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EFFECT OF Zanthoxylum acanthopodium DC EXTRACT ON THE INCREASE OF BRAIN CELLS IN THE SUBSTANTIA NIGRA OF WISTAR RATS THAT ARE ROTENONE-INDUCED hafizha, Shalli; Halim, Binarwan; Chiuman, Linda
International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Vol 6 No 3 (2024)
Publisher : The Islamic Education and Multiculturalism Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47006/ijierm.v6i3.413

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder due to the decline of dopaminergic neurons in the substantia nigra, with motor and non-motor symptoms. Oxidative stress, inflammation, and mitochondrial damage play a role in its pathogenesis. andaliman fruit (Zanthoxylum acanthopodium DC), rich in alkaloids and flavonoids, has potential as an antioxidant with neuroprotective effects. The purpose of the study was to determine the effect of andaliman fruit extract (Zanthoxylum acanthopodium DC) on the increase of brain cells in the substantia nigra of rotenone-induced Wistar rats as a Parkinson's model. This research uses an experimental quantitative study with a post-test control group design. Data were analyzed using One Way ANOVA with a significance level of p < 0.05. The results showed that 70% ethanol extract of andaliman fruit (Zanthoxylum acanthopodium DC) can reduce the number of necrosis cells in the brain. On the 29th day, the average number of necrosis cells in each group was 0.4±0.54 (K-), 4.8±0.83 (K+), 4.4±1.14 (P1), 3.4±0.54 (P2), and 1.2±0.44 (P3). The administration of extracts at doses of 150 mg/kgBB, 300 mg/kgBB, and 450 mg/kgBB can increase the regeneration of brain cells that experience necrosis. Histopathological observations showed that 70% ethanol extract of andaliman fruit improved the histological structure of brain cells in the substantia nigra area.
HUBUNGAN KONSUMSI KOPI DENGAN PENYAKIT GASTROESOPHAGEAL REFLUX DISEASE PADA MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS PRIMA INDONESIA Dhillon, Neha Amar; Rusip, Gusbakti; Chiuman, Linda
Jurnal Kesehatan Tambusai Vol. 5 No. 3 (2024): SEPTEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i3.32740

Abstract

Gastroesophageal reflux disease (GERD) adalah penyakit yang sering diderita di kalangan masyarakat. GERD dijelaskan sebagai naiknya asam lambung ke esofagus atau kerongkongan sehingga menyebabkan regurgitasi makanan ke esofagus. Proporsi untuk GERD pada orang dewasa sekitar 13%, Asia Selatan dan Eropa Tenggara memiliki prevalensi GERD paling banyak sekitar 25%. Prevalensi GERD di Indoensia terus mengalami peningkatan sebanayak 22,8% di Jakarta. Penyakit GERD didefinisikan oleh gejala-gejala utama seperti regurgitasi oleh cairan dan heartburn yang mengulang. GERD bisa menjadi masalah yang berat jika tidak ditangani. Banyak faktor yang dapat memicu GERD, diantara lain yaitu konsumsi makanan rendah gizi dan tinggi lemak pada mahasiswa, olahraga yang tidak memadai, sehingga berat badan naik. Salah satu faktor lainnya yang dapat menyebabkan GERD pada mahasiswa adalah konsumsi kopi yang berlebihan. Di kalangan mahasiswa, kopi sangat digemari. Mahasiswa kedokteran sering mengonsumsi kopi untuk meningkatkan produktivitas saat belajar dan kopi banyak dikonsumsi pada masa ujian. Tujuan penelitian ini untuk mengetahui hubungan konsumsi kopi dengan penyakit gastroesophageal reflux disease pada Mahasiswa Fakultas Kedokteran Universitas Prima Indonesia. Studi ini menggunakan teknik Purposive Sampling dengan sampel sebanyak 32 orang di Fakultas Kedokteran Universitas Prima Indonesia dan dianalisis dengan uji Chi-Square. Didapatkan hasil uji Fisher’s exact test pada 32 subjek adalah p = 0,032 (p<0,05) yang dapat disimpulkan terdapat perubahan yang signifikan antara konsumsi kopi dan penderita GERD pada Mahasiswa Fakultas Kedokteran Universitas Prima Indonesia.
Factors Associated With Transmission Of Nosocomial Infectious Diseases From Patients To Nurses At Rsu Royal Prima Medan Halim, Michael; Ginting, Chrismis Novalinda; Chiuman, Linda
An-Nadaa: Jurnal Kesehatan Masyarakat (e-Journal) Vol 11, No 2 (2024): AN-NADAA JURNAL KESEHATAN MASYARAKAT (DESEMBER)
Publisher : Universitas Islam Kalimantan Muhammad Arsyad Al Banjari Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/ann.v11i2.14154

