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All Journal International Journal of Public Health Science (IJPHS) Jurnal Gizi dan Pangan Saintek Perikanan : Indonesian Journal of Fisheries Science and Technology JURNAL GIZI INDONESIA Journal of Nutrition College Jurnal Kesehatan Masyarakat Journal of Biomedicine and Translational Research Indonesian Journal of Human Nutrition agriTECH Mutiara Medika: Jurnal Kedokteran dan Kesehatan Jurnal Media Gizi Indonesia (MGI) Warta IHP (Warta Industri Hasil Pertanian) Medical Laboratory Technology Journal GIZI INDONESIA Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Syntax Literate: Jurnal Ilmiah Indonesia Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology AcTion: Aceh Nutrition Journal Jurnal Gizi Klinik Indonesia Indonesian Food Science and TechnologyJournal Jurnal Aplikasi Teknologi Pangan Amerta Nutrition Canrea Journal: Food Technology, Nutritions, and Culinary Journal Journal of Telenursing (JOTING) Jurnal Aisyah : Jurnal Ilmu Kesehatan Indonesian Journal of Global Health research Journal SAGO Gizi dan Kesehatan Berita Kedokteran Masyarakat Poltekita: Jurnal Ilmu Kesehatan JSSF : Journal of Sport Science and Fitness Jurnal Medika Indonesia
Anjani, Gemala
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Sorghum Tempeh Enteral Formula Reduces Inflammatory (IL-6) and Thrombotic (PAI-1) Markers in Atherogenic Diet-Induced Rats Bintang, Francisca Natalia; Resti, Nina; Lestari, Endang Sri; Muniroh, Muflihatul; Anjani, Gemala; Syauqy, Ahmad; Djamiatun, Kis; Afifah, Diana Nur
Media Gizi Indonesia Vol. 21 No. 2 (2026): MEDIA GIZI INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v21i2.185-195

Abstract

Atherosclerosis is predominantly an inflammatory process that is the key pathophysiological cause of ischemic coronary heart disease (CHD). Some studies suggest that sorghum can reduce atherosclerotic parameters through many biological activities, such as antioxidant, anti-inflammation, and anti-thrombotic properties. The primary objective was to evaluate the effect of an enteral sorghum tempeh formula on the levels of Plasminogen Activator Inhibitor-1 (PAI-1) and Interleukin-6 (IL-6) in an atherosclerotic rat model. A total of 24 male rats were utilized, with the experiment structured into an 8-week atherogenic diet induction period, followed by a 4-week intervention phase. The rats were divided into four groups: a healthy control, an atherogenic control, and two treatment groups supplemented with the formula at 0.75g/200 g and 1.50g/200 g body weight (BW), respectively. IL-6 and PAI-1 levels were quantified using Enzyme-Linked Immunosorbent Assay (ELISA). The atherogenic diet successfully induced a significant elevation in both IL-6 and PAI-1 levels compared to the healthy control group (p=0.000), indicating a heightened inflammatory and thrombotic state in the atherosclerotic group. Conversely, the groups receiving the sorghum tempeh-based formula exhibited a significant reduction in both IL-6 and PAI-1 levels compared to the atherogenic control group (p=0.000), suggesting potent anti-inflammatory and antithrombotic properties of the sorghum tempeh.
LITERATUR REVIEW : HUBUNGAN RIWAYAT PENYAKIT INFEKSI ISPA DAN DIARE DENGAN KEJADIAN UNDERWEIGHT PADA USIA 0-23 BULAN DI INDONESIA Aliyah, Any Rovikotul; Anjani, Gemala; Syauqi, Ahmad
Journal of Nutrition College Vol 15, No 2 (2026): April
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jnc.v15i2.49357

