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All Journal Jurnal Kesehatan Andalas Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Biologi Tropis Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun Oto Rhino Laryngologica Indonesiana Majalah Kedokteran Andalas Jurnal Sehat Mandiri Health and Medical Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Andalas obstetrics and gynecology journal Jurnal Ners Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks MAHESA : Malahayati Health Student Journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) International Journal of Health and Pharmaceutical (IJHP) Jurnal Riset Ilmiah JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Dia Rofinda, Zelly Dia
Bagian Patologi Klinik Fakultas Kedokteran Universitas Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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The Role of Transforming Growth Factor Beta (TGF-β) in Pelvic Organ Prolapse : A Systematic Review Yulia Margaretta Sari; Bobby Indra Utama; Zelly Dia Rofinda; Aisyah Elliyanti
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.58-69.2026

Abstract

Introduction: Pelvic organ prolapse (POP) is a gynaecological disorder with a rising prevalence, significantly affecting quality of life. While the pathogenesis of POP is multifactorial, alterations in the extracellular matrix (ECM) have been implicated, particularly the role of transforming growth factor-beta (TGF-β) in ECM remodelling. However, the precise relationship between TGF-β and POP remains unclear. Methods: A systematic review was conducted following PRISMA guidelines. Relevant studies were identified from PubMed, Scopus, Web of Science, and the Cochrane Library. Inclusion criteria focused on studies investigating TGF-β expression in women with POP. Data extraction included study design, patient demographics, TGF-β detection methods, and key findings. Results: Analysis of nine studies revealed mixed findings. Four studies reported a significant reduction in TGF-β1 expression in POP patients, suggesting impaired ECM regulation via the TGF-β1/Smad3 pathway. Three studies found no significant differences in TGF-β levels between POP and control groups, while one study linked increased TGF-β1 levels to severe prolapse, possibly as a compensatory response. Variations in methodology, sample size, and patient characteristics contributed to inconsistencies across studies. Conclusion: Current evidence suggests that TGF-β1 plays a role in POP pathogenesis, with lower levels potentially weakening ECM integrity and higher levels in advanced cases reflecting a failed reparative response. Further research is needed to explore TGF-β interactions with other biomarkers and assess its potential as a therapeutic target.
Factors Associated With The Empathetic of Staff at The Central Laboratory Installation of M. Djamil Hospital Padang Annisa Safitri; Zelly Dia Rofinda; Nelmi Silvia
International Journal of Health and Pharmaceutical (IJHP) Vol. 6 No. 1 (2026): February 2026
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v6i1.524

Abstract

Empathy is a crucial component for healthcare professionals to build relationships with patients and improve the quality of care. However, it is often overlooked among laboratory personnel who tend to focus more on technical aspects. Individual and organizational factors are suspected to contribute to decreased empathy among laboratory staff. This study aimed to identify the factors associated with empathy among staff at the Central Laboratory Installation of M. Djamil Hospital Padang. This study employed a Mixed Method design using a Concurrent Embedded model involving 53 laboratory staff. Data were collected through questionnaires, in-depth interviews, observations, and document reviews. Quantitative data were analyzed using chi-square tests and logistic regression, with statistical significance set at p < 0.05. The results showed that the majority of respondents were aged 30–42 years (52.8%), female (77.4%), held a diploma degree (81.1%), had ≥5 years of work experience (84.9%), and had low empathy levels (56.6%). There were significant associations between age (p=0.043), education level (p=0.042), organizational support (p=0.005), workload (p=0.003), work stress (p=0.045), and work motivation (p=0.023) with empathy levels. Meanwhile, gender, length of service, and seminar/training attendance were not significantly associated with empathy. Multivariate analysis revealed that organizational support, workload, and work stress were the key factors associated with empathy, with organizational support emerging as the most dominant factor (p=0.004). Qualitative data supported these findings, indicating that high workload, lack of organizational support, and performance pressure were major barriers to demonstrating empathy toward patients. In conclusion, laboratory staff empathy is influenced by age, education, organizational support, workload, job stress, and work motivation, with organizational support being the most dominant factor.
GAMBARAN KADAR TIROGLOBULIN PADA PASIEN KARSINOMA TIROID BERDIFERENSIASI POST TOTAL TIROIDEKTOMIDI RSUP DR. M. DJAMIL PADANG Muhammad Furqan; Yulia Kurniawati; Zelly Dia Rofinda
SINERGI : Jurnal Riset Ilmiah Vol. 3 No. 4 (2026): SINERGI : Jurnal Riset Ilmiah, April 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v3i4.2488

