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THE ANTIDIPHTHERIA ANTIBODIES OF SEROEPIDEMIOLOGY SURVEY AMONG ADOLESCENTS IN BANGKALAN AND KEDIRI DISTRICTS Dominicus Husada; Kristina Marbun; Desy Primayani; Leny Kartina; Dwiyanti Puspitasari; Parwati Setiono Basuki; Ismoedijanto Moedjito; Aris Wiji Utami; Eveline Irawan
Jurnal Berkala Epidemiologi Vol. 7 No. 2 (2019): Jurnal Berkala Epidemiologi (Periodic Epidemiology Journal)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (401.595 KB) | DOI: 10.20473/jbe.V7I22019.94-102

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Background: An increase in diphtheria cases has occurred in East Java Province since 2011. The resistance level to diphtheria is considered as the most important cause. Purpose: The study aims analyzed the immunity level immunity to diphtheria in adolescents aged 16-18 years old in Bangkalan and Kediri Districts. Methods: This study was a cross-sectional study, conducted on students in eleven grade of senior high schools (SMAN) from both districts. The inclusion criteria included being 16-18 years old and students in eleven grades of senior high schools in Bangkalan and Kediri. This study was approved by their parents/guardians. The exclusion criteria included immunocompromised students and those who have a history of diphtheria infection. The data were obtained from 204 samples, 89 samples in Bangkalan, and 115 samples in Kediri. The antidiphtheria antibodies examination was carried out by the Vero cell method. The antibodies levels were grouped according to WHO standard, consist of vulnerable, basic, full, and long-term. Further analysis was done with 2 tiers of immunity, consist of immune and vulnerable. Results: The immunization coverage for basic and booster diphtheria vaccine is better in Kediri than in Bangkalan. In contrast, levels of antibodies samples in Bangkalan District is better. The participants who were immune in Bangkalan were higher than those in Kediri (91% vs. 44.3%). Conclusion: The immunity adolescents of Bangkalan is higher than in adolescent Kediri District. The adolescents in Kediri have a greater risk to get infected by the disease
Correlation between Adolescents’ Temperament and Internet Addiction Levels in Junior High School in Surabaya, Indonesia Destasari Tri Hartanti; Yunias Setiawati; Dominicus Husada; Irwanto Irwanto
Jurnal Berkala Epidemiologi Vol. 9 No. 2 (2021): Jurnal Berkala Epidemiologi (Periodic Epidemiology Journal)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbe.V9I22021.192-201

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Background: Internet addiction has become a serious problem in the world, especially for adolescents. Temperament plays an important role in influencing internet addiction in adolescents. Purpose: The aim of this study was to analyze the relationship between students’ characteristics and temperament with their internet addiction levels in one of the junior high schools in Surabaya, Indonesia. Methods: This was a cross-sectional study, which used primary data that was obtained from students who filled out a questionnaire. The study sample included 114 students in one of the junior high schools in Surabaya. The dependent variable was the internet addiction level; the dependent variables were gender, age, student grade, and temperament. An Internet Addiction Test (IAT) and an Early Adolescents Temperament Questionnaire-Revised (EATQ-R) were the tools used for data collection. Data was collected in November 2019. The sample selection was done through the stratified random sampling technique. The data was subsequently analyzed using the Fisher’s exact and Spearman correlation tests. Results: There was a significant positive correlation between age (p<0.01), student grade (p<0.05), negative affectivity (p<0.01), and surgency (p<0.05) toward internet addiction levels. There was a significant negative correlation observed between effortful control (p<0.05) and internet addiction levels. Conclusion: There was a significant relationship between age, student grade, negative affectivity, surgency, and effortful control and adolescents’ internet addiction levels.
