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All Journal International Journal of Public Health Science (IJPHS) Majalah Kedokteran Bandung Althea Medical Journal Nexus Biomedika Nexus Kedokteran Translasional Jurnal Riset Kesehatan Majalah Obat Tradisional Smart Medical Journal Jurnal Kesehatan Manarang Al-sihah: The Public Health Science Journal Indonesian Journal of Medicine Journal of Maternal and Child Health Indonesia Jurnal Kebidanan YARSI Medical Journal Abdimas Universal World Nutrition Journal Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Abdidas Nusantara Science and Technology Proceedings Narra J Proceeding ISETH (International Summit on Science, Technology, and Humanity) Biocaster : Jurnal Kajian Biologi Literasi Kesehatan Husada: Jurnal Informasi Ilmu Kesehatan Jurnal Pendidikan Kesehatan Media Penelitian dan Pengembangan Kesehatan
Ida Nurwati
Fakultas Kedokteran, Universitas Sebelas Maret, Surakarta, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Evaluating autologous peritoneum grafting for enhanced healing of bile duct injuries: A preliminary data from an animal study Nugroho, Anung N.; Mudigdo, Ambar; Soetrisno, Soetrisno; Yarso, Kristanto Y.; Nurwati, Ida; Indarto, Dono; Pamungkasari, Eti P.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1873

Abstract

Increased incidence of laparoscopic cholecystectomy-related bile duct injuries (BDIs), combined with its risk of serious complications and mortality, highlights the need for a more effective repair technique. Although the use of autologous graft in BDI repair has been promoted, the role of autologous parietal peritoneum remains underexplored. The aim of this study was to evaluate the effect of autologous parietal peritoneum grafts in rabbit models of partial BDI, emphasizing its effect on the expression of cluster of differentiation 68 (CD68) and transforming growth factor-β (TGF-β). An experimental post-test-only design was employed, using 27 male New Zealand rabbits (Oryctolagus cuniculus) aged 8–10 months. The rabbits were allocated into three groups: control (primary closure), autologous parietal peritoneum graft, and autologous gallbladder graft. Partial BDI measuring 15×5 mm were surgically created and repaired according to group assignments. The expression of CD68 and TGF-β were measured via enzyme-linked immunosorbent assay (ELISA), while the anastomosis was pathologically examined through hematoxylin and eosin (H&E) staining on days 3, 7, and 14 post-surgery. Statistical analysis was performed using analysis of variance (ANOVA) followed by Bonferroni post hoc tests. No statistically significant difference was observed in the expression of CD68 or TGF-β among the three treatment groups on days 3, 7, and 14 post-surgery, indicating that the effects of autologous parietal peritoneum graft were comparable to the control and the autologous gallbladder graft in promoting wound healing. Fibroblast density on day 3 was significantly lower in the parietal peritoneum group (p=0.040), reflecting delayed recruitment, but normalized by day 14, indicating successful integration and remodeling. The study highlights the potential role of autologous parietal peritoneum grafts for BDI.
Evaluasi Respon Pendidikan Seksualitas Komprehensif Berbasis Sekolah Pada Siswa SMP Negeri Di Kabupaten Sragen Utami, Dyah Rahmawatie Ratna Budi; Nurwati, Ida; Lestari, Anik
JURNAL PENDIDIKAN KESEHATAN Vol. 5 No. 1 (2025): Jurnal Pendidikan Kesehatan
Publisher : LPPM Sekolah Tinggi Ilmu Kesehatan Pekanbaru Medical Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64931/jks.v5i1.125

Abstract

Kurangnya integrasi pendidikan seksual dengan kurikulum pada remaja menjadikan perlunya implementasi pendidikan seksual komprehensif berbasis sekolah. Penelitian ini bertujuan untuk melakukan evaluasi respon atas pelaksanaan pendidikan seksualitas komprehensif yang diselenggarakan di SMP Negeri Kabupaten Sragen. Penelitian dilakukan dengan metode kualitatif menggunakan pendekatan fenomenologi. Pengumpulan data menggunakan wawancara mendalam. Hasil penelitian menunjukkan pendidikan seksualitas komprehensif memberi dampak positif siswa dalam memahami dan menguatkan sikap serta memudahkan guru dalam mengajarkan materi kesehatan seksual reproduksi. Kesimpulan: Pendidikan seksualitas komprehensif efektif dalam meningkatkan pencegahan perilaku seksual berisiko bagi siswa dengan respon positif dari siswa maupun guru.
The Role of Interleukin 1β, Fibroblast Growth Factor, Fibroblasts, Keratinocytes, Granulation Tissue and Collagen Density in the Wound Healing Phase (Study of Wound Healing in the Inflammation, Proliferation, and Remodeling Phases) Christanto, Antonius; Cilmiaty, Risya; Setiamika, Made; Yudhani, Ratih Dewi; Dirgahayu, Paramasari; Pamungkasari, Eti Poncorini; Nurwati, Ida
Biocaster : Jurnal Kajian Biologi Vol. 5 No. 3 (2025): July
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v5i3.399

