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Ramadan Fasting and Anthropometric Parameters: The Role of MC4R rs17782313 Genotype in Adults Semarang, Indonesia Kurniawan, Kezia Yunandra; Yocku, Monica Hermina Sharon Otline; Savitri, Rachmania Anggita; Haq, Arynal; Maharani, Nani; Fulyani, Faizah; Noer, Etika Ratna; Pramono, Adriyan
Journal of Biomedicine and Translational Research Vol 12, No 1 (2026): April 2026
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v12i1.29501

Abstract

Background: The melanocortin-4 receptor (MC4R) gene regulates energy balance and food intake. The rs17782313 variant has been linked to altered homeostasis and eating behavior, and may also affect anthropometric and body composition responses during Ramadan fasting.Objective: To examine the effects of Ramadan fasting on anthropometric parameters, body composition, and macronutrient intake across different MC4R genotypes in adults.Methods: Thirty-five subjects were genotyped and grouped into recessive (TT, n=15) and dominant (TC+CC, n=20) allele carriers. Anthropometric and body composition measurements, dietary intake (SQ-FFQ), and physical activity (IPAQ-SF) were assessed before, during, and after Ramadan. Genetic data for rs17782313 were obtained from a prior investigation. Repeated Measures ANCOVA, adjusted for energy intake and physical activity, evaluated genotype and time effects.Results: The recessive group (TT) showed higher values than the dominant group (TC+CC), with significant differences in body weight, BMI, hip circumference, and visceral fat across all time points (p<0.05). Waist circumference differed significantly during and after Ramadan, while BMR differed only before fasting (p<0.05). Macronutrient intake and physical activity did not differ significantly, although protein and fat intake changes post-Ramadan were notable (p<0.05). A significant time–activity interaction was found for body weight (p=0.041). TT carriers experienced greater anthropometric benefits from Ramadan fasting compared to TC+CC carriers.Conclusion: Ramadan fasting significantly influences anthropometric parameters, body composition, and macronutrient intake across MC4R genotypes. Greater responses were observed in recessive carriers (TT), although fasting outcomes were also shaped by nutrition and physical activity. These findings highlight the interplay of genetic and environmental factors in energy regulation during Ramadan.
Foam rolling reduced total creatine kinase in acute muscle inflammation following long-distance running Ali, Mohammad Arif; Pangestu, Bayu; Rahayu, Setya; Anggita, Gustiana Mega; Kurniawati, Dewi Marfu’ah; Noer, Etika Ratna; Mohamed, Ani Mazlina Dewi
Journal Sport Area Vol 8 No 1 (2023): April
Publisher : UIR Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25299/sportarea.2023.vol8(1).12144

Abstract

Strenuous physical activity is able to cost muscle damage. In urban society, ten kilometers running has become a modern culture. It induces acute inflammation as a normal physiological response. Conversely, a foam roller is known as a self-myofascial release (SMR) technique which can be done individually. Previous studies stated that foam rolling (FR) could increase flexibility, and reduce muscle pain sensation. However, there is still a limited supply of scientific evidence to prove its positive effects, especially through biomarkers such as creatine kinase (CK). This study aims to elucidate the beneficial effects of a foam roller in CK concentration after 10 kilometers of running which induces DOMS. A quasi-repeated measures design was elected as an approach to conducting this study. The purposive sampling technique was used to obtain the subjects (n= 10). Creatine kinase measurements were performed before 10 km running and 3 days post running by using the COBAS INTEGRA 400 Plus Test (the UV-test concept). Repeated Measures ANOVA was used to determine the effect of FR on CK. Ten kilometers of running increased Total CK concentration, pre-test data was 146.2 ± 36.3 (U/L), and 24 hours was 452.3 ± 216.5 (U/L). Creatine Kinase decreased at 48 hours (300.6 ± 117.6 (U/L), and 72 hours (238.4 ± 67.5 (U/L) post-application of foam rolling. We conclude that long distance running increased significantly total CK, and foam rolling might decrease CK concentration in the blood.
Nutrition intake, insulin-like growth factor-1 hormone levels, somatotype score, and strength performance of adolescent athletes Zetta, Adelia Paradya; Susanto, Hardhono; Noer, Etika Ratna; Muniroh, Muflihatul; Widyastiti, Nyoman Suci
Journal Sport Area Vol 9 No 3 (2024): December
Publisher : UIR Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25299/sportarea.2024.vol9(3).17017