IDENTIFICATION OF BACTERIA CAUSING DIARRHEA IN UNDER-FIVES CHILDREN USING CULTURE METHODS IN BIMA, INDONESIA Muziburrahman Muziburrahman; Dominicus Husada; Budi Utomo
Jurnal Berkala Epidemiologi Vol. 10 No. 1 (2022): Jurnal Berkala Epidemiologi (Periodic Epidemiology Journal)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbe.V10I12022.95-102

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Background: Diarrhea is still a world health issue which is one of the leading causes of morbidity and mortality, with a mortality rate of close to more than 1.30 million deaths globally in 2015. The prevalence period of diarrhea in Indonesia for under-five children in 2018 is 12.30%. The West Nusa Tenggara province is third of the ranks based on doctor’s diagnosis (13.45%) and clinical symptoms (15.12%).  Purpose: This study aims to identify the bacterial infection that causes diarrhea among under-five children in Bima District, West Nusa Tenggara Province. Methods: The cross-sectional study was conducted on under-five children brought to Bolo and Wawo’s Public Health Center with diarrhea and diagnosed with acute gastroenteritis. Results: The samples involved in this study were 102 samples and the results obtained were 1 to 2 types of bacteria in 1 sample. The order of bacteria from the most is E. Coli (29.53%), Klebsiella, sp (25,50%), Shigella, sp (18,79%), Staphylococcus aureus (16,78%), Salmonella Thypii (8,73%), Proteus, sp (0,67%), male (61.76%) had more diarrhea than female (38.24%), with an age range of 1-3 years (53.92%), 0-1 years (37.26%), and 3 until <5 years (8.82%). Conclusion: In this research, it was proven that E. coli bacteria are the leading cause of diarrhea in under-five children.
Clinical Features of Children with Diphtheria on Soetomo Hospital Dwiyanti Puspitasari; Erna Supatmini; Dominicus Husada
Jurnal Ners Vol. 7 No. 2 (2012): Oktober 2012
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (214.679 KB) | DOI: 10.20473/jn.v7i2.4012

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Introduction: Diphtheria is an important disease in children that could lead to fatal disease. East Java Province was declared to have Diphtheria outbreak in 2011 with increasing morbidity and mortality, including on Soetomo Hospital. Our paper aimed to describe the profi le of diphtheria cases in children admitted at dr Sutomo Hospital.Method: This descriptive study reviewed all medical records of diphtheritic patients admitted to Dr. Soetomo Hospital, January 2004–December 2010, of concerns were clinical presentations, age, sex, immunizations status, complications, and outcomes.Result: From 148 diphtheria cases, 22.3% were bacteriologically proven; 53.4% were male with sex ratio 1.1:1. The age proportion of ≤ 5 years old, 5- ≤ 10 years old, and > 10 years old were 61.5%, 31.8%, and 6.7%. Fever occurred in 99% cases, sore throat, stridor and bullneck occurred respectively in 62.2%, 39.9%, and 29.7% cases. There were 56.8% severe and 41.9% moderate diphtheria. Subjects were immunized in 84%, but none of them have adequate immunization. Myocarditis, being one of the commonest complications occurred in 11.4% cases and tracheostomy was the second (4.0%). All of the death cases (7.9%) were unvaccinated and in severe form.Discussion: The mostly prevalent clinical manifestations in diphtheria children were fever and sore throat. Half of the cases came with severe diphtheria and most cases were inadequately vaccinated. Death occurred in the unvaccinated and severe form.
