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All Journal Jurnal Fitofarmaka Indonesia Jurnal Penelitian Kesehatan Suara Forikes JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Journal of Dedicators Community Jurnal Farmasi Indonesia Jurnal Mandala Pharmacon Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Health Information : Jurnal Penelitian Jurnal Kefarmasian AKFARINDO Jurnal Aisyah : Jurnal Ilmu Kesehatan JURPIKAT (Jurnal Pengabdian Kepada Masyarakat) Open Access Indonesian Journal of Medical Reviews JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Formosa Journal of Multidisciplinary Research (FJMR) Jurnal Sains dan Teknologi Jurnal Pengabdian Kepada Masyarakat Mulawarman International Journal of Integrative Sciences Journal of Advances in Medicine and Pharmaceutical Sciences Riset Informasi Kesehatan Journal of Pharmaceutical and Sciences. Journal of Health Management and Pharmacy Exploration (JOHMPE) Medical Sains : Jurnal Ilmiah Kefarmasian International Journal Of Public Health International Journal of Contemporary Sciences (IJCS) Jurnal Mitra Pengabdian Farmasi Indonesian Journal of Global Health Research
Ika Purwidyaningrum
Faculty Of Pharmacy, Universitas Setia Budi, Surakarta
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Efektivitas Biaya Obat Kombinasi ACEI-CCB dan ARB-CCB pada Pasien Hipertensi dengan Diabetes Melitus Tipe 2 Hapysari, Yulinda Pristi Dwi; Purwidyaningrum, Ika; Harsono , Samuel Budi
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.477

Abstract

Komplikasi hipertensi sering terjadi salah satunya pada DM tipe 2. Dalam mencapai penurunan tekanan darah diperlukan terapi obat kombinasi dengan menggunakan ACEI-CCB dan ARB-CCB. Terapi obat kombinasi efektif dalam mengontrol tekanan darah, namun mampu membuat beban biaya pengobatan meningkat. Tujuan penelitian ini memiliki tujuan yakni mencari tahu gambaran obat kombinasi ACEI-CCB dan ARB-CCB pada pasien hipertensi dengan DM tipe 2, dalam rangka mengetahui keefektifan biaya, serta untuk mengetahui rencana perbaikan masalah cost-effectiveness pada lingkup rumah sakit. Penelitian berjenis observasional dengan pengambilan datanya dilakukan dengan cara retrospektif. Biaya yang dianalisis yaitu mencakup biaya terapi obat, biaya penunjang, biaya obat tambahan, dan biaya laboratorium, kemudian melakukan rencana perbaikan untuk cost-effectivenes dengan menggunakan metode analisis SWOT. Didapatkan sampel penelitian ini sebanyak 90 pasien, pengguna kelompok terapi ACEI-CCB sebanyak 38 pasien dan kelompok terapi ARB-CCB sebanyak 52 pasien. Hasil penelitian analisis rata-rata biaya pengobatan kombinasi antihipertensi pasien komplikasi DM Tipe 2 didapatkan pada kombinasi ACEI-CCB sebesar Rp. 635.663, sedangkan pada kombinasi ARB-CCB sebesar Rp. 570.314. Biaya penggunaan obat kombinasi yang paling efektif adalah kombinasi ACEI-CCB dengan nilai efektivitas 44,74% dan dengan nilai ACER sebesar Rp. 14.209 dan ICER yaitu Rp. 7.970,96. Hasil analisis SWOT dengan matriks IE ini berada pada sel I sehingga dapat diindikasikan rumah sakit yang peneliti jadikan lokasi penelitian ada pada posisi grow and build atau tumbuh dan membangun, sehingga strategi yang dapat diterapkan yaitu meliputi penetrasi, pengembangan dan integrase.
Uji Aktivitas Vasodilatasi Ekstrak Etanol Buah Okra (Abelmoschus Esculentus) dengan Parameter Kadar Nitrit Oksida (NO) Hafidah, Hafidah; Purwidyaningrum, Ika; Keswara, Yane Dila
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.553