Abstract

Background Problems: Currently, there is still limited identification of nutritional intake, hormonal, and physical performance in adolescent athletes in Indonesia. Research Objectives: This study aims to identify anthropometric, nutritional intake, IGF-1 hormone level, and adolescent athletes’s performance. Methods: The research method used a cross-sectional study. A convenient sample of 58 athletes under Balai Pemusatan Pendidikan dan Latihan Pelajar. The research instrument used Bioelectrical Impedance Analysis (BIA), leg dynamometer, hand grip dynamometer, tape measure, height stature, SQ-FFQ Form, and body fat caliper. Blood samples were collected and tested by a professional laboratory. Data analysis techniques used Pearson’s test for normally distributed data and Spearman’s rank for non-normally distributed data. Findings and Results: The result of this study found a significant (p < 0.05) correlation between energy intake, anthropometric measurement of z score (BMI/Age), and endomorph score with an athlete’s muscle strength. We also found significant differences (p < 0.05) in macronutrient and micronutrient consumption in male and female athletes, and we also found significant differences in somatotype score and muscle strength in male and female athletes. Conclusion: We conclude that many athletes are not consuming the recommended levels of carbohydrates, fat, protein, and some micronutrients. We found a correlation between energy intake and fat intake with leg muscle strength. However, there was no correlation between IGF-1 hormone levels and athlete strength. Intake is thought to indirectly affect grip strength and leg strength.
Efektifitas edukasi dan konseling faktor risiko hipertensi terhadap peningkatan pengetahuan, sikap dan frekuensi konsumsi natrium pada remaja dengan tekanan darah di atas normal Sri Noor Mintarsih; Zuhria Ismawanti; Kun Aristiati Susiloretni; Izzati Hayu Andari; Mardiana Mardiana; Etika Ratna Noer
Jurnal SAGO Gizi dan Kesehatan Vol 7, No 1 (2026): April
Publisher : Poltekkes Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/gikes.v7i1.3100

Abstract

Background: Hypertension is no longer limited to older adults and increasingly affects adolescents. Behavioral risk factors, such as high sodium intake, high fat consumption, and insufficient physical activity, contribute to an increased risk of hypertension. Limited knowledge and unfavorable attitudes toward hypertension prevention among adolescents may perpetuate unhealthy behaviors, highlighting the need for educational interventions as an early strategy to prevent non-communicable diseases.Objective: This study aimed to determine the effectiveness of education and counselling in improving adolescents’ knowledge, attitudes, and dietary patterns related to hypertension risk factors.Methods: An experimental study using a pretest–posttest control group design was conducted at SMAN 10, Semarang City, from June 19 to July 23, 2025. A total of 29 tenth-grade students with blood pressure >120/80 mmHg were randomly assigned to the intervention (n = 15) and control (n = 14) groups. The intervention consisted of nutrition education and counselling using a booklet entitled “Healthy Living to Prevent Hypertension.” The collected data included knowledge, attitudes, and frequency of sodium-rich food consumption. Data were analyzed using independent t-tests.Results: The mean increase in knowledge (6.6 points) and attitude (2.1 points) scores was higher in the intervention group (p=0.109; p=0.333), and the mean frequency score of sodium-rich food consumption decreased by 3 points (p=0.115) compared to that in the control group. However, these differences were not statistically significant. Based on effect size, the intervention showed a greater tendency to reduce the frequency of sodium-rich food consumption (12.9%) than to improve knowledge (10.5%) and attitudes (3.7%).Conclusion: Nutrition education and counselling have the potential to improve knowledge, attitudes, and sodium-related dietary patterns among adolescents, although the results were not statistically significant in this study. This intervention shows promise as a preventive strategy for hypertension in adolescents. 
Potensi Leunca (Solanum nigrum L.) sebagai Antiobesitas pada Tikus yang Diinduksi Diet Tinggi Lemak dan Sukrosa Sekar Ayu Putri Gunawan; Nurhanifah Muthmainnah Nurdin; Gemala Anjani; Siti Fatimah Muis; Etika Ratna Noer; Fitriyono Ayustaningwarno
Amerta Nutrition Vol. 10 No. 3 (2026): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v10i3.2026.451-456