Profile of Dengue Fever Complication in Infant at Tertiary Referral Hospital in East Java, Indonesia Khen Mikhael; Dominicus Husada; Pudji Lestari
Biomolecular and Health Science Journal Vol. 5 No. 1 (2022): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v5i1.34827

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Introduction: Dengue virus infection is caused by the dengue virus and transmitted through the bites of infected Aedes aegypti or Aedes albopictus mosquitoes. The spectrum of clinical manifestations is varied from asymptomatic, undifferentiated fever, dengue fever, dengue hemorrhagic fever, dengue shock syndrome, to expanded dengue syndrome. Data from 2016 in Indonesia revealed that dengue virus infection is common in the population, with a total of 333.821 cases of dengue hemorrhagic fever. Methods: This was a descriptive study with a cross-sectional design. The subjects in this study were children under 1-year-old, diagnosed with dengue virus infection, and had a complication. The number of subjects used is 60 infants. Results: Infection of dengue virus in infants is often found in the 7-9 month age group (36,6%). Clinical manifestations found were fever (100%), vomiting (62%), diarrhea (43%), petechiae (22%), bleeding (12%), and irritable (5%). Thrombocytopenia and leukopenia were found in 93,3% and 26,6% of infants respectively. Complications were found in the form of pleural effusion (66%), hypoalbuminemia (62%), hyponatremia (51%), liver involvement (49%), hypocalcemia (43%), hypokalemia (23%), bleeding (21%), brain involvement (21%), kidney involvement (13%), and ascites (11%).Conclusion: The most common clinical manifestations are fever, diarrhea, and vomiting, while the most common complications are pleural effusion, hypoalbuminemia, hyponatremia, liver involvement, and hypocalcemia.
Correlation between immunization status and pediatric diphtheria patients outcomes in the Sampang District, 2011-2015 Kevin Sastra Dhinata; Atika Atika; Dominicus Husada; Dwiyanti Puspitasari
Paediatrica Indonesiana Vol 58 No 3 (2018): May 2018
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (335.279 KB) | DOI: 10.14238/pi58.3.2018.110-15

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Background The number of diphtheria cases recently increased, such that an outbreak was declared in East Java Province, which includes the Sampang District. Immunization completion status is a determining factor for diptheria infection. Objective To investigate for correlations between immunization status and outcomes (severity level, fatality, and complications) of diphtheria patients in the Sampang District. Methods This analytic, cross-sectional study used secondary data from the East Java Provincial Health Office on diphteria patients aged 0-20 years during the 2011-2015 outbreak in the Sampang District and interviews with diphtheria patients in that region. The Diphtheria Research Team of Soetomo Hospital collected data on immunization status, diphtheria severity (mild, moderate, or severe), case fatality (died or survived), and complications in the patients (with or without complications). Spearman’s, Chi-square, and Fisher’s exact tests were used for data analyses, accordingly. Results Seventy-one patients with clinical diphtheria were identified, 17 of whom were confirmed with positive culture results. The case fatality rates were 7% in patients with clinical and 5.9% in confirmed diphtheria. There were no correlations between patient immunization status and severity (P=0.469 clinical, P=0.610 confirmed), or fatality (P=0.618 clinical, P=0.294 confirmed) of diphtheria in the clinical and confirmed diphtheria patients. However, there was a correlation between patient immunization status and the emergence of complications in clinical (P=0.013), but not in confirmed (P=0.620) diphtheria patients. Conclusion There is a correlation between immunization status and complications in clinical diphtheria patients. Such a correlation is not found in confirmed diphtheria cases because none of the patients had complete immunization status.
Faktor Yang Mempengaruhi Risiko Gangguan Perilaku Anak Dengan Human Immunodeficiency Virus Laili Primasari; Ahmad Suryawan; Dominicus Husada
Jurnal Keperawatan Muhammadiyah 2019: EDISI KHUSUS
Publisher : UNIVERSITAS MUHAMMADIYAH SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (405.61 KB) | DOI: 10.30651/jkm.v4i2.2349

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The number of child HIV patients in Indonesia in 2016 was 1,185 children. In pediatric and adolescent patients with perinatal HIV, the risk of psychological disorders can arise as a direct and indirect result of HIV infection. The direct effect is derived from HIV infection itself and the indirect consequences are caused by things related to HIV status. These problems include emotional, behavioral, cognitive and psychosocial disorders. At present a child's development check is carried out if a problem is suspected and there are no regular inspections. This includes examining the risk of behavioral disorders for children with HIV. Knowing the risk of behavioral disorders in children with HIV aged 6-18 years. The research respondents were outpatients at Poli UPIPI RSUD Dr Soetomo. Patients and guardians who were present were given an explanation and were asked to fill out informed consent as a sign of agreement to become respondents. All patients and guardians who came and met the criteria were taken as research respondents. This research was conducted by filling out a questionnaire regarding risk factors and research instruments. The instrument used was GPPH to assess the risk of behavioral disorders. Statistical analysis with logistic regression showed that the risk factors for hospitalization history (P = 0.031) and parental completeness (P = 0.011) were associated with risk of behavioral disorders. Children who have been hospitalized in the hospital have a possibility of 22,337 times greater risk of behavioral disorders. And children who don't have parents have a 40.586 times greater risk of behavioral disorders. There was a risk of behavioral disorders in children with HIV aged 6-17 years who do not have parents or had been hospitalized.
