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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya JOURNAL OF HEALTH SCIENCE (JURNAL ILMU KESEHATAN) Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Hearty : Jurnal Kesehatan Masyarakat Journal of Midwifery and Nursing Health and Medical Journal UMI Medical Journal PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Kedokteran Mulawarman MAHESA : Malahayati Health Student Journal Jurnal Ilmiah Kesehatan (JIKA) Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) International Journal of Health Science & Medical Research International Journal of Health Science and Technology Innovative: Journal Of Social Science Research Malahayati International Journal of Nursing and Health Science
Harahap, Muhammad Wirawan
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Risk factors for surgical site infection (ssi) in post-appendectomy patients at Massenrempulu Hospital, Enrekang Regency, 2023 Fahruddin, Annisa; Gani, Azis Beru; Harahap, Muhammad Wirawan; Purnamasari, Reeny; Mangarengi, Yusriani
Journal of Midwifery and Nursing Vol. 7 No. 3 (2025): September: Health Science
Publisher : Institute Of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/jmn.v7i3.6618

Abstract

Surgical Site Infection (SSI) is a major healthcare-associated infection that significantly increases morbidity, mortality, and healthcare costs. This study aims to analyze the risk factors for SSI in post-appendectomy patients at Massenrempulu Hospital, Enrekang Regency, using a cross-sectional method with secondary data from patient medical records. A total of 41 patients met the inclusion criteria. The results indicate that SSI was more prevalent in females (65.9%) compared to males (34.1%), with the highest incidence occurring in the 17-25 age group (34.1%). In terms of nutritional status, most SSI cases were observed in patients with abnormal BMI, including underweight (22%), overweight (29.3%), and obesity (7.3%). Additionally, 92.7% of patients had no comorbidities, while a small percentage had hypertension (4.9%) or fatty liver disease (2.4%). Surgical duration was also a critical factor, as most SSI cases (92.7%) were associated with moderate-duration surgeries (60-120 minutes), while only 7.3% occurred in short-duration surgeries (<60 minutes). These findings highlight the importance of monitoring SSI risk factors, particularly among younger patients, females, and those with abnormal nutritional status. The study emphasizes the need for improved infection control strategies, proper nutritional management, and enhanced postoperative care to minimize SSI occurrence. Future research should consider primary data collection and additional variables to further explore risk factors. Additionally, healthcare facilities should enhance infrastructure and transition from manual to electronic medical records to improve patient management and reduce infection rates.
Potential of Soursop Leaf Extract (Annona Muricata L.) as an Antimicrobial Against Staphylococcus epidermidis Fauziy, Aqil; Waspodo, Nurelly N.; Irwan, Andi Alamanda; Sodiqah, Yani; Karina, Dhian; Harahap, Muhammad Wirawan
International Journal of Health Science and Technology Vol. 7 No. 1 (2025): Juli
Publisher : Universitas 'Aisyiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31101/ijhst.v7i1.3966

Abstract

Staphylococcus epidermidis is an opportunistic bacterium that can cause infections, particularly in individuals with weakened immune systems. The increasing resistance to antibiotics has encouraged the use of medicinal plants such as soursop leaves (Annona muricata L.), which contain antibacterial compounds. This study aims to evaluate the antibacterial effectiveness of soursop leaf extract against the growth of Staphylococcus epidermidis at concentrations of 50%, 75%, and 100%. The study specifically investigated the inhibition zones formed at each concentration (50%, 75%, and 100%) of Annona muricata L. extract against Staphylococcus epidermidis, and compared the antibacterial activity across these three concentrations. This research used a laboratory experimental design with the Kirby-Bauer disc diffusion method to assess the antibacterial activity. The extract was prepared using 96% ethanol and tested at the concentrations stated. Gentamicin 10 μg was used as a positive control, while sterile distilled water served as the negative control. The inhibition zones were observed after 24 hours of incubation at 37°C. The results showed that soursop leaf extract at 50% and 75% concentrations produced inhibition zones categorized as resistant. At 100% concentration, the inhibition zone ranges from resistant to intermediate. The comparison across all three concentrations indicates that the 100% concentration demonstrated notable antimicrobial activity against Staphylococcus epidermidis.
Characteristics of Hypertension Patients at Lanto Dg Pasewang Jeneponto Regional General Hospital 2022-2023 Saputra, Muh Farhan; Royani, Ida; Hamzah, Pratiwi Nasir; Harahap, Muhammad Wirawan; Tahir, Akina Maulidhany
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i3.1718

