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All Journal Media Kedokteran Hewan Indonesian Journal of Cancer Chemoprevention Jurnal Medik Veteriner JPSCR : Journal of Pharmaceutical Science and Clinical Research JFIOnline Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Ovozoa: Journal of Animal Reproduction journal of Basic Medical Veterinary Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Iwan Sahrial Hamid
Bagian Klinik Hewan, Fakultas Kedokteran Hewan, Universitas Udayana, Bali
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Physics Public Health Veterinary

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Moringa oleifera leaf extract restored the diameter and epithelium thickness of the seminiferous tubules of rat (Rattus norvegicus) injected with gentamicin Mardatillah, Meidy; Wurlina, Wurlina; Yudaniayanti, Ira Sari; Primarizky, Hardany; Plumeriastuti, Hani; Hamid, Iwan Sahrial
Ovozoa: Journal of Animal Reproduction Vol. 11 No. 1 (2022): Ovozoa: Journal of Animal Reproduction
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ovz.v11i1.2022.15-21

Abstract

This research aims to determine the effect of Moringa oleifera leaf extract (MLE) on the diameter and epithelium thickness of the seminiferous tubules of rats induced with gentamicin. This study used 25 male rats (Rattus norvegicus) aged 8-12 weeks with 150-200 grams body weight. Negative control group (C-) was injected with aquadest and given 0.5% Na-CMC orally, positive control group (C+) was induced with gentamicin injection of 5 mg/kg BW/day and given 0.5% Na-CMC orally, while groups T1, T2, and T3 were induced with gentamicin at the same dose and treated orally with MLE of 200, 316, 500 mg/kg BW/day. Analysis of variance showed significant differences and further analysis using Duncan Multiple Range Test showed difference in each group. The results showed that treatment with MLE of 500 mg/kg BW/day improved the diameter and epithelium thickness of the seminiferous tubules of rats injected with gentamicin. It could be concluded that MLE restored the diameter and epithelium thickness of the seminiferous tubules of rats induced with gentamicin.
pH and ferning score of cervical mucus related to gestation and calf gender of Holstein Friesian crossbreed cows Ferdiansyah, Muhammad Billy; Hamid, Iwan Sahrial; Hermadi, Herry Agus; Samik, Abdul; Hernawati, Tatik
Ovozoa: Journal of Animal Reproduction Vol. 11 No. 1 (2022): Ovozoa: Journal of Animal Reproduction
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ovz.v11i1.2022.22-26

Abstract

This study aimed to compare the ferning score based on the pH of the cervical mucus and its relation with gestation and the calf gender of cows. Ten Holstein Friesian crossbreed cows which were detected in estrus and about to be artificially inseminated, were used for this study. Sample of cervical mucus was collected using Metricheck for pH and ferning observations. Pregnancy diagnosis was conducted two months after insemination, and the gender of the calves was recorded at parturition. This study indicated that cervical mucus pH did not affect the ferning characteristics, ferning score, and pregnancy of cows. However, higher ferning scores tended to result in the pregnancy of cows. Also, alkaline pH tended to result in male calves and vice versa. Further study is needed with a more significant number of samples related to the application of ferning display as an indicator of estrus to obtain a higher pregnancy rate.
Efektivitas Patch Transdermal Ekstrak Etanol Daun Insulin (Smallanthus sonchifolius) Terhadap Kadar Glukosa Darah dan Histopatologi Pankreas Tikus Putih Wijayanti, Ni Putu Pirna; Hendriati, Lucia; Hamid, Iwan Sahrial; Widodo, Teguh; Kuncorojakti, Suryo
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 8, No 2 (2023)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v8i2.59508

