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All Journal Jurnal Delima Harapan Jurnal Farmasi Higea Jurnal Dunia Farmasi Jurnal Analis Farmasi PREPOTIF : Jurnal Kesehatan Masyarakat Abdi Masyarakat PUBLIKASI PENELITIAN TERAPAN DAN KEBIJAKAN Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Kesehatan Tambusai Jurnal Farmasi Jurnal Ilmiah Wahana Pendidikan Journal of Fundamental and Applied Pharmaceutical Science JAF (Jurnal Analis Farmasi) Proceedings of the International Conference on Nursing and Health Sciences JIFI (Jurnal Ilmiah Farmasi Imelda) Indonesian Community Journal Veteran Society : Jurnal Pengabdian Masyarakat Jurnal Farmasi Sains dan Praktis Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) JURNAL JAMU KUSUMA Duta Pharma Journal Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Detector: Jurnal Inovasi Riset Ilmu Kesehatan Jurnal Ilmiah Global Farmasi Jurnal Pengabdian Masyarakat dan Riset Pendidikan EduInovasi: Journal of Basic Educational Studies Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Ilmiah Farmasi Indonesia (JIFIN) Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Wardani, Tatiana Siska
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Uji Aktivitas Antidiabetes dari Ekstrak Daun Salam (Syzygium polyanthum) Menggunakan Metode Inhibisi Enzim α-Amilase Secara In Vitro Devi Nur Indah Sari; Kharisma Jayak P; Tatiana Siska Wardani
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 3 (2025): Desember : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i3.6852

Abstract

Diabetes Mellitus is a metabolic disorder caused by the pancreas failing to produce insulin hormone adequately. Based on the cause, diabetes mellitus is classified into three types, including type 1 DM, type 2 Diabetes Mellitus, and gestational diabetes mellitus. Hyperglycemia can also occur due to food consumed that is not balanced with physical activity carried out so that fat accumulates in the body and causes blood to be unable to enter the body's cells, ultimately increasing blood sugar levels. Signs and symptoms that often appear in Diabetes Mellitus patients are polydipsia (excessive thirst), polyuria (frequent urination due to excessive urine production), polyphagia (quickly feeling hungry even though you eat a lot and want to eat continuously) and weight loss without a clear cause. Symptoms of diabetes mellitus can be controlled by increasing physical activity, following a healthy diet, and getting enough rest. Several studies have proven that bay leaves have the potential as an antidiabetic. This study aims to determine the content of secondary metabolic compounds and the antidiabetic activity of bay leaf extract using α-amylase enzyme inhibition in vitro. This research method uses laboratory experiments. This study uses α-amylase enzyme inhibition to determine the antidiabetic activity contained in bay leaf extract. The method used is DNSA. The results of this study obtained a yield of bay leaf extract of 30%, water content of simplicia of 6.24%, drying loss of simplicia of 5.3%, ash content test of 5.6%, water content test of extract of 6.34%, drying loss test of extract of 7.03%. Bay leaf extract positively contains secondary metabolite compounds, namely saponins, tannins, flavonoids, and alkaloids. The results of IC50 in bay leaf extract of 66.705 ppm are classified as strong antidiabetic. The results of acarbose of 56.818 ppm are classified as strong antidiabetic.
daun pegagan (Centella Asiatica UJI EFEK DIURETIK EKSTRAK ETANOL 96% DAUN PEGAGAN (Centella Asiatica (L.) Urb) PADATIKUS PUTIH JANTAN GALLUR WISTAR (Rattus Norvegicus) NOVISYIAHGIANT, DINA AMALIA; Anita Dwi Septiarini; Tatiana Siska Wardani
Duta Pharma Journal Vol. 3 No. 2 (2023): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/djp.v3i2.3129

