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Journal : Universa Medicina

Aloe vera extract reduces 8-oxo-2-deoxyguanosine levels and improves total antioxidants in streptozotocin-induced diabetic rats Christijanti, Wulan; Marianti, Aditya; Isnaeni, Wiwi
Universa Medicina Vol 36, No 1 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.34-41

Abstract

BackgroundDiabetes mellitus is a chronic disease caused by lack of insulin production in the pancreas or by insulin resistance, the disease being characterized by elevated blood glucose levels. Hyperglycemia in diabetes could lead to oxidative stress due to the rise in 8-oxo-2-deoxyguanosine (8-oxo-dG) levels and the decrease in levels of total antioxidant status (TAS). The purpose of this study was to assess the effect Aloe vera extract on 8-oxo-dG level and total antioxidant status in diabetic rat testis. MethodsThis was an experimental laboratory study with 20 rat samples which were divided into 4 groups (1 control group and 3 treatment groups). Diabetes was induced in the rats by streptozotocin (STZ) at 65 mg/kgBW. The diabetic rats were then treated for 28 days with Aloe vera extract at 0 mg (P0), 200 mg rind (P1), 200 mg pulp (P2), respectively. The level of 8 -oxo-dG was measured by ELISA and total antioxidant status with 2,2 -azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS). Data were analyzed with ANOVA and Least Significant Difference Advanced Test at P<0.05. Results8-Oxo-dG levels were significantly different between the control group and both P0 and P2, but not between the control group and P1. Among the treatment groups the 8-oxo-dG levels were significantly different. Mean total antioxidant status was significantly different between control and treatment groups, and also between treatment groups (p<0.05). ConclusionsAloe vera extract reduced free radicals (level of 8-oxo-dG) and increased the total antioxidant status in diabetic rat testis. 
Co-Authors ,, Indriyati - Suprihatin, - ., Lisdiana Abdiyadul Fitriyah Abyadul Fitriyah Abyadul Fitriyah Aditya Marianti Agus Yuwono Ai Astuti, Ai Aidah, Nur Ain Amalia Rahmawati Aini, Siti Hairatul Alfian, Denis Amalia, Devi Amin Retnoningsih Andin Irsadi Andreas Priyono Budi Prasetyo Anggoro, Naufal Sebastian Ani Rusilawati, Ani Ani Rusilowati Ari Yuniastuti Arif Widiyatmoko, Arif Asri, Widi Aswanti, Novita Hawsari Atikah Kurniawati, Atikah Atip Nurwahyunani, Atip Badingatus Sholihah Bambang Subali Bambang Subali Barus, Robi Agape Budi Naini Mindyarto, Budi Naini Candra Abdillah Deni Ebit Nugroho Desy Fatmawati Dewanto, Herdiatmaja Nugroho Dewi, Novi Ratna Djuniadi Djuniadi Dua Bunga, Maria Herliyani Dwi Widya Arumsari Dyah Rini Indriyanti Edi Daenuri Anwar Eko Handoyo Eli Trisnowati Elis Risyanti Ellianawati, Ellianawati Ely Rudyatmi, Ely Endang Susilaningsih Enni Suwarsi Rahayu Evira Yustika F. Putut Martin Herry Budijantoro F. Putut Martin, F. Putut Fakhruddin Fakhruddin Fardiana, Rina Farid Ahmadi Faridah, Indah Fathayati, Siti Firdaus Firdaus Fitriana, Noorma Fitriyanti, Wahyuning Furi Intan Wahyuni, Furi Intan Ghaida Nisa Hari Bakti Mardikantoro Hartono Hartono Hartono Hartono Hartono Hartono Hastuti Hastuti Heriana, Dena Emarani Heru Setiawan Heru Setiawan Imam Supardi, Kasmadi Irma Paramita, Irma Isti Nur Hayanah Kartika Widyaningrum Kasmadi Imam Supardi Katrina Ramadhani Kukuh Santosa Kumaidi Kumaidi Kusumawati, Vita Langlang Handayani Lia, Roudloh Muna Lia Linda Retnowati Lisdiana Lisdiana Lisdiana M. Khumaedi Ma'rifah, Amriyah Ummi Martien Herna Susanti Masrukan Masrukan Masturi Masturi Merdhenita Restuti MIFTAKHUL JANNAH Miftakhul Jannah Mohammad Agus Prayitno Muhammad Khumaedi Muhammad Reza Muhartati, Dwi Muhartati, Dwi Mustika Sari, Mustika Mutiara Nurul Lita Azizah Nana Kariada Trimartuti Naufal Sebastian Anggoro Ngudy Jaka Surasa Ngudy Jaka Surasa, Ngudy Jaka Ning Setiati Ning Setiati Ning Setyani Ningsih, Eni Widya Noor Aini Habibah Nugrahaningsih Nugrahaningsih Nugrahaningsih WH, Nugrahaningsih Nuni Widiarti Nur Rahayu Utami Nur Rahayu Utami Nurahman, Nurul Iman Nurhikmah Nurhikmah Nurkaenah, Nurkaenah Nurul Lita Azizah, Mutiara Prabawati, Desi Ayu Prabawati, Desi Ayu Priyanto, Yudi Pujiasih, Pujiasih Putra, Ngurah Made Darma Putri Handayani Putri Handayani Rachmawati, Rivanna C Ramadhani, Katrina Ramadhani, Novanda Adelia Rapi, Muhamad Restuti, Merdhenita Retno Wulandari Ristianafi, Diana Putri Rizki Winarsih Rizky Himayanti Roudloh Muna Lia Rusdiyana Rusdiyana Rusdiyana Rusdiyana Sa'idah, Nailiya Sabdhosih, Has Saiful Ridlo Sandra Atikasari, Sandra Sari, Elok Fariha Sari, Nanda Devita Sarie, Fitria Novita Sarini Rahayu Sarwi Sarwi Setiawan, Joko Tia Setiyadi, Hafid Setiyorini , Sri Rejeki Shabrina Caesharah Aulia Shoimatun Febriyani, Shoimatun Sholihah, Badingatus Sigit Saptono Siti Alimah Siti Harnina Bintari Slamet Firdaus Sri Jumini Sri Mulyani Endang Susilowati, Sri Mulyani Endang Sri Sulistriorini Sudarmin Sudarmin Sugianto Sugianto Sugianto Sugiarto, Deasy Renaningtyas Suharto Linuwih Sukestiyarno Sukestiyarno SUMADI SUMADI Sun'an, Ulin Nuha Sun’an, Ulin Nuha Supriyadi Supriyadi Supriyadi Supriyadi suraji suraji Sutikno Sutikno Suwito Eko Pramono Syarofatin, Ririn Hamidatus Sylvia Ervina Safitri Tolang, Korsini Heru Setiawan Tsaniyyah, Dinda Wahyu Hardyanto Wahyu Sejati, Dwi Jayanti Wakano, Rafsan Widyaningrum, Kartika Wijanayu, Adiratna Wijayanti, Jihan Sela Wiyanto Wiyanto Woro Sumarni Wulan Christijanti Yudi Priyanto Zaenuri Mastur Zahra, Nur Izhma Adzkia