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All Journal Farmaka Microbiology Indonesia Jurnal Kesehatan Masyarakat Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia The Indonesian Biomedical Journal Indonesian Journal of Chemistry JMM (Jurnal Masyarakat Mandiri) Pharmacology and Clinical Pharmacy Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kreativitas PKM FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Pengabdian Farmasi Malahayati (JPFM) Majalah Farmasetika Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Community Development Journal: Jurnal Pengabdian Masyarakat Indonesian Journal of Biological Pharmacy Proceeding of Mulawarman Pharmaceuticals Conferences Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kesehatan Sciences of Pharmacy Jurnal Ilmiah Global Farmasi Parapemikir Jurnal Ilmiah Farmasi Journal of The Indonesian Society of Integrated Chemistry Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Tropical Pharmacy and Chemistry
TIANA MILANDA
Fakultas Farmasi Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Other

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Uji Aktivitas Antibakteri dari Isolat Daun Tendani (Goniothalamus Macrophyllus Hook. f. & Thomson.) Viriyanata Wijaya; Supriyatna Supriyatna; Tiana Milanda
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 4 (2016): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v3i4.121

Abstract

Tumbuhan tendani (Goniothalamus macrophyllus) secara empiris digunakan sebagai obat luar untuk infeksi kulit pada suku Dayak Punan. Penelitian ini bertujuan untuk mengetahui aktivitas senyawa aktif antibakteri yang terkandung dalam isolat dari fraksi etil asetat Daun G. macrophyllus. Fraksi etil asetat adalah fraksi teraktif yang diperoleh dari hasil pengujian aktivitas antibakteri. Isolat diperoleh dari proses pemisahan dan pemurnian menggunakan kromatografi kolom dan kromatografi lapis tipis preparatif. Isolat diuji dengan menggunakan metode difusi agar. Hasil uji aktivitas antibakteri isolat dengan konsentrasi 1,2 mg/50 μL (2,4 %) terhadap S. aureus ATCC 25923 menghasilkan diameter zona hambat sebesar 7,85 mm. Kata kunci : Goniothalamus macrophyllus, aktivitas antibakteri, Staphylococcus aureus, isolat, senyawa aktif
Kefir: Minuman Fermentasi dengan Manfaat Antibakteri Kurniawan, Kurniawan; Milanda, Tiana; Fitri Kusuma, Sri Agung
Jurnal Ilmiah Global Farmasi (JIGF) Vol. 3 No. 1 (2025): JIGF - Januari
Publisher : PC IAI Sragen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/jigf.v3i1.97

Abstract

Kefir susu adalah minuman fermentasi yang diperoleh melalui inokulasi susu dengan butiran kefir yang mengandung simbiosis bakteri asam laktat, asam asetat, dan ragi. Proses fermentasi ini menghasilkan beragam senyawa bioaktif seperti asam organik, etanol, karbon dioksida, dan peptida antimikroba yang memiliki aktivitas antibakteri signifikan. Berbagai penelitian menunjukkan bahwa kefir susu mampu menghambat pertumbuhan bakteri patogen seperti Escherichia coli, Salmonella typhimurium, dan Staphylococcus aureus. Aktivitas antibakteri kefir susu disebabkan oleh kombinasi efek dari pH yang rendah, produksi senyawa antimikroba, dan keberadaan mikroorganisme probiotik. Selain itu, konsumsi kefir susu secara rutin diketahui dapat memperkuat sistem imun, menjaga keseimbangan mikrobiota usus, serta meningkatkan ketahanan tubuh terhadap infeksi. Dengan sifat fungsional dan terapeutiknya, kefir susu memiliki potensi besar untuk dikembangkan sebagai minuman kesehatan alami dengan manfaat antibakteri yang menjanjikan.
UTILIZING CHEESE WHEY AS A KEFIR DRINK: REVIEW Kurniawan, Kurniawan; Milanda, Tiana
Jurnal Ilmiah Global Farmasi (JIGF) Vol. 3 No. 1 (2025): JIGF - Januari
Publisher : PC IAI Sragen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/jigf.v3i1.98

Abstract

Whey is a by-product of the cheese industry that is rich in lactose, protein, and minerals, but is often considered as waste. The use of whey as a basic ingredient for kefir drinks is an innovative solution that not only reduces environmental impacts but also produces functional food products with high added value. This article reviews the potential of cheese whey as a substrate in kefir fermentation, including the chemical characteristics of whey, the kefir whey production process, the health benefits of the resulting bioactive compounds, and the challenges and prospects for its development. Studies have shown that whey fermentation with kefir culture can produce probiotic drinks with beneficial effects on gastrointestinal health, the immune system, and lipid and glucose metabolism. By optimizing fermentation technology and adding complementary nutrients, whey kefir can be an alternative functional drink that is economical, nutritious, and environmentally friendly
REVIEW : AKTIVITAS ANTIHIPERGLIKEMIK DAN HIPOLIPIDEMIK EKSTRAK PEPAYA ( Carica papaya Linn ) TERHADAP TIKUS DIABETES YANG DI INDUKSI OLEH ALOKSAN DAN GLIBENKLAMID Sukmawati, Sukmawati; Susilawati, Yaswinar; Milanda, Tiana
Parapemikir : Jurnal Ilmiah Farmasi Vol 7, No 2 (2018): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v7i2.986

