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The Effect of Sacha Inchi Leaf Extract (Plukenetia volubilis) with Different Doses on Reducing Uric Acid Levels in Mice (Mus musculus) Mulyani, Leni Sri; Mulyaningsih, Sri; Alya, Rahma; Taufik, De Budi Irwan
Journal Of Biology Education Research (JBER) Vol. 6 No. 2 (2025): JBER (Journal Of Biology Education Research), Vol.6 No.2 (2025)
Publisher : Program Studi Pendidikan Biologi FKIP Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55215/jber.v6i2.47

Abstract

Sacha inchi (Plukenetia volubilis) is an ancestral plant native to the Amazon rainforest that has been adopted as a food source due to its high nutritional value, which has gradually been recognized for its potential health benefits for humans. One of its benefits is as a natural agent for lowering uric acid levels, due to its antioxidant content and active compounds such as flavonoids, which function as anti-inflammatory and cell protective agents. Although P. volubilis seeds have been extensively studied, the potential of its leaves as an alternative treatment for hyperuricemia remains largely unexplored. This study aims to determine the effect of sacha inchi (P. volubilis) leaf extract at different doses 0.35 mL/mouse, 0.40 mL/mouse, and 0.45 mL/mouse on reducing uric acid levels in mice (Mus musculus) and to identify the most effective dose for reducing uric acid levels in mice. This study used 24 male mice aged 3–4 months with a body weight not exceeding 25 g. The study design used a Randomized Block Design (RBD) with four treatments and six replicates. The treatments consisted of control (without extract), doses of 0.35 mL, 0.40 mL, and 0.45 mL of P. volubilis leaf extract. The P. volubilis leaf extract was administered orally via a mouth tube. The extract was obtained from the leaves of the P. volubilis using the maceration method. The mice were first induced with hyperuricemia using 1 mL of chicken liver juice per mouse. Uric acid levels were measured before and after treatment using a GCU test strip. Data were analyzed using a one way ANOVA test followed by a Duncan test at a significance level of 5%. The results showed significant differences between treatments (p = 0.001 < 0.05). The 0.45 mL dose was the most effective in lowering uric acid levels, from an average of 4.7 mg/dL to 3.4 mg/dL, and was significantly different from other doses based on Duncan's test. This study concluded that sacha inchi leaf extract has the potential to be used as a natural alternative for lowering blood uric acid levels.  
Who Gets Included in Community Supported Agriculture? Governance Design, Transaction Costs, and Socio-Demographic Patterns among Small Organic Farmers in Indonesia Rahmatika, Maula Fadhilata; Mulyaningsih, Sri; Ulayya, Amira Hasnanuha
International Journal of Emerging Research and Review Vol. 4 No. 1 (2026): March
Publisher : IKIP Widya Darma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56707/ijoerar.v4i1.161