Abstract

Background: Cardiovascular diseases, including hypertension (blood pressure >/140/90 mmHg), contribute to heart and vascular damage. Risk factors include non-modifiable factors (age, gender, family history) and modifiable factors (smoking, behavior, alcohol). Objective: This study aimed to identify the characteristics and risk factors of hypertensive patients at RSUD Lanto DG Pasewang Jeneponto. Methods: A descriptive study using secondary data from medical records of hypertensive patients at RSUD Lanto DG Pasewang Jeneponto was conducted in September 2024. Data were analyzed descriptively by age, gender, hypertension grade, body mass index (BMI), and comorbidities. Results: A total of 93 patients were included. Most patients were aged 61–70 years (31.2%), followed by 51–60 years (26.9%). Females (59.1%) were more affected than males (40.9%). The majority (92.5%) had grade 2 hypertension. Based on BMI, 63.4% were normal, 21.5% overweight, and the rest underweight, obese, or grade 2 obese. Comorbidities included heart disease (76.3%), diabetes (14%), and kidney failure (9.7%). Conclusion: Most hypertensive patients at RSUD Lanto DG Pasewang Jeneponto were aged 60–70 years, female, had normal nutritional status, grade 2 hypertension, and a history of heart disease.
PERAN POLA MAKAN DAN AKTIVITAS FISIK DALAM PENGENDALIAN DIABETES MELITUS TIPE 2 DI PUSKESMAS BARA BARAYA MAKASSAR Subhan, Waode Aqilla Putri Pratama; Harahap, Muhammad Wirawan; Masdipa, Andi; Kanang, Indah Lestari Daeng; Karim, Abdul Mubdi Ardiansar Arifuddin
Jurnal Kedokteran Mulawarman Vol 12, No 2 (2025): Jurnal Kedokteran Mulawarman
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v12i2.20091

Abstract

Diabetes mellitus tipe 2 (DM Tipe 2) semakin meningkat secara global, termasuk di Indonesia. Pola makan dan aktivitas fisik yang buruk berperan dalam pengembangan dan pengelolaan DM Tipe 2. Penelitian ini bertujuan untuk mengetahui hubungan antara pola makan dan aktivitas fisik dalam pengendalian DM Tipe 2 di Puskesmas Bara Baraya Makassar. Metode penelitian ini menggunakan teknik observasional dengan desain cross-sectional dilakukan pada 36 pasien diabetes tipe 2. Data dikumpulkan melalui kuesioner pola makan (FFQ), aktivitas fisik (IPAQ), dan pengukuran kadar glukosa darah puasa serta HbA1c. Analisis bivariat dilakukan dengan uji Chi-square menggunakan SPSS. Hasil analisis menunjukkan hubungan signifikan antara pola makan dengan indeks glikemik sedang dan tinggi terhadap kadar gula darah puasa dan HbA1c (p-value
FAKTOR – FAKTOR YANG MEMENGARUHI KEJADIAN POST-OPERATIVE DELIRIUM (POD) PADA PASIEN YANG MENJALANI OPERASI DENGAN GENERAL ANESTHESIA Dewanty, Ashita Mary; Sommeng, Faisal; Karim, Abdul Mubdi Ardiansar Arifuddin; Dwimartyono, Fendy; Harahap, Muhammad Wirawan
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 2 (2024): AGUSTUS 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i2.31957

