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Review Article : Potensi Senyawa Antioksidan Pada Tanaman Herbal Terhadap Formulasi Sediaan Kosmetik Dan Nanokosmetik Sebagai Upaya Anti-Aging Kulit Ciptaningrum, Sekar Rahmasari Ratna; Adjeng, Andi Nafisah Tendri; Oktoba, Zulpakor; Nurmasuri, Nurmasuri; Widodo, Alya Rahmah; Athallah, Muhammad Muzhafar
Sains Medisina Vol 2 No 5 (2024): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/snsmed.v2i5.405

Abstract

ABSTRAK. Kulit merupakan bagian terluar dalam tubuh dan bersifat memproteksi bagian tubuh bagian dalam. Apabila tidak dilakukan perawatan dengan baik, maka akan memicu terjadinya penuaan atau aging dan menyebabkan perubahan struktur kulit. Untuk mencegah hal tersebut, maka diperlukan sediaan yang mengandung antioksidan sebagai penangkal radikal bebas. Sediaan kosmetik maupun nanokosmetik dengan bahan aktif dari tanaman herbal telah banyak diformulasikan karena selain ramah lingkungan juga lebih aman karena minim timbulnya efek samping. Namun, pada sediaan kosmetik berbahan alam dengan teknologi nanopartikel masih sedikit yang mengembangkannya, sehingga diperlukannya studi literatur lebih lanjut agar dapat menjadi sumber acuan untuk pengembangan sediaan kosmetik maupun nanopartikel berbahan tanaman herbal. Metode dalam memperoleh sumber data studi literatur ini bersumber pada Google Scholar dan Science Direct dengan rentang tahun 2016-2024. Didapatkan hasil yaitu sebanyak total 27 jurnal mengenai formulasi sediaan kosmetik juga nanokosmetik sebagai antioksidan, dengan total tanaman sebanyak 22 tanaman ekstrak dan diperoleh dari berbagai bagian tanaman (kulit, kayu, buah, bunga, biji, rimpang, minyak atsiri, dan daun) serta dijadikan sediaan kosmetik yang juga bervariasi (gel, krim, spray, serum, lotion, dan masker peel of).
Literature Review: Faktor-Faktor Penyebab Kejadian Rehospitalisasi Pada Pasien Congestive Heart Failure (CHF) Kylalona, Gracylia; Suri, Nurma; Aulia Ramdini, Dwi; Sukohar, Asep
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1039

Abstract

Congestive Heart Failure (CHF) is a health disorder with a poor prognosis due to functional or structural heart defects that interfere with ventricular filling or blood ejection into the systemic circulation. CHF remains a significant global health concern with high rates of morbidity and mortality. The number of diagnosed CHF leading to frequent rehospitalization or re-admission due to symptom recurrence. Patients who experience readmitted to the hospital after initial admission have a risk of mortality, with about 50% dying within 6 months and 25-35% passing away within 12. In this review focuses on exploring the factors contributing to rehospitalization among CHF patients. The methodolgy involved analyzing electronic database for relevant studies published over the past decade. Factors identified as leading to rehospitalization in CHF patients include a history of hypertension, non-compliance with taking medication, and an unhealthy lifestyle. Pharmacists play an important role in providing education to patients and helping to fulfill patient medication compliance.
Profil Penggunaan Antibiotik Pada Pasien Infeksi Saluran Pernapasan Akut (ISPA) Balita di Beberapa Pelayanan Kesehatan Salsabilla, Kharisma; Nurmasuri, Nurmasuri; Wardhana, Muhammad Fitra
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1082