Abstract

Pegagan (Centella asiatica (L.) Urb) merupakan bahan alami yang dapat dimanfaatkan oleh masyarakat. Pegagan mengandung senyawa flavonoid yang memiliki efek diuretik dengan mempercepat produksi urin. Penelitian ini bertujuan untuk mengetahui aktivitas diuretik ekstrak pegagan dengan etanol 96% pada tikus jantan. Penelitian ini merupakan penelitian eksperimental dan diekstraksi dengan metode maserasi dalam pelarut etanol 96%. Tikus jantan sebanyak 25 ekor dibagi menjadi 5 kelompok yaitu kelompok kontrol negatif (Na CMC 0,5%), kelompok perlakuan (ekstrak etanol dosis 200, 300 dan 400 mg/KgBB) dan kelompok kontrol positif (spironolakton 1,8mg/kgBB). Uji efek diuretik dilakukan dengan mengukur pengeluaran urin setiap 2 jam selama 6 jam, kemudian data dianalis uji One-way Anova dan dilanjutkan dengan uji Tukey HSD. Hasil penelitian pada ekstrak etanol 96% daun pegagan (Centella asiatica (L.) Urb) dengan variasi dosis 200 mg/kg BB, 300 mg/kg BB, 400 mg/kg BB manunjukkan bahwa mempunyai efek diuretik yang optimal pada kelompok V dengan dosis 400 mg/Kg BB dengan P< 0,05 atau ada perbedaan yang signifikan.
Uji Aktivitas Antioksidan Ekstrak dan Fraksi Daun Rambutan (Nephelium lappaceum L.) dengan Metode FRAP (Ferric Reducing Antioxidant Power) serta Penetapan Flavonoid Total Pratiwi, Dian; Tatiana Siska Wardani; Bagas Ardiantoro
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 3 (2025): November : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i3.8371

Abstract

Free radicals are unstable and highly reactive molecules that can cause oxidative stress, leading to cell damage and the development of degenerative diseases such as cancer, cardiovascular disorders, diabetes, and premature aging. To counteract these harmful effects, antioxidant compounds are required to inhibit oxidative reactions and protect cellular structures. Rambutan leaves (Nephelium lappaceum L.) are rich in bioactive compounds, including flavonoids, tannins, and saponins, which are reported to have strong antioxidant potential. The objective of this study was to evaluate the antioxidant activity of rambutan leaf extracts and their fractions, as well as to determine the IC₅₀ value using the Ferric Reducing Antioxidant Power (FRAP) method. Fractionation was performed using solvents of varying polarity, namely n-hexane, ethyl acetate, and water, to obtain different active fractions. Antioxidant activity was measured based on the ability of extracts and fractions to reduce Fe³⁺ ions to Fe²⁺ at a wavelength of 595 nm. The findings revealed that rambutan leaf extract exhibited very strong antioxidant activity, indicated by an IC₅₀ value of 20.65 ppm. Moreover, the activity increased proportionally with concentration, confirming a significant positive linear correlation. These results suggest that rambutan leaves are a promising natural source of antioxidants with potential applications in the development of pharmaceutical products, functional foods, and nutraceuticals aimed at preventing oxidative stress-related diseases.
UJI EFEK TONIKUM SEDUHAN HERBAL KOMBINASI JAHE MERAH (ZINGIBER OFFICINALE VAR. RUBRUM) DAN DAUN KAYU MANIS (CINNAMOMUM BURMANNI) TERHADAP MENCIT PUTIH JANTAN GALUR SWISS WEBSTER Toyang, Gresilia; Fitriawati, Anna; Wardani, Tatiana Siska
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 2 (2024): AGUSTUS 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i2.29047

Abstract

Jahe merah (Zingiber Officinale Var. Rubrum) merupakan salah satu tanaman obat tradisional yang mengandung senyawa oleoresin dan minyak atsiri yang memiliki khasiat sebagai tonikum. Daun kayu manis (Cinnamomum burmanni) mengandung   senyawa alkaloid, flavonoid, saponin dan minyak atsiri yang mempunyai banyak manfaat salah satunya yaitu tonikum, stimulan dan menyegarkan. Penelitian ini menggunakan hewan uji mencit putih jantan galur Swiss Webster yang dikelompokan menjadi 7 kelompok dan setiap kelompok terdiri dari 5 ekor hewan uji. ke-7 kelompok terdiri dari kontrol negatif (aquadest), kontrol positif (kafein), FI sediaan jahe merah (100%), FII sediaan daun kayu manis (100%), FIII kombinasi sediaan jahe merah daun kayu manis (75% : 25%), FIV kombinasi sediaan jahe merah dan daun kayu manis (25% : 75%), FV kombinasi jahe merah dan daun kayu manis (50% : 50%). Berdasarkan hasil penelitian diperoleh hasil sediaan seduhan tunggal jahe FI lebih efektif. Hasil uji efek tonikum pada sediaan FI sebesar 9,42 menit, FII 7,22 menit, FIII 10,36 menit,  FIV 8,23 menit, dan FV 8,64 menit.  Dapat disimpulkan hasil penelitian yang didapatkan yaitu sediaan seduhan tunggal jahe merah FI lebih efektif dibandingkan sediaan seduhan kombinasi FIV, dan FV karena tidak ada perbedaan yang signifikan.
Perbandingan Aktivitas Antibiofilm Ekstrak Biji Kopi Hijau dan Sangrai Kopi Robusta terhadap Staphylococcus aureus Urip, Sri Khanti; Wardani, Tatiana Siska; Listyani, Tiara Ajeng
Publikasi Penelitian Terapan dan Kebijakan Vol 6 No 2 (2023): Publikasi Penelitian Terapan dan Kebijakan
Publisher : Badan Penelitian dan Pengembangan Daerah Provinsi Sumatera Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46774/pptk.v6i2.547