IDENTIFIKASI KRIPTOSPORIDIOSIS DI PASIEN ANAK HIV DENGAN DIARE KRONIS DI RUANG GASTRO ANAK Jusak Nugraha; Febtarini Rahmawati; Dominicus Husada
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 18, No 1 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v18i1.349

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Based on the results of overseas researchers, Cryptosporidiosis occurs in immunosuppressive cases with chronic diarrhoea. In this study the researchers would like to know exactly whether that Cryptosporidiosis occurs also in paediatric HIV patients. The latest data show that the incidence of opportunistic infection is characterized by persistent diarrhoea and severe malnutrition as a complication of the paediatric HIV-infected patients is increasing. The objects of the research were fifteen paediatric HIV-infected patients which treated at the Paediatric Gastro Ward of Dr. Soetomo Hospital Surabaya due to persistent diarrhoea. Paediatric patients were less than five years old, suffered persistent diarrhoea more than two weeks with severe malnutrition. Stool specimens were transported using 10% formalin. The stool suspension was filtered, and distilled water was added followed by centrifugation (sedimentation method). The precipitate material was placed on a glass object and dried, and then fixed by methanol and stained with Acid Fast Staining and trichrome staining. The protozoa Cryptosporidium spp. was observed under a binocular microscope with 100× magnification (immersion oil) objective. The result was confirmed as positive if a red spherical or oval formation of oocyste of 4–6 micron appeared. Sixty percent of the 15 paediatric HIV-infected patients with chronic diarrhoea showed positive cryptosporidiosis. Cryptosporidiosis is one of the opportunistic infections resulting in chronic diarrhoea in paediatric HIV-infected patients. The results of the present research indicate that the enteric parasite Cryptosporidium spp. was the main cause of persistent diarrhoea in paediatric HIV-infected patients
PROKALSITONIN SEBAGAI PENANDA PEMBEDA INFEKSI BAKTERI DAN NON BAKTERI Bastiana Bastiana; Aryati Aryati; Dominicus Husada; M.Y. Probohoesodo
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 2 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i2.1019

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Early diagnosis of an infection and prompt administration of an antibiotic can dramatically reduce morbidity and mortality.Procalcitonin (PCT), a precursor of calcitonin, has been proposed as a marker of bacterial infection. The aim of this study is to assess theefficiency of procalcitonin in children for the diagnosis of bacterial vs. non bacterial infection. This was a prospective, cross-sectional study.The subjects were enrolled consecutively, consisting of feverish children (temperature ³38.5° C) admitted to the Pediatric EmergencyDepartment with ages up to 12 years old. The subjects were divided into two groups according to their final diagnosis, bacterial and nonbacterial infection. Serum PCT concentration was measured by enzyme linked fluorescent assay (ELFA) method. Sensitivity, specificity,positive predictive and negative predictive values, and receiver operating curve (ROC) of PCT were calculated. Out of 54 patients,24 (44.4%) had a final diagnosis of bacterial infection. PCT showed a wide concentration range in the bacterial infection group (median:1.09 ng/mL, lower (L)=0.05 ng/mL, upper (U)=128.7 ng/mL) compared with non bacterial infection group (0.21 ng/mL; L=0.05ng/mL; U=12.15 ng/mL). There was a significant difference in PCT between the 2 groups (p=0.020). ROC analysis demonstrated anarea under curve (AUC) of 0.686 (95% CI, 0.534 to 0.838). Using a cut-off point of 0.5 ng/mL, the sensitivity, and specificity, positivepredictive and negative predictive values of PCT were 66.7%, 76.7%, 69.6%, 74.2%, respectively. In this study, PCT may be useful fordifferentiation of bacterial vs. non bacterial infection in children.