Abstract

Acute Respiratory Infection (ARI) is a disease caused by the transmission of pathogens that infect the respiratory tract and result in disruption of normal respiratory activities in individuals. The cause of ARI itself can come from a viral or bacterial infection. Therapy for ARI caused by bacteria can use antibiotics. Giving antibiotics for ARI depends on the bacteria causing it. The principles of using antibiotic therapy are empirical therapy and definitive therapy. This literature study aims to determine the percentage of antibiotic use and the choice of antibiotics most frequently given to ARI patients. This research uses a literature review method with a search for articles using Google Scholar, Science Direct and Pubmed published in 2018-2024. Journals are collected using journal websites from searches using relevant keywords. After that, they are assessed regarding eligibility according to relevant researchers' criteria and a relevant review is carried out. The results of the review show that the use of antibiotics as ARI therapy often occurs, the use of antibiotics being the most frequently used in ARI such as amoxicillin and cephalosporin which have the same function and effectiveness. Antibiotics for clinical symptoms should be given based on clear indications, antibiotic administration should be based on the results of microbiological examination. This literature review can be used to evaluate the appropriateness of using antibiotics as an effort to prevent resistance.
Review Artikel: Aktivitas Farmakologi Daun Alpukat (Persea americana Mill.) Rahmadhita, Elmira; Iqbal, Muhammad; Oktoba, Zulpakor; Nurmasuri, Nurmasuri; Triyandi, Ramadhan
Medula Vol 14 No 7 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i7.1174

Abstract

Indonesia possesses abundant natural resources, including the abundant fish, which are considered an alternative to modern diets. Fish, particularly alpaca, have high economic value and potential for local consumption. Alpaca is rich in protein, selenium, minerals, and anti-inflammatory properties that can help maintain health and prevent kidney damage.Alpukat (Persea america Mill.) is a rich, commercially valuable, and potentially beneficial food source for local consumption. Research has shown that alpaca can help prevent kidney damage by providing essential nutrients like potassium, magnesium, vitamin E, flavonoid, saponin, alkaloid, steroid, vitamin E, mineral, natrium, tanin, alkaloida, quersetin, polifenol, asam lemak tidak jenuh, zat filantik, and kalium. Alpukat also contains flavonoid and quersetin, which help prevent cholesterol accumulation and reduce the risk of lipid oxidation. Flavonoid and quersetin also help prevent glucosa absorption and oxidative stress, which can lead to cancer and other health issues. Alpukat also contains potassium with diuretic effects, which can be used for treating ginkgo biloba, kencing biloba, tinggi, and sakit kepala. Diuretik, a substance that increases urine volume and excretion of waste, can help prevent kidney damage. In conclusion, Indonesia has a rich and diverse food supply, including various types of fish, which have significant economic and health benefits.
GAMBARAN PENERAPAN PELAYANAN KEFARMASIAN DI APOTEK DI KOTA BANDAR LAMPUNG: THE IMPLEMENTATION OF PHARMACEUTICAL SERVICES STANDARD IN PHARMACIES IN BANDAR LAMPUNG MUNICIPALITY suri, Nurma; Zakiah Oktarlina, Rasmi; Aulia Ramdini, Dwi; Prabamukti, Ilyas; Antika Sintia, Nova
JFL : Jurnal Farmasi Lampung Vol. 13 No. 1 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i1.1356

Abstract

Peraturan Menteri Kesehatan Republik Indonesia No. 73 Tahun 2016 merupakan tolak ukur dalam menyelenggarakan pelayanan kefarmasian. Penelitian ini bertujuan untuk mendapatkan gambaran terkait penerapan standar pelayanan kefarmasian di apotek yang ada di Kota Bandar Lampung. Studi merupakan penelitian survei menggunakan kuesioner dengan metode deskriptif kuantitatif. Sampel ditentukan dengan teknik stratified random sampling. Jumlah minimum sampel dihitung berdasarkan rumus slovin dengan kelonggaran ketidaktelitian karena kesalahan pengambilan sampel yang ditolerir sebesar 0,1. Hasil penelitian memperoleh sebanyak 124 sampel dari 124 apotek di 20 Kecamatan di Kota Bandar Lampung yang memenuhi kriteria inklusi dan eksklusi. Analisis memperlihatkan 25% apotek dimiliki oleh apoteker. Golongan obat yang banyak dibeli oleh pelanggan adalah analgesik 32,06%, antipiretik 22,14% dan antibiotik 16,79%. Pelaksanaan penerapan standar pelayanan kefarmasian apotek setiap komponen mencapai lebih dari 70%, kecuali untuk sub-komponen home care (56,5%), monitoring efek samping obat (46%), medication record (47,6%) dan penilaian kepuasan pelanggan (58,1%). Kesimpulan dari penelitian ini adalah sebagian besar penerapan standar pelayanan kefarmasiaan di Apotek di Kota Bandar Lampung baik tetapi pelaksanaan pelayanan didominasi oleh tenaga non-apoteker.
POTENSI TANAMAN HERBAL SEBAGAI STIMULAN SISTEM SARAF PUSAT: LITERATURE REVIEW ARTICLE Suri, Nurma; Oktoba, Zulpakor; Yulianti, Mega Intan
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.960

