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All Journal Journal of Food and Pharmaceutical Science Jurnal Penelitian Saintek Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis Statistika Indonesian Journal of Cancer Chemoprevention Program Kreativitas Mahasiswa - Penelitian Indonesian Journal of Biotechnology Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) Jurnal Akuntansi dan Perpajakan INDONESIAN JOURNAL OF PHARMACY Pharmascience JURNAL BIOLOGI INDONESIA Jurnal Farmasi Sains dan Komunitas Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Majalah Farmaseutik Indonesian Journal of Chemistry Media Ilmu Kesehatan JPSCR : Journal of Pharmaceutical Science and Clinical Research JFIOnline INTEGRITAS : Jurnal Pengabdian Jurnal Farmasi Journal of Community Development Populer: Jurnal Penelitian Mahasiswa Jurnal Kedokteran Hewan Journal of Food and Pharmaceutical Sciences Agri Analytics Journal Jurnal Medika: Medika Indonesian Journal of Pharmacology and Therapy Jurnal Pengabdian Masyarakat Manage
Retno Murwanti
Departemen Farmakologi Dan Farmasi Klinik, Fakultas Farmasi, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : JURNAL BIOLOGI INDONESIA

 1 
Efek Penghambatan Terhadap Pertumbuhan Tumor Paru dan Uji Ketoksikan Akut Ekstrak Kapsul Chang Sheuw Tian Ran Ling Yao Pada Mencit (Mus musculus) dan Tikus (Ratus tanezumi) Fudholi, Ahmad; Meiyanto, Edy; Donatus, Imono Argo; Nurrochmad, Arief; Hakim, Arief Rahman; Murwanti, Retno
JURNAL BIOLOGI INDONESIA Vol 5, No 1 (2008): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.692 KB) | DOI: 10.14203/jbi.v5i1.3202

Abstract

Inhibitory Phases Effect of The Lung Cancer And Acute Toxicity of Chang Sheuw Tian RanLing Yao Capsule Extracts in House mice (Mus musculus) and Rat (Ratus tanezumi). Effortsto find anticancer agents have been developed nowadays, some of them are focused in traditionalherbs. One of the available products in the market that claims effective to cure cancer isthe Chang Sheuw Tian Ran Ling Yao, PT. Daun Teratai extract containing CAPSULE (CSTRLYextract). The aim of this study is to examine of confession of some people which are usingthe useful of medicine CSTRLY extract capsule through inhibitor laboratory effect of theCSTRLY extract in the initiation and post initiation phases of the lung cancer in mice and ratsthat had been induced by eather Benzo[?]pyrene (BP) or Dimetilbenz[?]antrazene (DMBA)and to clarify the potency of acute toxicity and specific toxic manifestations of thephytopharmaca.The results showed that the CSTRLY extract can reduce the cancer incidence caused bycarcinogen, BP and DMBA. Moreover, the extract can also inhibit the cancer growth in themice and rats, especially in the early post-initiation phase. Further, the histopathologicalevaluation showed that up to the highest dose level that technically could be administrated tothe animals (12500 mg/kg bw), no animal death was occurred. Furthermore, the ADG values formale and female rats indicated no significant different (P > 0.05) that relative to the controlgroup. No animals were shows physical symptom as a toxic manifestation. It’s indicated thatthe phytopharmaca no influenced to somatomotor and nervous system. Within the dose rangeadministrations, no detectable morphological toxic effects or histophatological changes of theliver, spleen, heart, and lungs were observed. the acute toxicity value of Chang Sheuw TianRan Ling Yao Capsule was very low (or minimal almost non-toxic with LD50 > 12500 mg/kg bw)and the spectrum of toxic effects of the phytopharmaca were considered negligible.Key words: Ekstract, CSTRLY, mice and rat, BP, DMBA, carsinogenesis, lung cancer
EFEK PENGHAMBATAN TERHADAP PERTUMBUHAN TUMOR PARU DAN UJI KETOKSIKAN AKUT EKSTRAK KAPSUL CHANG SHEUW TIAN RAN LING YAO PADA MENCIT (MUS MUSCULUS) DAN TIKUS (RATUS TANEZUMI) Fudholi, Ahmad; Meiyanto, Edy; Donatus, Imono Argo; Nurrochmad, Arief; Hakim, Arief Rahman; Murwanti, Retno
JURNAL BIOLOGI INDONESIA Vol 5, No 1 (2008): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jbi.v5i1.3202