Abstract

Penyakit jantung iskemik (IHD) adalah suatu kondisi medis jantung tidak mendapatkan oksigen dan nutrisi yang cukup karena adanya penyempitan atau sumbatan pada arteri koroner. Efek vasodilatasi pada IHD dapat membantu mengatasi beberapa komplikasi yang timbul dari penyakit ini. Buah okra (Abelmoschus esculentus) merupakan tanaman yang berpotensi memberikan efek vasodilatasi karena mengandung kuersetin. Tujuan penelitian ini adalah menguji aktivitas ekstrak buah okra (Abelmoschus esculentus) dan dosis efektifnya dalam memberikan efek vasodilatasi. Buah okra diekstraksi dengan metode maserasi menggunakan pelarut etanol 70%. Penelitian ini menggunakan hewan uji tikus putih (Rattus novergicus) jantan galur Sprague Dawley dengan variasi tiga dosis ekstrak buah okra yaitu dosis 75 mg/kg bb, 150 mg/kg bb, dan 300 mg/kg bb. Digunakan kontrol positif Isosorbide mononitrat dan kontrol negatif CMC 0,5%. Aktifitas vasodilatasi ekstrak buah okra diamati melalui parameter kadar nitrit oxide. Data hasil pengamatan dari masing-masing parameter dianalisis dengan menggunakan one way ANOVA. Hasil penelitian menunjukan bahwa ekstrak etanol buah okra (Abelmoschus esculentus) dapat memberikan aktivitas efek vasodilatasi terhadap tikus putih (Rattus novergicus) jantan galur Sprague Dawley. Ekstrak buah okra yang memiliki dosis paling efektif adalah dosis 75 mg/kg bb tikus.
Education Influence Using Leaflet Media on the Level of Knowledge, Compliance, and Therapy Outcomes in Prolanis Hypertension Patients at X Clinic Surakarta Andrianto, Dita; RA Oetari; Purwidyaningrum, Ika
Formosa Journal of Multidisciplinary Research Vol. 3 No. 3 (2024): March 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/fjmr.v3i3.8342

Abstract

Hypertension prevalence in Indonesia reached 34.4%. Chronic Disease Management Program or Program Pengelolaan Penyakit Kronis (PROLANIS) was one of the preventive and promotive strategies from BPJS, carried out to reduce or prevent complications of chronic diseases, including hypertension. Aim of this study was to determine education influence using leaflet media on the level of knowledge, compliance and therapy outcomes in prolanis hypertension patients at X Clinic, Surakarta. Method of this study used a quasi-experimental with pre-test and post-test design with 40 patients in each control and treatment group. Knowledge level assessed using HK-LS questionnaire, compliance assessed using MARS questionnaire, and therapy outcomes collected from medical record. The results of this study showed that education using leaflet media influenced level of knowledge with a value of p = 0.014, level of taking medication adherence with a value of p = 0.015 and results of systolic blood pressure therapy with a value of p = 0.000. There were an influence of education using leaflet media on the level of knowledge, compliance and therapy coutcome for prolanis hypertension patients at X Clinic, Surakarta.
Improvement Strategy for Procurement Using the Hanlon Method at the Public Health Centers in Kediri Prasetyawan, Fendy; Widodo, Gunawan Pamudji; Purwidyaningrum, Ika
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 1 (2023): November 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v1i1.7254

Abstract

Public Health Center (PHC) was a health center that needed and demanded by the community, accordingly availability and quality of medicines at PHC should met the needs. Purpose of this study were to determine the level of conformity and specify selection and procurement strategies for pharmaceutical service standards in Kediri's PHC based on priority scale of problem using Hanlon analysis. Design of this study was a non-experimental study, with data were analyzed quantitative and qualitative, collected using questionnaire instrument by conducting interviews, while results of this study was data in the form of counting results from respondent’s answers. The research results indicate that the procurement compliance level at the Public Health Centers in Kediri City has one problematic indicator, namely the percentage of procurement compliance with the actual usage for each drug item. Meanwhile, three indicators that are in compliance include the frequency of procurement for each drug item, the frequency of invoice errors, and the frequency of delayed payments by Puskesmas in relation to the established timelines.
Projected Customer Growth Rate of Hospital Pharmacy Installation in Blitar from 2021 to 2023 Wahyuningtiyas, Triya; Purwidyaningrum, Ika; Wijayanti, Tri
International Journal of Integrative Sciences Vol. 3 No. 8 (2024): August 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijis.v3i8.11100

