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All Journal Farmaka Indonesian Journal of Pharmaceutical Science and Technology JURNAL PHARMASCIENCE IDJP (Indonesian Journal of Pharmaceutics) Jurnal Kesehatan Bakti Tunas Husada IKRA-ITH Teknologi Jurnal Sains dan Teknologi Journal of Pharmacopolium Majalah Farmasetika Pharmacoscript Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Riset Kefarmasian Indonesia Indonesia Natural Research Pharmaceutical Journal (INRPJ) Science Midwifery Karya Kesehatan Siwalima Jurnal Pengabdian Masyarakat (Jupemas) Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan Jurnal Kesehatan Bakti Tunas Husada Jurnal Sains Farmasi dan Kesehatan Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Galenika Analit: Analytical And Environmental Chemistry Journal of Pharmascience
Garnadi Jafar, Garnadi
Fakultas Farmasi, Universitas Bhakti Kencana
Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary Other

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Journal : science midwifery

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Preliminary study of blood pressure and arterial stiffness monitoring using the niva device (non-invasive vascular analyzer) Avianningsih, Reformia; Hasimun, Patonah; Jafar, Garnadi; Putriyanti, Al-fira; Zakaria, Hasballah
Science Midwifery Vol 13 No 6 (2026): February: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i6.2212

Abstract

Introduction: Measuring vascular parameters using the NIVA (Non-Invasive Vascular Analyzer) is an important step in assessing the health of blood vessels in the community, especially in groups at risk of hypertension. Objective: This study aims to describe the results of baseline blood pressure and vascular parameter examinations in respondents before further intervention. Methods: Respondents underwent an initial screening process including informed consent, anamnesis, and baseline blood pressure measurement. Results: The graph shows a balanced gender distribution and a dominance of the 31-40 and 41-50 age groups, which are age groups at high risk of experiencing increased arterial stiffness. The hand and foot blood pressure graphs show variations in systolic and diastolic values ​​​​in the mild to moderate hypertension range, indicating that the hemodynamic condition of the respondents is stable and safe for NIVA examination. NIVA measurements were performed by attaching a cuff to the upper arm and left ankle to obtain parameters such as baPWV, ABI, MAP, PP, and Vascular Age. Blood pressure variations in the baseline graph support accurate reading of vascular parameters, especially because there was no indication of peripheral stenosis based on the comparison of hand and foot blood pressure. The data recording and validation process was performed by comparing the measurement results to the baseline, which was consistent with the initial graph. Conclusion: The examination results indicate that the respondents' initial condition met the requirements for non-invasive vascular evaluation and provided a representative picture of blood vessel health status prior to clinical intervention.
Nanophytosome delivery model based on a combination of bay leaf (syzygium polyanthum) and binahong (anredera cordifolia) extracts in gel formulation as a therapy for diabetic ulcers Saifurrohman, Arip; Jafar, Garnadi; Sutrisno, Entis
Science Midwifery Vol 14 No 1 (2026): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i1.2314

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia and associated with various complications, including diabetic foot ulcer (DFU), which may lead to infection, gangrene, amputation, and even death. Natural-based topical therapies have potential to support DFU healing; however, the limited solubility and permeability of active compounds, particularly polar phytochemicals, often reduce their therapeutic effectiveness. Nanophytosomes, a phospholipid–phytoconstituent complex system, are considered capable of enhancing the stability and penetration of herbal compounds. This study aimed to design and develop nanophytosomes containing a combination of bay leaf extract (Syzygium polyanthum) and binahong leaf extract (Anredera cordifolia), characterize the system, incorporate it into a gel formulation, and evaluate its wound-healing activity in a diabetic wound model. The study involved preparation of nanophytosomes from the combined extracts followed by characterization of particle size, polydispersity index (PDI), zeta potential, entrapment efficiency, and particle morphology. The nanophytosome system was then formulated into a gel and evaluated for physical quality parameters including pH, viscosity, spreadability, and stability. Wound-healing activity was assessed using a diabetic wound model in experimental animals by observing wound closure and histological parameters. The expected results include the formation of nanophytosomes with favorable physicochemical characteristics, a stable gel formulation, and improved diabetic wound healing compared with the control group. It is anticipated that the nanophytosome gel combining S. polyanthum and A. cordifolia extracts may serve as a promising innovative topical therapy for DFU.
Nanophytosome delivery system and in vivo test of combination of binahong leaf extract (Andredera cordifolia) and bay leaf (Syzygium polyanthum) as a diabetic wound healer Saifurrohman, Arip; Jafar, Garnadi; Sutrisno, Entris; Senjaya, Fathurahman Ari
Science Midwifery Vol 14 No 1 (2026): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i1.2326

