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All Journal UNEJ e-Proceeding JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Dinamika Pengabdian (JDP) Universa Medicina Journal of Islamic Medicine CARADDE: Jurnal Pengabdian Kepada Masyarakat PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JFIOnline Community Development Journal Indian Journal of Forensic Medicine & Toxicology Humanism : Jurnal Pengabdian Masyarakat Berkala Ilmiah Kimia Farmasi Berkala Penelitian Hayati Jurnal Masyarakat Madani Indonesia Indonesian Journal of Pharmacy and Natural Product Media Farmasi
Idha Kusumawati
Fakultas Farmasi Universitas Airlangga
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Journal : Universa Medicina

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Toxic compounds of Curcuma aeruginosa causes necrosis of mice hepatocytes Eka Pramyrtha Hestianah; Idha Kusumawati; Lucia Tri Suwanti; Sri Subekti
Universa Medicina Vol. 33 No. 2 (2014)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2014.v33.118-125

Abstract

BACKGROUNDPeople have been using Curcuma aeruginosa rhizome as a traditional herbal medicine as appetite stimulant, without realizing its side effects. Herbal plants contain tens to hundreds of compounds, some of which are toxic. The aim of this research was to determine which toxic compound of Curcuma aeruginosa rhizome has an impact on apoptosis and PARP-1 expression of hepatocytes in male mice.METHODSEighty eight male Balb C mice were divided into 10 groups treated respectively with Curcuma aeruginosa rhizome cloroform extract, methanol extract, essential oil, infusion, and press juice, at dosages of 0.004g/kgBW and 0.06g/kgBW, and 1 control group. The treatment was given orally once a day for 10 days and on the 11th day, the research animals were sacrificed, and their liver taken for histopathologic slide preparation with Apopteq Detection Kit, and immunofluorescence. Compounds in Curcuma aeruginosa rhizome were analyzed with gas chromatography/mass spectrometry. The data obtained were analyzed by one-way ANOVA, and Partial Least Squares to determine which compounds had an impact on murine hepatocytes.RESULTSThe result of one way ANOVA showed that the chloroform groups at dosages of 0.004g/kgBW and 0.06g/kgBW showed the highest apoptosis of mice’s hepatocytes (p<0.05). There were significant differences in PARP-1 expression between control and treatment groups. The highest PARP-1 expression was in the essential oil group at a dosage of 0.06g/kg BW (p<0.05).CONCLUSIONCurcuma aeruginosa rhizome given to mice orally causes necrosis of mice’s hepatocytes.
Co-Authors Abdul Rahman Abdul Rahman Achmad Toto Poernomo Amalia, Savira Rizky Meisya Ana Yuda Anang Teguh Eko Santoso Andi Hermansyah Aprelita Nurelli Dwiana Asri Darmawati Aty Widyawaruyanti Bambang Purwanto Bambang Tri Purwanto Dewanthy, Kyrana Sekar Dewi Isadiartuti Dewi Melani Hariyadi Dian Rahmawaty Diana Nurus S Diyah, Nuzul Wahyuning Dwi Setyawan Eka Pramyrtha Hestianah Ekapratista, Belinda Nabilah Esti Hendradi Estu Mahanani Dhilasari Fajar Jamaluddin Sandhori Fauzia Azzahra, Fauzia Fauzia, Alfi Nur Firmansyah Ardian Ramadhani Fitria, Anisa Lailatul Gamar, Fahmi Haitsami Ibnu Gemparing Bayu Wiyoto Hadi Poerwono Haliza, Nabila Nur Handayani, Rosita Hanif Rifqi Prasetyawan Hardiyanti, Merry Hari Basuki Notobroto Hari Setiono Harjono Suko Hermansyah, Andi Herra Studiawan Isnaeni Isnaeni Isnaeni Isnaeni Jusak Nugraha Laksmi, Farika Dyani Laksmi Lucia Tri Suwanti, Lucia Tri Mahalaksmi, Alika Sabrina Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Mega Ferdina Suwito Muhammad Agus Syamsur Rijal Munandar, Tristiana Erawati Najlaa, Fatimah Ahla Neni Purwitasari Ni Made Mertaniasih Novian, Farah Kusuma Wardhani Nur Hayati Nurrosyidah, Iif Hanifa Paramita, Diajeng Putri Pattymahu, Charlyna Veronika Puspitasari Pradnyanantha, I Putu Bagus Pramesti, Ragil Putri Prasetyawan, Hanif Rifqi Pratama, Yusuf Alif Pratiwi Soesilawati Primaharinastiti, Riesta Primaharinastiti Purwitasari, Neni Puspitasari, Hanni Prihastuti Puspitasari, Hanni Prihhastuti Rakhmawati - - Ramadhani, Firmansyah Ardian Rania, Athaya Putri Retno Sari Retno Widyowati Rice Disi Oktarina Riesta Primaharinastiti Riesta Primaharinastiti, Riesta Rifqi Prasetyawan, Hanif Rohana, Melissa Rohman Hadi Rohmania Rohmania Ruzainah Ali Salam, Anisa Rakhmania Samirah Samirah, Samirah Sandhori, Fajar Jamaluddin Sari Retno Sholika Sari, Trisiyana Siammita, Dhea Anansya Sri Subekti Subhan Rullyansyah Suciati Suciati Suciati Suciati Sudjarwo Sudjarwo Sugiyartono, . Sugiyartono, . Sukardiman Suprapto Maat Suprapto Maat Syailendra Mahatmaputra Tristiana Erawati Tutiek Purwanti Tutik Sri Wahyuni Wahjo Djatmiko Wahjo Dyatmiko Wahjo Dyatmiko Wardhana, Brahma Wisnu Kusuma Warsito, Mega Ferdina Wiwied Ekasari Yoes Prijatna Dachlan Yusuf, Helmy Yusuf, Helmy Yuwono Mochamad Zamrotul Izzah