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The Role of Bay Leaf Extract in Reducing Liver Inflammation in Mice (Mus Musculus) Induced by Potassium Oxonate Evy Silvia Awwalia; Hotimah Masdan Salim; Mochammad Faishal Riza; Mulyadi Mulyadi
Jurnal Ilmiah Kesehatan Vol 17 No 01 (2024): Vol. 17 No. 01 (2024): Jurnal Ilmiah Kesehatan (Journal of Health Science)
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/jhs.v17i01.5613

Abstract

Hyperuricemia is characterized by elevated uric acid levels in the blood, often stemming from increased uric acid production or inadequate uric acid excretion, resulting in levels exceeding 7 mg/dL. If left unmanaged, this condition can lead to gout arthritis. Elevated serum uric acid levels have also been linked to liver damage, as evidenced by findings in patients diagnosed with Non-alcoholic fatty liver disease (NAFLD), showing increased serum uric acid levels associated with liver damage. This study investigates the potential role of bay leaf extract in reducing liver inflammation related to uric acid metabolism. This study employed a true experimental approach with a post-test control group design, utilizing 8-week-old Mus musculus as experimental animals. The groups were divided as follows: Group 1 (control), Group 2 (Potassium oxonate-PO), Group 3 (PO with administration of bay leaf extract at 75mg/kg body weight), Group 4 (PO with administration of bay leaf extract at 150mg/kg body weight), and Group 5 (PO with administration of bay leaf extract at 300mg/kg body weight). Histological examination of the liver in the PO administration group revealed cell infiltration compared to the control group. However, a significant reduction in damaged hepatocyte cells was observed by administering bay leaf extract in PO+EDS-1, PO+EDS-2, and PO+EDS-3 groups (P<0.05). Bay leaf extract demonstrates hepatoprotective effects in hyperuricemia induced by potassium oxonate.
Co-Authors Abdul Muhith Achmad Hilman Fahmy Aditya Bhayusakti Adyan Donastin Afiyah, R. Khairiyatul Ahmad Ali Firdaus, Abraham Ainul Rofik Aisyah Aisyah Aji, Audi Ikhfina Tanra Akas Yekti Pulih Asih Akbar Reza Muhammad Alam, Ilham Putera Alam, Ilham Putra Alfina Andasari Alief Aditya Permana Andi Roesbiantoro Andreas Putro Ragil Santoso, Andreas Putro Ragil Anggara Kidung Pranata Ardianti, Ami Arif Rahman Hakim Atika Maulida Inastiti Audi Ikhfina Tanra Aji Awwaliya, Evi Awwaliyah, Evi Sylvia Awwaliyah, Evy Silvia Bagas Setiawan Ihsan Zaini Bagas Setiawan Ihsan Zaini Bariyah, Khadijah Khairul Bermawi, Bastiana Bintarti, Tri Wahyuni Charissa Balqis Choiriya, Dian Dakwatul Choirotussanijah Choirotussanijah Choirotussanijjah Choirotussannijah Choirotussannijah Danny Irawan David Sajid Muhammad Dayu Satriya Wibawa Deny Febriwijaya Romadhani Desi Irawati, Adinda Devyana Dyah Wulandari Devyana Dyah Wulandari Dewi Masitah Dewi, Uke Maharani Diah Retno Kusumawati Dian Dakwatul Choiriya Dwi Arman Prasetya Dwimantoro Dwimantoro Iman Prilistyo EBISINTEI, PRECIOUS Edza Aria Wikurendra Eka Satria Akbar Ferdinan Hanafi Endah Budi Permana Putri Endah Budi Permana Putri Erfina Miftakhul Zannah Ersalina Nidianti Evi Octavia Djamaludin Evy Silvia Awwalia Fadilah Nisa Purwanti Fahrizal Amin Nurfaizi Faraadies, Rangga Azhaar Farah Dina Amalia Farhatu Aini Fariska Zata Amani Fatmawati, Ulik Ferdinan Hanafi, Eka Satria Akbar Fifi Khoirul Fitriyah Garfansa, Marchel Putra Hafid Algristian Hanafi, Eka Satria Akbar Ferdinan Handayani Handayani Heryanti Pusparisa Hudzaifah Hamidy Ika Mardiyanti Ika Maysaroh Lesparwati Ilham Putera Alam Ilham Putra Alam Ima Kurniastuti Ismail Ibrahim Ismail, Zainul Hadi Wildan Iswahyudi Iswahyudi ISWAHYUDI ISWAHYUDI Izki Masyaqqoni Pujiana Jamhuri, Nur Syazwani Jazuli, Muhammad Aqil Siroj Jessica Puspa Kencana Jinan, Puspita Rahmatul Joko Sulistyo Karina Dwiyanti Khadijah Khairul Bariyah Khuzaimah Nur Juhanifah Rihhadatulays Lea Maera Shanty Lintan Farizqi Kurnia Lysa Veterini Machmudah Machmudah Machmudah, Machmudah Maria Ulfa Marinda Dwi Puspitarini Marotur Rohima Marselli Widya Lestari Meidyta Sinantryana Widyaswari, Meidyta Sinantryana Michio Shimabukuro Miftakhul Dwi Ersanti Mochammad Faishal Riza Mufidah Sheena Andani Prastini Muhammad Aqil Siroj Jazuli Muhammad, Akbar Reza Muhammad, David Sajid Muhammada, Davida Sajid Mukhtar Adi Nugroho Muliani, Nurlina Mulyadi Mulyadi Mulyadi Mulyadi Mutmainnah Nadia Nisaussholihah Nadzirah Sylvia Nahdatien, Ima Nanda Fadhilah Witris Salamy Nanik Handayani Nanik Handayani Nisaussholihah, Nadia Novera Herdiani Nur Azizah AS Nur Hidayah Nurdianto, Arif Rahman Nurul Munawaroh Oktaviana Ainurokhim Pramesti, Rosandhy Alfiyah Pramesti, Rosandhy Alifyah Pramesti, Rosandhy Alifyah Pramesti Puspita Rahmatul Jinan Puspitasari, Mia R.A. Hani Faradis Rangga Azhaar Faraadies Raniyah Diva Rosalbah Ratna Ariesta Dwi Andriani Renny Novi Puspitasari Reza Hery Mahendra Putra Reza Mahendra Rezky Dwinda Pratiwi Rihhadatulays, Khuzaimah Nur Juhanifah Rining Sulistya Rahayu rofiq, ainul Romadhani, Deny Febriwijaya Rosandhy Alifyah Pramesti Rosda Rodhiyana Salfa Salsabilah Zain Savitri, Ardyarini Dyah Siti Nur Hasina Siti Robi’atus Sholiha Sohaimi, Ainur Elliana Sonny Edbert Syafiuddin, Achmad Thoriqi, Mochammad Hafitd Tri Deviasari Wulan Tri Wahyu Bintarti Ubaidillah Zuhdi Widya Dio Kharisma Wiratama, Rahardyan Dika Yanti, Alfiyah Indah Yasi Anggraini Yenni Arista Cipta Ekalaturrahmah Yuani Setiwati Zainul Hadi Wildan Ismail Zamirah Mabarroh El Haque