Abstract

This study aimed to develop and characterize a nanophytosome system containing combined extracts of bay leaf (Syzygium polyanthum) and binahong leaf (Anredera cordifolia), and to evaluate its wound healing activity through in vivo study. The extracts were prepared by maceration using 96% ethanol and characterized through phytochemical screening and LC-MS/MS analysis. Nanophytosomes were formulated using phospholipid complexes with variations of surfactants, followed by homogenization and sonication. The formulations were evaluated for particle size, polydispersity index, zeta potential, and entrapment efficiency. The results showed that particle size ranged from 16.30 to 927.18 nm, with the smallest size observed in Tween 80-based formulation. The polydispersity index ranged from 0.20 to 0.86, indicating better homogeneity in Tween 80 systems. Zeta potential values ​​were in the range of −6 to −17 mV, suggesting moderate stability. Entrapment efficiency was high in all formulations (92.5–97.3%), with the highest value observed in Cremophor-based formulation. In vivo evaluation demonstrated that the nanophytosome significantly accelerated wound healing compared to control groups, as indicated by faster wound contraction and improved tissue regeneration. In conclusion, the nanophytosome system enhanced the physicochemical properties and delivery of bioactive compounds, showing potential as an effective therapeutic approach for wound healing.
219-13FR Sacha inchi oil-based nanoemulsion of bay leaf (syzygium polyanthum) and binahong leaf (anredera cordifolia) extracts and in vitro release using a dialysis membrane Hidayat, Dudy Agustian; Jafar, Garnadi; Rachmawati, Winasih; Aliza, Rieztya; Ratmoko, Sulthan Abdul Basith
Science Midwifery Vol 14 No 1 (2026): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i1.2327

Abstract

This study aimed to develop and characterize a nanoemulsion system containing combined extracts of bay leaf (Syzygium polyanthum) and binahong leaf (Anredera cordifolia) using sacha inchi oil, and to evaluate its in vitro release profile using a dialysis membrane method. The extracts were prepared by maceration using 96% ethanol and characterized through physicochemical and phytochemical analyses. Nanoemulsions were formulated using Cremophor RH40 and PEG 400, followed by homogenization and sonication. The formulations were evaluated for particle size, polydispersity index (PDI), zeta potential, and morphology. The results showed that the optimized formulation (NEC5) exhibited the smallest particle size (130.06 ± 56.66 nm), acceptable PDI (0.45 ± 0.12), and moderate zeta potential (−14.15 ± 4.88 mV), indicating good stability. Morphological analysis confirmed spherical and uniformly distributed droplets. In vitro release studies demonstrated an initial burst release followed by a more controlled release pattern, with the nanoemulsion showing more stable release compared to the extract. In conclusion, the nanoemulsion system successfully improved the physicochemical properties and controlled release behavior of the plant extracts, indicating its potential as an effective delivery system for plant-derived bioactive compounds.
Formulation and characterization of nanoparticles combination of binahong leaves and bay leaves as a thin oral herbal preparation for diabetes prevention Priana, Eka; Jafar, Garnadi; Kusriani, R. Herni; Meilani, Intan; Fitriani, Ranti
Science Midwifery Vol 14 No 1 (2026): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i1.2328

Abstract

Diabetes mellitus is a chronic metabolic disease with a steadily increasing prevalence globally. Binahong leaves (Anrederacordifolia) and bay leaves (Syzygiumpolyanthum) contains flavonoids, such as kaempferol, which have the potential as antidiabetics, but its use is limited by the low solubility, stability, and bioavailability of the active compounds. This study aims to formulate and characterize a nanoparticle herbal medicine combining the two leaves using PlantCrystal technology, and develop it into an oral thin herbal preparation. The simplicia was processed through sorting, washing, drying, grinding, and sieving, then characterized and screened for phytochemicals. The nanoparticle herbal medicine was evaluated based on particle size, polydispersity index, zeta potential, and particle morphology. The membrane lysis release test showed an increase in the release of active substances compared to the simplicia. Furthermore, the formulation was developed into an oral thin herbal and evaluated for its physical properties, including organoleptic, water content, pH, film thickness, fold resistance, weight uniformity, and disintegration time.
Formulation and characterization of nanostructured lipid carriers of curcumin and their development in topical gel preparations for drug delivery systems Jafar, Garnadi; Choerrunisa, Choerrunisa; Sukmawati, Ika Kurnia; Putriyanti, Al-fira
Science Midwifery Vol 14 No 1 (2026): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i1.2339

