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Penyakit Parkinson : Tinjauan Terpadu Biomedis dan Kemajuan Terapi Terkini Sari Mariyati Dewi Nataprawira; Triyana Sari; Erick Sidarta
Jurnal Kesehatan Amanah Vol. 9 No. 2 (2025): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v9i2.914

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta, which plays a crucial role in regulating movement. The hallmark pathology of PD is the formation of Lewy bodies, abnormal protein aggregates composed primarily of α-synuclein. The pathophysiological mechanisms of this disease are multifactorial, involving a complex interaction between genetic and environmental factors. Molecularly, several key mechanisms involved include mitochondrial dysfunction, oxidative stress, chronic neuroinflammation, and genetic mutations in the LRRK2, DJ-1, PINK1, and SNCA genes, which have been shown to influence susceptibility to PD. In addition to genetic factors, the risk of developing PD is also influenced by environmental exposures, including pesticides, heavy metals, and exposure to certain toxins that can accelerate neuronal damage. The clinical manifestations of PD are characterized by classic motor symptoms, namely resting tremor, bradykinesia, rigidity, and gait disturbances, which are often accompanied by non-motor symptoms such as sleep disturbances, depression, autonomic dysfunction, and cognitive decline. Diagnosis generally follows the UK Brain Bank clinical criteria, supported by neuroimaging techniques such as DaTSCAN and MRI, and the development of biomarkers based on α-synuclein detection to improve the accuracy of early diagnosis. The main treatment option currently is pharmacological therapy, particularly levodopa, often combined with dopamine agonists or MAO-B inhibitors to optimize symptom control. In advanced cases, surgery in the form of deep brain stimulation can provide significant improvement. Innovative therapies such as gene therapy, stem cell therapy, and the integration of wearable devices and artificial intelligence are being developed to improve symptom monitoring and personalize treatment. Current research focuses on the development of more sensitive diagnostic methods and neuroprotective therapies that can slow disease progression.  
HUBUNGAN PENGETAHUAN DAN SIKAP DENGAN PERILAKU SEKSUAL REMAJA: STUDI CROSS-SECTIONAL DI SMA X PONTIANAK SELATAN Savitry, Chairun Nisa; Sari, Triyana
Jurnal Mutiara Kesehatan Masyarakat Vol 10 No 2 (2025): Jurnal Mutiara Kesehatan Masyarakat
Publisher : Program Studi Kesehatan Masyarakat Universitas Sari Mutiara Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar belakang: Usia remaja selalu menjadi tahap transisi yang kompleks dan krusial, dicirikan dengan perkembangan sosial, biologis, dan psikologis. Pada periode ini, rasa ingin tahu terhadap seksualitas meningkat, sementara kontrol diri dan pemahaman tentang kesehatan reproduksi kerap kali masih kurang. Kondisi tersebut turut memicu meningkatnya kecenderungan perilaku seksual berisiko dan kasus kehamilan pada remaja, khususnya di Provinsi Kalimantan Barat. Tujuan: untuk menelaah keterkaitan antara pengetahuan dan sikap dengan perilaku seksual pada siswa SMA X yang berlokasi di Pontianak Selatan. Metode: Studi ini dilakukan melalui pendekatan kuantitatif dengan desain potong lintang (cross-sectional). Sebanyak 94 responden dipilih menggunakan metode consecutive non-random sampling. Instrumen berupa kuesioner yang telah tervalidasi digunakan untuk pengumpulan data, kemudian analisis dilakukan dengan uji Chi-square menggunakan taraf signifikansi p < 0,05. Hasil: Ditemukan bahwa tingkat pengetahuan tidak memiliki hubungan yang signifikan dengan perilaku seksual (p = 0,747; OR = 0,8). Namun, terdapat hubungan yang signifikan antara sikap dan perilaku seksual remaja (p = 0,000; OR = 4,6), dimana responden dengan sikap positif kemungkinan berperilaku seksual aman yang lebih besar 4,6 kali dibandingkan dengan mereka yang bersikap negatif. Kesimpulan: Hasil penelitian ini menunjukkan bahwa tingkat pengetahuan tidak memiliki hubungan yang signifikan terhadap perilaku seksual. Namun, sikap memiliki hubungan yang signifikan lebih besar terhadap perilaku seksual remaja.
Korelasi Lingkar Lengan Atas dan Lingkar Betis sebagai Prediktor Sarkopenia dengan Kadar IGF-1 pada Kelompok Lanjut Usia Triyana Sari; Erik Sidharta; Alexander Halim Santoso; Yohanes Firmansyah; Edwin Destra; Farell Christian Gunaidi; Angel Sharon Suros; Naufal Rayhan
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 2 (2025): Mei : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i2.4053

