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All Journal PHARMACON Pharmascience Jurnal Surya Medika Syntax Literate: Jurnal Ilmiah Indonesia Pharmacology and Clinical Pharmacy Research KACANEGARA Jurnal Pengabdian pada Masyarakat Martabe : Jurnal Pengabdian Kepada Masyarakat IJISTECH (International Journal Of Information System & Technology) JIK- JURNAL ILMU KESEHATAN Journal of Education, Humaniora and Social Sciences (JEHSS) Jurnal Hukum Positum Jurnal Sehat Mandiri Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Jurnal Abdimas Mahakam Jurnal Dunia Farmasi Jurnal Pendidikan dan Konseling Jurnal Kesehatan Masyarakat Celebes Jurnal ABDINUS : Jurnal Pengabdian Nusantara Jurnal Riset Kefarmasian Indonesia HSG (Health Science Growth) Journal Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Penelitian Farmasi dan Herbal IJISTECH Jurnal Ilmiah Wahana Pendidikan Jurnal EduHealth Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Pemberdayaan dan Pendidikan Kesehatan Jurnal Farmasetis PharmaCine : Journal of Pharmacy, Medical and Health Science Journal of Sustainable Community Service Journal of Pharmaceutical and Sciences. JUKEJ: Jurnal Kesehatan Jompa Jurnal Kesehatan Cendikia Jenius Jurnal Sains dan Kesehatan Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia Preventif : Jurnal Kesehatan Masyarakat
Indah Laily Hilmi
Universitas Singaperbangsa Karawang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Effectiveness of Clinical Pharmacy Interventions in Medication Adherence for Geriatric Patients: Literature Review Ilham, Febrian Dzikri; Hilmi, Indah Laily; Sudarjat, Hadi
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i2.1654

Abstract

Background: Medication adherence in geriatric patients is a major challenge as polypharmacy increases the risk of drug-related problems (DRPs). The role of clinical pharmacy is important in addressing these issues through evidence-based approaches. Objective: To review the effectiveness of various clinical pharmacy interventions in improving medication adherence in geriatric patients. Methods: This article used a systematic review of 13 literature selected from 934 articles based on inclusion criteria in the last 10 years, using PubMed and Google Scholar databases. The focus of the analysis included education, monitoring, and the use of tools such as pill cards and medication reminder charts. Results: Clinical pharmacy interventions, such as the use of Beers and STOPP/START criteria, counseling, and educational programs using tools, were shown to improve adherence in geriatric patients. Programs such as pill boxes increased adherence by 83.33%. However, some tools such as medication reminder charts had limited effectiveness. Conclusion: A collaborative approach, including patient and family education, monitoring, and clinical criteria-based therapy adjustments, is essential to improve medication adherence in geriatric patients, which directly improves their quality of life.
Studi Literatur: Analisis Pengetahuan dan Sikap Mahasiswa Farmasi dalam Pembuangan Limbah Obat dengan Perspektif Ekofarmakologi Putriyani, Shalum; Hilmi, Indah Laily; Ratnasari, Devi
Jurnal Sehat Mandiri Vol 20 No 1 (2025): Jurnal Sehat Mandiri, Volume 20 Nomor 1 Juni 2025
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v20i1.1638

Abstract

This literature study aims to evaluate pharmacy students' knowledge and attitudes regarding pharmaceutical waste disposal from an ecopharmacology perspective. Ecopharmacology is a branch of science that examines the environmental impact of drug residues, particularly how pharmaceutical compounds affect ecosystems after disposal. This perspective is important because unused or improperly discarded medications can contaminate water and soil, and disrupt ecological balance. The study employs a qualitative literature review method by analyzing articles from the PubMed and Scopus databases over the past ten years. The results show that although pharmacy students possess basic knowledge about the environmental risks of improper drug disposal, there remains a gap in practical application. Ecopharmacology education has proven to play a significant role in raising awareness and fostering environmentally responsible attitudes. Conclusion: Pharmacy students have basic knowledge about the environmental impact of drug disposal, but its implementation is still suboptimal.Recommendation: It is recommended to integrate ecopharmacology into the pharmacy curriculum and provide proper and easily accessible pharmaceutical waste disposal facilities.
Literature Review: Pengaruh Efek Samping Obat Anti Tuberkulosis (OAT) Terhadap Kepatuhan Minum Obat Pasien Tuberkulosis di Indonesia: Literature Review: The Influence of Side Effect of Anti-Tuberculosis Drugs (Oats) on Drug Compliance of Tuberculosis Patients in Indonesia Hermawan, Deri; Hilmi, Indah Laily; Sudarjat, Hadi
Jurnal Surya Medika (JSM) Vol. 11 No. 2 (2025): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v11i2.8554