Abstract

Nosocomial infection is an infection acquired in the hospital for at least 72 hours, and the patient does not show symptoms of infection when admitted to the hospital. Nosocomial infections can have an impact on patients and their families which results in loss of sources of income, danger, disability, death, additional treatment periods, increased expenses for the hospital and can result in a lowered image of the hospital. The purpose of this study was to analyze the factors associated with the transmission of nosocomial infectious diseases from patients to nurses at RSU Royal Prima Medan. The type of research used is quantitative research with a cross sectional approach. The sample in this study were 200 nurses. Data analysis used univariate, bivariate and multivariate analysis. The results showed that partially there was a relationship between knowledge, attitudes, facilities, and cleanliness towards the transmission of nosocomial infectious diseases from patients to nurses at RSU Royal Prima Medan. Simultaneously or jointly the independent variables in this study are related to the transmission of nosocomial infectious diseases from patients to nurses at RSU Royal Prima Medan. The variable that is most related to the transmission of nosocomial infectious diseases from patients to nurses at RSU Royal Prima Medan is the attitude variable
Pengaruh pemberian ekstrak daun belimbing wuluh (averrhoa bilimbi l.) Terhadap histopatologi dan fungsi ginjal Tikus model hiperurisemia Utomo, Wilbert Waldo; Ginting, Chrismis Novalina; Chiuman, Linda; Tambunan, Andika Zayani; Amir, Widya Pasca
An-Nadaa: Jurnal Kesehatan Masyarakat (e-Journal) Vol 11, No 2 (2024): AN-NADAA JURNAL KESEHATAN MASYARAKAT (DESEMBER)
Publisher : Universitas Islam Kalimantan Muhammad Arsyad Al Banjari Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/ann.v11i2.15505