Abstract

Green Coffee Beans (Coffea canephora P.) and Roasted Robusta Coffee (Coffea canephora L.) contain compounds including caffeine, polyphenols, flavonoids, chlorogenic acid. Chlorogenic acid is a phenolic compound contained in coffee beans which functions as an antifungal and antibacterial. Some infectious diseases caused by Staphylococcus aureus are boils, acne and wound infections and have the ability to inhibit biofilm. Biofilms are aggregates of microorganisms covered by an extracellular polymer matrix produced by microorganisms. This study aims to test the antibiofilm inhibition and destruction of green coffee bean extract (Coffea canephora P.) and roasted robusta coffee (Coffea canephora L.) against Staphylococcus aureus ATCC 25923. The antibiofilm activity test consists of a biofilm formation test, a biofilm inhibition test, and a destruction of biofilm using the Microtitter Plate Biofilm Assay method on extract samples macerated with 96% ethanol. The antibiofilm activity test used concentrations of 2, 4.8, 16 mg/mL. The results of testing the antibiofilm activity of green coffee bean extract and roasted robusta coffee had inhibitory activity with calculated IC50 values of 4.14 mg/mL and 2.13 mg/mL. The results of the crushing activity of green coffee bean extract and roasted robusta coffee with calculated EC50 values were 10.18 mg/mL and 19.32 mg/mL.
Evaluasi Kepuasan Pasien Rawat Jalan terhadap Kualitas Pelayanan di Instalasi Farmasi Rumah Sakit X di Kabupaten Klaten: Evaluation of Outpatient Satisfaction with Service Quality at the Pharmacy Department of Hospital X in Klaten Regency Cahyono, Imam Sahid; Khasanah, Isna Nur; Wardani, Tatiana Siska
Jurnal Ilmiah Farmasi Indonesia (JIFIN) Vol 1 No 02 (2023): JIFIN: Jurnal Ilmiah Farmasi Indonesia
Publisher : UIMA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33221/jifin.v1i02.2783

Abstract

Patient satisfaction is an assessment of a patient between service performance or perceived and expected satisfaction. Patient satisfaction will be fulfilled if the services provided are in accordance with patient expectations. Assessment of satisfaction is not only limited to physical recovery, but also from communication, physical facilities, friendliness of staff, responsiveness of officers in serving patients. This study aims to evaluate outpatient patient satisfaction with the quality of pharmacy services at the X Hospital, Klaten Regency. This research was conducted using the Service Quality (SERQUAL) method which has five dimensions, namely tangible, reliability, responsiveness, assurance and empathy. The results of this study are questionnaire data from 380 respondents getting results from the five dimensions of service quality consisting of 25 questions having a positive gap value. The highest gap value is 0.13 on the responsiveness dimension and the lowest gap value is 0.04 on the tangible dimension. Based on the results of this study, it can be concluded that the services provided by the X Klaten hospital to patients can be said to be good, and the results of these measurements can be used as an evaluation in improving the quality of hospital.
Formulasi Sabun Cair Berbahan Baku Virgin Coconut Oil VCO dengan Penambahan Ekstrak Daun Pepaya Carica Papaya L. untuk Peningkatan Aktivitas Anti Bakteri Staphylococcus Epidermidis ATCC 12238 Raden Rara Anteng Pujowati; Anna Fitriawati; Tatiana Siska Wardani
EduInovasi:  Journal of Basic Educational Studies Vol. 4 No. 3 (2024): EduInovasi:  Journal of Basic Educational Studies
Publisher : Intitut Agama Islam Nasional Laa Roiba Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47467/edu.v4i3.4842