Abstract

Diabetes adalah gangguan metabolisme pada tubuh disebabkan abnormalitas sekresi insulin, kerja insulin atau keduanya, yang ditandai dengan gangguan  metabolisme karbohidrat, lemak, dan protein. Satu satu tumbuhan obat yang memiliki aktivitas antihiperglikemik dan hipolipidemikadalah pepaya(CaricapapayaLinn).Dari hasil review beberapa artikel diketahui bahwa ekstrak air  biji pepaya. ekstrak air daun  pepaya dan ekstrak metanol kulit batang pepaya menunjukkan adanya aktivitas antihiperglikemik. Waktu  penelitian bervariasi selama 21 dan 30 hari, menggunakan tikus yang diinduksi oleh aloksan dan glibenklamid. Dosis efektif pada pengujian ekstrak air biji pepaya dan ekstrak daun pepaya adalah   400 mg/kg bb, sedangkan dosis efektif pada ekstrak metanol kulit batang pepaya adalah 500 mg/kg bb
Characterization of Lactococcus garvieae Isolated from Wadi Papuyu (Anabas testudineus Bloch) Fermentation of Indonesian Origin as a Probiotic Candidate Soemarie, Yulistia Budianti; Pratama, Rizki Rahmadi; Milanda, Tiana; Barliana, Melisa Intan
Sciences of Pharmacy Volume 4 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0402317

Abstract

Lactococcus garvieae was isolated from the traditional fermented food Wadi Papuyu (Anabas testudineus Bloch) and characterized for its potential as a probiotic candidate. Growth assays demonstrated that L. garvieae could proliferate in MRS medium, reaching cell counts exceeding 107 CFU/mL after 72 h of anaerobic incubation. The isolate exhibited optimal growth at both 30 °C and 37 °C, as indicated by significant increases in absorbance at these temperatures. However, in the bile salt tolerance test using 0.5% (w/v) bile salts, L. garvieae showed a marked decline in growth, with absorbance values decreasing substantially after 24 and 48 h, indicating insufficient bile tolerance. The autoaggregation assay revealed values below 10%, suggesting limited autoaggregation capability and reduced potential for colonization in the gastrointestinal tract. In contrast, the co-aggregation assay showed that L. garvieae was able to coaggregate with pathogenic bacteria such as Escherichia coli, Salmonella spp., and Shigella spp., with co-aggregation percentages exceeding 40% after 5 h. Antimicrobial activity tests demonstrated that L. garvieae produced strong inhibition zones (diameters >10–20 mm and >20 mm) against Gram-positive and Gram-negative pathogenic bacteria. These findings indicate that while L. garvieae exhibits promising antimicrobial activity and co-aggregation ability, its limited bile salt tolerance and autoaggregation capacity are significant constraints in its development as a probiotic candidate.
Phytochemical Screening And Antioxidant Activity Test of Lupun Root (Poikilospermum suaveolens (Blume) Merr) from South of Borneo Mardiana, Lia; Milanda, Tiana; Hadisaputri, Yuni Elsa; Chaerunisaa, Anis Yohana
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.51350

Abstract

Lupun root is the local name for Poikilospermum suaveolens (Blume) Merr. in the Aranio region, South of Borneo, Indonesia. P.suaveolens is a medicinal plant traditionally used to treat various ailments and to enhance the body’s immune function. This study aimed to investigate the secondary metabolites and antioxidant capacity of the ethanol extract derived from the root of Lupun (P. suaveolens). Samples were collected from Aranio, South Borneo. Extraction was performed by maceration using 96% ethanol. The analysis included phytochemical screening and evaluation of antioxidant activity using the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay measured by a UV-Vis spectrophotometer. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, and phenolic compounds in the Lupun root extract. The antioxidant assay showed an IC50 value of 20.44 µg/mL, indicating strong antioxidant potential of the ethanol extract. These results highlight the plant’s promise as a candidate for pharmaceutical development.
Aktivitas Farmakologi Senyawa Aktif yang Diisolasi dari Tumbuhan Obat Alifia Hasna Hamidah; Tiana Milanda
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 1 (2025): January: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i1.1070

Abstract

Traditional medicine is currently developing rapidly, especially those based on plants. Active plant compounds are the main basis for the development of new drugs, which after further research, can be commercialized and used in pharmaceutical treatment. This review was conducted to identify the pharmacological effects of active drug compounds isolated from medicinal plants by conducting a literature study. The results of the literature review contained 37 articles that met the inclusion criteria. Until now, there are several active drug compounds from plants that are sold commercially in the form of modern drugs. Some of the pharmacological effects found are cardiac glycosides, anticholinergics, antiplatelets, analgesics, anticancer, sympathomimetics and antimalarials. This search shows that natural materials are still used as a potential source of active drug compounds, thus encouraging research to find new active compounds from medicinal plants to overcome diseases in the future.
Phytochemical Analysis and Anti-Thrombocytopenic Activity of Dayak Onion (Eleutherine palmifolia (L.) Merr) Extract and Fractions with HR-LCMS Profiling of Active Compounds Apriliana, Anita; Milanda, Tiana; Susilawati, Yasmiwar; Wilar, Gofarana
Indonesian Journal of Chemistry Vol 26, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.104534