Abstract

Sarcopenia is a common condition among the elderly. Identifying individual risk factors associated with sarcopenia is essential for developing effective prevention strategies. This cross-sectional study aimed to investigate the association between insulin-like growth factor (IGF) levels and the incidence of sarcopenia, as assessed through mid-upper arm circumference and calf circumference, among older adults residing at Panti Werdha Bina Bhakti. Anthropometric measurements were obtained using a standard measuring tape, while IGF levels were measured through venous blood sampling and analyzed in a laboratory setting. Statistical analysis was performed using the Spearman correlation test. The study found that the average age of participants was 74.34 years, with 84.1% being female. The mean mid-upper arm circumference was 23.73 cm, and the mean calf circumference was 28.58 cm. The average IGF level was 14.43. Spearman’s rho analysis revealed a significant correlation between mid-upper arm and calf circumferences (r = 0.550; p < 0.001), as well as between mid-upper arm circumference and IGF levels (r = 0.237; p = 0.032). However, no significant correlation was observed between calf circumference and IGF levels (r = 0.176; p = 0.114). In conclusion, mid-upper arm circumference was significantly correlated with both calf circumference and IGF levels, whereas calf circumference showed no significant correlation with IGF in this elderly population. Keywords: Calf Circumference, Mid-Upper Arm Circumference, Older adults, Sarcopenia
Dismenore Primer dan Tingkat Stres: Studi Pada Siswi SMAN X Jakarta Najwa Anindya; Triyana Sari
An-Nadaa : Jurnal Kesehatan Masyarakat (e-Journal) Vol 12 No 2 (2025): AN-NADAA JURNAL KESEHATAN MASYARAKAT (DESEMBER)
Publisher : Universitas Islam Kalimantan Muhammad Arsyad Al Banjari Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/ann.v12i2.20546

Abstract

Dismenore primer adalah nyeri atau kram perut saat menstruasi yang umum terjadi pada perempuan tanpa kelainan patologis pada organ reproduksi. Kondisi ini memiliki prevalensi tinggi, terutama di kalangan remaja, dan dapat mengganggu aktivitas belajar. Stres diduga menjadi faktor yang memengaruhi timbulnya dismenore primer. Masa remaja adalah periode transisi dengan perubahan fisik, psikologis, dan sosial yang dapat meningkatkan kerentanan terhadap stres. Faktor stres pada remaja umumnya berasal dari beban akademik, tuntutan sosial, konflik keluarga, atau permasalahan pergaulan. Penelitian ini bertujuan untuk menganalisis hubungan antara tingkat stres dan kejadian dismenore primer di kalangan siswi SMAN X Jakarta. Penelitian ini menggunakan desain potong lintang (cross-sectional) dengan pendekatan kuantitatif. Sebanyak 170 siswi menjadi responden dalam penelitian ini. Data dikumpulkan menggunakan kuesioner yang telah teruji validitasnya, kemudian dianalisis dengan metode statistik. Hasil penelitian menunjukkan adanya hubungan signifikan antara tingkat stres dan kejadian dismenore primer dengan p-value < 0,001. Kesimpulannya, tingkat stres berpengaruh terhadap kejadian dismenore primer, yang menekankan pentingnya pengelolaan stres dan edukasi bagi siswi SMA untuk mencegah atau mengurangi gejala dismenore.
Kegiatan Edukasi Dan Skrining Asam Urat Dalam Pencegahan Terjadinya Gagal Ginjal Kronis Di Usia Dewasa Triyana Sari; Alexander Halim Santoso; Edwin Destra; Tosya Putri Alifia; Nabila Jingga Permatasari
Gotong Royong Vol. 2 No. 2 (2025)
Publisher : CV. Akira Java Bulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63935/gr.v2i2.165