Abstract

Acne is a chronic inflammatory disease caused by Staphylococcus epidermidis. Papaya leaves (Carica papaya L.) contain antibacterial substances, namely alkaloids carpaine, flavonoids, tocophenols. Of this study was to determine the physical quality of liquid soap, increasing antibacterial activity. Papaya leaves were extracted with 96% ethanol solvent, then evaporated with a water bath. Antibacterial activity test using the disc diffusion method in concentrations of 5%, 15% and 25% and liquid soap will be made F0 0%, F1 5%, F2 10%, and F3 25% against Staphylococcus epidermidis ATCC 12238. Amoxicillin tab as a positive control and distilled water as a negative control. Bacterial activity appears a clear zone around the disc paper. And see the physical quality test according to the requirements. The results of the bacterial test data are made in table form, and analyzed using the SPSS method Formula with the addition of papaya leaf extract can be made and according to the physical quality conditions of liquid soap. The results of the 25% concentration extract test are an inhibition zone of 20.8 mm, the highest liquid soap formula is an inhibition zone of 23.8 mm in inhibiting the growth of Staphylococcus epidermidis ATCC 12238. Liquid soap preparations and papaya leaf extract have antibacterial activity against Staphylococcus epidermidis ATCC 12238 bacteria and according to the physical quality requirements of liquid soap.
Uji Aktivitas Antiinflamasi Estrak Sirih Cina (Peperomia Pellusida) Pada Tikus Jantan Galur Wistar Yang Diinduksi Karagenan Achmad Fauzi; Anita Dwi Septiarini; Tatiana Siska Wardani
Detector: Jurnal Inovasi Riset Ilmu Kesehatan Vol. 1 No. 3 (2023): Agustus : Jurnal Inovasi Riset Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/detector.v1i3.2428

Abstract

Chinese betel plant (Peperomia pellucida), an herbal plant belonging to the Piperaceae family, Chinese betel plant (Peperomia pellucida). Research Stages: sample collection, extract preparation, extract standardization, determination of non-specific parameters, phytochemical screening, preparation of test solutions, anti-inflammatory activity tests, treatment of test animals. The results of maceration were filtered using filter paper, then the entire filtrate was concentrated using a vacuum evaporator and water bath at 60℃ to obtain a thick extract. The yield of 96% ethanol extract from Chinese betel powder (Peperomia pellucida) obtained was 4.531%. Based on the results, it has non-specific characteristics, namely drying shrinkage of 9.26%, ash content of 7.9% and water content of 4.15%. Phytochemical screening the compound tested was positive, A dose of 150 mg/kgBB is also an effective dose in inhibiting the formation of edema seen from the effect it gives is stable and has the highest percentage of edema inhibition compared to other doses, which is 34,35%.
Uji Efektivitas Antibakteri Ekstrak dan Fraksi Bunga Telang (Clitoria Ternatea L.) terhadap Pertumbuhan Staphylococcus Aureus ATCC 25923: Penelitian Tantri Dwi Lestari; Tatiana Siska Wardani; Vivin Marwiyati Rohmana
Jurnal Pengabdian Masyarakat dan Riset Pendidikan Vol. 3 No. 3 (2025): Jurnal Pengabdian Masyarakat dan Riset Pendidikan Volume 3 Nomor 3 (Januari 202
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jerkin.v3i3.389

Abstract

Acne is a skin disease where the oil glands are blocked by dirt that can be infected by bacteria. One way to cure acne is by using compounds that have antibacterial effects. Butterfly pea flowers contain compounds that are believed to inhibit bacterial growth at a certain percentage. The purpose of this study was to determine the antibacterial effectiveness of butterfly pea flower extracts and fractions in certain concentrations. This type of research uses experimental. This study was divided into 6 groups with 4 different concentrations, namely positive control (Gentamicin), negative control (DMSO 10%), Butterfly pea flower extract (15%, 20%, 30%, 40%), Aquadest Fraction (15%, 20%, 30%, 40%), N-hexane Fraction (15%, 20%, 30%, 40%), and Ethyl acetate fraction (15%, 20%, 30%, 40%). The results of the bacterial inhibition zone data were analyzed using SPSS 26 with a confidence level of 95%. The results of this study indicate that the extract and fraction of butterfly pea flowers provide antibacterial effects on the growth of staphylococcus aureus bacteria at concentrations of 15%, 20%, 30%, and 40%. The best inhibition zone is in the ethanol extract of butterfly pea flowers with an average inhibition zone of 9.3 mm at a concentration of 40%.
Training On The Making Of Solid Soap By Utilizing Used Cooking Oil Waste By Pembinaan Kesejahteraan Keluarga (PKK) Women In Wangen Village Tatiana Siska Wardani; Erna Chotidjah Suhatmi
VSJ | Veteran Society : Jurnal Pengabdian Masyarakat Vol. 1 No. 2 (2020): Veteran Society : Jurnal Pengabdian Masyarakat
Publisher : Fakultas Hukum, UPN Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/vsj.v1i2.11

