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Antibacterial Activity Test Of Extracts And Fractionsn-Hexane, Ethyl Acetate, And Pineapple Peel Water (Ananas Comosus(L.) Merr.) Against Bacteria Propionibacterium Acnes ATCC 6919 Dian Fatimatus Salwa; Tatiana Siska Wardani; Bangkit Riska Permata
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.655

Abstract

Acne vulgaris is a common dermatological problem in adolescents in Indonesia's tropical climate related to the activity of Propionibacterium acnes bacteria. Long-term use of antibiotics risks causing resistance, so natural antibacterial alternatives are needed. This study aims to evaluate the antibacterial activity of ethanol extract and fractions of n-Hexane, ethyl acetate, and pineapple peel water against Propionibacterium acnes ATCC 6919, and to determine the most active fraction and MIC and MBC values. This study is a quantitative experimental study. The study population was the bacterial culture of P. acnes ATCC 6919, with samples in the form of pineapple peel extract and fraction. The research instruments included disc diffusion and liquid and solid dilution methods, while data analysis used the Shapiro-Wilk, Levene, and Kruskal-Wallis tests. The results showed that the ethanol extract had moderate to strong antibacterial activity, the ethyl acetate fraction showed the highest activity compared to other fractions, while the n-hexane fraction showed no activity. MIC and MBC values ​​were obtained at a concentration of 20 percent. The conclusion of this study is that pineapple peel has the potential as a natural antibacterial source against P. acnes and the ethyl acetate fraction is the most active fraction.
Antibacterial Activity Test Of Ethanol Extract And N-Hexane Fraction, Ethyl Acetate, Moringa Leaf Water (Moringa Oleifera L) Against Streptococcus Mutans ATCC 25175 Bacteria Wahdah Sri Rahayu; Tatiana Siska Wardani; Tiara Ajeng Listyani
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.662

Abstract

Dental caries remains a major oral health problem globally and in Indonesia, triggered by Streptococcus mutans biofilm. Chemical agents such as chlorhexidine have side effects, encouraging the use of natural alternatives from Moringa oleifera L. leaves. This study aims to evaluate the antibacterial activity of ethanol extracts and n-hexane, ethyl acetate, and water fractions against Streptococcus mutans ATCC 25175, identify the most active fraction, and determine the MIC and MBC. This quantitative study used diffusion and dilution methods. Bacteria: Streptococcus mutans ATCC 25175; samples: ethanol extract of Moringa oleifera L. leaves and n-Hexane, ethyl acetate, and water fractions. Data analysis used SPSS 25 One-Way ANOVA, Tukey (p<0.05). Results showed that the ethyl acetate fraction was the most active with 12.36 mm inhibition at 45%; MIC and MBC were 30% ANOVA significant (p=0.000). The ethyl acetate fraction has strong caries prevention potential, supporting herbal development.
Antibacterial Activity Test Of Extract, N-Hexane Fraction, Ethyl Acetate And Water Of Kesum Leaves (Polygonum Minus H) Against Escherichia Coli ATCC 25922 Bacteria Wahana Ayu Saputri; Tatiana Siska Wardani; Anna Fitriawati
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.663

