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All Journal Jurnal Delima Harapan Jurnal Farmasi Higea Jurnal Dunia Farmasi PREPOTIF : Jurnal Kesehatan Masyarakat Abdi Masyarakat PUBLIKASI PENELITIAN TERAPAN DAN KEBIJAKAN Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Kesehatan Tambusai Jurnal Farmasi Jurnal Ilmiah Wahana Pendidikan Journal of Fundamental and Applied Pharmaceutical Science Proceedings of the International Conference on Nursing and Health Sciences JIFI (Jurnal Ilmiah Farmasi Imelda) Indonesian Community Journal Veteran Society : Jurnal Pengabdian Masyarakat Jurnal Farmasi Sains dan Praktis Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) JURNAL JAMU KUSUMA Duta Pharma Journal Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Detector: Jurnal Inovasi Riset Ilmu Kesehatan Jurnal Ilmiah Global Farmasi Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Jurnal Pengabdian Masyarakat dan Riset Pendidikan Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat EduInovasi: Journal of Basic Educational Studies Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Ilmiah Farmasi Indonesia (JIFIN) Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Wardani, Tatiana Siska
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Evaluation of the Rationality of Antibiotic Drugs in Patients with ISPA (Acute Respiratory Tract Infection) at Dr. Moewardi Regional General Hospital (RSUD) Surakarta Nurchaina Aprilia Dewi; Kharisma Jayak Pratama; Tatiana Siska Wardani
International Journal of Health Engineering and Technology Vol. 4 No. 5 (2026): IJHESS JANUARY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i5.560

Abstract

Acute Respiratory Tract Infection (ARTI) remains a major infectious disease in Indonesia, significantly affected by inappropriate antibiotic utilization, potentially increasing bacterial resistance. This study aims to evaluate the rationality of antibiotic use among ARTI inpatients at Dr. Moewardi General Hospital, Surakarta. Utilizing a quantitative, retrospective descriptive design, all medical records of ARTI inpatients from 2023 to 2025 meeting the inclusion criteria were included as samples (total sampling). Data were collected using structured forms and processed using Microsoft Office and IBM SPSS Statistics 20; analysis was performed descriptively following Gyssens' criteria. The study found that although most patients received correct antibiotics with respect to indication (94.7%), drug type (94.7%), dose (100%), and timing (100%), only 34.2% received antibiotics for the appropriate duration. Rational antibiotic use by Gyssens' method was found in only 34.2% of cases. These findings highlight the high rate of duration errors and emphasize routine audits and educational interventions. It is concluded that, despite strengths in dosage and selection, duration of antibiotic use remains a challenge for rational therapy.
Determination Of Sun Protection Factor (SPF) Values Of Water, Ethyl Acetate, And N-Hexane Fractions Of Kepok Banana Flowers (Musa acuminata x M. balbisiana) Using The UV-Vis Spectrophotometry Method Evi Eriani; Septian Maulid Wicahyo; Tatiana Siska Wardani
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.636

Abstract

Indonesia as a tropical country faces high UV exposure which causes premature skin aging and cancer risk, so it is necessary to have natural sunscreen from antioxidant-rich plants such as kepok banana flowers (Musa acuminata x M. balbisiana). This study aims to determine the Sun Protection Factor (SPF) value and protection category of water, ethyl acetate, and n-hexane fractions of kepok banana flowers. This type of research is descriptive experimental with ethanol maceration method, multilevel fractionation, phytochemical screening, TLC, and UV-Vis spectrophotometry (290-320 nm, Mansur formula).The results showed that the different types of solvents in each fraction influenced the resulting SPF value. The ethyl acetate fraction showed the highest protective activity compared to the other fractions. The SPF values ​​of the kepok banana flower water fraction with concentrations of 60 ppm, 80 ppm, 100 ppm, 120 ppm, and 140 ppm were 4.662; 7.757; 9.055; 11.944; 15.264, respectively, with moderate-ultra protection. The ethyl acetate fraction obtained SPF values ​​of 18.433; 18.968; 19.203; 19.672; 20.203 with ultra protection. The n-hexane fraction obtained SPF values ​​of 1.190; 1.762; 2.278; 3.575; 4.598 with the category of no-moderate protection.. Concludedthat kepok banana flowers have potential as a natural sunscreen agent, where the ethyl acetate and water fractions provide the most optimal sun protection effectiveness (SPF) compared to the n-hexane fraction.
Antibacterial Activity Test Of Extracts And Fractionsn-Hexane, Ethyl Acetate, And Pineapple Peel Water (Ananas Comosus(L.) Merr.) Against Bacteria Propionibacterium Acnes ATCC 6919 Dian Fatimatus Salwa; Tatiana Siska Wardani; Bangkit Riska Permata
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.655