Abstract

Social welfare can be improved in various ways that can be done, for example, through community empowerment programs. The part of the community that can be empowered are housewives who are members of the PKK organization, especially in Wangen Village, Polanharjo District, Klaten Regency. The impact of environmental pollution is due to the disposal of used cooking oil and is followed by an increase in the use of cooking oil due to the appeal to stay at home during the Covid-19 pandemic. The existence of this makes a training program and assistance for the utilization of cooking oil waste into soap is the right thing to deal with this problem. The specific goals and targets to be achieved in this activity are that PKK mothers are interested and motivated to become entrepreneurs, to form groups of PKK members who become economically independent by producing soap. In order to achieve this goal, a community service program was carried out by a lecturer at the University of Duta Bangsa Surakarta who provided soap production training conducted by PKK women in Wangen Village. The result of this service is an increase in the skills of PKK Village women in Wangen in making soap from used cooking oil waste.
Co-Authors ACHMAD FAUZI Agung Widiastuti Agustina, Isnaini Akbar, Finica Dwi Al Fajri Razid Faizur Muhammad Alfi Risna Fadilla Aminnulloh, Muhammad Anita Dwi S Anita Dwi Septiarini Anita Dwi Septiarini Anita Dwi Septiarini Anna Fitriawati Annisa Kusuma Wardhani Ariyanti Ariyanti Artini, Kusumaningtyas Siwi Bagas Ardiantoro Bagas Ardiyantoro Baiq Mitasari Bangkit Riska Permata Belinda Arbitya Dewi Cahyono, Imam Sahid Chahyaningrum, Dhiyan Danang Raharjo Desy Ayu Irma Permatasari Devi Nur Indah Sari dewi mei ika widiyastuti Dian Fatimatus Salwa Dian Pratiwi Dinar Aditama Nugroho Erikania, Susanti Erna Chotidjah Suhatmi Erna Chotidjah Suhatmi Evi Eriani Faizah Ariqoh Fazlin Fauzi Febriyani, Rima Ferdian, Erick Fitriana, Lydia Haikal Zanki hanif fathur rohman, muhammad Ikrima Rahmasari Iqbal Sirajudin Maulidinawan Istiara Subekti Jannah, Dikta Anggraini Miftahul Kezia Putri Maha Dewi Kharisma Jayak P Kharisma Jayak Pratama Khasanah, Isna Nur Khilda Hilyatul 'Ulya Khusain, Muhammad Fuad Zidane Kristanti Prihatin Sri Rejeki, Melinia Mega Kusumaningtyas Siwi A Kusumaningtyas Siwi Artini Kusumaningtyas Siwi Artini Lindra Putri, Jessika Ukurmehuli Listyani, Tiara Ajeng Luthfiyanti, Niken Mahadewi Putri Kezia Masruroh, Sururul Kamalin Muhammad Abdul Azis Muhammad Andira Ibnu Shina Muhhamad Aminulloh Muladi Putra Mahardika Mutiara Marzalina Wardhani Nadia Nurul Wachida Nesya Sucitra Ni Luh Ari Yusasrini NOVISYIAHGIANT, DINA AMALIA Nurchaina Aprilia Dewi Pamungkas, Rezky Ardika Phiapresia, Safara Zulfa Pratama, Kharisma Jayak Purwaningsih Purwaningsih Raden Rara Anteng Pujowati Rahadyana, Riskaldila Zahra Rahmat Hidayat Rahmatillah, Annie rani, fahrenza meta Ratna Sari Dewi Ria, Septiyana Rita Anita Tanikolan Riztiandi Ardiansyah Rohmana, Vivin Marwiyati Sahadatun, Angga Aulia Saifana, Cindy Septia Santoso, Aris Priyo Agus Septian Maulid Wicahyo Septiyana Ria Siti Nur Hikmah Siwi, Melati Daru Suhatmi, Erna Chotidjah Tantri Dwi Lestari Toyang, Gresilia tri Mastuti, eni Triya Choirin Nisa Urip, Sri Khanti Utomo Kartika Endrat Verentika, Jumini Voen-Na, Cut Dara Wahana Ayu Saputri Wahdah Sri Rahayu Wahyu Budi Utomo Wali Jati, Ilham Weri veranita Wimpy, W Yusuf, Dea Sagitarina