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All Journal Jurnal Delima Harapan Jurnal Farmasi Higea Jurnal Dunia Farmasi PREPOTIF : Jurnal Kesehatan Masyarakat Abdi Masyarakat PUBLIKASI PENELITIAN TERAPAN DAN KEBIJAKAN Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Kesehatan Tambusai Jurnal Farmasi Jurnal Ilmiah Wahana Pendidikan Journal of Fundamental and Applied Pharmaceutical Science Proceedings of the International Conference on Nursing and Health Sciences JIFI (Jurnal Ilmiah Farmasi Imelda) Indonesian Community Journal Veteran Society : Jurnal Pengabdian Masyarakat Jurnal Farmasi Sains dan Praktis Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) JURNAL JAMU KUSUMA Duta Pharma Journal Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Detector: Jurnal Inovasi Riset Ilmu Kesehatan Jurnal Ilmiah Global Farmasi Jurnal Pengabdian Masyarakat dan Riset Pendidikan EduInovasi: Journal of Basic Educational Studies Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Wardani, Tatiana Siska
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Formulasi dan Uji Aktivitas Antibakteri Sabun Cair Ekstrak Daun Jeruk Purut (Citus hystrix) terhadap Bakteri Staphylococcus aureus ATCC 25923 dan Escherichia coli ATCC 25922 Iqbal Sirajudin Maulidinawan; Tatiana Siska Wardani; Bagas Ardiyantoro
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 3 (2025): Desember : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i3.6647

Abstract

Skin that is prone to bacterial infections requires proper care using products containing antibacterial agents. One potential alternative is kaffir lime leaves (Citrus hystrix), which are known to contain antibacterial compounds. This study aimed to evaluate the formulation of liquid soap containing kaffir lime leaf extract and to determine the optimal concentration for inhibiting bacterial growth. An experimental laboratory design was applied, and the antibacterial effectiveness was tested using the disk diffusion method against two test bacteria, namely Staphylococcus aureus and Escherichia coli. Statistical analysis was performed using One-Way ANOVA, followed by Scheffe’s post-hoc test to identify significant differences among treatment groups. The results indicated that the liquid soap containing kaffir lime leaf extract exhibited good physical quality and met standard parameters, including organoleptic evaluation, pH, viscosity, and foam height tests. Antibacterial testing showed that the highest inhibition zone against Staphylococcus aureus was observed at a 15% concentration with a zone diameter of 18.28 mm (strong category), while the highest inhibition zone against Escherichia coli was also at a 15% concentration with a diameter of 19.03 mm (strong category). The One-Way ANOVA results showed a significance value (p < 0.05), indicating a statistically significant difference among treatments for both bacterial species. These findings suggest that liquid soap formulated with kaffir lime leaf extract, particularly at a 15% concentration, has strong antibacterial activity and potential as an effective skin care product. Further studies are recommended to evaluate safety, stability, and long-term effectiveness.
FORMULASI DAN UJI EFEKTIVITAS ANTIBAKTERI SEDIAAN MOUTHWASH DARI EKSTRAK DAUN KEMANGI (Ocimum x africanum L.) TERHADAP BAKTERI Staphylococcus aureus Voen-Na, Cut Dara; Wardani, Tatiana Siska; Wicahyo, Septian Maulid
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 8 No. 2 (2025): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v8i2.1856

