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Ekowati Handharyani
Departemen Klinik Reproduksi Patologi, Fakultas Kedokteran Hewan, IPB University, Kampus IPB Dramaga Bogor, 16680, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Environmental Science Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Pharmascience

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Essential Oil and Ethanolic Extract of Curcuma Inhibits Mammae Tumors in Rats Induction by DMBA Akhmad Endang Zainal Hasan; Ekowati Handharyani; Sri Wahyuni
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.13215

Abstract

Curcuminoids and xanthorizol are active components that may act as anticancer in the rhizome of Curcuma xanthorrhiza. The purpose of this study was to determine the content of the class of compounds in curcuma extract and essential oil using the phytochemical screening test method, the Folin-Ciocalteu method to determine the total phenolic content and the AlCl3 method for the total fentuconoid content. In addition, the activity of curcuma in inhibiting the influence of DMBA on the growth of breast cancer in rats was determined. Curcuma extract used is the result of extraction using 70% ethanol on an industrial scale. Total phenolic content and flavonoid extract of curcuma were determined by spectrophotometer. Inhibition testing of tumors formed due to DMBA induction was carried out by administering temulawak extract at doses of 35, 70, 140, 210 and 280 mg/kg body weight. Based on the phytochemical analysis, the ethanol extract of curcuma contained terpenoids, alkaloids, phenolic compounds and flavonoids. The results of the analysis of the ethanol extract of curcuma contained total phenols and flavonoids with concentrations of 42.96 mg GAE/g and 3.96 mg QE/g, respectively. The group that was given curcuma extract as the control group (p<0.05) had a significant difference. Based on the Mann-Whitney analysis, the third group with a dose of 140 mg/kg BW had the highest effect on tumor inhibition. The hope is that the development of curcuma extract into a standardized herbal medicine so that it can be used for the treatment of breast cancer can use the results of this research.
Co-Authors ., Chairul A Winarto Adi Winanto Adi Winarto Afiff , Usamah Agus Buono Agus Setiyono Ahmad Biharidin Ahmad Sulaeman Akhmad Endang Zainal Hasan Aldo Yanuar Wuriyantara Armenia Eka Putriana Arni Diana Fitri Aulia Andi Mustika Aziz Kustiyo Bambang Kiranadi Bambang Sumiarto Bambang Widyo Prastowo BIBIANA W LAY Budiono, Novericko Ginger Chairul - Chairul Chairul Clara Meliyanti Kusharto Deni Noviana Denny Widaya Lukman Dewa, Wisnu Jaka DEWI APRI ASTUTI Dewi Ratih Agungpriyono Dewi Ulfa Trisdiani Dhany Nugraha Ramdhany Dondin Sajuthi Dwi Santy Damayati Dwi Utari Rahmiati Eflisa Endah Putri Elly Munadziroh Eny Palupi Erni Sulistiawati Erwin Erwin Etriwati E Evy Damayanthi Fadjar Satrija Fajar Kawitan Firmansyah, Hardi Fitri Ariyani Fitri, Arni Diana Franciscus Dhyana Giri Suyatna Geneva Ariesta Giriwono, Puspo E. Gunanti . Hadi Riyadi Handayu Untari Hapsari Mahatmi Hardi Firmansyah HERA MAHESHWARI Hernomoadi . Hernomoadi Hernomoadi Herwin Pisestyani Hidayah Dwiyanti Huda Shalahudin Darusman I wayan Teguh Wibawan Ikeu Ekayanti Irma Herawati Suparto K Ochiai Karsi Ambarwati Katrin Roosita KHOIRIYAH, ROMYUN ALVY Kiranadi Bambang Komariah Komariah Komariah Lili Andriani Lina Noviyanti Sutardi M.B. Malole . MARIA BINTANG Masdiana C. Padaga Masriani . Nabilah, Avida Shahnaz Nasution, Zuraidah Ni Luh Putu Ika Mayasari Nisrina Rosyida Noor Rifai Novera Nirmalasanti Nugraha, Arifin Budiman Nugroho, Setyo Widi Octarina Okti Nadia Poetri Olga Purnama Bakti Opyn Mananta Perdhana, Ika Satya Putra Wijaya, Erlangga Putri Puncak Anjani R. Susanti Rahayu WoroWiranti Retno Damajanti Soejoedono Retno Damayanti Soejoedono Retno Setyaningsih Retno Setyaningsih Rimbawan , Rimbawan Rimbawan Risti Rosmiati Riyadh Firdaus Rizal M Damanik, Rizal M Ruqiah Ganda Putri Panjaitan safrina dyah hardiningtyas Sangko Sayuti Nasution Sangko Sayuti Nasution, Sangko SEDARNAWATI YASNI SILMI MARIYA Sophia Setyawati Sri Anna Marliyati sri murtini . Sri Purwaningsih Sri Rahmatul Laila Sri Wahyuni Suhendi, Adnan Rizal Surachmi Setiyaningsih Tanjung Penataseputro Tantri, Aida Rosita Trini Suryowati, Trini Umi Cahyaningsih Wasmen Manalu Wibowo, Artdhea Regita Wiwin Winarsih Yetty Ramli Yuli Purwandari Kristiangingrum Yuni Andriani Yusuf Ridwan Zulfa Zakiah