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Journal : INDONESIAN JOURNAL OF PHARMACY

MACARANGIN, A GERANYLATED FLAVONOID AND ANTICANCER ACTIVE COMPOUND ISOLATED FROM ETHYL ACETAT FRACTION OF Macaranga gigantifolia LEAVES Darmawan, Akhmad; Suwarso, Wahyudi P.; Kosela, Soleh; Kardono, Leonardus B.S.; Fajriah, Sofa
INDONESIAN JOURNAL OF PHARMACY Vol 26 No 1, 2015
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (705.678 KB) | DOI: 10.14499/indonesianjpharm26iss1pp52

Abstract

Macaranga known locally as mahang-mahangan has uniquely ecological function, and also became a part of traditional medicine in Indonesia. Macaranga genus also known as a sources of terpenoid and phenolic (flavonoid) compounds which have biological activity as antioxidant and anticancer (cytotoxicity).There are few phytochemical investigations have been done on M. gigantifolia species. As a part of our continuing research of isolation anticancer compound from natural product, a geranylated flavonoid compound (macarangin) has been isolated from ethyl acetate fraction of Macaranga gigantifolia leaves using chromatography methods. The isolated compund (isolat MG) was elucidated to gain the chemical structure based on spectroscopic data (LC-MS and FT-NMR). Cytotoxicity test of this compound was tested against MCF 7 cell lines, showed that macarangin has a potential activity with IC50 value 119.12μg/mL. Key words: Macarangin, geranylated  flavonoid, Macaranga gigantifolia, MCF 7 cell lines.
Co-Authors ., Alfalisyado A.A. Ketut Agung Cahyawan W Ahmad Randy Ahmad Wahyudin Aisya, Sitti Amir Amir Anggelina, Yosita Anggraini, Intan Anggun Puspita Ariani, Novita Arini Hidayah, Arini Aris, Muhammad Rizqie Aryawibawa, Anja Dwi Aryoko, Yudhistira Pradhipta Aryoko, Yudistira Pradipta Bagis, Fatmah Barlian, Putri Bekti Divayani, Naelin Dinda Condro Nur Alim Dewijanti, Indah Dwiatmi Endang Saepudin, Endang Erny Rachmawati Fadzilah, Rizqiya Nur Fitriati, Azmi Galuh Widiyarti Hani Mulyani, Hani Haryanto, Totok Hengky Widhiandono Heri Syahrian, Heri Hermin Endratno Indah Rahmawati Indahsari, Ninik Dewi Irfanesa, Irfanesa Jamhari Jamhari Jaroenwanit, Pensri Kharismasyah, Alfato Yusnar Kurnia, Kesih Leonardus B.S. Kardono Lia Meilawati Lotulung, Puspa Dewi N. Maharani, Adinda Safirah Maharani, Annisa Dwi Maharani, Wilia Krisna Maulida Nurul Innayah Maulidiyah Mawaddah, Apriani Medi Hendra, Medi Megawati Megawati - Megawati, Melliana, Sinta Bella Miftahuddin, Muchammad Agung Minarti Minarti Muhammad Hanafi Muhammad Nurdin Mulyani, Hanny Naelati Tubastuvi Nina Artanti Nisa, Ainun Nofianingsih, Elsa Nugroho, Bambang Haryo Nur Umami, Kharisma Aulia Nurfiani, Aisah Pratama, Bima Cinintya Pratama, Bintang Rizki Pratiwi, Firda Ardianti Primahana, Gian Purnadi Purnadi, Purnadi Puspa Dewi Narrij Lotulung Putragita, Yudhistira Rahmawati, Dwi Vina Rahmawati, Ika Yustina Randikaparsa, Irawan Restu Frida Utami Rimbawan, Bagas Akbar Dwi Pangestu Rizna Triana Dewi Satria, Agri Bayu Setiyaningrum, Anggun Siska Liana Sofa Fajriah Soleh Kosela Sri Wahyuni SUKIRNO Sunardi Sunardi Supriadi, Edi Suwarsito Suyono Suyono Teni Ernawati Tri Septin Muji Rahayu, Tri Septin Tri Utami Wahyudi P. Suwarso, Wahyudi P. Wida Purwidianti Widyaningtyas, Dian Widyasmara, Meriska Yogi Widzayanto, Luthfi Arie Wiranti, Elza Devi Yasin, Roqi Yundari, Yundari Yuswandani, Arafah Esa