Abstract

Diarrheal disease caused by Escherichia coli is a serious health problem in Indonesia, especially in toddlers, with increasing antibiotic resistance. Kesum leaves (Polygonum minus H.) have antibacterial potential because they contain flavonoids, phenols, alkaloids, and saponins. To evaluate the antibacterial activity of 70% ethanol extract and fractions of n-hexane, ethyl acetate, and kesum leaf water against E. coli ATCC 25922, to identify effective concentrations, and to determine the MIC and MBC of the most active fraction. Laboratory experimental study with 70% ethanol maceration extraction and liquid-liquid fractionation. E. coli ATCC 25922 population, 7 kg of simplex samples from Sambas, West Kalimantan. Instruments include an incubator, SPSS 25. Analysis techniques: disc diffusion, liquid/solid dilution, ANOVA.  The ethyl acetate fraction was the most effective (inhibition zone 12.36 mm, at a concentration of 40%, strong category), followed by the extract (inhibition zone 11.31 mm, at a concentration of 30%, medium category), n-hexane (10.46 mm), water (8.86 mm). MIC and MBC of the ethyl acetate fraction were 30%. The extract and fraction of kesum leaves have moderate to strong antibacterial activity against E. coli ATCC 25922, supporting the development of anti-diarrhea herbal medicine.
Antibacterial Activity Test Of Extract And Fraction Of N-Hexane, Ethyl Acetate And Water Of Pineapple Peel (Ananas Comosus (L.) Merr.) Against Staphylococcus Epidermidis ATCC 12228 Bacteria Nadia Nurul Wachida; Tatiana Siska Wardani; Rahmat Hidayat
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.670

Abstract

Staphylococcus epidermidis is a bacteria that causes mild skin infections accompanied by abscesses, with a high  prevalence in Indonesia, requiring natural alternatives due to antibiotic resistance. This study aimed to evaluated antibacterial activity of 96% ethanol extract and n-hexane, ethyl acetate, water fractions of pineapple peel (Ananas comosus L. Merr.) against S. epidermidis ATCC 12228 and to determined MIC/MBC of the most active fraction. This quantitative and experimental study used the disk diffusion and liquid/solid dilution. methods. Population: pineapple peels from Blitar, East Java; sample: 700 g Simplicia powder. The nstruments included rotary evaporator, incubator, autoklaf, laminar air flow; data were analyzed using the Kruskal-Wallis (SPSS 25). Results showed that extract produced inhibition zones ranging from 5.63–11.43 mm, ethyl acetate fraction 3.80–7.55 mm, water 2.35–6.88 mm, n-hexane was inactive. The MIC and MBC values of the extract were 25%; ethyl acetate fraction MIC and MBC were 50%. Extract, ethyl acetate, and water fractions exhibited antibacterial activity aginst S. epidermidis, with extract being the most effective.
In-Silico Study Of The Potential Of Neem Leaf Active Compounds (Azadirachta Indica) As A-Amylase Enzyme Inhibitors Through Molecular Docking And ADMET Analysis Mutiara Marzalina Wardhani; Tiara Ajeng Listyani; Tatiana Siska Wardani
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.687

Abstract

Indonesia has reached 20.4 million adults with the fifth highest number of diabetes in the world and is estimated to be 28.6 million by 2050. The use of acarbose has side effects such as digestive problems to potential for the liver and kidneys, so these problems can be overcome with herbal plant treatment, one of which is the active compound of neem leaves (Azadirachta indica). This study aims to analyze the interaction of 20 neem leaf compounds with α-amylase enzymes through the molecular docking approach, ADMET prediction, and modification of potential new compounds as antidiabetic candidates. This research was conducted in silico using PyRx-AutoDock Vina for docking, VegaZZ, PyMOL, and Discovery Studio for optimization and visualization, SwissADME for ADME prediction, and Toxtree for toxicity test. The docking method validation is expressed in RMSD values of <2 Å. The docking results showed that Kaempferol had a ΔGBinding of -7.9 kcal/mol, an RMSD value of 1.229 Å and had a similarity of amino acid residues to the native ligands ASP:197. Kaempferol has a good ADME profile, High (III) category toxicity and is mutagenic and carcinogen. The design of the new compound of Kaempferol i.e. 2-(4-hydroxycyclohexyl)-1-methoxybutane-1,4-diol has amino acid residue similarity to the native ligands ASP A:197, ΔGBinding -5.6, RMSD value 1,704 Å and has good ADME, Low (I) category toxicity. The active compound of neem leaves has the potential to be an inhibitor of the enzyme α-Amylase.
Uji In Silico Senyawa Andrographis paniculata terhadap Mutasi EGFR G719S penyebab Resistensi pada Terapi Non-Small Cell Lung Cancer Ferdian, Erick; Listyani, Tiara Ajeng; Wardani, Tatiana Siska
Jurnal Analis Farmasi Vol 11, No 1 (2026): JURNAL ANALIS FARMASI
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jaf.v11i1.25135