Abstract

Acne vulgaris is a common dermatological problem in adolescents in Indonesia's tropical climate related to the activity of Propionibacterium acnes bacteria. Long-term use of antibiotics risks causing resistance, so natural antibacterial alternatives are needed. This study aims to evaluate the antibacterial activity of ethanol extract and fractions of n-Hexane, ethyl acetate, and pineapple peel water against Propionibacterium acnes ATCC 6919, and to determine the most active fraction and MIC and MBC values. This study is a quantitative experimental study. The study population was the bacterial culture of P. acnes ATCC 6919, with samples in the form of pineapple peel extract and fraction. The research instruments included disc diffusion and liquid and solid dilution methods, while data analysis used the Shapiro-Wilk, Levene, and Kruskal-Wallis tests. The results showed that the ethanol extract had moderate to strong antibacterial activity, the ethyl acetate fraction showed the highest activity compared to other fractions, while the n-hexane fraction showed no activity. MIC and MBC values ​​were obtained at a concentration of 20 percent. The conclusion of this study is that pineapple peel has the potential as a natural antibacterial source against P. acnes and the ethyl acetate fraction is the most active fraction.
Antibacterial Activity Test Of Ethanol Extract And N-Hexane Fraction, Ethyl Acetate, Moringa Leaf Water (Moringa Oleifera L) Against Streptococcus Mutans ATCC 25175 Bacteria Wahdah Sri Rahayu; Tatiana Siska Wardani; Tiara Ajeng Listyani
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.662

Abstract

Dental caries remains a major oral health problem globally and in Indonesia, triggered by Streptococcus mutans biofilm. Chemical agents such as chlorhexidine have side effects, encouraging the use of natural alternatives from Moringa oleifera L. leaves. This study aims to evaluate the antibacterial activity of ethanol extracts and n-hexane, ethyl acetate, and water fractions against Streptococcus mutans ATCC 25175, identify the most active fraction, and determine the MIC and MBC. This quantitative study used diffusion and dilution methods. Bacteria: Streptococcus mutans ATCC 25175; samples: ethanol extract of Moringa oleifera L. leaves and n-Hexane, ethyl acetate, and water fractions. Data analysis used SPSS 25 One-Way ANOVA, Tukey (p<0.05). Results showed that the ethyl acetate fraction was the most active with 12.36 mm inhibition at 45%; MIC and MBC were 30% ANOVA significant (p=0.000). The ethyl acetate fraction has strong caries prevention potential, supporting herbal development.
Antibacterial Activity Test Of Extract, N-Hexane Fraction, Ethyl Acetate And Water Of Kesum Leaves (Polygonum Minus H) Against Escherichia Coli ATCC 25922 Bacteria Wahana Ayu Saputri; Tatiana Siska Wardani; Anna Fitriawati
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.663

Abstract

Diarrheal disease caused by Escherichia coli is a serious health problem in Indonesia, especially in toddlers, with increasing antibiotic resistance. Kesum leaves (Polygonum minus H.) have antibacterial potential because they contain flavonoids, phenols, alkaloids, and saponins. To evaluate the antibacterial activity of 70% ethanol extract and fractions of n-hexane, ethyl acetate, and kesum leaf water against E. coli ATCC 25922, to identify effective concentrations, and to determine the MIC and MBC of the most active fraction. Laboratory experimental study with 70% ethanol maceration extraction and liquid-liquid fractionation. E. coli ATCC 25922 population, 7 kg of simplex samples from Sambas, West Kalimantan. Instruments include an incubator, SPSS 25. Analysis techniques: disc diffusion, liquid/solid dilution, ANOVA.  The ethyl acetate fraction was the most effective (inhibition zone 12.36 mm, at a concentration of 40%, strong category), followed by the extract (inhibition zone 11.31 mm, at a concentration of 30%, medium category), n-hexane (10.46 mm), water (8.86 mm). MIC and MBC of the ethyl acetate fraction were 30%. The extract and fraction of kesum leaves have moderate to strong antibacterial activity against E. coli ATCC 25922, supporting the development of anti-diarrhea herbal medicine.
Antibacterial Activity Test Of Extract And Fraction Of N-Hexane, Ethyl Acetate And Water Of Pineapple Peel (Ananas Comosus (L.) Merr.) Against Staphylococcus Epidermidis ATCC 12228 Bacteria Nadia Nurul Wachida; Tatiana Siska Wardani; Rahmat Hidayat
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.670

Abstract

Staphylococcus epidermidis is a bacteria that causes mild skin infections accompanied by abscesses, with a high  prevalence in Indonesia, requiring natural alternatives due to antibiotic resistance. This study aimed to evaluated antibacterial activity of 96% ethanol extract and n-hexane, ethyl acetate, water fractions of pineapple peel (Ananas comosus L. Merr.) against S. epidermidis ATCC 12228 and to determined MIC/MBC of the most active fraction. This quantitative and experimental study used the disk diffusion and liquid/solid dilution. methods. Population: pineapple peels from Blitar, East Java; sample: 700 g Simplicia powder. The nstruments included rotary evaporator, incubator, autoklaf, laminar air flow; data were analyzed using the Kruskal-Wallis (SPSS 25). Results showed that extract produced inhibition zones ranging from 5.63–11.43 mm, ethyl acetate fraction 3.80–7.55 mm, water 2.35–6.88 mm, n-hexane was inactive. The MIC and MBC values of the extract were 25%; ethyl acetate fraction MIC and MBC were 50%. Extract, ethyl acetate, and water fractions exhibited antibacterial activity aginst S. epidermidis, with extract being the most effective.
In-Silico Study Of The Potential Of Neem Leaf Active Compounds (Azadirachta Indica) As A-Amylase Enzyme Inhibitors Through Molecular Docking And ADMET Analysis Mutiara Marzalina Wardhani; Tiara Ajeng Listyani; Tatiana Siska Wardani
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.687