Abstract

Objective: This study aims to examine how Community Supported Agriculture (CSA) governance design shapes the socio-demographic inclusion of small organic farmers. While CSA has gained attention as an alternative agri-food system, existing research remains predominantly consumer-oriented and provides limited explanation of how different categories of farmers are included or excluded. This study addresses this gap by reframing farmer participation as an institutional outcome rather than an individual choice. Method: The study adopts a qualitative comparative case study approach, focusing on two contrasting CSA models in Mojokerto, Indonesia. Data were collected through in-depth interviews with 38 farmers, CSA managers, and coordinators, complemented by document analysis and field observations. Guided by Transaction Cost Economics (TCE), qualitative data were analyzed using Atlas.ti through a deductive–inductive thematic analysis followed by cross-case comparison. Results: The findings show that CSA governance design plays a decisive role in shaping farmer inclusion. Decentralized, community-based governance relies on peer coordination and informal monitoring, effectively favoring experienced, land-owning farmers with strong social embeddedness. In contrast, centralized, organization-led governance internalizes coordination, monitoring, and certification costs, lowering entry barriers for younger, landless, or less experienced farmers, albeit with reduced autonomy. Socio-demographic characteristics thus emerge as reflections of governance compatibility rather than direct determinants of participation.  Novelty: This study contributes to CSA scholarship by conceptualizing farmer inclusion as an institutional outcome shaped by transaction cost allocation. By extending Transaction Cost Economics to alternative agri-food networks, it provides a governance-based explanation of inclusion and exclusion dynamics in CSA, particularly in developing-country contexts.
Co-Authors -, Nova Anggreni . Djumali A. Hiola, Fidyawati Aprianti Aceng Ahmad Rodian Susila Ahmad, Ardha Nurul Ahmad, Zul Fikar Alamri, Luthfia Ali, Rizky Nikmathul Husna Ali, Rizky Nikmathulhusna Alya, Rahma Anastasya, Yolanda Andhika Djalu Sembada Anggreni, Nova Annajmi, Annajmi Arcat, Arcat Arief, Syachrul Arif Budi Setianto Arif Wardana, Muhammad Baba, Abdul Faisal Budi Hariyono Budi Priyono Busro, Djumali dabutar, afif handika De Budi Irwan Taofik Devi, L R Devi, L R Diah Ika Putri Dina Tania DJUMALI DJUMALI, DJUMALI Dwi Indah Purnamawati, Dwi Indah Edhy Sutanta (Jurusan Teknik Informatika IST AKPRIND Yogyakarta) Emilliana Natalia Trisakti Susanti, Maria Endang Darmawan Ery Fatarina Purwaningtyas Euis Erlin Fathoni, Shalsabila Destyari Fatmah Zakaria, Fatmah Fifi Ishak Firsty, Girly Risma Gustiani, Nur Hadi, Mareta Hasan, Nuradnin Hasanuddin, Mentari Heikal, Jerry Herbawati, Herbawati Heri Prabowo Heriyadi, Nur Widi Astanto Agus Tri Hidayah, Radhitya Adzan Hidayati, Fika Hiola, Fidyawati Aprianti A. Husadani, Y T Husadani, Y T Husna Ali, Rizky Nikmathul Husni Mubarak Ichwan Ridwan Rais IGAA. INDRAYANI, IGAA. Iis Wahyuningsih Imam Riadi Indrawati Wilujeng Irawan, S N Irawan, S N Isa, Mohamad Rodi Ishak, Fifi Jussac Maulana Masjhoer Karwanto, Karwanto Katili, Dwi Nur Octaviani Katili, Tressan Eka putri Laila, Wahyu Kumil Leni Sri Mulyani Leny Rauf, Efri Lestari, Taufika Putri Levana Sondakh Lusi Eka Afri Maghfirah, Rahmayani Mahendra, Rendy Surya Manjurungi, Gia Arista Putri Meylina, Meylina Millah, Azzahro Imada Mindhayani, Iva Moch. Saiful Bachri Mufarrihul Hazin MUHAMMAD SHOLEH Muhammad Suyanto, Muhammad Nikmathul Husna Ali, Rizky Nining Sugihartini Nur Amalia, Sofiyanti Nur Handayani Nur Mahdi Nur Rahmawati Nurdin, St Surya Indah Nurdin, St.Surya Indah Nurrahmawati Nusi, Dewanti R Pertiwi, Citra Prakoso, Aditha Agung Pratama, Abdillah Richi Priyanto, Sabda Elisa Rahayu, Hanifah Aulia Rahmandhala, Ilvan Dino RAHMATIKA, MAULA FADHILATA Ranila, Suciati Rauf, Efri Leny Ria Indah Pratami Rohman, Nadya Revania Samuel Kristiyana Sanjoto, Siwi Sapto Yuliani Septina, Norma Dewi Sidiq, Purnomo Siti Fatmawati Fatimah, Siti Fatmawati Suhartono Supratno, Haris Supriyadi, Asep Adang Taufik, De Budi Irwan Teger Basuki Ulayya, Amira Hasnanuha Umar, Siskawati Umboro, P A Vienastra, Septian Widayati, Wiludjeng Wiloso, Danis Agoes Wirono, Maryani Eka Wiwik Handayani Yosef Prihanto, Yosef Yuliandary Yunus Yunengsih, Yuyun