Abstract

Curcumin is a bioactive compound derived from Curcuma longa with anti-inflammatory and antioxidant activities; however, its topical application is limited due to poor solubility and stability. The development of nanoparticle-based delivery systems such as Nanostructured Lipid Carriers (NLC) can enhance drug stability and skin penetration. This study aimed to formulate curcumin-loaded NLC, evaluate its physicochemical characteristics, and develop a gel dosage form based on the optimized NLC formulation. The research methods included preliminary solubility testing of curcumin in various lipid and surfactant components, compatibility analysis using Differential Scanning Calorimetry (DSC), formulation of five NLC formulations using hot homogenization and probe sonication methods, and characterization including particle size, polydispersity index, zeta potential, entrapment efficiency, and morphology using Transmission Electron Microscopy (TEM). The selected NLC formulation was subsequently incorporated into a gel system and evaluated for pH, viscosity, and spreadability. The results demonstrated that the curcumin NLC exhibited nanoscale particle size with relatively uniform distribution, stable zeta potential values, and high entrapment efficiency. TEM analysis confirmed spherical particle morphology. The NLC-based gel formulation showed acceptable physicochemical properties, including skin-compatible pH, suitable viscosity, and optimal spreadability. In conclusion, curcumin was successfully formulated into an NLC system and further developed into a topical gel formulation with promising physicochemical characteristics as a lipid-based drug delivery system.
Co-Authors Abdul Mulki Irpani Agung Laksono S, Moch Agus Sulaeman Agus Sulaeman Aligita, Widhya Aliyya Kurniasih Agustiani Aliza, Rieztya Amalia Putri, Amalia Anggraeni, Vina Juliana Ani Anggriani Arif Rubianto Ariqa Hidayatun Nisa Avianningsih, Reformia Bachrudin, Panji Buana Irviana Prita Choerrunisa, Choerrunisa Dadih Supriadi Damayanti, Hilda Deden I Dinata Deden Indra Dinata Deden Indra Dinata, Deden Indra Deny Puryani Devianti Sagita, Novaliana Dila Anggraeni Dinayanti, Westi Nur Dini Auliya Azmi Dwi C, Alya Elis Susilawati Elisabeth Weya Elsa Yunita Septiani Elvano, Deki Rifa Embas Saraswati, Dewa Ayu Emma Emawati, Emma ERISKA AGUSTIN Faisha Farras Kartanagara Fatmawati Fenti Fatmawati Karim Fatmawati, Fenti Fenti Fatmawati Fenti Fatmawati Fitriani, Ranti Ghea Nadira Shinta Gustana, Erick Kurniawan Halizah, Arin Nur Hanaya, Cicia Rosa Hasimun, Patonah Helen Fitri Novianti Herni Kusriani, R. Hidayat, Dudy Agustian Iceu Mulyati Iin Siti Aminah, Iin Siti Ira Adiyati Jajang Japar Sodik Karim, Fatmawati Khiong, Tjia Khie Kusriani, R Herni Latifah, Zahra Alfa Lia Marliani Mahran A, Ghani Maisyah, Aini Marita Kaniawati Meilani, Intan Mindiarto, Ahmad Bagus Muhamad Reza Pahlevi Muthmainah, Siti Saidah Ningrum, Windi Pratama Novaliana Devianti Sagita Novianti, Tamia Rizqi Nurfadillah, Rizal Nurfaiza, Putri Nurul Rahmalia Olivia Eka Putri Pahlevi, Muhamad Reza Pasha, ED Yunisa Mega Patonah, Patonah Pebriawati, Silpi Pramudiahwardani, Ananda Rota Pratama, Reza Priana, Eka Putriyanti Al-fira Putriyanti, Al-fira R. Awaludin Nazal N Rachmat Mauludin Rachmawati, Winasih Rahmat Santoso Raisya Salsabila Ramadhoni, M Ayodia Ratmoko, Sulthan Abdul Basith Ratu Fania Aprilyanti Reza Pahlevi, Muhamad Ria Riantini Riantini, Ria Rismawanti, Rusi Roganda Situmorang Rosyana, Nasywa Rusi Rismawanti Sagita, Novaliana Devianti Saifurrohman, Arip Saleh Wikarsa, Saleh Salsabilla, Syifa Sasanti Tarini Darijanto, Sasanti Tarini Senjaya, Fathurahman Ari Septianti, Regina Dwi Shelvy E Suherman Siti Jamilah Siti Raeyuni Maulidia Belina Siti Saidah Muthmainah Situmorang, Roganda Sofian, Ryan Soni Muhsinin Sukmawati, ika kurnia Susilawati, Elis Sutiyah, Siti Sutrisno, Entis Sutrisno, Entris Syarfa, Ahmad Syerliana Syerliana Tambunan, Irisanna Wahyu Wijayanti Wijaya, Teguh Pradinata Winasih Rachmawati Yani Mulyani Yani Mulyani Yolanda Putri Aloenida Yuyun Yuyun Zakaria, Hasballah Zakiyah, Nadhira Zalfa Dary Pernadi Ziska, Rahma