Abstract

ABSTRACTBackground: The prevalence of underweight in children aged 0-23 months in Indonesia has increased from 16.3% to 17% based on data from the 2021 Indonesian Nutritional Status Study (SSGI). Underweight is a nutritional problem identified using the BB/U indicator (comparing the child's relative weight to age). The direct cause of underweight is infectious diseases (ARI, diarrhea, measles, pulmonary TB)Objective: To determine the relationship between infectious diseases and the occurrence of underweight in children aged 0-23 months in Indonesia.Method: The research method used in this study is a literature review. This research was conducted by collecting and analyzing data from written sources such as scientific journals, books, articles, and other documents related to the research topic.Results: This literature review study shows that several infectious diseases that often occur in toddlers such as ARI and diarrhea, result in underweight if not handled quickly and appropriately. Factors that influence the occurrence of ARI and diarrhea are the availability of drinking water sources, types of feces disposal and waste disposal that do not meet requirements and are far from being adequate or dirty.Conclusion: The results of the entire literature review indicate that there is a relationship between a history of ARI and diarrhea and the incidence of underweight in toddlers aged 0-23 months. Toddlers aged 0-23 months are more likely to be underweight than children who do not have a history of infectious diseases in the last three months.Keywords: infectious diseases, underweight, toddlers ABSTRAKLatar belakang: Prevalensi underweight pada usia 0 – 23 bulan di Indonesia mengalami peningkatan dari 16,3% menjadi 17% berdasarkan dari data Studi Status Gizi Indonesia (SSGI) tahun 2021. Underweight merupakan permasalahan gizi yang diidentifikasi dengan menggunakan indikator BB/U (membandingkan berat badan relatif anak terhadap usia). Penyebab langsung underweight yaitu penyakit infeksi (ISPA, diare, campak, TB paru). Tujuan: Mengetahui hubungan penyakit infeksi dengan adanya kejadian underweight pada anak usia 0-23 bulan di Indonesia.  Metode: Metode penelitian yang digunakan dalam penelitian ini adalah berupa tinjauan literature review. Penelitian ini dilakukan dengan cara mengumpulkan dan menganalisis data dari sumber-sumber tertulis seperti jurnal ilmiah, buku, artikel, dan dokumen lainnya yang terkait dengan topik penelitian.  Penelitian ini merupakan literature review yang dilakukan melalui pencarian artikel pada basis data PubMed, Google Scholar, dan ScienceDirect. Artikel yang digunakan dipilih menggunakan kriteria inklusi tahun penelitian 2020-2025, populasi anak usia 0-23 bulan di Indonesia dan memiliki variabel infeksi berupa ISPA dan diare, serta status gizi underweight. Sebanyak 11 artikel memenuhi kriteria dan dianalisis secara tematik untuk mendapatkan kesimpulan yang relevan.Hasil: Penelitian literatur review ini menunjukkan bahwa beberapa penyakit infeksi yang sering terjadi pada balita seperti ISPA dan diare, mengakibatkan underweight jika tidak cepat dan tepat cara menanganinya. Faktor yang berpengaruh terjadinya ISPA dan diare yaitu ketersediaan sumber air minum, jenis tempat pembuangan tinja dan pembuangan sampah tidak memenuhi syarat dan jauh dari kata layak ataupun kotor.Simpulan; Penelitian menunjukkan adanya hubungan antara riwayat penyakit ISPA dan diare terhadap kejadian underweight pada balita usia 0-23 bulan. Balita usia 0-23 bulan memiliki kemungkinan lebih besar mengalami underweight dibandingkan anak yang tidak mempunyai riwayat penyakit infeksi dalam kurun waktu tiga bulan terakhir.Kata kunci: Penyakit infeksi; underweight; balita
Co-Authors Abyyudha, Dany Adriyan Pramono Agustina, Ayu Widiawati ahmad syauqi, ahmad Ahmad Syauqy Ahmad Syauqy Ahmad Syauqy Ahmad Zulfa Juniarto Al-Baari, Ahmad Ni’matullah Aleda Florince Oyay Aliyah, Any Rovikotul Amin Husni Anang M Legowo Anggray Duvita W Anggriany, Nissa Ani Margawati Ariani Ariani Ayu Rahadiyanti Ayu, Azzahra Mutiara Ayustaningwarno , Fitriyono Binar Panunggal Bintang, Francisca Natalia Christanto, Monica Lemuela Denny Nugroho Sugianto Deny Yudi Fitranti Dewi Marfu'ah Kurniawati Diana Nur Afifah Diana Nur Afifah, Diana Nur Dwi Ratna Sari Edarni Zebua Edward Kurnia Setiawan Limijadi Edward Kurnia Setiawan Limijadi, Edward Kurnia Setiawan Ekowati Chasanah Endang Mahati Endang Mahati Endang Mahati Endang Sri Lestari Endang Sri Lestari Endang Yuli Purwani, Endang Yuli Enny Probosari Etika Ratna Noer Faizah Fulyani Fatih Az Zahra Fitriyono Ayustaningwarno Fulyani, Faizah Furkaniaty, Annisa Galuh Dwi Astuti Gunawan, Sekar Ayu Putri Hardhono Susanto Hartanti Sandi Wijayanti Hastuti, Vivilia Niken Hunaefi, Dase Indrastati, Nandia Indriyanti, Risa Ivena Claresta Jaeri, Santoso Jalasena, Rizka Akbar Jaswir, Irwandi Juwita, Riza Iska Kis Djamiatun Kusmiyati Tjahjono Kusmiyati Tjahjono Lili Nor Indah Sari Lubis, Syahrani Aulia MADE ASTAWAN Mambaya, Helvi Desi Maria Mexitalia Masruroh, Zulfatul Maulana, Reza Achmad Miftahul Adnan Millah, Shoffyyatul Mira Dian Naufalina Mohammad Sulchan Mohammad Zen Rahfiludin Muchlis Achsan Udji Sofro Muchlis Achsan. Udji Sufro Mumpuni, Ocka Febrian Muniroh, Muflihatul Nafisah Nafisah Nafisah Nani Maharani Nani Maharani Nareswara, Anastu Regita Ninik Rustanti Ninik Rustanti Ninik Rustanti Nur Afifah, Diana Nur Faizah Nurdin, Nurhanifah Muthmainnah Nurhidayati, Lisa Rosyida Nurmasari Widyastuti Nuryanto Nuryanto Pramesti, Yuli Prasetyo, Dwi Yanuar Budi Pristina Adi Rachmawati Putri, Sylvia Rahmi Putut Har Riyadi Rachma Purwanti Rafika, Muhana Rahayu, Gita Riski Rahmawati, Irma Sarita Rahmawati, Siti Irma Randenia, Nabila Ratna Ratna Rena Budiyatri Resti, Nina Retnaningsih Retnaningsih Rimadhani Ulfa Rohmatul Ummah Rusyanto, Widya S Fatimah Muis Septiani Septiani Setyawati, Amalia Rani Shauma, Claradhita Ayu Sherlin Regina Jami Siti Fatimah Muis Siti Fatimah Muis Siti Fatimah-Muis Siti Fatimah-Muis Sofro, Muchlis AU Sumardi Widodo Suwito, Maria Rebecca Sylvia Rahmi Putri Tasya Safira Meliasari Teddy Wahyu Nugroho, Teddy Wahyu Tiffany Nisa Arviyani Tri Winarni Agustini Triyanto, Bagaskara Putra Untari Utama, Affini Nurratri Utami, Wahyu Widyasari Velicia, Velicia Welresna Juliatri Putri Rupiasa Widya, Fiona Christina Zhu, Fan Zulfa, Fairuz