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All Journal Biospecies Jurnal Kedokteran Brawijaya JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) BERITA BIOLOGI The Indonesian Biomedical Journal Lantanida Journal Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Kesehatan Komunitas Window of Health : Jurnal Kesehatan Indonesian Journal of Medicine Jambura Journal of Health Sciences and Research Journal Health & Science : Gorontalo Journal Health and Science Community Jurnal Kesehatan Poltekita : Jurnal Ilmu Kesehatan Jurnal Keperawatan Priority Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Prima Medika Sains An-Nadaa: Jurnal Kesehatan Masyarakat AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) Jurnal Ilmiah METADATA Eureka Herba Indonesia Jurnal Kesehatan Tambusai MAHESA : Malahayati Health Student Journal Journal of Multidisciplinary Applied Natural Science Interdisciplinary Social Studies Jurnal EduHealth International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Jurnal Locus Penelitian dan Pengabdian Buletin Kedokteran dan Kesehatan Prima Pharmaceutical Sciences and Research (PSR) International Journal of Health and Pharmaceutical (IJHP) Jurnal Farmasi Kryonaut
Chiuman, Linda
Universitas Prima Indonesia
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Efektivitas Ekstrak Bawang Putih Tunggal Terhadap Gambaran Histopatologi Ginjal Dan Kadar Ureum Kreatinin Rattus Novergicus Yang Mengalami Dislipidemia Rambe, Natasya Septiana; Suandy, Suandy; Chiuman, Linda
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i10.62239

Abstract

Heart disease and kidney failure are both increased by dyslipidemia. There are a lot of antioxidant and nephroprotective chemicals in just one clove of garlic (Allium sativum L.), including allicin, flavonoids, and organosulfur compounds. This study set out to examine the effects of a single garlic extract on the urea, creatinine, and uric acid levels in rats with dyslipidemia (Rattus norvegicus). There was an examination of the renal histopathology picture as well. This research used an experimental tack by using a control group design with pre- and post-tests. Each of the four groups consisted of 24 male Wistar rats' tails: the control group (aquades), the experimental group (simvastatin 2.1 mg/kgBB), the garlic extract alone group (200 mg/kgBB), and the highest dose (400 mg/kgBB). Each group followed a high-fat diet for a full month. Both the 200 mg/kgBB and 400 mg/kgBB doses of garlic extract significantly decreased the levels of ureum, creatinine, and uric acid (p<0.05) as compared to the negative control group. Kidney histopathology also revealed improvement, with less congestion, necrosis, and cell death. The positive control and the 400 mg/kgBB group showed similar effects after delivery. Rats with dyslipidemia showed improvements in renal histology and decreased levels of ureum, creatinine, and uric acid after administration of a single garlic extract.
HUBUNGAN AKTIVITAS FISIK TERHADAP PERUBAHAN KARDIORESPIRASI PADA MAHASISWA KEDOKTERAN UNIVERSITAS PRIMA INDONESIA Sagala, Agasy Gideon Admiral; Rusip, Gusbakti; Chiuman, Linda
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 2 (2024): AGUSTUS 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i2.31517

Abstract

Penelitian ini bertujuan untuk mengetahui hubungan aktivitas fisik dengan perubahan fungsi kardiorespirasi pada mahasiswa kedokteran Universitas Prima Indonesia. Penelitian ini menggunakan pendekatan eksperimen semu dengan desain one-group pre-and post-test untuk menguji hubungan tersebut. Purposive sampling dengan rumus Federer digunakan untuk memilih sampel yang berjumlah 32 orang mahasiswa kedokteran Universitas Prima Indonesia. Queen's College Step Test digunakan untuk mengukur kebugaran kardiorespirasi dan aktivitas fisik dalam data yang dikumpulkan. Analisis data memakai SPSS versi 27 serta Uji Wilcoxon digunakan untuk analisis statistik, dengan ambang signifikansi P <0,05. Temuan penelitian menunjukkan bahwa di kalangan mahasiswa kedokteran Universitas Prima Indonesia, aktivitas fisik dan perubahan fungsi kardiorespirasi berhubungan (P=0,005). Dari tiga puluh dua orang mahasiswa kedokteran Universitas Prima Indonesia didapati Delapan orang mahasiswa kedokteran Universitas Prima Indonesia semuanya mengalami perubahan pada sistem kardiorespirasi mereka sebelum dan sesudah melakukan aktivitas fisik (4,50). Artinya Terdapat hubungan aktivitas fisik dengan perubahan fungsi kardiorespirasi pada mahasiswa kedokteran Universitas Prima Indonesia.
Formulation and Effectiveness Testing of Moringa Leaf (Moringa Oleifera) Ethanol Extract Lotion as A Skin Moisturizer Nasution, Isna Gita Amalia; Ginting, Chrismis Novalinda; Chiuman, Linda
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 4 (2024): February
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i4.3477