DIAGNOSTIC OF C-REACTIVE PROTEIN IN FEBRILE CHILDREN Johanis Johanis; Aryati Aryati; Dominicus Husada; Djoko Marsudi; M. Y. Probohoesodo
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 18, No 2 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v18i2.1010

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The measurement of C-reactive protein (CRP), an acute-phase protein synthesized by hepatocytes, is valuable to distinguish bacterialinfection from non-bacterial infections in children. The aim of this study is to know the diagnostic properties of quantitative CRPassociated with clinically bacterial and non-bacterial infection in febrile children. Febrile children which was studied were presentingin the Paediatric Emergency Department, their ages were up to 12 years, with axillary’s temperature ≥38.5° C, and the clinicallyundetectable source of fever were enrolled in this consecutive study from September, 2009, up to August, 2010. Informed consent wasobtained for the use of CRP evaluation. The CRP concentration was measured with immunoturbidimetry method (Pure auto S CRP latex(SS-type), Sekisui Medical Co., Ltd) and an auto photometer TMS 1024i. The main outcome result was the presence of the laboratoryexamination results, blood culture, or radio graphically. The receiver operator characteristic (ROC) curve was modelled for quantitativeCRP to identify the optimal test value. Eighty-six patients were enrolled in this study. Forty-one (47.6%) had bacterial infection and 45(52.3%) had non-bacterial infection. The CRP concentration was significantly different between the two groups (p=0.003). The ROCanalysis demonstrated an area under curve (AUC) 0.689, standard error (SE) 0.059, and 95% confidence interval (CI): 0.573-0.805.The optimal cut-off point for CRP in this data set at 5 mg/L, achieved sensitivity of 0.61, specificity of 0.71, and likelihood ratio 2.11(Kappa 0.003, McNemar 0.711) for the detection of bacterial infection in this population. The Quantitative CRP concentration is avaluable laboratory test for the evaluation of febrile children who are at risk of bacterial infection.
Co-Authors A’yuni, Zera Qurrota Adnyana , I Made Dwi Mertha Aflahudin, M. Ahda Naufal Agung Dwi Wahyu Widodo Ahmad Suryawan Akbar Panjinegara, Muhammad Alfi Layali Muntaza Anang Endaryanto Andi Airina Binti A Agus Annisa Fira Salsabila anomsari, hanna dyahferi Arguni, Egi Ari Prayitno Ari Prayitno, Ari Arien Dwi Ajeng Adhe Safitri Arina Setyaningtyas Aris Wiji Utami Aryati Aryati Aryati Aryati Atika Atika Atika Atika Atika Bangkit Putrawan Bastiana Bermawi Basuki, Setio Budi Prasetyo Budi Utomo Budi Utomo Budiono Budiono Bulqis Inas Sakinah Candra Maulana Catarina Rani Cissy B Kartasasmita Cissy B. Kartasasmita Cita Rosita Sigit Prakoeswa Darto Saharso Dessy Putri Pratiwi Destasari Tri Hartanti Desy