Abstract

Agen infeksi yang menyebabkan Tuberkulosis (TB) masih menjadi salah satu masalah kesehatan terbesar di Indonesia adalah Mycobacterium tuberculosis. Faktor kunci dalam keberhasilan pengobatan tuberkulosis adalah komitmen pasien terhadap regimen terapi jangka panjang. Namun, kepatuhan pasien terhadap terapi sering kali sangat terhambat oleh adanya efek samping Obat Anti-Tuberkulosis (OAT). Tujuan penelitian ini untuk mengevaluasi dampak efek samping OAT terhadap kepatuhan pengobatan pada pasien tuberkulosis di Indonesia. Metode yang digunakan dalam pembuatan review artikel ini adalah literatur review dari sumber data sekunder Google Scholar dan Pubmed. Hasil penelitian ini menunjukkan efek samping Obat Anti-Tuberkulosis (OAT) yang paling sering terjadi adalah mual, muntah, nyeri sendi, gangguan pencernaan, dan perubahan warna pada urin berperan dalam kepatuhan minum obat pasien Tuberkulosis di Indonesia. Kesimpulan yang didapat, berdasarkan analisis terhadap 14 artikel, Semakin berat efek samping yang dialami, semakin rendah tingkat kepatuhan pasien terhadap pengobatan, sehingga diperlukan pemantauan terhadap pasien guna meningkatkan tingkat kepatuhan pengobatan Tuberkulosis di Indonesia.
Evaluasi Bukti dari Uji Klinis tentang Interaksi Antibiotik dan Antasida: Suatu Tinjauan Sistematis Literatur Al Qindy, Wildan Hidayah; Nurdin, Fitri Oktaviani; Khaerunisa, Aulia; Putri, Meisya Diffa Amalia; Hilmi, Indah Laily; Putri, Mukarromah Dita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1093

Abstract

Drug interactions between antibiotics and antacids represent an important clinical issue that can affect therapeutic efficacy and increase the risk of treatment failure. The concurrent use of these drug classes frequently occurs in clinical practice, particularly in patients receiving antibiotic therapy who also present with gastrointestinal complaints. This systematic literature review aims to evaluate the clinical trial evidence regarding antibiotic–antacid interactions, focusing on pharmacokinetic and pharmacodynamic mechanisms, clinical implications, and current research limitations. Relevant articles were identified through PubMed, Google Scholar, and other scientific databases using standardized keywords. Literature selection followed the PRISMA guidelines to ensure the quality and relevance of included studies. The analysis revealed that antacids and proton pump inhibitors (PPIs) can significantly reduce the bioavailability of antibiotics, especially fluoroquinolones and tetracyclines, through chelation with metal ions and by increasing gastric pH, thereby impairing drug absorption. Concomitant use of antibiotics and PPIs was also associated with a higher risk of Clostridioides difficile infection (CDI), particularly in elderly or comorbid patients. Conversely, newer acid-suppressing agents such as vonoprazan demonstrated good efficacy in Helicobacter pylori eradication regimens without compromising antibiotic activity. Despite these findings, most studies were retrospective, with limited sample sizes and specific populations. Therefore, large-scale prospective clinical trials are needed to strengthen the evidence base. A comprehensive understanding of antibiotic–antacid interactions is essential to support rational, safe, and effective prescribing practices in clinical settings.
DEVELOPMENT OF PLASMID-BASED FOR EXTERNAL CONTROL MATERIALS OF CYP2D6*10 (rs1065852) GENE PCR-BASED DETECTION Malau, Jekmal; Zahra, Aliya Azkia; Kasasiah, Ahsanal; Rahmasari, Ratika; Raekiansyah, Muhareva; Rohmah, Siti; Meilani, Nanda Diva; Septi, Annisa Frastica; Zahro, Aurora Fatimatuz; Annajla, Fathina; Hermosaningtyas, Anastasia Aliesa; Hilmi, Indah Laily
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 10 No. 2 (2023)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2023.2557