Abstract

Penelitian ini didorong oleh permasalahan resistensi terapi pada Non-Small Cell Lung Cancer (NSCLC) akibat mutasi EGFR G719S dan kebutuhan akan alternatif inhibitor EGFR berbasis bahan alam untuk mengurangi efek samping dari inhibitor sintetik. Tujuan penelitian adalah mengevaluasi potensi senyawa aktif dari Andrographis paniculata sebagai inhibitor EGFR pada NSCLC dengan mutasi G719S secara in silico. Metode yang digunakan meliputi molecular docking menggunakan PyRx–AutoDock Vina, visualisasi interaksi molekul dengan PyMOL dan BIOVIA Discovery Studio, prediksi ADME melalui SwissADME, serta analisis toksisitas menggunakan ToxTree. Validasi metode docking dilakukan dengan acuan nilai RMSD 2 Å. Hasil docking menunjukkan bahwa beberapa senyawa dari Andrographis paniculata memiliki afinitas yang signifikan terhadap reseptor EGFR. Senyawa (E)-4-hydroxy-4-(3-hydroxybut-1-en-1-yl)-3,5,5-trimethylcyclohex-2-en-1-one memberikan hasil terbaik dengan nilai RMSD 1,855 Å dan energi bebas ikatan −5,4 kcal/mol, serta membentuk interaksi residu asam amino yang serupa dengan ligan natif gefitinib. Prediksi ADME senyawa ini memenuhi kriteria aturan Lipinski (Rule of Five), dan uji toksisitas menunjukkan tingkat rendah (Class I). Dengan demikian, senyawa dari Andrographis paniculata berpotensi dikembangkan sebagai kandidat inhibitor EGFR untuk NSCLC dengan mutasi G719S, meskipun validasi tambahan melalui uji in vitro dan in vivo tetap diperlukan.Kata kunci: Andrographis paniculate, EGFR G719S, Gefitinib, Non-Small Cell Lung Cancer
Analisis Docking Molekuler Senyawa Daun Kelor (Moringa oleifera) Terhadap Enzim Cyclooxygenase-2 (COX-2) Beserta Prediksi ADME dan Toksisitas Sebagai Obat Antiinflamasi Pamungkas, Rezky Ardika; Listyani, Tiara Ajeng; Wardani, Tatiana Siska
Jurnal Analis Farmasi Vol 11, No 1 (2026): JURNAL ANALIS FARMASI
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jaf.v11i1.25067

