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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Nexus Kedokteran Komunitas Nexus Biomedika Nexus Kedokteran Translasional Mutiara Medika: Jurnal Kedokteran dan Kesehatan Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Jurnal SPORTIF : Jurnal Penelitian Pembelajaran Jurnal Respirologi Indonesia Abdimas Universal JOSSAE (Journal of Sport Science and Education) Jurnal Aisyah : Jurnal Ilmu Kesehatan Ahmar Metakarya: Jurnal Pengabdian Masyarakat Smart Society Empowerment Journal Jurnal Kesehatan Plexus Medical Journal Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute Media Penelitian dan Pengembangan Kesehatan National Journal of Occupational Health and Safety Folia Medica Indonesiana
Selfi Handayani
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Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Platelet-Rich Plasma as a Pharmacopuncture Agent in Cervical Myofascial Pain Nareswari, Irma; Kamal, Achmad Fauzi; Mihardja, Hasan; Yunus, Reyhan Eddy; Jusuf, Ahmad Aulia; Harahap, Alida Roswita; Wahyuni, Luh Karunia; Werdhani, Retno Asti; Handayani, Selfi; Rukmindar, Dion
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 9 No. - (2025): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v9i-.310

Abstract

Chronic cervical myofascial pain (CMP) is a prevalent musculoskeletal disorder characterized by persistent neck pain, inflammation, functional impairment, and altered pain processing. Conventional treatments, including pharmacological therapy and physical rehabilitation, often provide limited and temporary relief. Increasing evidence suggests that chronic CMP involves not only peripheral nociceptive input but also nociplastic pain mechanisms driven by sustained neuroimmune dysregulation and central sensitization. Pharmacopuncture, combining acupuncture point stimulation with localized injection of therapeutic agents, has evolved with the introduction of regenerative biologics such as platelet-rich plasma (PRP). PRP contains concentrated platelets and bioactive growth factors, including VEGF, PDGF, and TGF-β, which exert anti-inflammatory and tissue-reparative effects. Emerging data indicate that PRP pharmacopuncture may reduce pro-inflammatory cytokines (e.g., IL-1β and TNF-α), modulate regulated cell death pathways (e.g., apoptosis and pyroptosis), and promote the restoration of myofascial tissue homeostasis. These mechanisms may contribute to both peripheral tissue repair and attenuation of nociplastic pain processing. This narrative review synthesizes current clinical and experimental evidence on the biological mechanisms and therapeutic potential of PRP pharmacopuncture in chronic CMP. Available studies report meaningful improvements in pain intensity and functional outcomes compared with conventional acupuncture or pharmacotherapy alone. However, substantial methodological heterogeneity may arise from PRP preparation protocols, acupoint selection, and outcome measures, limiting the ability to draw definitive conclusions. High-quality randomized controlled trials incorporating standardized protocols and mechanistic biomarkers are required to establish PRP pharmacopuncture as an evidence-based integrative treatment for chronic CMP.
Co-Authors . Balgis . Muthmainah . Muthmainah Achmad Fauzi Kamal Agus Sugeng Riyanto Agustina Wulandari Ahmad Aulia Ahmad Isnaini Shidqi Nurhani Annisa Aghnia Rahma Annisa Budiastuti Arif Setyoko Arpin, Wilson Aryoseto, Lukman Asyiraq, Muhammad Ferdy Balgis . Balgis Balgis Betty Saptiwi Betty Saptiwi Budiono, Enrico Ananda Budiyanti, Novita Danus Hermawan Dhoni Akbar Ghozali Diniyati, Hilda Dono Indarto Dwi rahayu Dwi Rahayu Dyah Ratna Budiani Dyonisa Nasirochmi Pakha Endang Listyaningsih Endang listyaningsih Endang Listyaningsih Enrico Ananda Budiono Fara Ayu Febyawati, Hani Firnadi, Jossefa Gozali, Dhoni Akbar Hakim, Fikar Arsyad Handayani Putri Cahyaningrum Harahap, Aletta Khaerunnisa Putri Harahap, Alida Roswita Hardjono . Hasan Mihardja Hastami, Yunia Hermawan, Danus Hernowo Setyo Utomo Ida Nurwati Ilyas, Muhana Fawwazy Itsna Ulin Nuha Jarot Subandono Jarot Subandono Kiyatno . kusnandar kusnandar Kusuma, Pranata Aji Luh Karunia Wahyuni, Luh Karunia Lukman Aryoseto M Abdul Basith Maria Mumtaz Martini Martini Muhammad Afif Muhammad Luthfiyanto Muhammad Syauqi Ridhallah Muhana Fawwazy Ilyas Muthmainah Muthmainah Muthmainah Muthmainah Nanang Wiyono Nanang Wiyono Nareswari, Irma Nisa'u Luthfi Nur Azizah Nur Dwi Fajarini Nurhani, Ahmad Isnaini Shidqi Paksi Suryo Bawono Raditya Perdana Aryasatya Rahma, Annisa Aghnia Reflioni, Silvi Retno Asti Werdhani Reyhan Eddy Yunus Ridhallah, Muhammad Syauqi Risya Cilmiaty Risya Cilmiaty A. R. Riyanto, Agus Sugeng Rosyadah, Prima Aprilia Rukmindar, Dion Sarsono Sarsono Shabrina, Syania Siti Marufah Siti Munawaroh Siti Munawaroh slamet Riyadi Slamet Riyadi Sunggoro, Agus Jati Susanti, Widia Syania Shabrina Widia Susanti Yundari, Yundari