Abstract

Penggunaan tanaman obat untuk penyembuhan suatu penyakit didasarkan pada pengalaman yang secara turun -temurun diwariskan dari generasi ke generasi. Hiperurisemia merupakan keadaan dimana terjadinya peningkatan kadar uric acid/ asam urat serum di atas normal, seseorang dikatakan mengalami hiperurisemia bila kadar asam urat dalam darah melebihi kadar asam urat normal, hiperurisemia menjadi permasalahan seluruh lapisan masyarakat baik di Indonesia maupun di seluruh dunia. Beberapa penelitian menyatakan bahwa daun belimbing wuluh memiliki aktivitas antidiabetes, antihiperkolesterolemia, antihipertensi, antimikroba, menurunkan demam, dan nyeri sendi, pada penelitian sebelumnya, ekstrak daun belimbing wuluh diketahui memiliki aktivitas antihiperurisemia. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pemberian ekstrak daun belimbing wuluh (Averrhoa bilimbi L.) terhadap gambaran histopatologi dan fungsi ginjal tikus model hiperurisemia. Jenis penelitin ini merupakan penelitian eksperimen dengan menggunakan pre and post test control group design. Sampel penelitian ini menggunkan hewan uji tikus galur wistar dengan jumlah sampel sebanyak 25 ekor tikus yang dibagi kedalam 5 kelompok dengan kelompok 1 sebagai kontrol negatif tanpa perlakuan, kelompok 2 diberikan alopurinol, kelompok 3 diberikan ekstrak daun belimbing wuluh dengan dosis 100 mg, kelompok 4 diberikan ekstrak daun belimbing wuluh dengan dosis 500 mg dan kelompok 5 diberikan ekstrak daun belimbing wuluh dengan dosis 800 mg. Hasil penlitian menunjukkan pada ekstrak daun belimbing wuluh (Averrhoa bilimbi L.) positif mengandung senyawa alkaloid, steroid, terpenoid, saponin dan flavonoid. Pemberian ekstrak daun belimbing wuluh (Averrhoa Bilimbi L.) efektif terhadap fungsi ginjal tikus model hiperurisemia dimana terdapat penurunan pada kadar kreatin setelah pemberian ekstrak daun belimbing wuluh (Averrhoa Bilimbi L.) p-value < 0,05. Pemberian ekstrak daun belimbing wuluh (Averrhoa bilimbi L.) berpengaruh dalam memperbaiki kerusakan glumerolus ginjal tikus model Hiperurisemia. Dosis ekstrak daun belimbing wuluh (Averrhoa bilimbi L.) yang paling efektif terhadap fungsi ginjal tikus model hiperurisemia adalah dosis 800 mg/KgBB/Hari
Pengaruh pemberian ekstrak daun belimbing wuluh (averrhoa bilimbi l.) Terhadap histopatologi dan fungsi hati tikus model hiperurisemia Ginting, Chrismis Novalinda; gan, claris cyntha deninta; Chiuman, Linda
An-Nadaa: Jurnal Kesehatan Masyarakat (e-Journal) Vol 11, No 2 (2024): AN-NADAA JURNAL KESEHATAN MASYARAKAT (DESEMBER)
Publisher : Universitas Islam Kalimantan Muhammad Arsyad Al Banjari Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/ann.v11i2.15211

Abstract

Tanaman belimbing wuluh dapat dimanfaatkan dalam kehidupan sehari-hari. Bagian yang digunakan diantaranya bunga, buah, daun, dan batangnya. Daun belimbing wuluh mengandung senyawa flavonoid, fenol, alkaloid, tanin, dan kumarin, ekstrak daun belimbing wuluh diketahui memiliki aktivitas antihiperurisemia. Tujuan dari penelitian ini adalah mengetahui pengaruh pemberian ekstrak daun belimbing wuluh (Averrhoa bilimbi L.) terhadap histopatologi, fungsi hati dan hematologi tikus model hiperurisemia. Jenis penelitin ini merupakan penelitian eksperimen dengan menggunakan pre and post test control group design. Sampel penelitian ini menggunkan hewan uji tikus galur wistar. Analisis data dalam penelitian ini menggunakan metode One Way Anova. Dilanjutkan dengan uji Post Hoc Tukey HSD untuk melihat perbedaan antar konsentrasi. Hasil penelitian menunjukkan pada ekstrak daun belimbing wuluh (Averrhoa bilimbi L.) positif mengandung senyawa flavonoid, tanin, terpenoid dan saponin. Terdapat pengaruh pemberian ekstrak daun belimbing wuluh (Averrhoa bilimbi L.) terhadap gambaran histopatologi hati tikus model hiperurisemia dimana terdapat perbaikan pada bagian hati yang rusak pada tikus model hiperurisemia. Terdapat pengaruh pemberian ekstrak daun belimbing wuluh (Averrhoa bilimbi L.) terhadap fungsi hati tikus model hiperurisemia dimana terdapat penurunan nilai SGOT dan SGPT setelah pemberian ekstrak daun belimbing wuluh (Averrhoa bilimbi L.) p-value < 0,05. Dosis ekstrak daun belimbing wuluh (Averrhoa bilimbi L.) yang paling efektif terhadap fungsi hati tikus model hiperurisemia adalah dosis Dosis 800 mg.
Effectiveness of Durian Fruit Seed Extract (Durio Zibethinus) on Kidney Function and Histopathology of Rats Induced by Wistar Streptozotocin Virgoh, Livia; Suyono, Tan; Chiuman, Linda; Nurlaela, Lia; Kosasih, Michaela; lister , Clarissa
International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Vol 6 No 3 (2024)
Publisher : The Islamic Education and Multiculturalism Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47006/ijierm.v6i3.430

