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All Journal Biospecies Jurnal Kedokteran Brawijaya JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) BERITA BIOLOGI The Indonesian Biomedical Journal Lantanida Journal Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Kesehatan Komunitas Window of Health : Jurnal Kesehatan Indonesian Journal of Medicine Jambura Journal of Health Sciences and Research Journal Health & Science : Gorontalo Journal Health and Science Community Jurnal Kesehatan Poltekita : Jurnal Ilmu Kesehatan Jurnal Keperawatan Priority Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Prima Medika Sains An-Nadaa: Jurnal Kesehatan Masyarakat AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) Jurnal Ilmiah METADATA Eureka Herba Indonesia Jurnal Kesehatan Tambusai MAHESA : Malahayati Health Student Journal Journal of Multidisciplinary Applied Natural Science Interdisciplinary Social Studies Jurnal EduHealth International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Jurnal Locus Penelitian dan Pengabdian Buletin Kedokteran dan Kesehatan Prima Pharmaceutical Sciences and Research (PSR) International Journal of Health and Pharmaceutical (IJHP) Jurnal Farmasi Kryonaut
Chiuman, Linda
Universitas Prima Indonesia
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Effectiveness of red betel leaf extract cream for healing burn wounds Hidayatti, Mustika; Tarigan, Setia Budi; Chiuman, Linda
Jurnal Prima Medika Sains Vol. 5 No. 2 (2023): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v5i2.4398

Abstract

Burns are a frequent type of wound that can cause complications, infection and bleeding. The use of plants and natural materials as wound-healing remedies has been known for a considerable period, although more scientific proof is required. The objective of this investigation is to examine the efficacy of red betel leaf extract ointment in curing burns on the backs of white wistar rats. The study used a pre-test post-test design with a control group. Twenty white rat samples were employed. The samples were split into four groups, consisting of five rats each. Betel leaf extract was prepared through maceration, whilst betel leaf extract cream was made using the oil-in-water emulsion method (M/A). A histopathology test was carried out to observe growth of fibroblast cells. Rat skin biopsy was taken from a 2 x 2 cm area, and data normality was tested with the Shapiro-Wilk test (p > 0.05). The One-way Anova test (p < 0.05) was used to assess the differences between the groups. To determine the most effective treatment group, a post hoc test using LSD technique was performed. The findings showed that the average percentage of burn wound healing in the control group (P0) compared to groups P1, P2, and P3 was very different.  The analysis reveals that the application of 15% betel leaf extract cream proves to be superior in treating burns in white mice in contrast to 7.5% and 10% betel leaf extract cream. At a 15% concentration, secondary metabolite compounds found in betel leaf extract are already effective in treating wounds. However, at lower concentrations they only inhibit microorganisms, making them less effective in promoting wound healing.
Celery leaf extract cream is a potential wound healing agent Akalili, Cory Cintia; Pratama, Irza Haicha; Chiuman, Linda
Jurnal Prima Medika Sains Vol. 5 No. 2 (2023): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v5i2.4400

Abstract

Natural ingredients have been widely used for wound care and healing because of their flavonoid, saponin, and tannin contents, which can facilitate the healing process. This study aimed to examine the efficacy of celery leaf extract cream in the treatment of cutaneous wounds on the surfaces of white Wistar rats. This study involved laboratory-based experimental research utilizing a pretest-posttest with a control group design. Twenty white rats were sampled for this study and divided into four groups, each consisting of five rats, including one control group and three treatment groups. The extract was obtained via maceration, whereas the celery leaf extract cream contained an oil-in-water emulsion. A one-way Anova test was used to test differences between groups (p < 0.05), and a Post Hoc test with LSD technique was conducted to determine the most effective treatment group. Celery leaf extract cream has been found to be more efficient in accelerating skin regeneration and stimulating fibroblast proliferation than base cream. This is evidenced by the superior performance of the celery leaf extract cream treatment group in closing the incision wound, as well as the group's higher production of fibroblasts that are essential for wound healing, compared to the base cream group. This is evidenced by the superior performance of the celery leaf extract cream treatment group in closing the incision wound, as well as the group's higher production of fibroblasts that are essential for wound healing, compared to the base cream group. The anti-inflammatory and antioxidant properties of the flavonoids found in celery leaves can potentially prevent the formation of free radicals and expedite wound healing.
Effectiveness of bay leaf extract in reducing malondialdehyde levels Puspitasari, Dwi; Suyono, Tan; Chiuman, Linda
Jurnal Prima Medika Sains Vol. 5 No. 2 (2023): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v5i2.4401