Abstract

Quality of pharmaceutical services can be measured by the performance of the Blitar General Hospital Pharmacy Installation which focuses on customer growth rates. This study aims to determine the growth rate of outpatient and inpatient customers of the Blitar General Hospital Pharmacy Installation from 2021 to 2023. This research uses a qualitative descriptive approach. Data were collected through in-depth interviews, observations, and document studies, which were then analyzed using a qualitative approach. The results showed that the total customer growth rate increased over time; in 2021, there were 12,786 customers; in 2022, there were 44,833 customers; while in 2023, there were 58,850 customers
Analysis of Drug Management and Improvement Strategies Using the Hanlon Method at the Pharmacy Installation of Dr. Oen Kandang Sapi Hospital, Surakarta, Indonesia Vidya Dharma, Cakka Kumara; Titik Sunarni; Ika Purwidyaningrum
Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 1 (2024): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v4i1.530

Abstract

Medication management is an important factor in ensuring the level of drug availability. The aim of this research is to analyze and provide strategies for improving drug management in the Pharmaceutical Installation of Dr. Oen Kandang Sapi Hospital Surakarta using the Hanlon method. This research uses a descriptive design, with data taken retrospectively and concurrently. Data was obtained from the selection, procurement, distribution, and use stages. In the selection stage, the results obtained were drug suitability with the National Formulary (65.14%) and suitability with the Hospital Formulary (75.07%); Procurement stage: frequency of procurement per year (96 times), frequency of delayed payments from hospitals (0 time). In the distribution stage, the percentage of expired date medicines damaged (0.15%), the accuracy of the data on the number of medicines on the stock card was (95.78%), and the percentage of dead stock (3.61%). Stage of use: number of items per prescription sheet (3.18 sheets), percentage of antibiotic drug prescriptions (8.53%), percentage of injection drug prescriptions (29.86%), the average time to serve prescriptions (non-concocted 8.88 minutes and concocted 17.52 minutes), the percentage of drugs that can be submitted (99.95%), percentage of drugs that are fully labeled (100%). Percentage of prescriptions with generic names (49.26%). The results of analysis using the Hanlon method show that drug management in the Pharmacy Installation of Dr. Oen Kandang Sapi Hospital Surakarta is quite good but needs to be improved continuously.
Effects of Moringa Leaf Extract on a Mouse Model of Dementia on Spatial Memory, MDA Levels, and Hippocampal Pyramidal Cell Count (CA1 & CA3) Melati, Fitri; Purwidyaningrum, Ika; Harmastuti, Nuraini
Journal of Health Management and Pharmacy Exploration Vol. 3 No. 2 (2025): August 2025
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v3i2.633

Abstract

Antioxidants are substances needed by the body to neutralize free radicals and prevent damage caused by free radicals. Moringa leaves contain flavanoids, alkaloids, saponins and tannins that are antioxidants because of their ability to capture free radicals. This study aims to determine the effect of moringa leaf fractions on spatial memory ability using the Radial Arm Maze method, a decrease in malondialdehyde levels and inhibition of damage to the number of hippocampal pyramidal cells in CA1 & CA3 areas. Moringa leaves were extracted using the maceration method with 70% ethanol solvent. Then the ethanol extract of Moringa leaves was fractionated using the liquid-liquid method with n-hexane, ethyl acetate and water as solvents. Next, the mice were subjected to induction treatment with lead acetate, then observed for 21 days with the Radial Arm Maze, then the mice underwent surgery and their brains were removed for MDA level testing and histopathological observation. Data were analyzed statistically using one-way ANOVA (p<0.05) followed by Tukey's test. Based on the results obtained, the ethyl acetate fraction, n-hexane fraction and water fraction can influence the improvement of spatial memory by reducing latency time and type B errors, reducing malondialdehyde levels with TBARS and inhibiting damage to CA1 and CA3 hippocampal pyramidal cells which are characterized by pknotic neuron nuclei (shriveled), dark, solid, and vacuolized.
Uji Aktivitas Ekstrak Etanol Daun Benalu Mangga (Dendrophthoe pentandra L.) pada Indeks Fagositosis Mencit (Mus musculus) Vistaloka, Yusnita Mayang; Purwidyaningrum, Ika; Widyasti, Jena Hayu
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.884