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to impaired insulin secretion or action. Diabetic nephropathy, a microvascular complication of type 2 DM, causes damage to kidney function due to progressive hyperglycemia. This study analyzed the potential of durian seed extract in reducing blood sugar levels (KGD) and improving kidney function and histopathological features in streptozotocin (STZ)-induced Wistar rats. Rats were divided into six groups: normal, positive control (STZ + metformin), negative control (STZ), and three treatment groups with durian seed extract doses of 150, 300, and 450 mg/kgBB. The extract was given for 14 days, followed by examination of kidney function and histopathology. The results showed that a dose of 450 mg/kgBB was most effective in reducing KGD, equivalent to metformin, which could improve kidney function and histopathology. Durian seed extract 450 mg/kgBB has the potential as an effective antidiabetic in reducing kidney damage.
In-Vitro Antioxidant Activity of Eggplant (Epicarp Solanum Melongena L) Skin Extract on Aflatoxin-B1-Induced Rats Chintya Darma, Gladys; Ginting, Chrismis Novalinda; Chiuman, Linda; Yuliansyah, Jeri; Hasya, Muhammad Nawal
International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Vol 7 No 1 (2025)
Publisher : The Islamic Education and Multiculturalism Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47006/ijierm.v7i1.439

Abstract

Eggplant skin is the outer part of the eggplant fruit (Solanum Melongena L) which has therapeutic activities such as anti-inflammatory, anti-oxidant, anti-viral, anti-bacterial and anti-cancer. This study aims to evaluate the antioxidant potential of ethanol extract of eggplant skin through phytochemical analysis, antioxidant activity through ABTS and DPPH examination by assessing IC50, and its effect on oxidative stress-related enzymes in aflatoxin B1 (AFB1)-induced rats such as MDA, LPO-4HNE, and evaluating SOD levels in rat serum. The results showed that ethanol extract of eggplant peel has significant antioxidant activity in radical scavenging activity. The antioxidant activity of ethanol extract of eggplant skin in ABTS and DPPH methods showed IC50 values with strong antioxidant potential. In the In-Vivo test, aubergine skin ethanol extract showed a good protective effect against oxidative stress with decreased MDA and LPO-4HNE levels, and increased SOD activity in AFB1-induced rats. The optimal dose of aubergine skin ethanol extract in this study is the treatment with a dose of 600mg/kgBB, which gives the best results in reducing MDA and LPO-4HNE levels, and increasing SOD activity close to the neutral group.
Description of Hematological Parameters and Severity Levels of COVID-19 Patients and Disease Progression at Royal Prima Hospital, Medan, North Sumatera, Indonesia Azah, Yunita Wannur; Novalinda Ginting, Chrismis; Chiuman, Linda; Ferdinand, Sahna
Indonesian Journal of Medicine Vol. 8 No. 4 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.4.690