Abstract

Indonesia has reached 20.4 million adults with the fifth highest number of diabetes in the world and is estimated to be 28.6 million by 2050. The use of acarbose has side effects such as digestive problems to potential for the liver and kidneys, so these problems can be overcome with herbal plant treatment, one of which is the active compound of neem leaves (Azadirachta indica). This study aims to analyze the interaction of 20 neem leaf compounds with α-amylase enzymes through the molecular docking approach, ADMET prediction, and modification of potential new compounds as antidiabetic candidates. This research was conducted in silico using PyRx-AutoDock Vina for docking, VegaZZ, PyMOL, and Discovery Studio for optimization and visualization, SwissADME for ADME prediction, and Toxtree for toxicity test. The docking method validation is expressed in RMSD values of <2 Å. The docking results showed that Kaempferol had a ΔGBinding of -7.9 kcal/mol, an RMSD value of 1.229 Å and had a similarity of amino acid residues to the native ligands ASP:197. Kaempferol has a good ADME profile, High (III) category toxicity and is mutagenic and carcinogen. The design of the new compound of Kaempferol i.e. 2-(4-hydroxycyclohexyl)-1-methoxybutane-1,4-diol has amino acid residue similarity to the native ligands ASP A:197, ΔGBinding -5.6, RMSD value 1,704 Å and has good ADME, Low (I) category toxicity. The active compound of neem leaves has the potential to be an inhibitor of the enzyme α-Amylase.
Co-Authors ACHMAD FAUZI Adhe Wibawa Mahardika Putra Agung Widiastuti Agustina, Isnaini Akbar, Finica Dwi Al Fajri Razid Faizur Muhammad Alfi Risna Fadilla Aminnulloh, Muhammad Anita Dwi S Anita Dwi Septiarini Anita Dwi Septiarini Anita Dwi Septiarini Anna Fitriawati Annisa Kusuma Wardhani Ariyanti Ariyanti Artini, Kusumaningtyas Siwi Bagas Ardiantoro Bagas Ardiyantoro Baiq Mitasari Bangkit Riska Permata Cahyono, Imam Sahid Chahyaningrum, Dhiyan Danang Raharjo Desy Ayu Irma Permatasari Devi Nur Indah Sari dewi mei ika widiyastuti Dian Fatimatus Salwa Dian Pratiwi Dinar Aditama Nugroho Erikania, Susanti Erna Chotidjah Suhatmi Erna Chotidjah Suhatmi Evi Eriani Faizah Ariqoh Fazlin Fauzi Febriyani, Rima Fitriana, Lydia Haikal Zanki hanif fathur rohman, muhammad Ikrima Rahmasari Iqbal Sirajudin Maulidinawan Istiara Subekti Kezia Putri Maha Dewi Kharisma Jayak P Kharisma Jayak Pratama Khasanah, Isna Nur Khilda Hilyatul 'Ulya Khusain, Muhammad Fuad Zidane Kristanti Prihatin Sri Rejeki, Melinia Mega Kusumaningtyas Siwi A Kusumaningtyas Siwi Artini Kusumaningtyas Siwi Artini Lindra Putri, Jessika Ukurmehuli Listyani, Tiara Ajeng Luthfiyanti, Niken Mahadewi Putri Kezia Masruroh, Sururul Kamalin Muhammad Abdul Azis Muhammad Andira Ibnu Shina Muhhamad Aminulloh Muladi Putra Mahardika Mutiara Marzalina Wardhani Nadia Nurul Wachida Nesya Sucitra Ni Luh Ari Yusasrini NOVISYIAHGIANT, DINA AMALIA Nurchaina Aprilia Dewi Phiapresia, Safara Zulfa Pratama, Kharisma Jayak Purwaningsih Purwaningsih Raden Rara Anteng Pujowati Rahadyana, Riskaldila Zahra Rahmat Hidayat Rahmatillah, Annie rani, fahrenza meta Ratna Sari Dewi Ria, Septiyana Rita Anita Tanikolan Riztiandi Ardiansyah Rohmana, Vivin Marwiyati Sahadatun, Angga Aulia Saifana, Cindy Septia Santoso, Aris Priyo Agus Septian Maulid Wicahyo Septiyana Ria Siti Nur Hikmah Siwi, Melati Daru Suhatmi, Erna Chotidjah Tantri Dwi Lestari Toyang, Gresilia tri Mastuti, eni Triya Choirin Nisa Urip, Sri Khanti Utomo Kartika Endrat Verentika, Jumini Voen-Na, Cut Dara Wahana Ayu Saputri Wahdah Sri Rahayu Wahyu Budi Utomo Wali Jati, Ilham Weri veranita Wimpy, W Yusuf, Dea Sagitarina