Abstract

The oral cavity is susceptible to bacterial infections because it has direct exposure to the outside environment, one of which is Staphylococcus aureus, which can cause oral health problems. The use of mouthwash as an additional treatment helps maintain optimal oral hygiene. Basil leaves (Ocimum x africanum L.) contain secondary metabolite compounds that have the potential to inhibit the growth of S. aureus. This study aims to determine the physical quality test of mouthwash of basil leaf extract and test its antibacterial effectiveness against S. aureus. This research method is laboratory experimental. Basil leaf simplicia powder (Ocimum x africanum L.) is macerated with 96% ethanol. Mouthwash formulations are made in concentrations of 4%, 6%, 8%, and 10%. Testing was carried out using the disc diffusion method to assess the antibacterial effectiveness against S. aureus ATCC 25923. Physical quality tests are also carried out on mouthwash preparations. The data from the antibacterial test results were analyzed using the One-Way ANOVA method. The results showed that the mouthwash preparation formula of basil leaf extract had good physical quality in terms of organoleptics, pH, specific gravity, viscosity, and clarity. The results of the statistical test showed a significant difference in the diameter of each group (P<0.05); mouthwash preparation at F4 (10%) had an inhibitory power against S. aureus bacteria of 8.46 mm with a bacterial inhibition zone of the medium category.
UJI AKTIVITAS ANTIBAKTERI SEDIAAN MASKER GEL EKSTRAK DAUN TAPAK DARA (Catharanthus roseus (L) G. Don) TERHADAP BAKTERI Staphylococcus aureus Agustina, Isnaini; Wardani, Tatiana Siska; Luthfiyanti, Niken
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 8 No. 2 (2025): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v8i2.1864

Abstract

Gel masks are semi-solid preparations that serve as skincare products with benefits, such as addressing various skin problems. This study aims to conduct a physical quality test on gel masks containing tapak dara leaf extract, determine the antibacterial activity of tapak dara leaf extract and evaluate the antibacterial activity of the tapak dara leaf extract gel mask against Staphylococcus aureus ATCC 25923 bacteria. This study uses both qualitative and quantitative analysis with experimental methods. The extraction of virgin leaves is carried out using the maceration method with a 70% ethanol solvent. The extracts and preparations are made into three concentrations: 10%, 20%, and 30%. The physical quality testing of tapak dara leaf gel masks includes organoleptic evaluation, homogeneity, pH, dispersion, and drying time. The results of one-way ANOVA for pH (sig. = 0.815), dispersion (sig. = 0.695), and drying time (sig. = 0.251) showed that the significance values were greater than 0.05. Tapak dara leaf extract demonstrates antibacterial activity against Staphylococcus aureus bacteria, with inhibitory zone diameters of 3.5 mm, 7.87 mm, and 9.85 mm. The gel mask preparation of virgin palm leaf extract exhibits antibacterial activity against Staphylococcus aureus bacteria, with inhibition zone diameters of 3.67 mm, 4.77 mm, and 7.4 mm. The results of one-way ANOVA on the activity of virgin palm leaf extract against Staphylococcus aureus bacteria showed a significance value less than 0.05.
UJI MUTU FISIK SEDIAAN LIP BALM DAN KADAR TOTAL ANTOSIANIN EKSTRAK DAUN JATI (Tectonagrandislinn., F.) Lindra Putri, Jessika Ukurmehuli; Hidayat, Rahmat; Wardani, Tatiana Siska
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 8 No. 2 (2025): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v8i2.1866

Abstract

Lip balm is a product that serves to prevent dryness of the lips by increasing moisture and protecting them from the adverse effects of the environment. In making this lip balm, Teak leaves (Tectonagrandislinn., F) are used as a natural colorant because they contain pigments, especially anthocyanins. Anthocyanins are flavonoid compounds that have antioxidant properties. This study aims to determine the total anthocyanin content in teak leaf extract and design a lip balm formulation that meets physical quality standards. In addition, the study also tested variations in concentration to find the best formulation. The type of research used with experimental methods involving physical quality tests of lip balm preparations and total anthocyanin levels of teak leaf extract.The results showed that lip balms with formula 0 (no extract), formula I (2% extract), formula II (3% extract), and formula III (4% extract) met the physical quality standards based on SNI 1-4399-1996, including in the aspects of homogeneity, adhesion, spreadability, viscosity, and pH. The total anthocyanin content in teak leaf extract was 68.298 mg/L. In addition, variations in extract concentration also affected the panelists' level of liking, where formula III with a concentration of 4% was the most preferred because it had an even composition, suitable pH, good spreadability and adhesiveness, and did not cause irritation.
FORMULASI DAN UJI EVALUASI SEDIAAN LIP BALM KOMBINASI EKSTRAK ETANOL DAGING LIDAH BUAYA (Aloe vera) DAN DAGING BUAH ALPUKAT (Persea americana Mill) SEBAGAI PELEMBAB BIBIR Masruroh, Sururul Kamalin; Wardani, Tatiana Siska; Listyani, Tiara Ajeng
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 1 (2025): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i1.1980