Abstract

This study delves into the formulation of a lotion using different concentrations (0.5%, 2%, and 5%) of Moringa oleifera leaf ethanol extract, aiming to address the constant exposure of the skin to a prooxidant environment. In Indonesia, the rising interest in exploring natural plants for traditional skincare formulations is attributed to their perceived lower side effects compared to chemical substances. Employing an experimental research approach with a pre-test and post-test control group design, the study focuses on observing and controlling the formulation and effectiveness of Moringa oleifera leaf extract lotion in various skin-enhancing aspects.The research findings reveal that the formulated lotions exhibit distinctive aroma, soft texture, ease of spread, and semi-solid or gel consistency without stickiness. Physical homogeneity suggests a well-blended composition, and the pH values (6.32 for 0.5%, 6.30 for 2%, and 6.28 for 5%) fall within the ideal range, ensuring skin compatibility. Spreadability tests show the 5% concentration has the highest spreadability, while adhesive strength analysis indicates all concentrations meet the criteria for good cream adhesive strength.Furthermore, the efficacy of the lotion is assessed for moisturizing, smoothing, pore-shrinking, wrinkle-reducing, and collagen fiber density-increasing properties. Results indicate the 5% concentration is the most effective across these parameters.In conclusion, the ethanol extract lotion formulated from Moringa oleifera leaves holds promise for enhancing skin health, with the 5% concentration demonstrating the highest efficacy. This research contributes valuable insights to the development of natural skincare products with potential applications in dermatology and cosmetology, aligning with the growing interest in sustainable and effective skincare solutions.
Analisis Akar Masalah dan Waktu Tunggu Pelayanan Obat di Instalasi Farmasi Rawat Jalan Pinem, Sabriela Br; Ginting, Chrismis Novalinda; Chiuman, Linda
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 8 (2025): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i8.4594

Abstract

Waktu tunggu pelayanan farmasi merupakan indikator penting dalam penilaian mutu pelayanan kesehatan di rumah sakit. Penelitian ini bertujuan menganalisis akar masalah dan waktu tunggu yang dibutuhkan untuk mendapatkan obat di instalasi farmasi rawat jalan RSU Royal Prima Medan. Metode penelitian menggunakan pendekatan deskriptif kualitatif dengan teknik wawancara mendalam kepada 5 informan manajemen dan observasi terhadap 50 pasien rawat jalan. Analisis data dilakukan melalui reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan akar masalah utama meliputi kurangnya SDM di instalasi farmasi, kelengkapan berkas pasien yang belum terpenuhi, ketersediaan obat yang terbatas, penggunaan sistem resep elektronik dan manual secara bersamaan, banyaknya resep di luar formularium nasional, tingginya permintaan obat racikan, dan kesulitan membaca tulisan dokter. Waktu tunggu rata-rata untuk obat non racikan adalah 24,8 menit dan obat racikan 49,44 menit, yang masih sesuai dengan Standar Pelayanan Minimal (SPM). Meskipun demikian, terdapat 8 dari 50 pasien yang mengalami waktu tunggu melebihi SPM. Penelitian ini memberikan kontribusi penting dalam identifikasi faktor-faktor yang mempengaruhi efisiensi pelayanan farmasi dan dapat menjadi dasar pengembangan strategi perbaikan sistem pelayanan.
Effectiveness Test of Ethanol Extract of Red Betel Leaves (Piper Crocatum Ruiz & Pav) Against Histopathological Features of The Pancreas and Blood Sugar Levels of Alloxan-Induced Male Mice (Mus Musculus L) Sembiring, Mahral Effendi; Nasution, Ali Napiah; Chiuman, Linda
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes Mellitus induces hyperglycemia. Low insulin production causes insulin resistance and altered protein, fat, and carbohydrate metabolism. Much research has shown that traditional herbal treatments can treat diabetes. Diabetes increases free radical production. Secondary metabolic plants include antioxidants that treat extreme illnesses like diabetes. This study examines the efficacy of ethanol extract from red betel leaves (EERBL) in lowering blood glucose levels in vivo, the optimal dose, secondary metabolite content based on phytochemical screening, and alloxan-induced pancreatic hyperglycemia histopathology. Mouse. Six 20-30 gram groups of mice were treated. Group III got 0.65 mg/kgBW glibenclamide, and Groups IV, V, and VI received oral gavage EERBL 100, 300, and 500 mg/kgBW. Group I was in standard control without alloxan, and Group II was in alloxan control. Hyperglycemic mice received 150 mg/kg BW intraperitoneal alloxan. Red betel is 96% ethanol-macerated. Oral red betel leaf extract was given for 21 days to monitor blood glucose and pancreatic function. Splitting red betel leaves to male mice significantly altered blood glucose and pancreatic histology. Red betel goes low cuts close and pancreatic histology by 58.4%. Blood glucose readings were Kruskal-Wallis significant at 0.004 or 0.05. Red betel leaf extract reduced blood glucose and enhanced pancreatic histology in male mice.
Effectiveness of Earthworm Extract on the Lipid Profile of Diabetic Wistar Rats Suandy, Suandy; Chiuman, Linda; Halim, Angel Jonathane
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.3