Abstract

Diabetes melitus adalah penyakit metabolik yang ditandai dengan hiperglikemia akibat kelainan sekresi insulin, kerja insulin atau keduanya. Salah satu permasalahan yang dihadapi dalam pengobatan pasien diabetes adalah kepatuhan terhadap terapi obat. Daun insulin (Smallantus sonchifolius) memiliki efek menurunkan kadar gula darah, tetapi pada penggunaan jangka panjang per oral dapat menimbulkan efek samping terbentuknya lesi ginjal. Rute penghantaran alternatif untuk meningkatkan kepatuhan pasien dan menurunkan efek samping adalah penghantaran transdermal. Tujuan penelitian ini untuk mengetahui efek patch transdermal ekstrak etanol daun insulin terhadap kadar gula darah dan gambaran histopatologi pankreas tikus. Tikus putih yang telah diinduksi aloksan dibagi menjadi 6 kelompok perlakuan yaitu: kontrol positif (metformin per oral), patch tanpa ekstrak daun insulin dengan peningkat penetrasi Tween 60, patch tanpa ekstrak daun insulin dengan peningkat penetrasi Span 80, patch ekstrak daun insulin dengan Tween 60, dan patch ekstrak daun insulin dengan Span 80.  Dosis ekstrak etanol daun insulin yang digunakan sebesar 400 mg/kgBB. Pengamatan terhadap kadar gula darah dan gambaran histopatologi pankreas dilakukan selama 14 hari. Analisis data menggunakan Anova satu jalan. Penggunaan patch transdermal ekstrak daun insulin menurunkan gula darah tikus sejak hari ke-1 dan pada hari ke-9 menghasilkan kadar gula darah tikus lebih rendah dibandingkan metformin per oral. Penambahan peningkat penetrasi Tween 60 dan Span 80 meningkatkan penurunan kadar gula darah. Hasil yang sama juga didapatkan pada parameter gambaran histopatologi pankreas tikus.  Berdasar hasil penelitian, pemberian patch transdermal ekstrak etanol daun insulin (Smallanthus sonchifolius) dapat menurunkan kadar glukosa darah dan mempengaruhi gambaran hispatologi pankreas pada tikus putih. 
Co-Authors A.A. Ketut Agung Cahyawan W Abdul Samik, Abdul Agnes Theresia Soelih Estoepangestie Aksono HP., Eduardus Bimo Annise Proboningrat Ardy, Carolina Arianto, Intan Diah Safitri Arimbi Budi Utomo Chairul Anwar Dermayati, Cyntia Zain Dermayati, Cyntia Zain Desy Fatmawati Dewi, Sapna Kurnia Dwi, Welyanto Kurniawan E Bimo Aksono Epy Muhammad Luqman Erma Safitri Fachrur Rozi Faisal Fikri Fedik Abdul Rantam Ferdiansyah, Muhammad Billy Firdausyi, Aulia Amatul Fransiska, Eunike Melanda Hani Plumeriastuti Harelas, Genoveva Callista Hermadi, Herry Agus Hestiana, Eka Pramyrtha Hidanah, Sri IMAM MUSTOFA Ira Sari Yudaniayanti Ivanalee, Angela Swasti Jeanita, Winny Kadek Rachmawati Kariyaningtias, Vivi Kartikasari, Anjani Marisa Kresnamurti, Angelica Kuncorojakti, Suryo Kusumaningrum, Putri Anggraheni Lake, Werenfridus Kono Lastoaji, Firman Lianny Nangoi Lita Rakhma Yustinasari Lokapirnasari, Widya Paramitha Lovela, Aprinda Ratna Lucia Hendriati Mafruchati, Maslichah Mardatillah, Meidy Meles, Dewa Ketut Muhammad, Abdul Latif Mustofa Helmi Effendi Muzhaffar, Adam Maulana Novitasari, Seline Putri Nugrahani, Anggi Dwi Nusdianto Triakoso octavia, Arinda Praja, Ratih Novita Pramesti, Nugraheni Anggara Prastiya, Ragil Angga Primarizky, Hardany Puspitasari, Vina Putrianirma, Rizki Rahmahani, Jola Rahmatullah, Aldin Akbar Rahmi Sugihartuti, Rahmi Rasdianto, Dwi Damayanti Ratna Damayanti Retno Bijanti Salahuddin, Muhammad Soleh Santoso, Kuncoro Puguh Saputro, Amung Logam Satria, Rafif Galih Solikhah, Tridiganita Intan Sri Mulyati Sri Pantja Madyawati Sucita, Ricky Eka Suherni Susilowati Sukmanadi, Mohammad Sunarso, Agus Supriyadi Supriyadi Suresti, Suresti Surya, Regiskha Hermandanie Suryanie Sarudji Suwarno Suwarno Tatik Hernawati Teguh Widodo Tito, Muhammad Tjuk Imam Restiadi Tri Wahyu Suprayogi Tyasningsih, Wiwiek Wahjuni, Retno Sri Wahyudi, Alif Ekacahya Weliyani, Trima Wibawati, Prima Ayu Widiyatno, Thomas Valentinus Widjiati Widjiati, Widjiati Wijaya, Achmad Arby Wijayanti, Ni Putu Pirna Willyanto, Jennifer Rachel Wilujeng, Estiary Wurlina, W Yudhana, Aditya Yunita, Maya Nurwartanti Yuseni Kusuma P Zahro, Vida Seanita Zulianti, Brillia