Abstract

Thrombocytopenia, characterized by a low platelet count, poses significant clinical challenges and can arise from various etiologies. This study investigates the anti-thrombocytopenic effects of Dayak onion (Eleutherine palmifolia (L.) Merr) extracts and their fractions in Wistar rats. Ethanolic extracts and fractions were evaluated for their efficacy in enhancing platelet production. Male Wistar rats were administered doses of 100, 200, and 300 mg/kg, and platelet counts were measured at 24, 48, and 72 h post-treatment. Results indicated that all doses of the ethanolic extract significantly increased platelet counts over time, with the ethyl acetate fraction demonstrating the highest efficacy at a dose of 24.087 mg/kg, achieving significant increases as early as 24 h post-administration. Phytochemical analysis revealed substantial levels of phenolics (318.80 mg GAE/g) and flavonoids (45.63 mg QE/g) in the ethyl acetate fraction, with quercetin identified as a prominent compound via HR-LCMS. These findings suggest that Dayak onion possesses promising anti-thrombocytopenic properties, warranting further exploration as a therapeutic agent for accelerating platelet recovery in conditions such as dengue fever.
Co-Authors Ade Zuhrotun Adha, Syah Akbarul Adila Srebreneca AFINA DWI RACHMAWATI Ahmad Muhtadi Alam Jenuin Dwipratama Alifia Hasna Hamidah Amaliah Ihsani Anis Yohana Chaerunisaa Anis Yohana Chaerunisaa, Anis Yohana Anita Apriliana Arif S.W Kusuma Arif S.W Kusuma ARIF SATRIA WIRA KUSUMA, ARIF SATRIA WIRA ASTININGSIH DIAH PRAVITASARI Belinda, Andhara M. Bonar C. Saragih Dewi, Lisa K. Didi Susanto Dolih Gozali Dwi Indra Purnomo Ellin Febrina Erlianti, Karina Fachry Abda El Rahman FATHIA PEBRIANI Firda Aryanti Widyana Gofarana Wilar Hanny Hafiar Haryanto Dhanutirto Hasriana Hasriana Hasriana Hasriana, Hasriana Hasrianna Hasrianna Hasrianna, Hasrianna Ida P. Santoso Indah Suasani Wahyuni Intan Timur Maisyarah Irma Erika Herawati Irma Erika Herawati Irma Melyani Puspitasari Irma Meylani Puspitasari Ivan S. Pradipta Jutti Levita Karina Erlianti Karina Erlianti Karina Erlianti Keri Lestari Kurniawan Kurniawan Kusuma, Sri A. F. Lia Mardiana Lisa K. Dewi Maisyarah, Intan Timur Mardiana, Lia Marlia Singgih Wibowo Mayang Kusuma Dewi MAYANG KUSUMA DEWI, MAYANG KUSUMA Melisa I. Barliana Melisa Intan Barliana Moelyono Muktiwardojo Mohamad Taufik Ismullah Muchtaridi Muchtaridi Muhaimin Muhaimin Muhaimin Muhaimin Muhammad F. Wardhana Muhammad Fauzi Munir Alinu Mulki Mutakin Mutakin Mutakin Mutakin Nasrul Wathoni Nimas T. I. Tarina NURUL ANNISA Nurul Annisa Pradipta, Ivan S. QONITA ZAHRA FADHILA Raden Maya Febriyanti ragavendra ravee Rani Cyinthia Hani Renny Amelia Rhisanandra, Fathia Richie Agusta Iwan Chandra Riezki Amalia Rizki Rahmadi Pratama Rizky Abdulah Ronny Lesmana Rosidah Rosidah Saragih, Bonar C. Septiyani Mustikawati Sjafril, Astri K. Soemarie, Yulistia Budianti Sofa D. Alfian Sofa D. Alfian, Sofa D. Sri A. F. Kusuma Sri A. F. Kusuma Sri A. Sumiwi Sri Adi Sumiwi Sri Agung Fitri Kusuma, Sri Agung Sriwidodo Sriwidodo Steffi Liem Suharyani, Ine Sukmawati Sukmawati Sukmawati Sukmawati Sulistiyaningsih Sulistiyaningsih Sumiwi, Sri A. Supriyatna Supriyatna Supriyatna Supriyatna Susilawati, Yaswinar Syah Akbarul Adha SYIFA HANIFAH TERESYA PUTERI Tina Rostinawati TUTUS GUSDINAR Uce Lestari Uce Lestari Ulya Nabila Vesara A. Gatera Vesara A. Gathera Wa Ode Ida Fitriah Wardhana, Muhammad F. Wijaya, Viriyanata Yasmiwar Susilawati Yaswinar Susilawati Yuli Andriani Yulistia Budianti Soemarie Yulistia Budianti Soemarie Yulistia Budianti Soemarie Yuni Elsa Hadisaputri Yuyun Wahyuni