Abstract

Background: Long-term consumption of high-calorie foods can lead to obesity. Leunca fruit contains several phytochemicals that act as antioxidants and anti-obesity agents. Objectives: This study aims to analyze the potential of Solanum nigrum fruit as an anti-obesity agent in rats induced with a high-fat sucrose diet (HFSD) to prevent weight gain. Methods: This study was experimental. The sample consisted of 30 male Sprague -Dawley rats, divided into 5 groups: K1 (standard diet), K2 (HFSD), P1 (HFSD + leunca 0.8 g/200 gBW), P2 (HFSD + leunca 1.6 g/200 gBW), and P3 (HFSD + leunca 2.4 g/200 gBW). The study was conducted at the Nutrition Laboratory, Center for Food and Nutrition Studies, Gadjah Mada University (PSPG PAU UGM), Yogyakarta, from January to March 2024. Results: This study was experimental. The sample consisted of 30 male Sprague -Dawley rats, divided into 5 groups: K1 (standard diet), K2 (HFSD), P1 (HFSD + leunca 0.8 g/200 gBW), P2 (HFSD + leunca 1.6 g/200 gBW), and P3 (HFSD + leunca 2.4 g/200 gBW). The study was conducted at the Nutrition Laboratory, Center for Food and Nutrition Studies, Gadjah Mada University (PSPG PAU UGM), Yogyakarta, from January to March 2024. Conclusions: Components such as fiber, antioxidants, vitamin A, vitamin C, flavonoids, and tannins contained in leunca fruit have an anti-obesity effect. Leunca fruit at a dose of 1,6 g/200 gBW and 2,4 g/200 gBW is the most effective dose in preventing weight gain in rats induced by a high-fat sucrose diet.
Co-Authors ,Adriyan Pramono Adhimah, Ayu Fauziyyah Adriyan Pramono Ahmad Syauqy Akifah, Adzro'ul Ali Rosidi Amalia Nita Widyastuti, Amalia Nita Ameliora Dwi Astani Amirullah, M Fadil Anggit Wicaksono Anggriany, Nissa Ani - Margawati Ani Margawati Ani Margawati Anjani, Gemala Apoina Kartini Arfinanda, Najwa Diva Khoirunnisa' Argan Caesar Budiatmaja Arwinda Nugraheni Aryu Candra Astrine Permata Leoni Ayu Rahadiyanti Befi Sundari Binar Panunggal BR Purba, Martalena Candra, Adiska Rani Ditya Damayanti, Yuliana Kusuma Danarsi, Chorina Swasti Denny Nugroho Sugianto Deny Yudi Fitranti Deny Yudy Fitranti Desi Sofiyana destiana - florencia Destikasari, Widya Dewanti Dewanti Dewi Kurnia Sandi Dewi Marfu’ah Kurniawati Dewi, Luthfia Dian Ratna Sawitri Diana Nur Afifah, Diana Nur Djuara P Lubis Elvizahro Leiyla Endang Mahati Endrinikapoulos, Ariana Enny Probosari Erin Ratna Kustanti Etisa Adi Murbawani Faizah Fulyani Fajrani, Alifia Mukti Fajrani, alifiaA muktiM Farid Agung Rahmadi, Farid Agung Fatih Az Zahra Febriani, Brilliantika Resy Fidiasari, Intan Sepna Fillah Fithra Dieny Fillah Fitra Dieny Fitriyanti, Addina Rizky Fitriyono Ayustaningwarno Fronthea Swastawati Fulyani, Faizah Gunawan, Sekar Ayu Putri Gustiana Mega Anggita Haq, Arynal Hardhono Susanto Hartanti Sandi Wijayanti Hastuti, Vivilia Niken Henny, Via Anugrah Hersanti Sulistyaningrum Hidayati Hidayati Ihat Hatimah Ilmiati, Fatia Ira Roza Milinda Izzati Hayu Andari Jamhari Jamhari Jauharany, Firdananda Fikri Khasanah, Dwi Puji Khikmaturrohman, Sya’bani Isnaen KIRANA LAKSMI Kun Aristiati Susiloretni Kurniawan, Kezia Yunandra Kusmiyati Tjahjono Kusuma, Donny Wira Yudha Laura, Cicilia Leo Nacion Santillana Lilis Endang Wijayanti, Lilis Endang Lingga Edytias Pratiwi Lora Sri Nofi Mardiana Mardiana Maria Martiani Maria Mexitalia Maria Mexitalia Maria Pangkrasia Kirimunun Marsa, Firdaus Shadiqa Martalena Br Purba MARTHA ARDIARIA Martha Irene Kartasurya Miftahul Adnan Mita Arini Mohamed, Ani Mazlina Dewi Mohammad Arif Ali, Mohammad Arif Mohammad Sulchan Mohammad Zen Rahfiludin Muflihatul Muniroh Muniroh, Muflihatul Mursid Tri Susilo Nani Maharani Nani Maharani Nawai, Fatmayanti Niken Puruhita Ninik Rustanti Novitasari, Anggi Nurahmatika, Prisma Nurdin, Nurhanifah Muthmainnah Nurhanifah Muthmainnah Nurdin Nurjanah, Ayu Nurmasari Widyastuti Nuryanto Nuryanto Nyoman Suci Widyastiti Pangestu, Bayu Perdanawati, Mia Permatasari, Mayang Januarti Pramita Ariawati Putri Purwita Wijaya Laksmi Rachma Purwanti Rahardiyanti, Ayu Rahma, Devi Elvina Randenia, Nabila Reny Sartika Ria Purnawian Sulistiani Ria Purnawian Sulistiani, Ria Purnawian Ristianingsih, Hanifa Robi Andoyo Roni Aruben Rosmalinda, Yusie Said Junaidi Sandi, Dewi Kurnia Savitri, Rachmania Anggita Sekar Ayu Putri Gunawan Setya Rahayu Siti Baitul Mukarromah Siti Fatimah Muis Siti Fatimah Muis Siti Fatimah Muis Sophia Rose Sri Achadi Nugraheni Sri Noor Mintarsih Sugiarto Sugiarto Sumardi Widodo Suroto Tiara Rosania Hestuningtyas Tiffany Nisa Arviyani Titis Rakhma Imtihani Tjahjono, Kusmiyati DK Tsani, A. Fahmy Arif Usydatul Falasifah Vanessa Yudha Azizul Ilmi Widayanti, Iftitan Setya Widya Destikasari Widyastuti, Trioni Winda Amalia Pertiwi Wita Rizki Amelia Yenni, Fitri Yocku, Monica Hermina Sharon Otline Yuswo Supatmo Zainab Sholihah Zainudin Amali Zelyn Damayanti Zetta, Adelia Paradya Zuhria Ismawanti