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Energy drinks are consumed as supplement to increase energy and reduce fatigue. Herbal medicine has proven reduce fatigue in the body. This literature review aims to determine the types of herbal medicine that have properties as stimulants. This study used descriptive methode using the Population-Intervention-Controling-Outcome Framework. A literature search on studies published in the period 2012-2022 on the Google Scholar and Pub-Med using the keywords: stimulant, central nervous system, tonic, and herbal. Articles that cannot be accessed in full and herbal medicine that are not original from Indonesia will be excluded as samples. There were 1937 articles obtained based on the keywords used, a total of 91 articles met the inclusion criteria and 60 articles were excluded. Based on 30 articles reviewed, there are 31 types of herbal medicines that can increase stimulants with the most family is zingiberaceae and piperaceae. The combination of plant has a better stimulant effect than using the single plants. In vivo test method with the swimming endurance test as the most widely used. Flavonoid, alkaloid and terpenoid compounds are most likely to be effective as stimulants which have the same mechanism with caffeine through inhibition of Adenosine A1 receptors. This study shows there are 31 herbal medicine that have the potential to increase stimulants. Secondary metabolites which stimulant effects are flavonoids, alkaloids and terpenoids
POTENSI INTERAKSI OBAT PADA PASIEN SKIZOFRENIA Suri, Nurma; Salsabila, Lyansaputri; Adjeng, Andi Nafisah Tendri; Oktafany, Oktafany
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1165

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In the treatment of schizophrenia, antipsychotics as the main therapy are generally combined with additional therapy. Combination therapy has a risk of drug interactions. The aim of the study was to describe the potential factors that influence drug interactions. The study was conducted using observational quantitative analytic methods with a retrospective cross-sectional approach. The sample was selected by total sampling method in the medical records of inpatients at the Lampung Mental Hospital from January-December 2022. The Lexicomp software was used to identify potential drug interactions. In the 265 samples, 344 treatment profiles were obtained with a total of 1349 drugs used. Then, 1786 potential drug interactions were classified as level of risk A (0%), B (0.8%), C (80.2%), D (19%), and X (0%). There was a significant relationship between gender, length of stay, and number of drugs (p<0.05) on potential drug interaction level D (major). Multivariate analysis showed the number of drugs had the strongest relationship (p=0.000 OR=8.233) to potential drug interactions. There was a significant relationship between gender, length of stay, and number of drugs with potential drug interactions level D. The number of drugs had the strongest with potential drug interactions.
Gambaran Penyakit Komorbid dan Pola Terapi pada Pasien Skizofrenia Suri, Nurma; Salsabila, Lyansaputri
Jurnal Pharmascience Vol 11, No 2 (2024): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i2.19835