Abstract

Post-operative delirium (POD) adalah kondisi yang ditandai dengan perubahan status mental, kognisi, perhatian, dan peningkatan stres. Terbagi dalam berbagai subtipe motorik, seperti hiperaktif, hipoaktif, campuran. POD tergantung pada demografi pasien, status, dan jenis operasi. Delirium dapat disebabkan oleh peningkatan faktor risiko seperti infeksi, pneumonia, dan kerusakan organ. POD dapat menyebabkan peningkatan tingkat morbiditas dan mortalitas. Faktor yang berkontribusi pada POD termasuk gangguan kognitif, gangguan fungsional, komorbiditas, penggunaan alkohol, dan kondisi kesehatan. Delirium dapat berkembang pada pasien sehat setelah operasi, tetapi juga bisa berkembang pada orang tua. Keparahan delirium tergantung pada jenis operasi, kondisi pasien, dan jenis operasi yang dilakukan. POD merupakan kondisi serius yang membutuhkan manajemen dan evaluasi yang baik. Tujuan penelitian ini untuk mengetahui Faktor-faktor yang memengaruhi kejadian Post-operative Delirium (POD) pada pasien yang menjalani operasi dengan General Anasthesia. Metode penelitian observasional analitik dengan pendekatan cross sectional, sampel penelitian ini sebanyak 47 subjek. Didapatkan jumlah responden yang menderita POD sebanyak 12 orang (25,5%) dan yang tidak menderita POD sebanyak 35 orang (74,5%). Pada uji Multiple Logistic Regression nilai R2, ketamin merupakan variabel yang paling signifikan berhubungan dengan outcome, dengan nilai OR=15,5% menunjukkan bahwa subjek dengan ketamin mempunyai efek perlindungan 15,5% kali terhadap kejadian POD dibandingkan dengan subjek yang tidak menggunakan ketamin.  Faktor yang berpengaruh terhadap kejadian POD adalah agen anastesi ketamin, yang mempunyai dampak protektif terhadap POD.
Faktor Risiko Kejadian Preeklampsia-Eklampsia Bakri, Sri Intan Akmal; Fujiko, Masita; Harahap, Muhammad Wirawan
Innovative: Journal Of Social Science Research Vol. 4 No. 6 (2024): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v4i6.15663

Abstract

Hypertension in pregnancy is a broad term that includes groups of chronic hypertension, gestational hypertension, preeclampsia and eclampsia. Preeclampsia can be found in pregnancies >20 weeks with increased blood pressure and proteinuria. Eclampsia is preeclampsia with seizures (generalized tonic-clonic or focal) without other causes. The method applied is Literature Review with Narrative Review design including an in-depth study exploring the influence of maternal age, parity, history of hypertension, and obesity on the incidence of preeclampsia-eclampsia. The results of the analysis showed that age factors, both young and old, parity, together with a history of hypertension, and obesity significantly increase the risk of preeclampsia-eclampsia.
Analysis of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Dengue-Infected Patients Sari, Nurul Adha; Julyani, Sri; Harahap, Muhammad Wirawan; Bima, Irmayanti Haidir; Karim, Abdul Mubdi Ardiansar Arifuddin
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 2 (2025): Volume 7 Nomor 2 Agustus 2025
Publisher : Sarana Ilmu Indonesia (salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i2.1375

Abstract

Dengue infection, caused by the dengue virus and transmitted by Aedes mosquitoes, remains a significant public health issue in Indonesia. The ability to identify reliable biomarkers for assessing disease severity is critical for improving clinical management. This study aimed to evaluate the relationship between the Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) as potential biomarkers of severity in dengue infection. An observational cross-sectional design was employed, analyzing 76 dengue cases at RSAU dr. Dody Sardjoto. Data were collected from medical records of patients during the critical fever period (days 4-7). The majority of patients were male and adult, with a higher incidence of Dengue Hemorrhagic Fever (DHF). Statistical analysis showed no significant correlation between NLR and PLR with disease severity (p-value >0,05), although a positive correlation between NLR and PLR was observed. However, neither NLR nor PLR effectively predicted hospitalization duration. These results suggest that while NLR and PLR reflect immune responses in dengue infection, they are not suitable biomarkers for assessing disease severity. Further research is needed to identify more reliable biomarkers for better management of dengue infection.
Risk factors influencing caesarean wound infection (CWI) Putri, Yolanda Salsabila Dwi; Juhamran, Reeny Purnamasari; Rambulangi, Ronaldo August; Mappaware, Nasrudin Andi; Harahap, Muhammad Wirawan
Malahayati International Journal of Nursing and Health Science Vol. 8 No. 9 (2025): Volume 8 Number 9
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v8i9.1342