Abstract

This scoping review explores the roles of interleukin 1β, fibroblast growth factor, fibroblasts, keratinocytes, granulation tissue, and collagen density in the wound healing process, focusing on inflammation, proliferation, and remodeling phases. A systematic literature search identified studies investigating molecular and cellular mechanisms involved in wound repair. Findings reveal that fibroblast-derived exosomes carrying miR-93-5p inhibit autophagy, delaying diabetic wound healing. Controlled growth factor delivery enhances angiogenesis, fibroblast proliferation, and collagen deposition, accelerating tissue regeneration. SPRR1B+ keratinocytes facilitate rapid re-epithelialization, while granulation tissue provides essential scaffolding for cell migration and neovascularization. Elevated IL-1β impairs healing by increasing matrix metalloproteinases, degrading collagen. Natural compounds like red fruit oil and Binahong leaf extract promote angiogenesis and collagen synthesis. Genetic variations in inflammatory cytokines influence healing outcomes, indicating potential for personalized therapies. This review consolidates current evidence, providing insights into cellular and molecular interactions critical for effective wound repair and guiding future regenerative medicine strategies.
Co-Authors A. Guntur Hermawan Ambar Mudigdo Anik Lestari Asrial, An A. Baihaqy, Fathu Thaariq Betty Saptiwi Betty Saptiwi Betty Saptiwi Brian Wasita Christanto, Antonius Danus Hermawan Danus Hermawan Dicky Maulana Lazuardi Diding H P Diding Heri Prasetyo Diding Heri Prasetyo Dono Indarto Dyah Rahmawatie Ratna Budi Utami Dyah Ratna Budiani Dyah Ratna Budiani Dyah Ratna Budiani Eriana Melinawati Eric Edwin Yuliantara Eti Poncorini Pamungkasari Fahmi, Muhammad Izzul Widad Gresmita Rindi Winarti Hadi, Cahyono Harioputro, Dhani Redhono Hermawan, Danus Ika Tristanti Jarot Subandono Jarot Subandono Jarot Subandono Khoirunnisa, Rahmi Lazuardi, Dicky Maulana Martini Martini Martini Martini Martini Martini Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Mutmainah Mutmainah Nabila Aushaf Prasetyo Nafisa, Putri Amalina Nanang Wiyono Noni Kartika Sari Nugroho, Anung N. Nur Hafidha Hikmayani Nur Hafidha Hikmayani Nutria Widya Purna Anggraini Octavia, Dhamayanti Eka Pamungkasari, Eti P. Paramasari Dirgahayu Prihandjojo Andri Putranto Pudjiastuti, Anggit Putranto, R. Prihandjojo Andri Putranto, Wachid Reviono Reviono Risya Cilmiaty A. R. Risya Cilmiaty AR Risya Cilmiaty, Risya Rosyida, Rufaida Sari, Noni Kartika Sarsanti, Arifa Sherina Noor Sarsono Sarsono Sarsono Sarsono Sarsono Sarsono Sarsono Sarsono Selfi Handayani Selfi Handayani Selfi Handayani Selfi Handayani Setiamika, Made Setianto, Budi Y. Sigit Setyawan Sineri, Dessy Ikasartika Siti Aisyah Siti Marufah Soetrisno Soetrisno Sri Hartati Hadinoto Sri Haryati Sri Sulistyowati Sumardiyono Sumardiyono Sumardiyono, S Uki Retno Budihastuti Vitri Widyaningsih Wahyu Anjas Sari Wesliaprilius, Todung Antony Wiyono, Nanang Yarso, Kristanto Y. yoseph Indrayanto Yudhani, Ratih Dewi Yulia Sari Yulyanti, Yulyanti