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Journal : Jurnal Sinaps

MIXED PAIN PADA LOW BACK PAIN: ELABORASI DAN IDENTIFIKASI Juwita; Dessy R. Emril; Rachmad Suhanda
Jurnal Sinaps Vol. 5 No. 3 (2022): Volume 5 Nomor 3, September 2022
Publisher : Neurologi Manado

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Abstract

Low back pain is a health problem that is very common and has an impact on the financial well-being of both patients and their families. Based on pathophysiology, pain can be divided into nociceptive, neuropathic, and central sensitization pain. In about 85% low back pain cases, it is not known which type of pain plays a greater role so that patients suffer from pain for more than 1 year. Currently known as Mixed Pain, namely pain with a combination of pathophysiology that underlies the pain such as nociceptive with neuropathic pain. The term pain cannot yet be formally defined, so the term mixed pain has not been used widely enough to define pain. It is necessary to conduct a search on clinical indicators of mixed pain so that the process of identifying the type of pain is better, the selection of therapy becomes more rational, and the patient's quality of life improves.
TINJAUAN BIOMOLEKULAR PATOFISIOLOGI DAN PENEGAKAN DIAGNOSIS Juwita; Hidayaturrahmi; Adista, Ansari; Khairunnisa
Jurnal Sinaps Vol. 6 No. 3 (2023): Volume 6 Nomor 3, September 2023
Publisher : Neurologi Manado

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Abstract

Cancer is characterized by the uncontrolled growth and spreading of abnormal cells. Cancer-induced bone pain (CIBP) is a significant problem affecting the majority of cancer patients, especially those suffering from metastatic disease due to cancer. The pathogenesis of CIBP involves tumor cells, bone cells, inflammatory microenvironment, and neural tissue. RNA noncoding miR-708-5p/CXCL13 has an important role in enhancement development of bone cancer pain through the initiation of neuroinflammation and hyperalgesia. Early recognition of bone pain in cancer and establishing a diagnosis are essential for timely intervention to relieve pain, prevent complications such as bone fractures, and improve the patient's quality of life. Management of bone pain in cancer patients is very complex and requires a multidisciplinary approach.
Co-Authors A. Nur Ilmi Amaliyah Passalowongi A.D. Resky Abdullah Adista, Ansari Adista, Muhammad Ansari Agus Hendra Al Rahmad Agus R, Abu Hasan Agus Riadi Ajis Sumantri Andi Nurul Afana Fitra Anita Annisa’, Tiara Nurul Arielyan, Nur Mismeitha Arini Noura Darina Arini Nuora Darina Azizatul Banat, Azizatul Bakri, M Biy Paidul S Citra Dewi CR. Yayang Saskia Pratiwi Dariusman Dessy R. Emril Diah Selviani, Diah Dian Zulfatul Iman Diana , Eli Diaz Capriani Dina , Tri Dina, Tri Dwi Nuryani, Dina Eka Merdekawati Djafar Eli Diana Fadly Umar Faiq Julia Iqna’a Fajlurrahman Jurdi Faridha Nasir Fatmawati Madya Feby Elra Perdima Filia Hanum Filza Ratu Nabila Fitriliana Fransiskus Hendra Ariwibowo Haloho, Diva Grasiella Hani, Ummi Hanum, Filia Hasanah, Alfatjil Defni Hebrian Ananda Hendri Alamsyah Herlina Hidayaturrahmi Hilda Dahniela Imma Rachayu, Imma Indryani Irfan Idris iswanto Jamal, Adam Juarsa , M.Sidik Karmini Karyati Karyati Khairunnisa Khoiroh, Ummul Lesmana , Sastria Agustian Lestari , Titje Puji Liza Salawati, Liza Lubis, Nurhanifah Lucky Nadia Luthfia , Izza Luthfia, Izza MAGPIKA HANDAYANI Maha, Inike Gujamela Marlina martiani Maryam Maryam MasrBABSi Mawardi, Kholiq Misbahul Arifin Mita Arnika Monica MS, Shaharuddin Muhammad Akil Musi Muhammad Antor Riady Muhammad Rizky Muhammad Syafrudin Muhani, Nova Mukminatus S, Toyyibatul Naifa Shabira Naswar Nelly Nurhaeda Nurhayati Nurwijayanti Putri Mauliza, Putri Rachmad Suhanda Raisya Muntazzia Nasution Reza Mahendra Rizqy Wahyuni Imran Roihana Rusmina, Cut Safitri, Yuni Ayu Saiful Amri Sardil Mutaallif Sinta Wulandari Siska Sartika, Siska Sitanggang, Grace Lestari Suryani , Novi Ade SUSANTI Susanto , Edy Suwarni Suwarni Suwarni Syahrizal Syamsuddin, Nurfiani Tampubolon, Teti Tasyarani, Nazla Tetra Dewi, Fatwa Sari Tiara Nurul Annisa' Tiara Nurul Annisa’ Umar, Fadly Utami, Winda Sherly Wanda Guna Putra WAODE MARATUN SHALEHA Wida Fadluna Widiati, Kusno Yuli Yana, Saifuddin Yani, M. Yenni Fitria Yores Andrianto Yose Rizal Yulyani, Vera