Abstract

Various metabolic diseases, such as diabetes mellitus, are characterized by hyperglycemia, stemming from decreased insulin action, secretion, or both. The use of chemical medicines for diabetes mellitus, especially acarbose, involves regulating the digestion and absorption of complex carbohydrates. However, acarbose may disrupt liver function, prompting exploration into alternative sources for treatment, such as earthworm extract. The purpose of this study was to identify the effectiveness of ethanol extract and coelomic fluid from earthworms (E. eugeniae) on the lipid profile of male diabetic wistar rats (R. norvegicus) in vivo. The research hypothesis is that earthworm extracts could effectively lower the lipid profile of diabetic Wistar rats. This research is experimental research with pre-test and post-test control study group design, using an in vivo method. The results of the one-way ANOVA test of HDL were p=0.441; p=0.441; p=0.000; for LDL were p=0.691; p=0.101; p=0.049; for total cholesterol were p=0.107; p=0.347; p=0.486; and for triglycerides were p=0.028; p=0.926; p=0.553 on days 0, 7, and 14, respectively. Based on the research data, both ethanol extract and a combination of ethanol extract and coelomic fluid were able to reduce lipid profile levels on the 7th and 14th days. Earthworm extract has the potential to promote repair of β cells and is anti-inflammatory which can be used to reduce lipid profile levels.
Analyzing Ethanol’s Antioxidant Extract of Pandanus Leaves through DPPH Method Hardianti, Siti; Chiuman, Linda; Ginting, Chrismis Novalinda; Adrian, Adrian
Interdisciplinary Social Studies Vol. 1 No. 5 (2022): Special Issue
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/iss.v1i5.128

Abstract

Background: Aging is a natural process and no one can avoid it. The aging process is also a physiological process that will occur in all living things. This process covers all organs of the body including the skin which is one of the body tissues that directly shows the occurrence of the aging process Aim: This research aims to analyze ethanol’s antioxidant extract of pandanus leaves through DPPH method. Method: This type of research is using experimental research designs to determine the antioxidant activity affected by time, and temperature with the DPPH method, a formulation of the effects of the ethanol extract of fragrant pandan leaves (Pandanus amaryllifous Roxb). Findings: It has active antioxidant activity and IC50 extract of fragrant pandan ethanol on the 5th day with a temperature of 50° C and on the 3rd day with a temperature of 35° C which is the best antioxidant activity.
- EFEKTIVITAS PRP TERHADAP PERUBAHAN PROFIL LIPID DARAH TIKUS PUTIH JANTAN (Rattus Norvegicus) DIABETES MELITUS YANG DI INDUKSI STREPTOZOTOCIN: EFEKTIVITAS PRP TERHADAP PERUBAHAN PROFIL LIPID DARAH TIKUS PUTIH JANTAN (Rattus Norvegicus) DIABETES MELITUS YANG DI INDUKSI STREPTOZOTOCIN Simarmata, Hans Pangestu; Saragih, Reyini Namora L.; Pasaribu, Jelita Pebriani; Sitorus, Josua Panangian; Chiuman, Linda; Janice, Janice
Biospecies Vol. 14 No. 1 (2021): Januari 2021
Publisher : Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/biospecies.v14i1.11252