Abstract

Thyroid carcinoma is the most common malignancy found in the endocrine glands and accounts for 1% of all malignancies. The average incidence of thyroid carcinoma cases according to the National Cancer Institute (NCI) from 2012-2017 was 14.3 per 100,000 total population per year, with an average mortality rate of 0.5 per 100,000 population per year. In Indonesia in 2000, thyroid carcinoma ranked ninth out of the ten most common carcinomas (4.3%) and covered 90% of all endocrine carcinomas. Based on medical record data at Dr. M. Djamil Padang General Hospital, the incidence of thyroid carcinoma in 2015 was 373 people and increased in 2016 to 850 people. Based on the problems described above, and there has not been much research on Thyroglobulin levels as a prognostic factor for recurrence of thyroid carcinoma in Indonesia, especially Padang. Encourage the author to conduct research on differentiated thyroglobulin levels after total thyroidectomy at Dr. M. Djamil Padang General Hospital.
Korelasi Kadar Vitamin D dengan Indeks Aterogenik Plasma pada Mahasiswa Penyandang Obesitas M. Ikhlasul Amal Eel Taslim; Zelly Dia Rofinda; Rismawati Yaswir
Jurnal Ilmu Kesehatan Indonesia Vol. 2 No. 4 (2021): Desember 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v2i4.521

Abstract

Latar Belakang: Defisiensi vitamin D telah menjadi masalah kesehatan dunia dan berkembang pesat selama beberapa tahun terakhir ini. Defisiensi vitamin D merupakan salah satu faktor risiko penyakit kardiovaskular. Indeks aterogenik plasma yang dirumuskan sebagai log10(TG/HDL) merupakan penanda aterogenesitas untuk memperkirakan risiko penyakit kardiovaskular. Defisiensi vitamin D dan nilai indeks aterogenik plasma yang tinggi sering ditemukan pada penyandang obes. Objektif: Penelitian ini bertujuan untuk mengetahui korelasi antara kadar vitamin D dengan indeks aterogenik plasma pada mahasiswa penyandang obes. Metode: Penelitian ini merupakan penelitian analitik observasional dengan desain cross sectional yang dilakukan di Fakultas Kedokteran Universitas Andalas dan Laboratorium Sentral RSUP Dr. M. Djamil Padang dari bulan Agustus 2020 hingga April 2021. Subjek penelitian ini adalah 30 mahasiswa angkatan 2017-2018 penyandang obes di Fakultas Kedokteran Universitas Andalas, yang terdiri dari 16 orang laki-laki dan 14 orang perempuan. Hasil: Hasil penelitian didapatkan rerata umur subjek 19,57±0,86 tahun dan rerata IMT 32,53±4,13 kg/m2. Rerata kadar vitamin D subjek 13,90±4,10 ng/mL dan rerata indeks aterogenik plasma subjek -0,025±0,237. Analisis bivariat didapatkan korelasi negatif sangat lemah dan tidak bermakna antara kadar vitamin D dengan indeks aterogenik plasma (r= -0,129; p= 0,498). Kesimpulan: Tidak terdapat korelasi yang bermakna antara kadar vitamin D dengan indeks aterogenik plasma pada mahasiswa penyandang obes.
Design and Optimization of a CD4 Primer for Quantitative Real-Time PCR (qRT-PCR) Puji Oktavia; Andani Eka Putra; Gestina Aliska; Zelly Dia Rofinda; Dwitya Elvira; Dessy Arisanty
Jurnal Biologi Tropis Vol. 26 No. 3 (2026): Juli - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i3.12832