Abstract

Inflamasi kronis merupakan kondisi patologis yang memengaruhi jutaan individu secara global dan menjadi salah satu masalah kesehatan utama di Indonesia. Prevalensi penyakit inflamasi, seperti osteoarthritis, dilaporkan cukup tinggi, khususnya di Provinsi Jawa Tengah dengan angka mencapai 6,78%. Terapi farmakologis yang umum digunakan untuk mengatasi inflamasi adalah obat golongan Non Steroid Anti-Inflammation Drugs (NSAID), seperti celecoxib. Meskipun efektif, penggunaan NSAID jangka panjang diketahui berisiko menimbulkan efek samping kardiovaskular dan gastrointestinal, sehingga diperlukan alternatif terapi yang lebih aman. Daun kelor (Moringa oleifera) diketahui mengandung berbagai senyawa bioaktif, terutama flavonoid dan fenolat, yang berpotensi sebagai inhibitor selektif cyclooxygenase-2 (COX-2). menganalisis interaksi senyawa aktif daun kelor terhadap protein COX-2 secara in silico, memprediksi profil farmakokinetik ADME, mengevaluasi toksisitas, serta mengidentifikasi senyawa paling potensial sebagai kandidat antiinflamasi. Penelitian menggunakan desain eksperimental berbasis komputer terhadap 30 senyawa daun kelor dengan celecoxib sebagai kontrol positif dan parasetamol sebagai kontrol negatif. Proses penelitian meliputi preparasi struktur senyawa dan protein, simulasi docking molekuler, serta analisis visualisasi ikatan menggunakan perangkat lunak ChemDraw, VegaZZ, PyRx, PyMOL, SwissADME, dan Toxtree. Penelitian menunjukkan bahwa senyawa sinapic acid memiliki afinitas ikatan terbaik dengan nilai energi bebas ikatan (ΔG) sebesar −6,7 kkal/mol dan nilai RMSD 1,168 Å. Senyawa ini membentuk interaksi dengan residu asam amino penting yang serupa dengan ligan natif valdecoxib dan celecoxib. Selain itu, sinapic acid memenuhi kriteria Lipinski’s Rule of Five, menunjukkan profil ADME yang baik, serta tergolong dalam kategori toksisitas rendah (Class I) berdasarkan Cramer rules. daun kelor (Moringa oleifera), khususnya senyawa sinapic acid, berpotensi sebagai kandidat inhibitor COX-2 antiinflamasi dan layak untuk diteliti lebih lanjut melalui uji in vivo.Kata kunci: Antiinflamasi, COX-2, Daun kelor,  Docking molekuler.
Uji In Silico Senyawa Andrographis paniculata terhadap Mutasi EGFR G719S penyebab Resistensi pada Terapi Non-Small Cell Lung Cancer Ferdian, Erick; Listyani, Tiara Ajeng; Wardani, Tatiana Siska
Jurnal Analis Farmasi Vol 11, No 1 (2026): JURNAL ANALIS FARMASI
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jaf.v11i1.25135

Abstract

Penelitian ini didorong oleh permasalahan resistensi terapi pada Non-Small Cell Lung Cancer (NSCLC) akibat mutasi EGFR G719S dan kebutuhan akan alternatif inhibitor EGFR berbasis bahan alam untuk mengurangi efek samping dari inhibitor sintetik. Tujuan penelitian adalah mengevaluasi potensi senyawa aktif dari Andrographis paniculata sebagai inhibitor EGFR pada NSCLC dengan mutasi G719S secara in silico. Metode yang digunakan meliputi molecular docking menggunakan PyRx–AutoDock Vina, visualisasi interaksi molekul dengan PyMOL dan BIOVIA Discovery Studio, prediksi ADME melalui SwissADME, serta analisis toksisitas menggunakan ToxTree. Validasi metode docking dilakukan dengan acuan nilai RMSD 2 Å. Hasil docking menunjukkan bahwa beberapa senyawa dari Andrographis paniculata memiliki afinitas yang signifikan terhadap reseptor EGFR. Senyawa (E)-4-hydroxy-4-(3-hydroxybut-1-en-1-yl)-3,5,5-trimethylcyclohex-2-en-1-one memberikan hasil terbaik dengan nilai RMSD 1,855 Å dan energi bebas ikatan −5,4 kcal/mol, serta membentuk interaksi residu asam amino yang serupa dengan ligan natif gefitinib. Prediksi ADME senyawa ini memenuhi kriteria aturan Lipinski (Rule of Five), dan uji toksisitas menunjukkan tingkat rendah (Class I). Dengan demikian, senyawa dari Andrographis paniculata berpotensi dikembangkan sebagai kandidat inhibitor EGFR untuk NSCLC dengan mutasi G719S, meskipun validasi tambahan melalui uji in vitro dan in vivo tetap diperlukan.Kata kunci: Andrographis paniculate, EGFR G719S, Gefitinib, Non-Small Cell Lung Cancer
Analisis Docking Molekuler Senyawa Daun Kelor (Moringa oleifera) Terhadap Enzim Cyclooxygenase-2 (COX-2) Beserta Prediksi ADME dan Toksisitas Sebagai Obat Antiinflamasi Pamungkas, Rezky Ardika; Listyani, Tiara Ajeng; Wardani, Tatiana Siska
Jurnal Analis Farmasi Vol 11, No 1 (2026): JURNAL ANALIS FARMASI
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jaf.v11i1.25067

