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All Journal INDONESIAN JOURNAL OF PHARMACY Indonesian Journal of Chemistry JCRS (Journal of Community Research and Service) Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Bivalen: Chemical Studies Journal Sevanam: Jurnal Pengabdian Masyarakat Jurnal Farmasi Klinik dan Sains Journal of Pharmaceuticals and Natural Sciences Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Jurnal Abdita Naturafarm Jurnal Riseta Naturafarm Jurnal Riseta Soshum
Rusman, Arman
Fakultas Farmasi, Universitas Mulawarman, Samarinda, Kalimantan Timur, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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NMR-Based Metabolic Profiling and Anticancer Activity of Nephelium ramboutan-ake and Nephelium lappaceum Flesh Febrina, Lizma; Rusli, Rolan; Samsul, Erwin; Rijai, Laode; Ahmad, Islamudin; Rusman, Arman; Hikmawan, Baso Didik; Rija'i, Hifdzur Rashif; Almeida, Maria
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.104162

Abstract

In this research, 1H-NMR-based metabolomics assessed the metabolite profiles of two Nephelium species flesh, specifically Nephelium ramboutan-ake and Nephelium lappaceum. Our research findings indicate that the metabolite profile of N. ramboutan-ake is qualitatively identical, although numerically distinct from that of N. lappaceum. The PLSDA data indicate that N. ramboutan-ake possesses elevated concentrations of acetic acid, malic acid, GABA, and succinic acid compared to N. lappaceum. In N. lappaceum, alanine and glucose serve as the distinguishing metabolites. Additionally, the anticancer efficacy of two Nephelium samples was assessed. As a result, the anticancer properties of N. ramboutan-ake were superior to those of N. lappaceum. PLS analysis indicated that GABA exhibited the most positive connection with the anticancer activity of Nephelium samples. These results indicate that the higher GABA concentrations of N. ramboutan-ake have a beneficial effect on its anticancer activity.
Co-Authors Agung Endro Nugroho Agung Endro Nugroho Agus Setiawaty Almaida, Maria Almeida, Maria Andi Tenri Kawareng Arfan Arfan Arfan Arfan Arifian, Hanggara Arifuddin, M Arifuddin, Muhammad Azmi, Fatur Rahman Badawi, Satriani Baso Didik Hikmawan Bone, Mahfuzun Bulan, Adisty Sindi Dwi Septiani, Kadek Ayu Erwin Samsul Fadraersada, Jaka Farah, Harra Ismi Farrah, Harra Ismi Febrina, Lizma Haeruddin Haeruddin Haeruddin Haeruddin Hafidzah, Nurul Herman Herman Herman Ibrahim, Arsyik Indrayanti, Wa Ode Dian Irman Idrus Irwansyah Irwansyah Islamudin Ahmad Islamudin Ahmad ISWAHYUDI ISWAHYUDI Jafar, Fahriani Istiqamah Junaidin Junaidin Junaidin, Junaidin Kasmawati, Henny Laode Rijai M. Arifuddin, M. M. Yogi Riyantama Isjoni Muhammad Faisal Muhammad Faisal Mus, Nurul Muhlisa Nur, Tajuddin Nurramadhani A. Sida Pasaribu, Handayani Putri, Novita Eka Kartab Ramadhan, M. Rahmad Ridhotulloh, Yusuf Isro Rija'i, Hifdzur Rashif Rijai, Hifdzur Rashif Rija’i, Hifdzur Rashif Riki RIKI RIKI, RIKI Rolan Rusli Rusli, Rolan Sari, Indah Dewi Setyowati, Widiastuti Agustina Eko Sida, Nurramadhani A. Sitti Sarfila Sulistyarini, Riski Supriatno Suwidjiyo Pramono Suwijiyo Pramono Syaiful Katadi Syamsiar, Syamsiar Wa Ode Dian Indrayanti Zamruddin, Nur Masyithah