Abstract

The lips are sensitive and prone to dryness and chapping, requiring special care. This study aimed to develop a Lip Balm preparation that meets physical quality standards and to determine its activity as a lip moisturizer. It also determined the optimal concentration for a Lip Balm formulation using a combination of 70% ethanol extract of Aloe vera and avocado (Persea americana Mill.) pulp. Aloe vera contains lignin, and avocado contains vitamins A, C, and E, which are essential for skin health. This study was conducted experimentally using five formula variations: F0 (0%), F1 (10%), F2 (15%), F3 (20%), and a positive control (Vaseline Repairing Jelly). Physical quality evaluation included organoleptic testing, homogeneity, pH, spreadability, adhesion, spreadability, moisture testing, irritation testing, hedonic testing, and stability testing. The results showed that all formulas had a semi-solid texture and color, varying depending on the extract concentration, were homogeneous, had a pH within the safe range (4.5-6.5), and met physical quality requirements. Moisture testing showed an increase in lip moisture levels after 14 days of use, with formula F3 providing the best moisturizing effect. In conclusion, the combination of Aloe vera and avocado (Persea americana Mill) extracts can be formulated into an effective Lip Balm as a natural lip moisturizer, with the best concentration in formula F3, with a moisture value of 47.3%.
MENGGALI DIMENSI ETIKA DALAM PELAYANAN FARMASI: SEBUAH TINJAUAN KOMPREHENSIF Chahyaningrum, Dhiyan; Fitriana, Lydia; Santoso, Aris Priyo Agus; Wardani, Tatiana Siska
Jurnal Ilmiah Global Farmasi (JIGF) Vol. 3 No. 3 (2025): JIGF - September
Publisher : PC IAI Sragen

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pelayanan farmasi penting untuk memberikan obat dan layanan berkualitas kepada pasien. Apoteker dan tenaga farmasi menghadapi berbagai situasi yang melibatkan pertimbangan etika. Tujuan penelitian ini adalah menganalisis dimensi etika terkait dengan pelayanan farmasi. Data dikumpulkan dari berbagai sumber, termasuk jurnal, buku, dan pedoman etika. Studi kasus dan contoh nyata dianalisis untuk menggambarkan situasi etis yang umum dihadapi oleh apoteker dan tenaga farmasi. Kode etik dan pedoman praktik yang dikeluarkan oleh organisasi profesi farmasi juga ditinjau. Hasil tinjauan ini mengungkapkan prinsip-prinsip etika yang relevan dalam pelayanan farmasi, seperti otonomi, keadilan, dan non-malefikasi. Konflik kepentingan dan komunikasi efektif juga penting. Tantangan etis lainnya termasuk privasi pasien, distribusi obat yang adil, dan pengelolaan konflik moral. Pelayanan farmasi yang etis adalah dasar penting dalam perawatan kesehatan. Memahami dan menerapkan prinsip-prinsip etika dalam praktik sehari-hari penting untuk pelayanan yang bermartabat. Penelitian dan pendidikan etika farmasi yang berkelanjutan dapat meningkatkan kesadaran dan kompetensi etika para profesional farmasi.   Kata kunci: etika; konflik kepentingan; pelayanan farmasi; prinsip etika; tenaga farmasi
In-Silico Study Of The Potential Of Neem Leaf Active Compounds (Azadirachta Indica) As A-Amylase Enzyme Inhibitors Through Molecular Docking And ADMET Analysis Mutiara Marzalina Wardhani; Tiara Ajeng Listyani; Tatiana Siska Wardani
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.687