Abstract

Tanaman benalu mangga memiliki kandungan senyawa seperti alkaloid, flavonoid, terpenoid, dan  polifenol yang mana kandungan tersebut berpotensi sebagai antiinflamasi, antioksidan, antikanker, dan immunomodulator. Penelitian ini bertujuan untuk mengetahui aktivitas pada indeks fagositosis dari ekstrak etanol daun benalu mangga pada mencit yang diinduksi karbon. Penelitian ini menggunakan 25 ekor mencit jantan yang dikelompokkan menjadi 5 kelompok yaitu kelompok kontrol negatif (CMC Na), kelompok kontrol positif (methylprednisolon) dengan dosis 1,04 mg/kg BB mencit, dan kelompok perlakuan ekstrak dosis 420 mg/kg BB, 840 mg/kg BB, dan 1.680 mg/kg BB. Mencit diberi perlakuan selama 7 hari peroral dan pada hari ke-8 diinduksi karbon secara intravena melalui ekor mencit. Metode yang digunakan adalah metode bersihan karbon dengan parameter indeks fagositosis mencit dan persentase indeks organ limpa. Hasil penelitian menunjukkan bahwa ekstrak etanol daun benalu mangga memiliki aktivitas penurunan pada indeks fagositosis dan persentase indeks organ limfa. Hal ini menunjukkan bahwa ekstrak etanol daun benalu mangga memiliki aktivitas dengan penurunan indeks dan persentase indeks organ limfa dengan dosis efektif 840 mg/kgBB yang sebanding dengan kontrol positif.
Analisis Pengendalian Persediaan Dan Strategi Perbaikan Di Instalasi Farmasi RSUD dr.Soehadi Prijonegoro Sragen Tahun 2021 Hutasoit, Melyanti Magdalena; Purwidyaningrum, Ika; Saptarini, Opstaria
Health Information : Jurnal Penelitian Vol 17 No 3 (2025): September-Desember
Publisher : Poltekkes Kemenkes Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36990/hijp.v17i3.1667

Abstract

Latar Belakang: Pengendalian persediaan obat yang tidak optimal menyebabkan kekosongan atau kelebihan stok di rumah sakit, sehingga diperlukan sistem analisis yang komprehensif untuk meningkatkan efisiensi biaya dan mutu pelayanan. Tujuan: Menganalisis pengendalian persediaan obat menggunakan metode ABC-VEN, EOQ, ROP, ITOR dan merumuskan strategi perbaikan melalui analisis SWOT di RSUD dr.Soehadi Prijonegoro Sragen tahun 2021. Metode: Penelitian deskriptif dengan data kualitatif dan kuantitatif yang dikumpulkan secara retrospektif periode Januari-Desember 2021. Hasil: Analisis ABC-VEN mengidentifikasi 68 item kategori AE bernilai Rp6.095.836.400 yang memerlukan prioritas pengendalian ketat. EOQ menunjukkan jumlah pemesanan optimum tertinggi 113.332 unit dengan ROP bervariasi hingga 1.271 unit. Nilai ITOR sebesar 4,34 kali/tahun menunjukkan perputaran obat masih di bawah standar ideal 8-12 kali. Matriks IFE (3,04) dan EFE (2,81) menempatkan rumah sakit pada kuadran IV dengan strategi pengembangan. Simpulan: Implementasi metode EOQ-ROP pada kategori AE berpotensi menghemat 25% biaya persediaan. Saran: Diperlukan integrasi sistem informasi manajemen, monitoring ITOR bulanan, dan pelatihan berkala staf farmasi
The Role of Pharmacy Management in Improving Patient Safety through the Prevention of Medication Errors: A Literature Review Novega Diyan Al Amanah Amanah; Nevi Nur Fitriasari Fitriasari; Mey Apriansyah; Wahyu Purwanto; Ika Purwidyaningrum
Indonesian Journal of Global Health Research Vol. 8 No. 2 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i2.1878