Abstract

Background: The severity of COVID-19 can be evaluated by checking several routine hematological parameters. Routine hematology examinations have an important role in early detection, diagnosis, disease management and disease progression. This study aims to determine the relationship between hematological parameters and disease progression and severity in COVID-19 patients. Subjects and Method: This was a cross sectional study conducted at Royal Prima Hospital, Medan, North Sumatera, Indonesia, from January to February 2022. A total of 93 patients who had confirmed COVID-19 were selected using a simple random sampling technique according to the inclusion and exclusion criteria. The research was The dependent variables of this research were disease progression and severity of COVID-19 patients. The independent variables are hematological parameters based on hospital medical record data. Data analysis used the Chi-Square test and logistic regression. Results: 75 people (80.6%) COVID-19 sufferers had severe disease. NLR and D-dimer levels were significantly related to disease progression in COVID-19 sufferers (p<0.05). Leukocyte, lymphocyte, NLR, CRP, D-dimer levels are related to the severity of COVID-19 sufferers (p<0.05). Leukocyte levels have the strongest relationship with the severity of COVID-19 with an OR value of 1.798. Conclusion: NLR and D-dimer levels are significantly related to disease progression and leukocyte. Lymphocyte, NLR, CRP, D-dimer levels are related to the severity of COVID-19 sufferers.
Hubungan Edukasi Dokter Keluarga Dan Pemberdayaan Keluarga Dengan Kemampuan Keluarga Melakukan Self Care Pada Pasien Diabetes Di Klinik Pratama Dandy Fahlevy, Ridho; Nasution, Ali Napiah; Chiuman, Linda
JURNAL PENELITIAN PENDIDIKAN, PSIKOLOGI DAN KESEHATAN (J-P3K) Vol 6, No 1 (2025): J-P3K
Publisher : Yayasan Mata Pena Madani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51849/j-p3k.v6i1.687

Abstract

Penelitian ini bertujuan untuk menganalisis hubungan antara edukasi dokter keluarga dan pemberdayaan keluarga dengan kemampuan keluarga dalam melakukan self-care pada pasien diabetes di Klinik Pratama Dandy. Desain penelitian yang digunakan adalah deskriptif korelatif dengan pendekatan cross-sectional. Populasi penelitian terdiri dari keluarga pasien dengan diagnosis diabetes mellitus, dengan jumlah sampel sebanyak 55 orang yang diperoleh melalui teknik total sampling, Penelitian ini dilaksanakan pada Agustus 2024. Analisis data dilakukan menggunakan aplikasi SPSS 16.0 dengan uji korelasi Chi-Square.Hasil penelitian menunjukkan bahwa sebagian besar responden menerima edukasi dokter keluarga dalam kategori baik, yaitu sebanyak 31 orang (56,4%). Kemampuan keluarga dalam melakukan self-care juga tergolong baik pada 32 responden (58,2%). Selain itu, pemberdayaan keluarga dalam merawat pasien diabetes berada dalam kategori baik pada 41 responden (74,5%). Uji statistik menunjukkan adanya hubungan yang signifikan antara edukasi dokter keluarga dengan pemberdayaan keluarga (p = 0,000) serta antara kemampuan keluarga dalam self-care dengan pemberdayaan keluarga (p = 0,000). Penelitian ini merekomendasikan agar penelitian selanjutnya menggunakan metode yang lebih komprehensif, seperti observasi dan wawancara, untuk mendapatkan data yang lebih mendalam
Investigation of Potential Molecular Targets of Zanthoxylum acanthopodium in Ovarian Cancer Using Network Pharmacology Assessments Wijaya, Johanna Fransiska; Chiuman, Linda; Syahputra, Hariyadi Dharmawan; Kaban, Vera Estefania; Razoki, Razoki; Ginting, Chrismis Novalinda; Iksen, Iksen
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.268