Abstract

Indonesia has reached 20.4 million adults with the fifth highest number of diabetes in the world and is estimated to be 28.6 million by 2050. The use of acarbose has side effects such as digestive problems to potential for the liver and kidneys, so these problems can be overcome with herbal plant treatment, one of which is the active compound of neem leaves (Azadirachta indica). This study aims to analyze the interaction of 20 neem leaf compounds with α-amylase enzymes through the molecular docking approach, ADMET prediction, and modification of potential new compounds as antidiabetic candidates. This research was conducted in silico using PyRx-AutoDock Vina for docking, VegaZZ, PyMOL, and Discovery Studio for optimization and visualization, SwissADME for ADME prediction, and Toxtree for toxicity test. The docking method validation is expressed in RMSD values of <2 Å. The docking results showed that Kaempferol had a ΔGBinding of -7.9 kcal/mol, an RMSD value of 1.229 Å and had a similarity of amino acid residues to the native ligands ASP:197. Kaempferol has a good ADME profile, High (III) category toxicity and is mutagenic and carcinogen. The design of the new compound of Kaempferol i.e. 2-(4-hydroxycyclohexyl)-1-methoxybutane-1,4-diol has amino acid residue similarity to the native ligands ASP A:197, ΔGBinding -5.6, RMSD value 1,704 Å and has good ADME, Low (I) category toxicity. The active compound of neem leaves has the potential to be an inhibitor of the enzyme α-Amylase.
Antioxidant Activity Evaluation from Tomatoes’ N-Hexane, Ethyl Asetate, and Water Fraction with DPPH Dewi, Ratna Sari; Permatasari, Desy Ayu Irma; Wardani, Tatiana Siska; Mahardika, Muladi Putra
Journal of Fundamental and Applied Pharmaceutical Science Vol. 2 No. 2 (2022): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v2i2.13023

Abstract

Antioxidants are compounds that can stabilize free radicals in the body. Free radicals are highly reactive molecules as they have unpaired electrons to interact with body cell molecules. Tomatoes contain flavonoids, saponins, solanine tannins, folic acid, malic acid, citric acid, protein, fat, vitamins, minerals, and histamine, which can be used as antioxidants. This study aims to evaluate the antioxidant activity of n-hexane, ethyl acetate, water fraction, and ethanol extracts of Tomatoes and to determine the greatest antioxidant activity between n-hexane, ethyl acetate, water and vitamin C. Tomatoes (Lycopersicum esculentum Mill.) was extracted using the maceration method with ethanol  followed by fractionation using n-hexane and ethyl acetate solvents. The test of antioxidant activity to DPPH radical was conducted on n-hexane, ethyl acetate, water, and vitamin C. The antioxidant activity results, expressed by IC50 value to the n-hexane, ethyl acetate, water fraction of Tomatoes fruit, were 4.4603 ppm; 4.0868 ppm; and 4.0527 ppm, respectively. Thus, the greatest antioxidant activity was the water fraction.
Antibacterial Activity of Abrus precatorius L. Leaves Against Streptococcus mutans ATCC 25175 Bacteria Andika, Nadia Aisy; Artini, Kusumaningtyas Siwi; Wardani, Tatiana Siska
Journal of Fundamental and Applied Pharmaceutical Science Vol. 3 No. 2 (2023): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v3i2.16206