Primayani Djoko Marsudi Dwi Prasetyo Dwi Prasetyo Dwiyanti Puspitasari, Dwiyanti Edward Adijaya Rusli Egi Arguni Endyka Erye Frety Erna Supatmini Erni Rosita Dewi Esti Yunitasari Estin Puspaningrum Eveline Irawan Fadilla, Aulia Nur Febtarini Rahmawati Ferdinandus, Euvanggelia Dwilda Fitri Ramadhani Fitriah Fitriah Fitriah, Muhammad Yasin Flora Ramona Sigit Prakoeswa Gatot Irawan Sarosa Gatot Irawan Sarosa, Gatot Irawan Gunadi Ranu, I Gusti Made Reza Hanifah Oswari Hanifah Oswari Haq, Arini Hardyanto Soebono Hari Basuki Notobroto Hartono Gunardi Hartono Gunardi Hasan, Nur Aini Hendrata, Adi Pramono Hilwana, Lutifta I Dewa Gede Ugrasena I Gusti Ngurah Twi Adnyana Ida Safitri Laksanawati Ilya Krisnana, Ilya Irawan, Eveline Irawan, Eveline Irene Ratridewi Irwanto Irwanto, Irwanto Ismoedijanto Isnin Anang Marhana Jihan Kalishah Johanis Johanis Juniastuti Juniastuti Juniastuti Juniastuti Jusak Nugraha Kartina, Leny Kevin Sastra Dhinata Khen Mikhael Kristina Marbun Kristoforus Samson Kusnandi Rusmil Kusnandi Rusmil Laili Primasari Laksmi Wulandari Lilik Djuari Linda Dewanti M. Y. Probohoesodo M. Yulianto Listiawan M.Y. Probohoesodo Maddepunggeng, Martira Martira Maddepunggeng Ma`ruf, Anwar Mei Neni Sitaremi Mei Neni Sitaresmi Mufidah Binti Eka Muhammad Akbar Panjinegara Muhammad Miftahussurur Muhammad Vitanata Arfijanto, Muhammad Vitanata Muntia Rizki Alzahra Mustikasari, Rahma Ira MUTHMAINNAH Muthmainnah Muthmainnah Muziburrahman Muziburrahman Nastiti Kaswandani Natalia Yuwono Nihar, Mahdiyyah Husna Nike Aprilidia Nugraheny, Risca Ayu Parwati S. Basuki Parwati Setiono Basuki Pasulu, Soraya Salle Polanunu, Masayu Ramadhani Praswitasari, Rengganis Prodjosoewojo, Susantina Pudji Lestari Raihan Raihan Raihan Raihan, Raihan Rania, Najwa Miftah Ratni Indrawanti Reka Elvia Dirda Prasasta Renaldy, Raden Bagus Yanuar Retno Asih Setyoningrum Retno Palupi Retnosari Widowati Risa Etika, Risa Rossyanti, Lynda Rusli, Musofa Sabrina, Haifa Rafiqa Sakinah, Bulqis Inas Salma Asri, Hanifa Irfani Salma, Zukhaila Samson, Kristoforus Santi Martini Sari, Arabella Vonia Sari, Marlita Mustika Sarjana, IWayan Savitri Laksmi Winaputri Sesilia Serly Kebo Setiawati, Yunias Setyo Handryastuti Soedjatmiko Soedjatmiko Soedjatmiko Soegianto, Sugi Deny Pranoto Soegianto, Sugi Deny Pranoto Sofia Alfarizi Sopha, May Ira Sri Rejeki H Hadinegoro. Sri Rezeki S. Hadinegoro, Sri Rezeki S. Sri Umijati Sri Utami Sriwijayanti Sulistyawati Suhintam Pusarawati Sukmawati Basuki Sulistiawati Sulistiawati Sulistiawati Sumaryono Sumaryono Sunari, I Gusti Agung Ayu Eka Putri Supiatun.M, Lilis Sri Susanti Susanti Susanto Nugroho Sutjonong, Tioky Theresia Indah Budhy Sulisetyawati Thiono, Marischa Tita Wafirotul Rizqi Hasanah Widodo Darmowandowo Woro Setia Ningtyas Yuli Astika Yulia Nadar Indrasari Yulida Mufidah Zakiudin Munasir Zakiudin Munasir