Abstract

Diabetes mellitus is a disease problem in Indonesia due to the inability of the pancreas to produce insulin so the body's metabolic processes are disrupted. Platelet Rich Plasma is widely known to be a treatment in various fields of medicine because it contains many growth factors (GFs) which are useful for triggering growth, tissue, and cell regeneration. This study was conducted to determine the effectiveness of PRP at doses of 0.5, 1.0, and 1.5 ml/kg BW for improving lipid profiles. This study used an experimental method where PRP was made twice centrifugation, then divided into each treatment, each group was given twice a week for three weeks. The Shapiro-Wilk test was used for normally distributed data followed by the Kruskal-Wallis test followed by the analysis Mann-Whitney with a significant value of P <0.05, that is, there was an effect of PRP administration on improving levels of lipid profiles. The PRP dose of 0.5 ml/kg BW gave the effect of increasing the lipid profile except for HDL levels and a higher PRP dose was required to significantly increase HDL levels compared to the control group.  
Autologous Dendritic Cell Immunotherapy Modulates Renal Perfusion and Hemodynamics in Diabetic Kidney Soekardi, Adi; Chiuman, Linda; Ginting, Chrismis Novalinda
The Indonesian Biomedical Journal Vol 18, No 1 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i1.3878

Abstract

BACKGROUND: Diabetic kidney disease (DKD) is driven by chronic inflammation and endothelial dysfunction, which often persist despite standard pharmacological treatments. Autologous dendritic cell (DC) immunotherapy offers a novel approach to restore immune homeostasis and improve renal vascular function. While the use of autologous DC for immune homeostasis has been previously discussed, not many studies have explicitly reported on the modulation of renal perfusion parameters, such as peak systolic velocity (PSV) and resistive index (RI), following DC immunotherapy. Therefore, this study was conducted to evaluate the effect of autologous DC administration on renal hemodynamics, including PSV and RI, as well as inflammatory biomarkers, including tumor necrosis factor (TNF)-α and vascular cell adhesion molecule (VCAM-1) in DKD patients.METHODS: Thirty-one DKD patients were selected via simple random sampling. All subjects underwent autologous DC therapy, which was administered via intravenous infusion at a concentration of approximately 1×107 cells suspended in 100 mL of normal saline. PSV and RI were measured using Renal Doppler Ultrasonography, while TNF-α and VCAM-1 were quantified using the Enzyme-Linked Immunosorbent Assay (ELISA) method. All measurements were conducted before intervention and 60 days after intervention to evaluate the therapeutic efficacy.RESULTS: DC therapy led to significant alterations in renal hemodynamic parameters. The mean PSV decreased from 52.74 to 38.21 cm/s (p=0.016), while RI showed a modest increase from 0.7350 to 0.7550 (p=0.028). Greater hemodynamic effects were observed in patients with well-controlled glycemia, lower serum urea, and microalbuminuria. In contrast, no significant changes were detected in TNF-α and VCAM-1 levels.CONCLUSION: Autologous DC therapy delivers measurable, statistically significant benefits in renal vascular parameters for DKD, particularly in early-stage disease and metabolically stable patients. These findings may support DC therapy as a promising adjunctive strategy to improve renal microcirculation in DKD. KEYWORDS: diabetic kidney disease, dendritic cell therapy, TNF-α, VCAM-1, PSV, RI
Effectiveness Of Incision Wound Healing Of Pandanus Amaryllifolius Roxb In Wistar Rats Muna Soraya Putri; Ermi Girsang; Linda Chiuman; Chrismis Novalinda Ginting
International Journal of Health and Pharmaceutical (IJHP) Vol. 2 No. 2 (2022): May 2022
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (747.609 KB) | DOI: 10.51601/ijhp.v2i2.33