Abstract

One of the herbal plants that have medicinal properties is Abrus precatorius L or commonly known as Saga in Indonesia. Empirically, the boiled water of saga leaves is widely used as an ingredient in cough medicine, cancer sores and swollen tonsils. The chemical constituents of antibacterial activity in the saga leaves are glycosides (abrusoside AD and abrusgenin), flavonoids and saponins (glycerin). This study aims to determine the antibacterial activity of extracts and fractions from saga leaves and the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the most active fraction of saga leaves on the growth of Streptococcus mutans ATCC 25175. Saga leaf powder was macerated using 96% ethanol, then fractionated using n-hexane, ethyl acetate, water as solvent, 96% ethanol extract, and n-hexane fraction. The antibacterial activity test using the diffusion method showed that the extract, n-hexane fraction, ethyl acetate fraction, and water fraction of saga leaves had antibacterial activity against Streptococcus mutans. The most active fraction was the ethyl acetate fraction, with a concentration of 50% with an average inhibition zone diameter of 12.2 mm. The ethyl acetate fraction from saga leaves had the most active antibacterial activity compared to ethanol extract, n-hexane fraction, ethyl acetate fraction, and water fraction, as seen from the average diameter of the inhibition zone obtained. The test results of the dilution method of the ethyl acetate fraction of saga leaves showed a Minimum Inhibitory Concentration of 12.5% and a Minimum Killing Concentration of 25%.
Co-Authors ACHMAD FAUZI Agung Widiastuti Agustina, Isnaini Akbar, Finica Dwi Al Fajri Razid Faizur Muhammad Alfi Risna Fadilla Aminnulloh, Muhammad Andika, Nadia Aisy Anita Dwi S Anita Dwi Septiarini Anita Dwi Septiarini Anita Dwi Septiarini Anna Fitriawati Annisa Kusuma Wardhani Ariyanti Ariyanti Artini, Kusumaningtyas Siwi Bagas Ardiyantoro Baiq Mitasari Belinda Arbitya Dewi Chahyaningrum, Dhiyan Danang Raharjo Desy Ayu Irma Permatasari Devi Nur Indah Sari dewi mei ika widiyastuti Dinar Aditama Nugroho Erikania, Susanti Erna Chotidjah Suhatmi Erna Chotidjah Suhatmi Faizah Ariqoh Fazlin Fauzi Febriyani, Rima Fitriana, Lydia Haikal Zanki hanif fathur rohman, muhammad Ikrima Rahmasari Iqbal Sirajudin Maulidinawan Istiara Subekti Kezia Putri Maha Dewi Kharisma Jayak P Khilda Hilyatul 'Ulya Khusain, Muhammad Fuad Zidane Kristanti Prihatin Sri Rejeki, Melinia Mega Kusumaningtyas Siwi A Kusumaningtyas Siwi Artini Kusumaningtyas Siwi Artini Lindra Putri, Jessika Ukurmehuli Listyani, Tiara Ajeng Mahadewi Putri Kezia Mahardika, Muladi Putra Masruroh, Sururul Kamalin Muhammad Abdul Azis Muhammad Andira Ibnu Shina Muhhamad Aminulloh Muladi Putra Mahardika Mutiara Marzalina Wardhani Nesya Sucitra Ni Luh Ari Yusasrini Niken Luthfiyanti NOVISYIAHGIANT, DINA AMALIA Permatasari, Desy Ayu Irma Phiapresia, Safara Zulfa Pratama, Kharisma Jayak Purwaningsih Purwaningsih Raden Rara Anteng Pujowati Rahadyana, Riskaldila Zahra Rahmat Hidayat Rahmatillah, Annie rani, fahrenza meta Ratna Sari Dewi Ratna Sari Dewi Ria, Septiyana Rita Anita Tanikolan Riztiandi Ardiansyah Rohmana, Vivin Marwiyati Sahadatun, Angga Aulia Saifana, Cindy Septia Santoso, Aris Priyo Agus Septian Maulid Wicahyo Septiyana Ria Siti Nur Hikmah Siwi, Melati Daru Suhatmi, Erna Chotidjah Tantri Dwi Lestari Toyang, Gresilia tri Mastuti, eni Triya Choirin Nisa Urip, Sri Khanti Utomo Kartika Endrat Verentika, Jumini Voen-Na, Cut Dara Wahyu Budi Utomo Wali Jati, Ilham Weri veranita Wimpy, W Yusuf, Dea Sagitarina