Abstract

Excessive physical activity can lead to oxidative stress, resulting in elevated levels of free radicals in the human body. Oxidative stress is believed to be a precursor of various degenerative and chronic disorders, including arthritis, autoimmune diseases, cardiovascular diseases, neurodegenerative disorders, inflammatory diseases, and cancer. Malondialdehyde serves as a biomarker for oxidative stress and lipid peroxidation. Hence, the use of antioxidants is imperative to restore the balance in the body. The aim of this study was to investigate the effect of bay leaf administration on malondialdehyde levels in male Wistar rats. A pre-test–post-test design with a control group was employed in this study. Bay leaf extract was prepared using a maceration method with 70% ethanol. The rats were divided into four groups, including one control group and three treatment groups based on the dosage. Technical terms were explained when first used, and concise objective language was employed throughout the report. The study adhered to the conventional structure with standard citations and was free from grammatical, spelling, and punctuation errors. Blood samples were collected from the retro orbital plexus on days 1 (pretest) and 15 (posttest). Blood MDA levels were measured using the thiobarbituric acid reactive substances (TBARs) method, which involves reacting blood plasma with 20% TCA, 1% TBA, and 50% glacial acetic acid. To determine the significance of differences between the test groups, one-way ANOVA was used at a 95% confidence level (p < 0.05). Post Hoc Test with LSD technique was conducted for additional analysis or testing. Phytochemical test results indicated the presence of flavonoids, steroids, and tannins as secondary metabolites in the bay leaf extract. Administering bay leaf extract significantly lowered the MDA levels. The group receiving a 5 ml dose demonstrated greater effectiveness in reducing MDA levels in male white Wistar rats induced with excessive physical activity, based on average MDA levels.
Potential of gambier leaf ethanol extract cream for incised wound healing Arif, Maria Nisaul; Lumbantobing, Christina J. R. Esmaralda; Chiuman, Linda
Jurnal Prima Medika Sains Vol. 5 No. 2 (2023): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v5i2.4403

Abstract

Incised wounds are highly susceptible to bacterial infection, which requires stimulation of healing and restoration of normal function of the injured body part. This study aimed to test the effect of gambier leaf ethanol extract cream administration on the acceleration of wound healing on the skin surface of male Wistar rats. The research used a pre-test post-test with a control group design. Twenty male white rats were divided into four groups: control group (P0), treatment group 1 (P1), treatment 2 (P2), and treatment 3 (P3). The incision wounds in white rats were treated twice a day (in the morning and evening) for 14 days. Wound healing was observed by measuring the average length of the wound every day, from the first day of wounding until day 14. Statistical tests used were one-way ANOVA and post-hoc LSD test (p < 0.05). In this study, it was found that the 15% gambier leaf extract cream was more effective in wound healing in white rats than the 5% and 7.5% gambier leaf extract creams. However, in the group treated with 7.5% gambier leaf extract cream, the situation was already close to that in the treatment group treated with 15% gambier leaf extract cream. This is because, at a concentration of 7.5%, the secondary metabolite compounds in the gambier leaf extract had an effect on wounds, but at a concentration of 15% gambier leaf extract cream, the effect was similar to that of 15% gambier leaf extract cream.
Antibacterial activity of palm leaf extract against Propionibacterium acnes and Staphylococcus aureus Harmileni, Harmileni; Hidayani, Tengku Rachmi; Chiuman, Linda; Marfitania, Taranipa
Jurnal Prima Medika Sains Vol. 6 No. 1 (2024): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i1.5258