Abstract

Di Indonesia, skizofrenia merupakan penyakit gangguan mental ketiga terbanyak setelah depresi dan gangguan cemas. Penelitian ini bertujuan untuk memperoleh gambaran penyakit komorbid dan pola terapi pada pasien skizofrenia yang dirawat inap di RSJ Daerah Provinsi Lampung. Metode penelitian dilakukan secara crosssectional. Pengambilan data dilakukan secara retrospective dengan menggunakan data rekam medis pasien yang memperoleh rawat inap selama tahun 2022. Sampel penelitian dipilih dengan metode total sampling. Data yang diperoleh dianalisa secara deskriptif, ditampilkan dalam bentuk tabel dan diagram. Hasil yang diperoleh ada 281 sampel dengan karakteritik 77,9% laki-laki, 77,6% berada pada rentang usia produktif (18-45 tahun), 94,66% didiagnosa skizofrenia paranoid, rerata obat yang diperoleh pasien selama rawat inap 4-5 jenis obat dan 61,6% pasien didiagnosa penyakit komorbid. Risperidone adalah jenis antipiskotik tipikal terbanyak yang digunakan secara tunggal (5,69%) dan penggunaan 2 kombinasi terbanyak yaitu risperidone-chlorpromazine (62,63%) dan risperidone-haloperidol (8,19%). Tifoid (44,07%), leukositosis (16,95%) serta penggunaan zat psikoaktif/alkohol (6,78%) menjadi tiga penyakit komorbid yang paling banyak diderita pasien skizofrenia. Kesimpulan yang diperoleh dari penelitian adalah 66% pasien memiliki diagnosa komorbid dengan infeksi dan penggunaan zat psikoaktif sebagai komorbid utama dan memperoleh terapi polifarmasi (penggunaan 4-5 jenis obat) yaitu kombinasi 2 antipsikotik dan terapi adjuvant. Kata Kunci: Infeksi, Skizofrenia, Penyakit Komorbid, Polifarmasi, Rawat Inap In Indonesia, schizophrenia represents the third most prevalent mental health condition, following depression and anxiety disorders. The objective of this study is to identify the prevalence of comorbid diseases and the patterns of therapeutic intervention among inpatients with schizophrenia at the Mental Health Hospital of Lampung Province. The research method employed a cross-sectional study utilising medical record data from patients who were hospitalised during 2022. The sample was selected using total sampling. The data were subjected to descriptive analysis. The study yielded a total of 281 samples, with the majority (77.9%) comprising male and belonging to the productive age range (18-45 years), 77.6%. The majority (94.66%) of the subjects were diagnosed with paranoid schizophrenia. The average number of drugs received by patients was 4-5 types of drugs. Additionally, 61.6% of patients were diagnosed with comorbid. The most commonly prescribed typical antipsychotic was risperidone, which was used in monotherapy (5.69%) and in two combinations: risperidone-chlorpromazine (62.63%) and risperidone-haloperidol (8.19%). The comorbid diseases most commonly suffered are typhoid (44.07%), leukocytosis (16.95%), and the use of psychoactive substances (6.78%). The findings of the study indicated that patients with schizophrenia 66% patient had comorbidity, with the primary comorbidity an infection and received polypharmacy therapy.
A Comprehensive Evaluation of Antibiotic Usage: Establishing a Foundation for Effective Antimicrobial Stewardship Suri, Nurma; Junando, Mirza; Afriyana, Regi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.298-311

Abstract

Background: The intensive care unit (ICU) is a significant area of antibiotic use, accounting for a substantial proportion of the overall antibiotic consumption. The inappropriate use of antibiotics in such settings has a notable impact on the emergence of antimicrobial resistance. Objective: This study evaluated the rationality of antibiotic use in the ICU of RSUD Abdul Moeloek Hospital in Lampung Province. Methods: This study was conducted between December 2022 and February 2023 using a prospective method and purposive sampling. An evaluation was conducted using the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) system for quantitative analysis and Gyssens criteria for qualitative assessment. The research subjects comprised 55 individuals, the majority of whom were male (58.2%), aged > 65 years (29.1%), remained in the ICU for less than seven days (78.2%), and subsequently continued their treatment in a non-ICU (69.1%). Results: Quantitative analysis demonstrated that the total number of antibiotics administered in this study was 394.83 DDD, with a DDD/100 patient-day value of 113.78. Ceftriaxone was the most frequently prescribed antibiotic (219 DDD), whereas gentamicin was the least frequently prescribed (1 DDD). Qualitative analysis revealed that 17.6% of the patients exhibited irrational antibiotic use. Conclusion: Irrational use of antibiotics was observed in the following categories: IV A (1.1%); IV D (2.2%); III A (2.2%); III B (2.2%) IIA, (3.3%); IIB (5.5%); and I (1.1%). The study concluded that there was still a considerable degree of irrational antibiotic use.
KAJIAN LITERATUR : FAKTOR – FAKTOR YANG MEMENGARUHI KETERSEDIAAN OBAT DI PUSKESMAS Diva Meylia; Rasmi Zakiah Oktarlina; Nurma Suri; Asep Sukohar
Medic Nutricia : Jurnal Ilmu Kesehatan Vol. 14 No. 2 (2025): Medic Nutricia : Jurnal Ilmu Kesehatan
Publisher : Cahaya Ilmu Bangsa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5455/nutricia.v14i2.11860