Abstract

Inhibitory Phases Effect of The Lung Cancer And Acute Toxicity of Chang Sheuw Tian RanLing Yao Capsule Extracts in House mice (Mus musculus) and Rat (Ratus tanezumi). Effortsto find anticancer agents have been developed nowadays, some of them are focused in traditionalherbs. One of the available products in the market that claims effective to cure cancer isthe Chang Sheuw Tian Ran Ling Yao, PT. Daun Teratai extract containing CAPSULE (CSTRLYextract). The aim of this study is to examine of confession of some people which are usingthe useful of medicine CSTRLY extract capsule through inhibitor laboratory effect of theCSTRLY extract in the initiation and post initiation phases of the lung cancer in mice and ratsthat had been induced by eather Benzo[?]pyrene (BP) or Dimetilbenz[?]antrazene (DMBA)and to clarify the potency of acute toxicity and specific toxic manifestations of thephytopharmaca.The results showed that the CSTRLY extract can reduce the cancer incidence caused bycarcinogen, BP and DMBA. Moreover, the extract can also inhibit the cancer growth in themice and rats, especially in the early post-initiation phase. Further, the histopathologicalevaluation showed that up to the highest dose level that technically could be administrated tothe animals (12500 mg/kg bw), no animal death was occurred. Furthermore, the ADG values formale and female rats indicated no significant different (P > 0.05) that relative to the controlgroup. No animals were shows physical symptom as a toxic manifestation. It?s indicated thatthe phytopharmaca no influenced to somatomotor and nervous system. Within the dose rangeadministrations, no detectable morphological toxic effects or histophatological changes of theliver, spleen, heart, and lungs were observed. the acute toxicity value of Chang Sheuw TianRan Ling Yao Capsule was very low (or minimal almost non-toxic with LD50 > 12500 mg/kg bw)and the spectrum of toxic effects of the phytopharmaca were considered negligible.Key words: Ekstract, CSTRLY, mice and rat, BP, DMBA, carsinogenesis, lung cancer
Co-Authors Abdul Rohman Adam Hermawan Agung Endro Nugroho Agung Endro Nugroho Ahmad Marzuki Alexxander, . Alexxander, . Amalia, Latifa Amilia Amilia, Amilia Anami Riastri Andayana Puspitasari Gani Andayana Puspitasari Gani Andayana Puspitasari Gani Annisa, Siti Nur Anselma Ivanawati Arief Nurrochmad Arief Nurrochmad Arief Nurrochmad Arief Nurrochmad Arief Rahman Hakim Arifka, Vigha Ilmanafi Aris Haryanto Ariska Deffy Anggarany, Ariska Deffy Ashfannada, Nuqya Asri Mega Putri Azizah Amin Azizah, Ulfah Laily Azmi Rahmadani Bambang Sulistiyo Ari Sudarmanto Bani Adlina Shabrina Bayu Irawan, Muhamad Bayu Prio Septiantoro Beni Lestari Budastra, Wayan Cintya Ganes Cahyo Nurani, Sekar Cindy Puspita Sari Devina Martina Devita Anggraeni Devita Anggraeni Devyanto Hadi Triutomo Dewi Kartikawati Paramita Dhania Novitasari Dhirgo Adji Dhirgo Adji Diana Rachma Ningsih Dwi Brilyani Sandy Dwi Salim, Rozin Dyah Afritasari Dyah Aryani Perwitasari Dyah Widiastuti Dyaningtyas Dewi Pamungkas Putri Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Effendi, Adha Maula Erna Prawita Setyowati Erna Prawita Setyowati Fikriansyah Fikriansyah Fita Rahmawati Fitri, Dafina Aisya Fitriana Hayyu Arifah Gagas Pradani Nur Ilmawati Gani, Andayana Puspitasari Ginna Zabrina Hayati, Farida Hendri Wasito Herwandhani Putri Hidayah, Alifia Brilliani Hilyatul Fadliyah I Gusti Ngurah Agung Dewantara Putra Ida Ayu Putu Sri Widnyani Idlohatud Dilalah Ika Puspita Sari Illian, Didi Nurhadi Imono Argo Donatus, Imono Argo Ina Kusrini Iren Wati Siahaan Jenie, Riris Istighfari Juang Juansa Khafi, Muhammad Khasanah, Aisyah Nur Khoerul Anwar Kustanto, Satya Prima Layung Sekar Sih Wikanthi Ledi, Ledi Klarismawati Lodyta Nawang Tika lubis, muhammad fauzan Lukman Hakim Luthfiyyah, Annisa Tiara Maharani, Astrid Martien , Ronny Mentari Widiastuti Miftahus Sa'adah Muharom, Luthfi Ali Mustofa Mustofa Naisbitt Iman Hanif, Naisbitt Iman Nanang Fakhrudin, Nanang Nanda Saifullah Sulaiman, Teuku Nastiti Wijayanti Ngurah Agung Dewantara Putra, I Gusti Nindi Wulandari Nindya Budiana Putri Nindya Budiana Putri Ningsih, Diana Rachma Norita Citra Yuliarti, Norita Citra Novrizal Abdi Sahid , Muhammad Nunung Yuniarti Nursani, Rabila Nurul Mukhlisa Pratiwi, Rima Dwi Prawitasari, Saptya Prisnu Tirtanirmala Probowulan, Diyah Purnomo, Kurnia Rahayu Purwantiningsih Purwantiningsih Rahmawaty Rachmady Rahmayani, Almira Retno S. Sudibyo Retno Sunarminingsih Sudibyo Riandari , Teti Mariam Rima Munawaroh Risa Umari Yuli Aliviyanti Ritmaleni, Ritmaleni Rizkita, Anggraini Ihza Rohmad Yudi Utomo Rohman, Abdul Roissinta, Agnesca Rommy Sagala, Reynelda Juliani Sardjiman . Sari Haryanti Sari Haryanti Sari, Laras Ratna Shofa Annur Siswadi Siswadi Sri Susilowati Sri Tasminatun Sri Wahdaningsih Subagus Wahyuono Sudarsono Sudarsono Sugeng Riyanto Sugiyanto . Sugiyanto . Sulaiman, T.N Saifullah Sumaiyah, Sumaiyah Susi Ari Kristina Suwijiyo Pramono Suwijiyo Pramono Tamhid, Hady Anshory Tampubolon, Keshia Thoriq Ziyad, Thoriq Tiffany, Ghea Rachella Triana Candraningrum Triana Hertiani Triawan Adi Cahyanto Ulfa Afrinurfadhilah Darojati Wahyu Utaminingrum Widya Leontin Susanti Wulandari, Febri Yance Anas Yoce Aprianto Yosi Bayu Murti Yundari, Yundari Zahrotul Ulum Ziana Walidah, Ziana