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All Journal Competitor : Jurnal Pendidikan Kepelatihan Olahraga Al-Lisan Jurnal Borneo Administrator: Media Pengembangan Paradigma dan Inovasi Sistem Administrasi Negara IQTISHADIA Dinamika An-Nisbah: Jurnal Ekonomi Syariah JIET (Jurnal Ilmu Ekonomi Terapan) Science and Technology Indonesia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Script Journal: Journal of Linguistic and English Teaching Jurnal Dinamika Ekonomi dan Bisnis Fokus Ekonomi Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) IRJE (Indonesian Research Journal in Education) JSFK (Jurnal Sains Farmasi & Klinis) Sangia : Jurnal Penelitian Arkeologi (Journal of Archaeology Research) ECOPLAN : JOURNAL OF ECONOMICS AND DEVELOPMENT STUDIES SCAFFOLDING: Jurnal Pendidikan Islam dan Multikulturalisme Abdimas Universal Dialektika: Jurnal Ekonomi dan Ilmu Sosial Jurnal Abdi Insani TERAJU : Jurnal Syariah dan Hukum wacana equiliberium (jurnal pemikiran penelitian ekonomi) Siyasatuna Jurnal Ilmiyah Mahasiswa Siyasah Syariyyah Iqtishadia: Jurnal Kajian Ekonomi dan Bisnis Islam Asy Syar'iyyah: Jurnal Ilmu Syari'ah dan Perbankan Islam Muttaqien; Indonesian Journal of Multidiciplinary Islamic Studies Jurnal Ilmiah Tarbiyah Umat Ar Rehla: Journal of Islamic Tourism, Halal Food, Islamic Traveling, and Creative Economy Istismar : Jurnal Kajian dan Penelitian Ekonomi dan Bisnis Islam Al-Lisan: Jurnal Bahasa TRANSFORMATIONAL LANGUAGE, LITERATURE, AND TECHNOLOGY OVERVIEW IN LEARNING (TRANSTOOL) Jurnal Teknologi dan Manajemen Industri Terapan Al-Irsyad: Journal of Education Science Jurnal Kedokteran Hewan West Science Interdisciplinary Studies West Science Interdisciplinary Studies AmaNU: Jurnal Manajemen dan Ekonomi JESKaPe: Jurnal Ekonomi Syariah, Akuntansi dan Perbankan Epistemé: Jurnal Pengembangan Ilmu Keislaman Ar Rehla: Journal of Islamic Tourism, Halal Food, Islamic Traveling, and Creative Economy An-Nisbah: Jurnal Ekonomi Syariah EMARA : Indonesian Journal of Architecture Jurnal Dinamika Penelitian: Media Komunikasi Penelitian Sosial Keagamaan Jurnal Wacana Kinerja: Kajian Praktis-Akademis Kinerja dan Administrasi Pelayanan Publik As-Syirkah: Islamic Economic & Financial Journal
Muhammad Aswad
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Journal : Jurnal Kedokteran Hewan

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THE EFFECTS OF SIMVASTATIN, ROSUVASTATIN, AND FENOFIBRATE ON THE BODY WEIGHT AND LIPID PROFILES OF FEMALE RATS TREATED WITH ORAL CONTRACEPTIVES AND A HIGH-FAT DIET Putri, Dwi Anggara; Djabir, Yulia Yusrini; Bahar, Muhammad Akbar; Alam, Gemini; Rahman, Latifah; Aswad, Muhammad; Arsyad, Muhammad Aryadi
Jurnal Kedokteran Hewan Vol 16, No 3 (2022): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v16i3.22196