Abstract

Ovarian cancer is a serious disease that affects the ovaries, and its early detection is challenging due to vague symptoms often dismissed as minor ailments. Currently, natural sources have gained attention for their potential role in anticancer treatment. This study aimed to utilize network pharmacology to explore the potential targets and mechanisms of Zanthoxylum acanthopodium in the treatment of ovarian cancer. This study utilized the KNApSAcK and Swiss Target Prediction to identify active compounds and target genes. Additionally, ovarian cancer-specific target genes were sourced from the GEO database. To identify possible key target genes, the network interaction between protein-protein using the STRING database and visualized them in Cytoscape. Subsequent analysis using Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enabled us to focus on primary therapeutic targets. Our investigation into Zanthoxylum acanthopodium revealed 10 active compounds that pass Lipinski rule of five and oral bioavailability with acceptable pharmacokinetic profiles, 88 therapeutic targets, and identified 5 hub genes: SRC, CCNB2, MMP9, PTGS2, and PTPRC, which are strongly associated with ovarian cancer progression. Pathway enrichment analysis highlighted several pathways significantly related to the pathogenesis of ovarian cancer. This study elucidates the therapeutic potential and mechanisms of action of Z. acanthopodium as a promising candidate for ovarian cancer treatment. However, further research, including both in vitro and in vivo studies, is necessary to understand its molecular mechanisms comprehensively.
Co-Authors Adrian Adrian Adrian Adrian Afina, Lubna Akalili, Cory Cintia Alexander Simanjuntak Amir, Widya Pasca Andika Zayani Tambunan Anggraeni, Wenti Arif, Maria Nisaul Azah, Yunita Wannur Bagas Dwi Sanjaya Binarwan Halim Br Ginting, Lois Eprillia Bukit, Christin Debora Chairun, Ryeo Ramadhan Chintya Darma, Gladys Chiuman, Veranyca Claudia Tanamal DEWI SARTIKA Dhillon, Neha Amar Dika Suranda Dwi Puspitasari Edy Fachrial Ermi Girsang Fahlevy, Ridho Fazwiansyah Darlin Muniro Felix, Jesslyn Ferdinand, Sahna Fiska Maya Wardhani gan, claris cyntha deninta Ginting, Chirmis Novalinda Ginting, Chrismis Novalina Ginting, Chrismis Novalinda Girsang, Ermi Grandis, Lexandria Gusbakti Gusbakti Rusip hafizha, Shalli Halim, Angel Jonathane Halim, Michael Handayani, Rr. Anisa Siwianti hardiansyah siregar Harmileni Hasya, Muhammad Nawal Hidayatti, Mustika Iksen, Iksen Indriani, Vidya Intan Hasibuan, Febria Nurul irza Haicha Pratama Janice Janice Kosasih, Michaela Kotsasi, Fransisca Krishna, Priyanka Kurniawan, Gracella Verren Leony, Catherine Levinna, Levinna Liena, Liena lister , Clarissa Lister, Gilbert Lumbantobing, Christina J. R. Esmaralda Marfitania, Taranipa Maswarni Mawarni, Evi Michael Michael MICHELLE HENDRIANI DJUANG Mukti, Ade Indra Muna Soraya Putri Nadapdap, Thomson Nasution, Ali Napiah Nasution, Isna Gita Amalia Nurlaela, Lia Olivia Laurent Ong, Gabriella Fransisca Pardianto, Gede Pasaribu, Jelita Pebriani Patriyuni, Tri Permata Khaira, Azzuhra Pinem, Sabriela Br Rambe, Natasya Septiana Razoki, Razoki Rizki, Kartika Sari Saepudin Sagala, Agasy Gideon Admiral Sahna Ferdinand Ginting Saragih, Reyini Namora L. Sembiring, Mahral Effendi Sihombing, Bungaran Simarmata, Hans Pangestu Siti Hardianti, Siti Sitorus, Josua Panangian Soekardi, Adi Stanliko, Stanliko Suandy, Suandy Sulistijanto, Eddy Surya, Mellisa Yohana Suyono, Tan Syahputra, Hariyadi Dharmawan Tambunan, Ridhona Tanamal, Claudia Tarigan, Elviyanti Tarigan, Setia Budi Tengku Rachmi Hidayani, Tengku Rachmi Tia Triyanti Tjendera, Mariaman Utami, Sherlinda Putri Utomo, Wilbert Waldo Varerina, Ria Br Perangin-angin Vera Estefania Kaban Virgoh, Livia WAHYU WIDOWATI Wijaya, Johanna Fransiska Wijaya, Linda Leonando Winda Sari Yosefa, Stephanie Renata Yuliansyah, Jeri Yusmaini, Yusmaini Zendrato, Ronauli Muliani