Abstract

Acne vulgaris is the most common skin disorder in adults and young adults. The growth of acne is caused by many factors, including excess sebum secretion and changes in microbial flora, mainly the colonization of Propionibacterium acnes and Staphylococcus aureus. This study aimed to determine the anti-bacterial activity of palm leaf extract against Propionibacterium acnes and Staphylococcus aureus. The research procedure includes palm leaf extraction and anti-bacterial tests. Palm leaf extraction was carried out using ultrasonication, while the anti-bacterial test was carried out using disc diffusion. The palm leaf extract obtained was diluted to 10, 20, 30, 50, and 50%, and each variation of this concentration was tested for anti-bacterial activity. The results of the anti-bacterial test showed that all palm leaf extract samples from 10% to 50% concentration could inhibit the growth of P. acnes and S. aureus bacteria. The 50% extract of ultrasonicated palm leaves had the largest inhibition zone diameter of 13.8 mm for P. acnes bacteria and 10.1 for S. aureus bacteria. From the results of this study, palm leaf extract has the potential to be used as a product for the prevention or treatment of acne vulgaris.
HUBUNGAN MOTIVASI KERJA DENGAN KINERJA PERAWAT DI RUMAH SAKIT UMUM ROYAL PRIMA MEDAN TAHUN 2017 Chiuman, Linda
Jurnal Keperawatan Priority Vol. 2 No. 2 (2019)
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jukep.v2i2.538

Abstract

Nursing services in hospital healthcare service is one of the crucial factors in defining the image and quality of a hospital. Nurse, a profession which has the highest amount of interaction with the patients and their family, is one of the core elements in determining the quality of healthcare service of a hospital. The purpose of this research is to discover the relation between internal as well as external motivations and the work related performance of the nurses, particularly those who are stationed at the wards in Royal Prima General Hospital Medan. The methodology used analytical study on the survey with cross-sectional approach. The respondents of the survey are all of the nurses who are stationed at the wards with total number of 168 respondents and the sampling method uses proportional random sampling method towards 110 respondents. The data obtained is analyzed with univariate, bivariate methods utilizing chi square as well as multivariate method utilizing double logistic binary regression test analysis with 5% of confidence interval.The outcome of the research shown that there are relations between internal as well as external motivations and work related performance of the nurses. Nurses with higher value of internal motivations have the chance of 3.061 times to perform better than those with lower value of internal motivations. Additionally, nurses with higher value of external motivations have the chance of 2.761 times to perform better than those with lower value of external motivations. Hence, it is much recommended to the hospital management boards to pay more attention towards the performance of the nurses by considering of giving incentives and rewards to the nurses based on their achievements and loyalty.
The Relationship between Work Motivation and Nurse Performance at RSU Royal Prima Medan In 2023 Utami, Sherlinda Putri; Ginting, Chirmis Novalinda; Chiuman, Linda
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Vol.10 No.1 Mei 2024
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v10i1.13438

Abstract

Motivation is an internal impulse that determines what a person does and the enthusiasm for doing it. Motivation itself consists of two types, namely internal and external motivation, internal motivation subvariables which have the strongest relationship with nurse performance in the form of recognition, achievement and development while external motivation subvariables which have the strongest relationship with nurse performance are working conditions, organizational policies, salary/ wages.. Objective: The aim of this research is to determine the relationship between work motivation and nurse performance at RSU Royal Prima Medan in 2023. The type of research used in this research is quantitative research with a cross-sectional design. The population used in this research were 349 nurses at RSU Royal Prima Medan in 2023. Sampling used the Slovin formula with a total sample of 78 samples. The research data used is primary data with the research instrument used, namely a questionnaire. Data analysis in this study used univariate, bivariate and multivariate analysis. The results of the analysis show that the majority of respondents' internal motivation in this study is high and there is a relationship between internal motivation and nurse performance at RSU Royal Prima Medan in 2023 p-value of 0.000 < 0.05. The majority of respondents' external motivation in this study was high and there was a relationship between external motivation and nurse performance at RSU Royal Prima Medan in 2023 p-value of 0.000 < 0.05. The independent variable that has the most influence on the dependent variable is the external motivation variable. There is a relationship between external motivation and the performance of nurses at RSU Royal Prima Medan.
EFFECT OF ANDALIMAN (Zanthoxylum Acanthopodium) NANOHERBAL EXTRACT ADMINISTRATION ON LIVER FUNCTION AND LIVER HISTOPATHOLOGY OF STREPTOZOTOCIN-INDUCED DIABETIC MALE WISTAR RATS Permata Khaira, Azzuhra; Ginting, Chrismis Novalinda; Chiuman, Linda; Chiuman, Veranyca; Sihombing, Bungaran
International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Vol 6 No 3 (2024)
Publisher : The Islamic Education and Multiculturalism Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47006/ijierm.v6i3.350