Abstract

This study aimed to compare the effects of simvastatin, rosuvastatin, and fenofibrate therapies on the body weight and lipid profiles of the female rats receiving a combination of oral contraceptives (COC) and a high-fat diet (HFD). Twenty female Wistar rats (130-200 g) were divided equally into four groups. The rats received a standard diet for seven days, and their baseline lipid profiles were analyzed. All rats also received COC containing 15.1 g/kg levonorgestrel/3.1 g/kg estradiol with HFD for 60 days. Starting on day 31, the rats were given the respected treatment. The control group received the vehicle, whereas the others were treated with either simvastatin (2.1 mg/kg), rosuvastatin (0.5 mg/kg), or fenofibrate (8.2 mg/kg). Blood samples were taken on days 30 and 60. The results showed that the administration of COC+HFD and vehicle for 30 days increased the rats body weight and dyslipidemia, characterized by a significant decrease in Low-Density Lipoprotein (HDL) and an increase in total cholesterol (TC) and triglycerides (TG) levels (P0.05). Among the treatments, only fenofibrate was found to be able to prevent a significant weight gain in rats. Both fenofibrate and rosuvastatin inhibited a significant rise in TG and TC levels. Meanwhile, the simvastatin administration failed to do the same. Although statistically insignificant, all treatments increased rats HDL levels. Thus, it can be concluded fenofibrate was the most effective treatment among all in reducing weight gain and improving the lipid profile of dyslipidemic rats induced by oral contraceptives and a high-fat diet.
Co-Authors . Hasbunallah AS Abd Halim Umar Abdul Gaffar Haris abdul Rauf Sulaeman Abidah, Asiska Nur Adlan, Muhamad Aqim Ahmad Abbas Ahmad Budiman, Ahmad Ahmed Sardi Aisyah Fatmawaty Ali H Ambo Lallo, Subehan Aminuddin Aminuddin Anwar Sewang Aqim Adlan, Muhammad Ardiansyah Ardiansyah Arsyad, Muhammad Aryadi Azizah, Irtifa Umi Bahktiar, Jusuf Barambangi, Jamil Burhan, Asril Dede Nurohman Deris Lazuardi Djabir, Yulia Yusrini Djalaluddin, Nurgadima Febrianto, M. Nanang Firmansyah JN, Muh Fitriah, Reski Fortunasari, Fortunasari Gemini Alam Hajati, Kartika HIDAYAT, MARZUL Hijayati, Siti Sofiyah Hijra Hudain, Muh. Adnan IRMA YULIA MADJID, IRMA YULIA Kamil, Dairabi Kasim, Athia Kurnia KHASANAH, KHOLIFATUL Latif, Wenry Deston Latifah Rahman Lestari, Anggita Della Lestari, Lisa Yuni Linawati, Diana Lomba Sultan M. Nanang Febrianto Mappaompo, M. Adam Marianti A Manggau Matias N Kolobani Muh. Akbar Bahar Muh. Akbar Bahar, Muh. Akbar Muhamad Aqim Adlan Muhammad Syahrul Hidayat Mulia Ardi Mulyani, Ariny Aggreni Mustika Nur Astuti Nur Adyla S Nur Iman Saal Nur Zamzam Nurchalis, Nur Fadillah Nurdina Rasjid Nurrohman, Dhika Nursal, Muhammad Akbar Nursamsiar Nursamsiar Oftafiana, Triya Prasojo, Hendris Agung Pratiwi, Putri Hidayanti Putri, Dwi Anggara RAFIQA RAFIQA, RAFIQA Raida Asfihana Ramadhani, Nur Risfah Yulianti Risfah Yulianty Rohmah, Siti Lailatur Rokhmat Subagiyo Rokhmat Subagiyo, Rokhmat Rusdiah Salsabila, Chairunnisa Santoso, Irvan Widi Singh, Amreet Kaur Jageer Sohrah Sohrah, Sohrah Sutikno, Johan Dwi Syamsu Nur, Syamsu Tadjuddin Naid Tumigolung, Aprilia Ester Eunike Utoro, Bambang Wahyu Hendrarti Yasir, Budiman Yensawai E. Rumbiak Yudi Azis Yusnita Rifai, Yusnita