Abstract

Hyperuricemia is a condition characterized by elevated uric acid levels in the blood, which can increase the risk of chronic kidney failure due to the deposition of uric acid crystals in renal tissue. Education and screening for uric acid levels are crucial for the early detection and prevention of hyperuricemia, particularly in the adult population. This community service program utilized the Plan–Do–Check–Act (PDCA) approach, encompassing counseling on risk factors of hyperuricemia, uric acid level screening with Point Of Care Testing (POCT), and education on strategies to prevent chronic kidney disease. The activity involved 40 participants of productive age, with an average age of 43.97 years. The mean uric acid level was recorded at 5.74 mg/dL. Educational interventions successfully increased participants’ awareness of the importance of maintaining uric acid levels within normal limits. Routine screening enables early identification of at-risk individuals and facilitates timely implementation of preventive measures. This program highlights the importance of public education and early detection in reducing the risk of chronic kidney disease and underscores the role of preventive health efforts in improving overall quality of life. Keywords: Education, Chronic Kidney Failure, Hyperuricemia, Prevention, Screening
Skrining dan Edukasi Kesehatan Metabolik melalui Pemeriksaan Profil Lipid pada Masyarakat Kelurahan Kota Bambu, Jakarta Barat: Metabolic Health Screening and Education through Lipid Profile Testing in the Bambu Village Community, West Jakarta Triyana Sari; Alexander Halim Santoso; Daniel Goh; Fidelia Alvianto; Syilvia Cendy Enike
Jurnal Pengabdian Masyarakat Bunda Delima Vol 5 No 1 (2026): EDISI FEBRUARI
Publisher : Akademi Keperawatan Bunda Delima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59030/jpmbd.v5i1.117

Abstract

Introduction: Lipid profile is an essential parameter in assessing metabolic health and cardiovascular risk. Total cholesterol, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) are the main components used to evaluate lipid metabolism balance, which is often disrupted in urban populations. This community service activity aimed to increase public awareness of metabolic health through education and simple screening of lipid profiles. Method: The program was conducted in Kelurahan Kota Bambu, West Jakarta, in June 2025, involving 168 participants across various age groups. Lipid profile measurements were performed using the Nesco BL-101 5in1 Lipid Panel Monitoring System, and interactive educational sessions were provided to promote healthy diet and dyslipidemia prevention. Results: The results showed that the average total cholesterol level was 208.24 mg/dL, HDL was 51.15 mg/dL, and LDL was 122.11 mg/dL. Classification revealed that most participants had high total cholesterol and LDL levels, while the majority of HDL levels were within the low category. These findings highlight a significant cardiovascular risk among urban communities. Conclusion: This activity emphasizes that simple lipid profile screening can serve as an effective early detection tool while simultaneously providing a basis for targeted education to prevent cardiovascular disease.
Peningkatan Kesadaran dan Deteksi Dini Dislipidemia melalui Pemeriksaan Kadar Trigliserida pada Komunitas Dewasa Gereja Baptis Cengkareng Triyana Sari; Alexander Halim Santoso
Jurnal Pengabdian Masyarakat Kesosi Vol. 9 No. 2 (2026): Juli: Jurnal Abdimas KESOSI
Publisher : Sekolah Tinggi Ilmu Kesehatan Kesetiakawanan Sosial Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/abdimas.v9i2.540