Abstract

Medication errors remain a major challenge in patient safety within healthcare facilities and may occur at any stage of the medication use process, including prescribing, preparation, dispensing, administration, and therapeutic monitoring. Such errors have the potential to cause adverse clinical outcomes, increase healthcare costs, and compromise the quality of care. Pharmacy management plays a strategic role in preventing medication errors through the development and implementation of integrated, patient safety–oriented medication management systems. This literature review aims to examine and synthesize findings from scientific journals concerning the role of pharmacy management in improving patient safety through the prevention of medication errors. The literature search was conducted using a narrative review approach of open-access scientific journal articles published within the period of 2019–2024 and retrieved from PubMed Central, Frontiers, BMC Journals, PLOS ONE, and DOAJ. The search was performed using combinations of keywords with Boolean operators as follows: (“pharmacy management” OR “pharmaceutical services” OR “medication management system”) AND (“medication errors”) AND (“patient safety”). A total of 285 records were identified through database searching. After the removal of duplicates and other ineligible records, 180 articles were screened, of which 80 were excluded. Subsequently, 100 full-text articles were assessed, and 30 studies were finally included in this review. articles comprised primary research studies relevant to pharmacy management, medication errors, and patient safety. The findings indicate that the role of pharmacy management in preventing medication errors can be categorized into several key themes, including the management of dispensing and drug distribution systems, optimization of clinical pharmacists’ roles in patient care, implementation of standard operating procedures in medication management, and the utilization of pharmacy technologies and information systems. An integrated pharmacy management approach has been reported to contribute to reducing the incidence of medication errors and enhancing patient safety across various healthcare settings. This review concludes that strengthening pharmacy management constitutes a critical component in efforts to improve patient safety and to develop safer healthcare delivery systems.  
Co-Authors Afriliza, Dini Aljufri Mahmud Almahera Almahera Amanta Rajendra Rafi Ramadani Ana Indrayati Andrianto, Dita Annisa Nur Safitri Annisa Ratna Fadilla Purba Argo Widianto Bunga Yuniasakti Dewi Ekowati Dewi Ekowati Dian Indrayanti Dwi Indah Kurnia Kusumawardani Eka Hayati Rhomah Erlinda Novita Sari Febryarti, Yossy Fendy Prasetyawan Galih Kurniawan Gunawan Pamudji Widodo Hafidah, Hafidah Hapysari, Yulinda Pristi Dwi Harsono , Samuel Budi Harsono, Samuel Budi Hutasoit, Melyanti Magdalena Inaratul Rizkhy Hanifah Ismi Rahmawati Ismi Rahmawati Istiqomah Iswandi Iswandi - Iswandi Iswandi Iswandi Iswandi Iyem Shahira Jason Merari Peranginangin Jason Merari Peranginangin Keswara, Yane Dila Khofifah Maharani Kresensia Stasiana Yunarti Kurniasari, Fitri Lering, Maria Nona Adriani Lukman Hakim Lukman Hakim M. Wahyu Ariawan Mamik Ponco Rahayu Mardiyono Mario Hendrik Refwalu Mariyo Jane Sanggel Melati, Fitri Meta Kartika Untari Meta Kartika Untari Meta Kartika Untari Mey Apriansyah Muhammad Dzakwan Mustika Wati Narimo Nevi Nur Fitriasari Fitriasari Novega Diyan Al Amanah Amanah Novita Sari, Erlinda Nugroho, Triyanto Nuke Fendiana Nuraini Harmastuti Octaviana Dyah Oentari Opstaria saptarini Pacheco, Mergita Angela Pristi Dwi Hapysari, Yulinda Pujitami, Sri Wahyuni RA Oetari Rina Herowati santi dwi astuti Sarimanah, Jamilah Sri Wahyuni Pujitami Titik Sunarni Titik Sunarni Tri Murti Andayani Tri Wijayanti Tri Wijayanti Tri Wijayanti Vidya Dharma, Cakka Kumara Vistaloka, Yusnita Mayang Vivin Nopiyanti Wahyu Purwanto Wahyuningtiyas, Triya Widyasti, Jena Hayu Widyastuti, Lita Wiwin Herdwiani Youpita, Nyoman Yurita Werdiningsih Hutami