Abstract

Abstract : Background: Diabetes Mellitus is a systemic disease with hyperglycemia, and can cause Non-Alcoholic Fatty Liver Disease (NAFLD). Nanoherbal of andaliman has an antioxidant effect on the body. Objective: This study aims to determine the effect of nanoherbal of andaliman on liver function and liver histopathology. Method: This study used an experimental method with a post-test-only control group design of 30 male wistar rats induced with streptozosin, divided into 6 groups with nano herbal of andaliman as the testing material. Results: There is no difference in the liver function (SGOT and SGPT) between the groups that are given andaliman and the ones that do not with the p values of 0,183 and 0,449 (p>0,05). There is a difference in liver histopathology between the groups with the p-value of 0,03 (p<0,05), it also shows that the groups that are given andaliman experienced liver degeneration. Conclusion: Nanoherbal of andaliman has the antioxidant effect that acts as hepatoprotection, but also includes some substances that can cause damage to the liver cells. The writer suggested adding more samples, doing the pre-test and post-test examinations, and also analyzing the effect of the steroid and terpenoid in andaliman on the liver cells.
ROLE OF CURCUMA ZEDOARIA EXTRACT ON PLACENTAL GROWTH FACTOR (PLGF) IN DIABETIC RETINOPATHY WHITE WISTAR RATS Ong, Gabriella Fransisca; Rusip, Gusbakti; Chiuman, Linda; Sulistijanto, Eddy; Tarigan, Elviyanti
International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Vol 6 No 3 (2024)
Publisher : The Islamic Education and Multiculturalism Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47006/ijierm.v6i3.400

Abstract

Diabetic retinopathy is damage to retinal capillaries in diabetics that can cause visual impairment, ranging from mild to permanent blindness. This study aims to analyze the effect of Curcuma zedoaria (temu putih) extract on placental growth factor (PLGF) levels in white Wistar rats with diabetic retinopathy. The research design used post-test only control group, involving six groups of wistar rats with five heads each. Data were analyzed using Oneway ANOVA and t-test. The results showed that the administration of Curcuma zedoaria extract at a dose of 500 mg/kgBB had the greatest effect on reducing PLGF in diabetic retinopathy rats. For reducing blood sugar levels (KGD), a dose of 7500 mg/kgBB proved to be the most effective. However, no significant relationship was found between PLGF levels and retinal histopathology results. Most of the rats had a retinal score of 0, which means no inflammatory cells were found in the retinal layer (0 cells/visual field). There were rats with a retinal score of 1, namely rats that received doses of 250 mg/kgBB and 500 mg/kgBB. In this score, inflammation was found in the outer plexiform layer (OPL). In addition, there were rats with a retinal score of 2 at a dose of 250 mg/kgBB, which also showed the distribution of inflammation in the OPL layer. In this study, Curcuma zedoaria extract can reduce PLGF and KGD in Wistar rats with diabetic retinopathy, although its effect on improving retinal histopathology is still limited.
Effect of Andaliman (Zanthoxylum Acanthopodium DC) Extracts on The Histological Display of Lewy Body in The Brain of Rotenone Induced Wistar Rats Afina, Lubna; Halim, Binarwan; Chiuman, Linda; Anggraeni, Wenti; Rizki, Kartika Sari
International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Vol 6 No 3 (2024)
Publisher : The Islamic Education and Multiculturalism Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47006/ijierm.v6i3.408

