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Dwi Lestari
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Journal : Jurnal Natural

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Antidiabetic Activity of Leaves Ethanol Extract Chromolaena odorata (L.) R.M. King on Induced Male Mice with Alloxan Monohydrate Marianne Marianne; Dwi Lestari; Elin Yulinah Sukandar; Neng Fisheri Kurniati; Rosnani Nasution
Jurnal Natural Volume 14, Number 1, March 2014
Publisher : Universitas Syiah Kuala

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Abstract

Chromolaena odorata or Tekelan has been used traditionally to cope with diabetes mellitus, but the scientific evidence as antidiabetic agent has not been previously reported. Therefore, it is necessary to test the antidiabetic activity using ethanol extract of the tekelan leaves in male mice induced by alloxan. Mice were induced intravenously by alloxan dose of 55 mg/kg bw. After 7 days, mice were diabetic ( KGD 200 mg/dL ) and were grouped into 6 groups: negative control group (only treated with CMC - Na) , positive control group (glibenclamide 0.45 mg/kg bw) and the 4 other groups were given ethanol extract of Tekelan leaves at doses of 5 , 25 , 125 and 250 mg/kg bw. Dosage administered for 28 days and blood glucose levels was checked every 7 days using a glucotest. Data were analyzed by one-way analysis of variation at 95% confidence level. Ethanol extract of tekelan’s leaves  at doses of 5 , 25 , 125 and 250 mg/kg bw can lower blood levels  from day 7 to day 28 and was significantly different compared to the negative control group ( p 0.05). Ethanol extract of tekelan’s leaves at doses of 5 , 25 , 125 and 250 mg/kg bw showed antidiabetic activity in alloxan-induced mice.
Co-Authors Achmad Ludvy adhirajasa shidqi muhamad Adina Latifaturrohmah Ahmad Zangim Aina Sarah Hafawati Albertus Djoko Lesmono Alya Khoyrunisa Amalia Rahmi Nasution Ambaria Nur Ana Yuliana Anisa Mutiara Rizky Annisa Maulidiyah Rahmi Lestari Anzu Elvia Zahara Arif, Nina Fapari Aris Harja Kusuma Aris Sunantyo Arita Marini Audi Alexandra Zeliyanti aulia sinta arianti Baiq Faridha Aulya Maharani Bambang Sumarno H.M. Bilal Ma'ruf Budiyono , Cecep Pratama Cindy Aldona Cornelia Budimarwanti David Effendi Deaz Aji Pratama Dedi Atunggal Dela, Delaamelia Desri Amrainum Desy Fitriani Dilla Aulia Ramadhani Dimas Pamungkas Dini Fadhliyah Naiborhu Dita Yuzianah Donny Fransiskus Manalu, Donny Fransiskus Dwi Mei Nandani Edy Purnomo Elin Yulinah Elsya Mayori Elvi Khairani Sofyan Eminugroho Ratna Sari ENDANG SUGIARTI Fadhilatul Amaliya Faishal Hasyim Faiza Adinda Fakhruddin Fatma Salsabila Fitriana Yuli S Fitriana Yuli Saptaningtyas Fuad Rahman Gita Puspa Artiani, Gita Puspa Haeki Manzis Heliani, Leni Sophia Hesti Endah Lestari Husna Arifah Indriasari Isnaini, Fatimah Noor Isnaniah Isnaniah Iyut Rosmita Putri Kuswan Hadji Lalu Diandra Surya Wardhana Lilis Ardini Made Sutha Yadnya Marianne Marianne Maryani Maryani Meirani Harsasi Metri Utami Krahayon Mila Karmila Miranti Wulan Saputri Muhammad Abu Fattahillah Muhammad Jumnahdi Mukrodi Muniroh Munawar Murwati . Musthofa Musthofa Mutiara Ashifa Nabila Inne Azri Nabilah Putri Nursuha Nanda Febriyani Putri Nanik Khurnia Neng Fisheri Kurniati Neng Fisheri Kurniati Netriwati Nicholas Adi Kusuma Nur Ariza Kurnia Dewi Nur Azlia Arumi Nur Wahid Muharrom Nurdin Nurdin Nurrohmat Widjajanti Parseno Parseno Putri Kusumawati Priyono Rahita Rahmadya Waluyo Rambe Roisuddin Ery Risna Putri Zahara Rohmah Nur Istiqomah Ronaan Maulana Basuki Roro Ranti Dea Alfathya Rosnani Nasution Ruknan Sahid Sahid Sahkholid Nasution Shinta Aulia Siallagan, Dorsinta Siska Rahmadani Suhaji Suhaji Sulhi Sungkowo Edy Mulyono Talita Dhea Alsabilla Tasya Putri Irawan Titin Agustin Nengsih Ulinnuha, Hilmiyati Wasiyem, Wasiyem Yayan Sudaryana yohana sandi wijayanti Yonisa Aisyah Fitri yunita, yunita nurul arifah Zahrani Nabilah Zakiah Zakiah