Abstract

Reliable clinical diagnosis of Single Nucleotide Polymorphisms (SNPs) is necessary for personalizing tamoxifen medication according to CYP2D6*10 genetic variations. Our research aimed to create a recombinant plasmid for external control material with a molecular size of 3812 bp. The recombinant plasmid was achieved by cloning an 838 bp gene insert of CYP2D6*10 rs1065852 into a 2974 bp pJET1.2 plasmid into Escherichia coli DH10B and selection on ampicillin agar medium. Isolated E. coli recombinants provided the plasmid molecules for analysis. Bi-directional sequencing and Real-Time PCR confirmed the presence of wild-type and mutant rs1065852 DNA fragments in the plasmid, namely homozygote CC and TT. The conclusion is that we have successfully introduced a novel recombinant plasmid developed by cloning the SNP rs1065852, which carries the 100C>T mutation, using pJET 1.2/blunt system, which could significantly enhance the accuracy of clinical SNP diagnostics for personalized medicine in breast cancer treatment.
Evaluasi Distribusi Produk Rantai Dingin pada Puskesmas di Kabupaten Karawang Komariah, Siti; Hilmi, Indah Laily; Ratnasari, Devi; Rachmawati, Ellin
JIK-JURNAL ILMU KESEHATAN Vol 6, No 2 (2022): JIK-Oktober Volume 6 Nomor 2 Tahun 2022
Publisher : UNIVERSITAS ALIFAH PADANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33757/jik.v6i2.537

Abstract

Menurut Badan Pengawas Obat dan Makanan No.9 tahun 2019 dalam setiap aspek dan rangkaian distribusi obat salah satunya pada produk rantai dingin. Produk rantai dingin merupakan obat yang labil, sensitif terhadap suhu perlu disimpan dalam lemari pendingin dengan suhu antara 2–8 C. Tujuan penelitian mengevalusi bagaimana operasional, personil/pelatihan dan bangunan/fasilitas, terhadap penerapan distribusi produk rantai dingin pada empat puskesmas di Kabupaten Karawang. Penelitian ini bersifat observasional  yang berbentuk deskriptif dengan pendekatan metode kualitatif. Pengambilan sampel dilakukan dengan menggunakan teknik purposive sampling. Semua kegiatan Alur distribusi pada puskesmas tersebut memiliki alur distribusi yang sama. Petugas penanggung jawab merupakan tenaga kesehatan yang telah mengikuti program pelatihan imunisasi, dari empat puskesmas 50 % masih belum memiliki bangunan dan ketidaksesuaian jarak/kondisi penyimapan dengan ketetapan standar. Kelengkapan alat penunjang dalam pengelolaan produk rantai dingin semua peralatan mematuhi seperangkat standar kinerja. Jadi, dari ke empat puskesmas yang berada di kabupaten karawang dengan presentase hasil nilai skala guttman yaitu 83,3 % efektif dalam pendistribusian, personil/petugas, pengelolaan produk rantai dingin vaksin dan juga setiap puskesmas dilengkapi oleh standar operasional prosedur. Pada puskemas untuk meningkatkan implementasi CDOB khususnya pengelolaan produk rantai dingin salah satunya pada aspek bangunan dan praktisi penanggung jawab.
Comparison of Varenicline’s Effectiveness with Nicotin Replacement Therapy (NRT) or A Combination of Both in Smoking Cessation: Literature Review Mahardika Urbaningrum, Lestari; Laily Hilmi, Indah
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (177.652 KB)

Abstract

Smoking is a cause of many chronic diseases such as lung cancer, oral cancer, to cardiovascular disease. Smoking addiction is caused by the nicotine in cigarettes. Thus Nicotine Replacement Therapy (NRT) was created as a substitute for nicotine consumption without smoking. While another drug that is widely prescribed is varenicline. However, varenicline is not yet available in Indonesia and the use of NRT is still very rare. Therefore, research is needed to compare the efficacy of the two. The research was conducted by studying the literature of international journals and obtained 12 journals that match the research title. As a result, varenicline monotherapy proved to be more effective than NRT or a combination of both.
The Dangerous Effects of Tramadol Abuse: Literature Review Prasetyo, Fajar; Indah Laily Hilmi
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.144 KB)

Abstract

Drug abuse is an act of using one or a combination of drugs in relatively high doses with the aim not for medication but to achieve a pleasure without regard to other aspects. Drug abuse can be motivated by several factors such as a weak personality, a high sense of curiosity, peer invitations, social problems and pressures, and the ease with which drugs can be obtained at low prices. One of the drugs that is often abused is tramadol. This is because tramadol can provide a euphoric effect. Without realizing it, tramadol abuse actually causes other, more dangerous effects. Therefore, writing this review article aims to provide an overview of other effects resulting from the abuse of tramadol drugs. The writing of this article review uses a systematic review method in which data is taken from national and international scientific articles or journals with a limitation of publication in the last 10 years. Articles obtained from searches using Google Scholar, PubMed, and Science Direct. From the results of the review, it is known that the misuse of tramadol drugs can be fatal because it can cause vomiting, seizures, sedation, and even death. Not only that, tramadol in high doses also affects fertility factors such as sperm defects and erectile dysfunction. Special attention is needed for cases of tramadol abuse because most of these activities are carried out by teenagers.
Literature Review The Effect Of Blood Supplements Tablet On Adolescent Girls In Anemia Alya Nafis; Indah Laily Hilmi
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (205.326 KB)