Abstract

The incision is a condition of tissue discontinuity that is commonly encountered with the risk of prolonged healing time, imperfect wound healing, infection, etc. Assessment of the wound healing activity of the incision is the purpose of this research, which includes an examination of wound contraction, the thickness of collagen fibers, and the number of new blood vessels formation. In total, 25 rats will be divided into 5 test groups, each consisting of 5 rats; the control group (cream base treated), standard group (Povidone Iodine), followed by the treated group with 10%, 20%, and 30% pandan leaf extract ointment. The preliminary screening of phytochemical analysisshowed the presence of alkaloids, saponins, flavonoids, tannins, triterpenoids, and steroids and glycosides, with the total content of phenols and flavonoids from the ethanolic extract of Pandan Wangi is 20.95 GAE mg/gram extract, and 23.57 TAE mg/gram extract. Wound contraction examination result showed a significant difference between the treatment groups on day 16 and a sign the pairs of groups after being given the ointment with each concentration (p <0.05), especially in the group with 30% fragrant leaves extract and the standard group. Examination of new blood vessels showed a significant difference (p <0.05), especially with 30% of the leaves extract ointment. There was also a significant difference in collagen density in the group given pandanus ethanol ointment, especially at the 30% pandanus extract content against the group that was only given the ointment base. This research strongly suggests that the fragrant pandan leaf extract ointment is effective in healing incisional wounds and promises the potential for further studies on the pharmacological aspects.
Co-Authors Adrian Adrian Adrian Adrian Afina, Lubna Akalili, Cory Cintia Alexander Simanjuntak Amir, Widya Pasca Andika Zayani Tambunan Anggraeni, Wenti Arif, Maria Nisaul Azah, Yunita Wannur Bagas Dwi Sanjaya Binarwan Halim Br Ginting, Lois Eprillia Bukit, Christin Debora Chairun, Ryeo Ramadhan Chintya Darma, Gladys Chiuman, Veranyca Claudia Tanamal DEWI SARTIKA Dhillon, Neha Amar Dika Suranda Dwi Puspitasari Edy Fachrial Ermi Girsang Fahlevy, Ridho Fazwiansyah Darlin Muniro Felix, Jesslyn Ferdinand, Sahna Fiska Maya Wardhani gan, claris cyntha deninta Ginting, Chirmis Novalinda Ginting, Chrismis Novalina Ginting, Chrismis Novalinda Girsang, Ermi Grandis, Lexandria Gusbakti Gusbakti Rusip hafizha, Shalli Halim, Angel Jonathane Halim, Michael Handayani, Rr. Anisa Siwianti hardiansyah siregar Harmileni Hasya, Muhammad Nawal Hidayatti, Mustika Iksen, Iksen Indriani, Vidya Intan Hasibuan, Febria Nurul irza Haicha Pratama Janice Janice Kosasih, Michaela Kotsasi, Fransisca Krishna, Priyanka Kurniawan, Gracella Verren Leony, Catherine Levinna, Levinna Liena, Liena lister , Clarissa Lister, Gilbert Lumbantobing, Christina J. R. Esmaralda Marfitania, Taranipa Maswarni Mawarni, Evi Michael Michael MICHELLE HENDRIANI DJUANG Mukti, Ade Indra Muna Soraya Putri Nadapdap, Thomson Nasution, Ali Napiah Nasution, Isna Gita Amalia Nurlaela, Lia Olivia Laurent Ong, Gabriella Fransisca Pardianto, Gede Pasaribu, Jelita Pebriani Patriyuni, Tri Permata Khaira, Azzuhra Pinem, Sabriela Br Rambe, Natasya Septiana Razoki, Razoki Rizki, Kartika Sari Saepudin Sagala, Agasy Gideon Admiral Sahna Ferdinand Ginting Saragih, Reyini Namora L. Sembiring, Mahral Effendi Sihombing, Bungaran Simarmata, Hans Pangestu Siti Hardianti, Siti Sitorus, Josua Panangian Soekardi, Adi Stanliko, Stanliko Suandy, Suandy Sulistijanto, Eddy Surya, Mellisa Yohana Suyono, Tan Syahputra, Hariyadi Dharmawan Tambunan, Ridhona Tanamal, Claudia Tarigan, Elviyanti Tarigan, Setia Budi Tengku Rachmi Hidayani, Tengku Rachmi Tia Triyanti Tjendera, Mariaman Utami, Sherlinda Putri Utomo, Wilbert Waldo Varerina, Ria Br Perangin-angin Vera Estefania Kaban Virgoh, Livia WAHYU WIDOWATI Wijaya, Johanna Fransiska Wijaya, Linda Leonando Winda Sari Yosefa, Stephanie Renata Yuliansyah, Jeri Yusmaini, Yusmaini Zendrato, Ronauli Muliani