Abstract

Background: Cesarean section (CS) is a delivery method that continues to increase and carries a risk of complications, one of which is surgical wound infection (SWI). SWI can hinder healing and increase morbidity. Risk factors for infection include preoperative, intraoperative, and postoperative conditions, necessitating analysis to prevent postoperative complications. Purpose: To identify risk factors for surgical site infection in Cesarean section procedures and to determine the association between nutritional status, hemoglobin levels, and wound care with the occurrence of surgical site infection. Method: This study is an observational analytical study using a cross-sectional approach conducted at RSIA Sitti Khadijah 1 Muhammadiyah Makassar from March to June 2025. Data were analyzed using univariate and bivariate analysis with the Chi-square test at a significance level of p < 0.05. Results: There was a significant association between several risk factors and the occurrence of postoperative wound infections following Cesarean section. Based on bivariate analysis, nutritional status, hemoglobin (Hb) levels, wound care, and type of cesarean section procedure were found to influence the occurrence of postoperative wound infections. However, although the duration of surgery showed a statistical association, the data obtained were not varied, so a definitive conclusion regarding the relationship between surgery duration and postoperative wound infections after cesarean section could not be drawn. Conclusion: Nutritional status, hemoglobin levels, wound care, and type of cesarean section are factors associated with the occurrence of postoperative wound infections after cesarean section. These findings highlight the importance of attention to maternal nutritional status, hemoglobin levels, wound care standards, and the selection of Cesarean section type in efforts to prevent postoperative infections. A comprehensive evaluation of these factors is necessary to minimize the risk of complications and improve patient safety.
EFFECT OF EPIDURAL AND GENERAL ANESTHESIA ON PERIOPERATIVE NEUTROPHIL LYMPHOCYTE RATIO CHANGES IN MASTECTOMY PATIENTS Damayanti, Fina; Harahap, Muhammad Wirawan; Karim, Abdul Mubdi Ardiansar Arifuddin; Sommeng, Faisal; Swarga, Tirta
International Journal of Health Science & Medical Research Vol 5, No 1 (2026): February 2026
Publisher : UNG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/ijhsmr.v5i1.36603

Abstract

Mastectomy induces a systemic inflammatory response that may be influenced by the anesthetic technique, as reflected by changes in the neutrophil–lymphocyte ratio (NLR). Unlike previous studies that assessed mixed breast surgeries, broadly evaluated regional anesthesia, or focused on combined general–epidural techniques and cytokine markers, this study uniquely compares perioperative pre–post changes in NLR (ΔNLR) between epidural anesthesia alone and general anesthesia alone in mastectomy patients using a routinely available biomarker. This quantitative experimental study was conducted at Ibnu Sina YW-UMI Hospital, Makassar, from August 2025, involving 30 mastectomy patients recruited consecutively and allocated into two independent groups (15 epidural, 15 general anesthesia). Venous blood samples were collected preoperatively and 24 hours postoperatively to calculate NLR, with ΔNLR as the primary outcome. Within-group analysis using the Wilcoxon test showed significant postoperative increases in NLR in both the epidural group (5.13 ± 5.42 to 7.65 ± 5.99; p0.001) and the general anesthesia group (4.12 ± 4.59 to 14.72 ± 8.43; p0.001). Between-group comparison using the Mann–Whitney test demonstrated that ΔNLR was significantly higher in the general anesthesia group (10.60 ± 7.23) than in the epidural group (2.52 ± 2.36; p0.001). These findings indicate that epidural anesthesia is associated with a smaller postoperative increase in NLR, suggesting better attenuation of the systemic inflammatory response after mastectomy. Further randomized studies with larger samples, additional inflammatory biomarkers, and clinical outcomes are recommended to enhance evidence strength and generalisability.
Gambaran Penggunaan Antibiotik pada Kasus Sepsis di Ruang Intensive Care Unit (ICU) Rumah Sakit Ibnu Sina YW-UMI Makassar Butang, Dwiputri Djaya; Irwan, Andi Alamanda; Pramono, Sigit Dwi; Sommeng, Faisal; Harahap, Muhammad Wirawan
Health and Medical Journal Vol. 8 No. 1 (2026): HEME January 2026
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v8i1.1838