Abstract

Inflamasi kronis merupakan kondisi patologis yang memengaruhi jutaan individu secara global dan menjadi salah satu masalah kesehatan utama di Indonesia. Prevalensi penyakit inflamasi, seperti osteoarthritis, dilaporkan cukup tinggi, khususnya di Provinsi Jawa Tengah dengan angka mencapai 6,78%. Terapi farmakologis yang umum digunakan untuk mengatasi inflamasi adalah obat golongan Non Steroid Anti-Inflammation Drugs (NSAID), seperti celecoxib. Meskipun efektif, penggunaan NSAID jangka panjang diketahui berisiko menimbulkan efek samping kardiovaskular dan gastrointestinal, sehingga diperlukan alternatif terapi yang lebih aman. Daun kelor (Moringa oleifera) diketahui mengandung berbagai senyawa bioaktif, terutama flavonoid dan fenolat, yang berpotensi sebagai inhibitor selektif cyclooxygenase-2 (COX-2). menganalisis interaksi senyawa aktif daun kelor terhadap protein COX-2 secara in silico, memprediksi profil farmakokinetik ADME, mengevaluasi toksisitas, serta mengidentifikasi senyawa paling potensial sebagai kandidat antiinflamasi. Penelitian menggunakan desain eksperimental berbasis komputer terhadap 30 senyawa daun kelor dengan celecoxib sebagai kontrol positif dan parasetamol sebagai kontrol negatif. Proses penelitian meliputi preparasi struktur senyawa dan protein, simulasi docking molekuler, serta analisis visualisasi ikatan menggunakan perangkat lunak ChemDraw, VegaZZ, PyRx, PyMOL, SwissADME, dan Toxtree. Penelitian menunjukkan bahwa senyawa sinapic acid memiliki afinitas ikatan terbaik dengan nilai energi bebas ikatan (ΔG) sebesar −6,7 kkal/mol dan nilai RMSD 1,168 Å. Senyawa ini membentuk interaksi dengan residu asam amino penting yang serupa dengan ligan natif valdecoxib dan celecoxib. Selain itu, sinapic acid memenuhi kriteria Lipinski’s Rule of Five, menunjukkan profil ADME yang baik, serta tergolong dalam kategori toksisitas rendah (Class I) berdasarkan Cramer rules. daun kelor (Moringa oleifera), khususnya senyawa sinapic acid, berpotensi sebagai kandidat inhibitor COX-2 antiinflamasi dan layak untuk diteliti lebih lanjut melalui uji in vivo.Kata kunci: Antiinflamasi, COX-2, Daun kelor,  Docking molekuler.
Formulation And Evaluation Of Lip Scrub Using Beetroot Extract (Beta Vulgaris L.) As A Natural Colorant Jannah, Dikta Anggraini Miftahul; Tatiana Siska Wardani; Rahmat Hidayat
International Journal of Health Engineering and Technology Vol. 5 No. 1 (2026): IJHET MAY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v5i1.847