Abstract

According to data from Riset Kesehatan Dasar (Riskesdas) in 2018, the prevalence of anemia in Indonesia was 48.9%, with the highest prevalence of anemia at the age of 15-24 years and the least at the age of 45-54 years. Factors for the occurrence of iron nutritional anemia in adolescent girls include lack of education about iron nutritional anemia, unsupportive environmental factors, lack of attention to daily nutritional intake, and lack of implementation of preventive measures from the government by consuming blood-added tablets. This study uses the review article method with research data sources based on journal publications on the internet. Based on the results of the review article conducted, it can be concluded that the effect of giving blood-added tablets can increase hemoglobin (Hb) levels so as to avoid the incidence of anemia (Hb <12 mg/dL) and reduce the prevalence of anemia in Indonesia..
The Relationship Of Hiv/Aids Events With Injecting Drug Use Deviana Farhani; Indah Laily Hilmi
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (185.45 KB)

Abstract

HIV stands for Human Immunodeficiency Virus infection and AIDS stands for Acquired Immunodeficiency Syndrome. HIV and AIDS cannot be separated because AIDS is a disease caused by the HIV virus. The HIV virus will attack the human immune system, more specifically attacking helper T cells, this will cause a decrease in the immune system of infected individuals. The risk of spreading HIV/AIDS infection occurs more through unsafe sex than through drug use. There are so many negative impacts obtained by ODHA both from the outside environment and from within themselves
Co-Authors Adi Supryatno Aditia Putra Tama Affandhy, Adhwa'a Kaylla Ahsanal Kasasiah Aisha K. Nur Aisiyah, Adella Al Qindy, Wildan Hidayah Aliya Azkia Zahra Alya Nafis Angga Prawira Kautsar Annajla, Fathina Annisa, Windy Aprida, Cantika Dewi Berliana Aryani, Ajeng Nita Audi Ichsani Ariwibowo Bunga Nur Annisa Cartas Cartas Cindhy Maulida Nurawaliah Devi Ratnasari Devi Ratnasari Deviana Farhani Dika Ramadhani Dinda Shafira Dzannuba, Fadya Laila Dzannuba Laila Ellin Rachmawati Fatharani, Adelia Fuji Ayu Diniarti Gun Gun Gumilar Gun Gun Gumilar Hajar Hartati Herdiana Verliani Hermawan, Deri Hermosaningtyas, Anastasia Aliesa Ibnu Mukti, Galih Ilham, Febrian Dzikri Imel Ramelia Hudaya Ineke Rossa Caroline Irene Virda Sakina Irvan Yoga Pardistya Irwansyah, Silvana Lestari Ita Novianti Jaja Muhammad Zakaria Jekmal Malau Jekmal Malau Khaerunisa, Aulia Lala Komala Sari Lely Sulfiani Saula Lestari, Sepiyani Ayu Maharani, Dhavina Mahardika Urbaningrum, Lestari Mally Ghinan Sholih Marisah Marisah Marsah Utami Maula, Kholida Atiyatul Meilani, Nanda Diva Moh Wahyudin Zarkasyi Muhammad Naufal Nurhadi Hidayat Muhareva Raekiansyah Munir Alinu Mulki MUTIARA ISKANDAR, PUTRI Nadia Andriani Nailuvar, Regita Nico Nico Nisrina, Hasna Nurdin, Fitri Oktaviani Nurhafidah, Zahra Nurlaela Nurlaela Oktavianti, Alfina Piantara, Seia Piantara Prasetyo, Fajar Putri, Meisya Diffa Amalia Putri, Mukarromah Dita Putria, Devy Kasih Putriyani, Shalum Rachmawati, Ellin Rahmasari, Ratika Rahmi Indian Rahmi Indiani Rahmi Zubaedah Rahmi Zubaidah Ramadhani, Rima Putri Ratnasari, Devi Rizky Abdulah Salman Salman Salman Salman Salman Salman Salsabila, Isyana salsabilla, Diva rizqi Sekar Ayu Maharani Septi, Annisa Frastica Septiani, Dia Shadrina, Jahra Almas Sholih, Mally Ghinan Siti Komariah Siti Rohmah Sophy Wulandari Sophy Wulandari Sridevi Anggraini Sudarjat, Hadi Sulastri Sulastri Tsani Arsy Mura Valensia, Rika Vina Luthfiana Hasna Wahyudin Wahyudin Wardani, Aulia Wildani Zakiyah Windari, Welly Wulandari, Sophy Wulandari, Yulia Eka Yuli Yuliani Yulianti Surasa, Triana Maudy Zahra, Aliya Azkia Zahro, Aurora Fatimatuz