Abstract

Quantitative real-time polymerase chain reaction (qRT-PCR) is being explored as an affordable alternative to flow cytometry for monitoring CD4+ T lymphocytes in HIV-infected patients, but detailed design and validation of CD4-specific primers are rarely reported. To design a CD4-specific primer-probe set for qRT-PCR, assess its in silico specificity, and determine the optimal annealing temperature. A forward primer, reverse primer, and hydrolysis probe targeting CD4 transcript were designed from published CD4 gene sequences. Specificity was evaluated using NCBI Primer-BLAST against the Human mRNA RefSeq database. Optimal annealing temperature was determined using an 8-point thermal gradient (54.0-66.0°C) on a Bio-Rad CFX96 system with SensiFAST™ Probe No-ROX chemistry, comparing Cq values across the gradient. Results: Primer-BLAST confirmed specificity of the forward (20nt, Tm 57.42°C, GC 50.00%) and reverse (24nt, Tm 57.69°C, GC 41.67%) primers, with low self-complementarity (3.00 and 2.00) and no 3' self-complementarity. Cq values were tightly clustered (23.25-23.76) across the gradient; with the lowest Cq (23.25) at 54.8°C. The CD4-specific primer-probe set showed confirmed specificity and robust tolerance across a wide annealing temperature range, with an optimum of 54.8°C, supporting its use as a foundational tool for CD4+ T lymphocyte monitoring where flow cytometry is inaccessible.
Co-Authors Ade Asyari Adelin, Prima Afdal, Afdal Afriwardi Afriwardi Aisah Aisah Aisyah Elliyanti Aisyah Ellyanti Aldian Mulyanto Lokaria Aldian Mulyanto Lokaria Alles Firmansyah Almurdi Almurdi Alqadri Alqadri Alvarino Amanda Rizki Andani Eka Putra Andry Kurniawan Andry Kurniawan Annisa Safitri Antonius, Puja Agung Arina Widya Murni Ashal, Taufik Asterina Asterina Aswiyanti Asri Atika Indah Sari Berliana Islamiyarti Hydra Berliana Islamiyarti Hydra Bobby Indra Utama Daan Khambri Daulat Azhari Defrin Defrin Dessy Arisanti Dessy Arisanty Desta Purwati Deswita Sari Desywar Desywar Desywar Desywar Desywar Desywar Dian Jenova Dian Pertiwi Dian Pertiwi Dinda Aprillia Dinda Aprillia Dwi yulia Dwi Yulia Dwi Yulia Dwitya Elvira Edison Edison Efrida Efrida Elfira Yusri Elfira Yusri Elizabeth Bahar Elizabeth Bahar Ellyza Nasrul Ellyza Nasrul Elmatris Sy Elvinawaty Elvinawaty Endrinaldi Erkadius Erkadius Eti Yerizel Etriyel Myh Evynatra Evynatra Fadil Oenzil Fauzan Arisyi Koto Fauzar Fauzar Fauzar Fauzar Febby Genta Wahyuni Febrita Joniarti Feby Febriatama Fiona Septi Mulya Firdawati Firdawati Gestina Aliska Gestina Aliska Gusti Revilla Hanifah Maani Hanifah Maani Hasmiwati Hendriati, Hendriati Hevrina Yufani Hevrina Yufani Husna Yetti Husni Husni Husni Husni Husni Husni Husnil Kadri Husnil Wardiyah Ira Ferawati Julizar Julizar Julizar Julizar Khaulah Karimah M. Ikhlasul Amal Eel Taslim M. Ikhlasul Amal Eel Taslim Masrul Djalal Masrul Syafri Mohamad Reza Muhammad Furqan Najirman Najirman Nanda Oktavia Nanda Oktavia Nelmi Silvia Novialdi . Nur Izzah Atirah Hardinur Puji Oktavia Putri Auliya Putri, Biomechy Oktomalio Rahmat Syawqi Rahmat Syawqi Rama Dhanivita Djamin Rani Novelty Rauza Sukma Rita Ricca Fitria Rika Susanti Rikarni Rikarni Rikarni Rikarni Rina Gustia Risma Isti Rismawati Yaswir Rismawati Yaswir Rizanda Machmud Rizki Rahmadian Rosfita Rasyid Rulli Firmansyah Salsabila Dhiyaa Syifa Saptino Miro Sharon Serafim Bosawer Siti Nurhajjah Sri Widyaningsih Suswita, Rini Syofiati Syofiati Tri Novriansyah, Wahyu Tuti Asryani Ulfa Badri Utami, Refi Amalia Verbrini Rifnayeni Willy Valerian Wirsma Arif Yhosie Anto Chicamy Yulia Kurniawati Yulia Margaretta Sari Yulistini, Yulistini Yusrawati Yusrawati Yustini Alioes