Abstract

Hypertriglyceridemia is an important risk factor for cardiometabolic disorders that often remains undetected among adults, despite contributing to an increased risk of cardiovascular disease and other metabolic complications. This community service program aimed to conduct triglyceride screening as an early detection effort for metabolic risk using the Plan-Do-Check-Act (PDCA) approach. A total of 109 adult participants with a mean age of 42.81 ± 13.55 years were involved in the activity. The results showed a mean triglyceride level of 162.13 ± 81.81 mg/dL with a median of 136 mg/dL (range 59-521 mg/dL), indicating considerable variation among participants. Categorically, 53.2% of respondents were within the normal range, while 46.8% were classified as having hypertriglyceridemia. Further analysis demonstrated a tendency for triglyceride levels to increase with age, although the association was relatively weak (R² = 0.037). These findings indicate a substantial proportion of individuals with elevated triglyceride levels in the community, highlighting the need for greater attention to metabolic health. Community-based screening proved effective as an early detection strategy for identifying metabolic risk factors. Therefore, follow-up promotive and preventive interventions are necessary, including dietary improvement, increased physical activity, weight management, and health education to reduce cardiometabolic risk and improve overall community health.
Co-Authors Alfianto Martin Andianto, Ivan Christian Angel Sharon Suros Arlends Chris Averina, Friliesa Brian Albert Gaofman Bruce Edbert Bryan Anna Wijaya Chairunnisa Savitri Damar Sajiwo Damar Sajiwo Daniel Goh Daniel Goh David Limanan Dean Ascha Wijaya DENY KURNIAWAN Destra, Edwin Dewi, Andriana Kumala Dorna Y.L. Silaban Dwiana, Alya Edbert, Bruce Edwin Destra Edwin Destra Enike, Syilvia Cendy Erick Sidarta Erick Sidharta Erik Sidharta Fadilah, Diana Farell Christian Gunaidi Farell Christian Gunaidi Fernando Nathaniel Fidelia Alvianto Fiona Valencia Setiawan Fladys Jashinta Mashadi Gabriella, Regina Gaofman, Brian Albert Geoffrey Christian Lo Giovani Evangelista Alfonsius Giovani Evangelista Alfonsius Giovanno Sebastian Yogie Goh, Daniel Gracienne Gracienne Gunaidi, Farell Christian Hartono, Vincent Aditya Budi I Made Satya Pramana Jaya Ivan Christian Andianto Jap, Ayleen Nathalie Johny Hartawan Sutrisno Joshua Kurniawan Kenzie Rafif Ramadhani Khoto, Anthon Eka Prayoga Kosasih, Robert Kristianto, Angeline Florencia Grace Kurniawan, Joshua Laura, Gabrielle Lucius, Steven Hizkia Lumintang, Valentino Gilbert Mashadi, Fladys Jashinta Meilani Kumala Muhammad Rifat Umar Alwini Nabila Jingga Permatasari Najwa Anindya Nataprawira, Sari Mariyati Dewi Naufal Rayhan Normala, Ajeng Olivia Charissa Peter Ian Limas Pratama, Dena Adistiya Rambe, Novitasari Reynardo, Reynardo Ribka Anggeline Hariesti Sajiwo, Damar Santoso, Alexander Halim Sara Jayanti Sari Mariyati Dewi Nataprawira Sari Mariyati Dewi Nataprawira Sari Mariyati Dewi Nataprawira Sari Mariyati Dewi Nataprawira Sari Mariyati Dewi Nataprawira Sari Mariyati Dewi Nataprawira Sari, Fadhilah Permata Satyanegara, William Gilbert Satyo, Yovian Timothy Savitry, Chairun Nisa Setiawan, Fiona Valencia Shirly Gunawan Sidarta, Erick Sidharta, Erik Silvia W. Lestari Sitorus, Ribka Angeline Hariesti Sugiharto, Hans Sukianto, Louise Audrey Sukmawati Tansil Tan Susilodinata Halim Sutrisno, Johny Hartawan Syarifah, Andini Ghina Syilvia Cendy Enike Teguh, Stanislas Kotska Marvel Mayello Tiara Rahmananda Tosya Putri Alifia Valentino Gilbert Lumintang Wijaya, Bryan Anna Wijaya, Christian William Gilbert Satyanegara Windiatmoko, Dhio Dwi Yani, Jovan Falian Yohanes Firmansyah Yovian Timothy Satyo