Abstract

Ketersediaan obat di Puskesmas merupakan aspek krusial dalam pelayanan kesehatan. Kajian literatur ini bertujuan untuk mengidentifikasi faktor-faktor yang memengaruhi ketersediaan obat di Puskesmas. Metode yang digunakan adalah kajian literatur dengan pencarian artikel menggunakan database Google dan Google Scholar. Kriteria inklusi meliputi artikel yang dipublikasikan tahun 2012-2025 berbahasa Inggris atau Indonesia dan tersedia dalam bentuk full paper yang dapat diakses dengan mudah. Hasil kajian dari 10 artikel yang dianalisis menunjukkan bahwa ketersediaan obat di Puskesmas dipengaruhi oleh beberapa faktor utama yakni metode perencanaan yang tepat, efisiensi sistem pengelolaan, sistem dan prosedur yang terstandarisasi, monitoring tingkat ketersediaan, peran aktif pengelola obat dan dokter, kualitas pendampingan dan supervisi, interaksi antar pemangku kepentingan serta kualitas pelayanan. Disimpulkan bahwa ketersediaan obat dipengaruhi oleh berbagai faktor yang saling terkait dan membutuhkan perbaikan simultan pada semua aspek. Sehingga optimalisasi ketersediaan obat dapat tercapai.
Co-Authors Abda Abda Afriyana, Regi Afriyani, Afriyani Al Rasyid, Muhammad Irfan Ambarwati, Endah Andrifianie, Femmy Antika Sintia, Nova Asep Sukohar Asep Sukohar Asti, Windi Athallah, Muhammad Muzhafar Atri Sri Ulandari Aufa Nurrohmah, Anna Aulia Ramdini, Dwi Axcellia Theresa Ayu SWP, Fadillah Cathartica, Allamanda Cheri F. A. Dera Chintia Dwi Tanasa Ciptaningrum, Sekar Rahmasari Ratna Citra Yuliyanda Pardilawati Damayanti, Ervina Dedy Miswar Devvy Wahyu Mulyaningsih Diva Meylia Dwi Melani Dwi, Farah Faliha, Raisati Hikmah Farhana, Lubna Farras Qanitah Rony Febriana, Triana Ihsanti Dwi Rahayu Junando, Mirza Kirana, Shela Sandra Kylalona, Gracylia Lilik Koernia Wahidah Mallarangeng, Andi Nafisah Tendri Adjeng Mega Intan Yulianti Meiliana, Made Laksmi Mirza Junando Muhammad Fitra Wardhana Sayoeti Muhammad Iqbal Muhammad Maulana Nawawi, As’ari Niken Dwi Astarina Oktafany Oktafany Oktafany Oktafany, Oktafany Oktarlina, Resmi Zakiah Oktoba, Zulpakor Pardilawati, Citra Yuliyanda Pius Ave Rafael Silalahi Prabamukti, Ilyas Primadiamanti, Annisa Putri, Oka Mahila Gustia Rahmadhita, Elmira Rahman, M. Bobby Ramadhina, Farrasyifa Ramdini, Dwi Aulia Rasmi Zakiah Oktarlina Ratih Anggun Komalasari Risanti, Yumna Dwi Rizki Nisfi Ramdhini Rony, Farras Qanitah Roviq Umam S Sabrina, Dewi Salsabila, Lyansaputri Salsabilla, Kharisma Saputri, Gusti Ayu Rai Sarnianto, Prih Suryadi Islami Syahputri, Devina Harti Tiara Aninditha Triyandi, Ramadhan Vanadis, Zifa Aisha Wardhana, Muhammad Fitra Widodo, Alya Rahmah Widodo, Subur Wirasutisna, Komar Ruslan Yati Sumiyati, Yati Yuli Wahyu Tri Mulyani Yulianti, Mega Intan