Abstract

Dementia Lewy Body (DLB) is a form of dementia characterized by abnormal accumulation of α-synuclein protein in the brain, forming lewy bodies that damage the function of neurons and nervous system. This study aimed to evaluate the effect of andaliman fruit extract (Zanthoxylum Acanthopodium DC), which is rich in antioxidants, on the number of lewy bodies in the brain of rotenone-induced Wistar male rats. Histology analysis was performed to observe the number of lewy bodies in the brain. The results showed a significant decrease in the number of lewy bodies in the treatment group compared to the positive control group (p<0.05). Increasing the dose of andaliman extract was directly proportional to the decrease in the number of lewy bodies, with the highest dose (450 mg/kgBB) providing the best protective effect. These findings suggest that the antioxidant content in andaliman extract can neutralize the oxidative stress caused by rotenone, thus protecting neurons from damage. This study supports the development of andaliman extract as an alternative therapy to prevent or inhibit the progressivity of DLB.
Co-Authors Adrian Adrian Adrian Adrian Afina, Lubna Akalili, Cory Cintia Alexander Simanjuntak Amir, Widya Pasca Andika Zayani Tambunan Anggraeni, Wenti Arif, Maria Nisaul Azah, Yunita Wannur Bagas Dwi Sanjaya Binarwan Halim Br Ginting, Lois Eprillia Bukit, Christin Debora Chairun, Ryeo Ramadhan Chintya Darma, Gladys Chiuman, Veranyca Claudia Tanamal DEWI SARTIKA Dhillon, Neha Amar Dika Suranda Dwi Puspitasari Edy Fachrial Ermi Girsang Fahlevy, Ridho Fazwiansyah Darlin Muniro Felix, Jesslyn Ferdinand, Sahna Fiska Maya Wardhani gan, claris cyntha deninta Ginting, Chirmis Novalinda Ginting, Chrismis Novalina Ginting, Chrismis Novalinda Girsang, Ermi Grandis, Lexandria Gusbakti Gusbakti Rusip hafizha, Shalli Halim, Angel Jonathane Halim, Michael Handayani, Rr. Anisa Siwianti hardiansyah siregar Harmileni Hasya, Muhammad Nawal Hidayatti, Mustika Iksen, Iksen Indriani, Vidya Intan Hasibuan, Febria Nurul irza Haicha Pratama Janice Janice Kosasih, Michaela Kotsasi, Fransisca Krishna, Priyanka Kurniawan, Gracella Verren Leony, Catherine Levinna, Levinna Liena, Liena lister , Clarissa Lister, Gilbert Lumbantobing, Christina J. R. Esmaralda Marfitania, Taranipa Maswarni Mawarni, Evi Michael Michael MICHELLE HENDRIANI DJUANG Mukti, Ade Indra Muna Soraya Putri Nadapdap, Thomson Nasution, Ali Napiah Nasution, Isna Gita Amalia Nurlaela, Lia Olivia Laurent Ong, Gabriella Fransisca Pardianto, Gede Pasaribu, Jelita Pebriani Patriyuni, Tri Permata Khaira, Azzuhra Pinem, Sabriela Br Rambe, Natasya Septiana Razoki, Razoki Rizki, Kartika Sari Saepudin Sagala, Agasy Gideon Admiral Sahna Ferdinand Ginting Saragih, Reyini Namora L. Sembiring, Mahral Effendi Sihombing, Bungaran Simarmata, Hans Pangestu Siti Hardianti, Siti Sitorus, Josua Panangian Soekardi, Adi Stanliko, Stanliko Suandy, Suandy Sulistijanto, Eddy Surya, Mellisa Yohana Suyono, Tan Syahputra, Hariyadi Dharmawan Tambunan, Ridhona Tanamal, Claudia Tarigan, Elviyanti Tarigan, Setia Budi Tengku Rachmi Hidayani, Tengku Rachmi Tia Triyanti Tjendera, Mariaman Utami, Sherlinda Putri Utomo, Wilbert Waldo Varerina, Ria Br Perangin-angin Vera Estefania Kaban Virgoh, Livia WAHYU WIDOWATI Wijaya, Johanna Fransiska Wijaya, Linda Leonando Winda Sari Yosefa, Stephanie Renata Yuliansyah, Jeri Yusmaini, Yusmaini Zendrato, Ronauli Muliani