATI Indah Setyaningsih Joharudin, Ade Karphiawati, Aldilla Shalsa Karsidin, Bambang KRISNAWWATI, IKE Lela Sulastri, Lela Lestar, Puri Mardhiyyah, Cut Ainul Meiria A, Dwi Meriska, Caroline Merita Kristianti Minhatul Maula, Ajni Mundzir, O. Ahmad Nabila, Esra Reinanda Nafi'ah, Rahma Nafilah, Nella noviani, Adis Nuari, Ris Ayu Nur Rahmi Hidayati, Nur Rahmi Nurhasanah, Sarah Nurkhasanah Nurkhasanah Nurkhasanah NURPATMAWATI, NURPATMAWATI Nurrahma Berlian, Febia Oktaviani, Dian Regar, Dhea Novakinanda Rizki Rahmah Fauzia Rubihatlan, Encis Sabarudin, Cecep Salafi, Akil Septiansyah, Luky Setriyadi, Dedy Sodik, Jajang Japar Sri Virgianti, Deby Subagja, Subagja Sugiharto, Anto Suharmono, Soni Sulistiorini Indriaty Sunandi, Retno Tresno Sundari, Retno T Sundari, Retno Tresno Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati Tsai, Mei Ling Utami, Amanda Dwi Wahyuni, Yenny Sri Widianingsih, Nining Wiguna, Taufik Marta Zakiah, Fitri Zanki, Alfriani Melia Zuniarto, Ahmad Azrul