Abstract

Latar Belakang: Sepsis adalah masalah kesehatan global yang signifikan, terutama di unit perawatan intensif (ICU), dengan tingkat morbiditas dan mortalitas yang tinggi. Pengobatan sepsis yang tepat waktu sangat penting, tetapi penggunaan antibiotik yang tidak tepat dapat menyebabkan resistensi. Tujuan: Penelitian ini bertujuan untuk mengetahui gambaran penggunaan antibiotik pada pasien sepsis di ICU Rumah Sakit Ibnu Sina YW-UMI Makassar, dengan fokus pada karakteristik pasien, organ yang bermasalah, penyakit penyerta, hasil kultur, dan jenis yang resisten dan resisten terhadap antibiotik. Metode: Penelitian ini menggunakan desain deskriptif retrospektif dengan pengambilan data dari rekam medis pasien sepsis di ICU Rumah Sakit Ibnu Sina YW-UMI Makassar selama periode Januari-Mei 2024. Subjek penelitian adalah pasien sepsis yang telah diberikan terapi antibiotik dan memiliki hasil kultur. Data dikumpulkan kemudian diolah untuk menarik kesimpulan tentang pola penggunaan antibiotik. Hasil: Dari 32 rekam medis, 13 pasien memenuhi kriteria inklusi. Mayoritas pasien adalah laki-laki (77%) dan berusia di atas 55 tahun (38%). Disfungsi organ gastrointestinal ditemukan pada 46% pasien, dan diabetes melitus adalah kondisi komorbiditas yang paling umum (31%). Hasil kultur menunjukkan Salmonella typhii (38%) sebagai patogen utama. Antibiotik yang paling resisten adalah amikasin, levofloksasin, ofloksasin, dan tetrasiklin (masing-masing 10%), sedangkan sefiksim (24%) dan ampisilin (16%) menunjukkan resistensi yang tinggi. Kesimpulan: Penelitian ini menunjukkan bahwa sepsis di ICU Rumah Sakit Ibnu Sina YW-UMI Makassar didominasi oleh pasien laki-laki dengan gangguan fungsi organ pencernaan. Resistensi antibiotik merupakan masalah yang serius, terutama untuk sefiksim dan ampisilin. Peningkatan praktik pengumpulan kultur bakteri dan pemantauan resistensi diperlukan untuk memastikan terapi yang lebih efektif dan mengurangi mortalitas sepsis.
Co-Authors Abdi, Dian Amelia Adinda Putri, Tasya Aisyah, Windy N. Alifya, Kafka Mutiara Amir, Suliati Amir, Suliati P Arifuddin Karim, Abdul Mubdi Ardiansar Arifuddin, Andi Tenri Sanna Aulia, Aulia Bahri, Miranda Ashari Bakri, Sri Intan Akmal Bamahry, Aryanti R Bima, Irmayanti Haidir Butang, Dwiputri Djaya Dahliah, Dahliah Damayanti, Fina Darussalam, Andi Husni Esa Daud, Nur Ramahdani Dewanty, Ashita Mary Dewi, Anna Sari Dwi Pratiwi Efendy, Annisa Al Adawiyah Fahruddin, Annisa Fauziy, Aqil Fendy Dwimartyono Fujiko, Masita Gani, Azis Beru Ghassani Rivai, Andi Fauzan Hamsah, M. Hamzah, Pratiwi Nasir Handayani, Dewi Sri Hasbi, Berry Erida Ida Royani Irmayanti Irmayanti, Irmayanti Irna, Ade Irwan, Andi Alamanda Jafar, Muh. Alfian Jaya, Gede Indra Juhamran, Reeny Purnamasari Kanang, Indah Lestari Daeng Karim, Abdul Mubdi Ardiansar Arifuddin Karina, Dhian Lantara, Andi Millaty Halifah Dirgahayu Maarif, Ahmad Safei Makmun, Armanto Mangarengi, Yusriani Mappaware, Nasruddin Andi Mappaware, Nasrudin Andi Masdipa, Andi Mokhtar, Shulhana Mulyadi, Farah Ekawati Nizam, Alyah Nasywa Alzena Nur, Muh Jabal Nurelly Noro Waspodo, Nurelly Noro Nurmadilla, Nesyana Nurulaisyah, Windy Pakaya, Nickyta S Pramono, Sigit Dwi Prema Hapsari Purnamasari, Reeny Putri, Andi Nur Afifah Maharani Putri, Rista Awanda Putri, Yolanda Salsabila Dwi Rambulangi, Ronaldo August Rasfayanah, Rasfayanah Safitri, Asrini Salsabila, Andi Hafidzah Qurani Saputra, Muh Farhan Sari, Nurul Adha Sodiqah, Yani Sommeng, Faisal Sri Irmandha K Sri Julyani Sri Vitayani Subhan, Waode Aqilla Putri Pratama Susilo, Wawan Swarga, Tirta Tahir, Akina Maulidhany Waskito, Farah Nadhilla Ramadhani Waspodo, Nurelly N. Yasya, Ghina Saniyyah Putri