Abstract

Lips are prone to dryness due to the thin stratum corneum layer and environmental exposure, driving the need for natural dyes to replace synthetic carcinogenic risks such as Rhodamine B. This study aims to formulate a lip scrub extract of beetroot (Beta vulgaris L.) at a concentration of 5%, 10%, 15%, measure betacyanin levels, and evaluate physical quality. Quantitative experimental types were conducted at the Duta Bangsa University Laboratory in Surakarta (April-June 2025); beetroot population in Boyolali, tuber samples aged 3-6 months; UV-Vis spectrophotometer instrument, rotary evaporator; SPSS analysis (ANOVA). The results showed a yield of 17.5% of the crude drug, 16.81% of the extract, 1.145 mg/L of betacyanin, good homogeneity, pH 5.33-6.03, no irritation (9 panelists), although the width of 3.75-4.58 cm was suboptimal. Conclusion: the formulation is safe and stable as a natural dye, although pigment stability needs optimization.
Co-Authors ACHMAD FAUZI Agung Widiastuti Agustina, Isnaini Akbar, Finica Dwi Al Fajri Razid Faizur Muhammad Alfi Risna Fadilla Aminnulloh, Muhammad Anita Dwi S Anita Dwi Septiarini Anita Dwi Septiarini Anita Dwi Septiarini Anna Fitriawati Annisa Kusuma Wardhani Ariyanti Ariyanti Artini, Kusumaningtyas Siwi Bagas Ardiantoro Bagas Ardiyantoro Baiq Mitasari Bangkit Riska Permata Belinda Arbitya Dewi Cahyono, Imam Sahid Chahyaningrum, Dhiyan Danang Raharjo Desy Ayu Irma Permatasari Devi Nur Indah Sari dewi mei ika widiyastuti Dian Fatimatus Salwa Dian Pratiwi Dinar Aditama Nugroho Erikania, Susanti Erna Chotidjah Suhatmi Erna Chotidjah Suhatmi Evi Eriani Faizah Ariqoh Fazlin Fauzi Febriyani, Rima Ferdian, Erick Fitriana, Lydia Haikal Zanki hanif fathur rohman, muhammad Ikrima Rahmasari Iqbal Sirajudin Maulidinawan Istiara Subekti Jannah, Dikta Anggraini Miftahul Kezia Putri Maha Dewi Kharisma Jayak P Kharisma Jayak Pratama Khasanah, Isna Nur Khilda Hilyatul 'Ulya Khusain, Muhammad Fuad Zidane Kristanti Prihatin Sri Rejeki, Melinia Mega Kusumaningtyas Siwi A Kusumaningtyas Siwi Artini Kusumaningtyas Siwi Artini Lindra Putri, Jessika Ukurmehuli Listyani, Tiara Ajeng Luthfiyanti, Niken Mahadewi Putri Kezia Masruroh, Sururul Kamalin Muhammad Abdul Azis Muhammad Andira Ibnu Shina Muhhamad Aminulloh Muladi Putra Mahardika Mutiara Marzalina Wardhani Nadia Nurul Wachida Nesya Sucitra Ni Luh Ari Yusasrini NOVISYIAHGIANT, DINA AMALIA Nurchaina Aprilia Dewi Pamungkas, Rezky Ardika Phiapresia, Safara Zulfa Pratama, Kharisma Jayak Purwaningsih Purwaningsih Raden Rara Anteng Pujowati Rahadyana, Riskaldila Zahra Rahmat Hidayat Rahmatillah, Annie rani, fahrenza meta Ratna Sari Dewi Ria, Septiyana Rita Anita Tanikolan Riztiandi Ardiansyah Rohmana, Vivin Marwiyati Sahadatun, Angga Aulia Saifana, Cindy Septia Santoso, Aris Priyo Agus Septian Maulid Wicahyo Septiyana Ria Siti Nur Hikmah Siwi, Melati Daru Suhatmi, Erna Chotidjah Tantri Dwi Lestari Toyang, Gresilia tri Mastuti, eni Triya Choirin Nisa Urip, Sri Khanti Utomo Kartika Endrat Verentika, Jumini Voen-Na, Cut Dara Wahana Ayu Saputri Wahdah Sri Rahayu Wahyu Budi Utomo Wali Jati, Ilham Weri veranita Wimpy, W Yusuf, Dea Sagitarina