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Faktor yang Mempengaruhi Penggunaan Obat Kategori Over the Counter pada Mahasiswa UNSIKA: Factors Affecting the Use of Over the Counter Drug Categories In UNSIKA Students Rahmi Indiani; Mally Ghinan Sholih; Indah Laily Hilmi
Jurnal Sains dan Kesehatan Vol. 5 No. 4 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i4.1364

Abstract

Survey conducted by the Statistics Indonesia in 2020 regarding self-medication, it was recorded that 88,28% people of West Java carried out self-medication, one of which was with over the counter drugs. The high use of this Over The Counter (OTC) category of drugs increases the possibility of abuse in terms of use. The purpose of this study is to identify the factors that influence the use of drugs in the OTC category and to test it againts Singaperbangsa Karawang University (UNSIKA) students. This research was conducted from January to March 2022 using a descriptive analytic design with a cross sectional approach. The instrument used is a questionnaire. The sampling technique used is the accidental sampling method with a sample consisting of 392 UNSIKA students who entered the inclusion criteria. The results of the univariate analysis shows that the majority of respondents have good knowledge, are influenced by product effectiveness and efficiency, have adequate information availability, believe in manufacturers, are influenced by usage preferences, and use drugs well. The results of the bivariate analysis using the Chi square method indicates that there is a relationship between knowledge, trust in manufacturers, and usage preferences for the use of drugs in the OTC category with a significance value of 0.001 (p 0.05). Keywords: OTC, drug use, self-medication, student Abstrak Survei Badan Pusat Statistik tahun 2020 tentang pengobatan mandiri menunjukkan 88,28% masyarakat Jawa Barat melakukan swamedikasi salah satunya dengan obat kategori over the counter. Tingginya penggunaan obat kategori Over The Counter (OTC) ini meningkatkan kemungkinan terjadinya penyalahgunaan dalam hal penggunaan obat. Tujuan penelitian ini adalah identifikasi faktor-faktor apa saja yang mempengaruhi penggunaan obat kategori OTC dan membuktikan faktor-faktor yang mempengaruhi penggunaan obat kategori OTC pada mahasiswa Universitas Singaperbangsa Karawang (UNSIKA). Penelitian ini dilakukan pada bulan Januari sampai Maret 2022 menggunakan desain deskriptif analitik dengan pendekatan cross sectional. Instrumen yang digunakan berupa kuesioner. Teknik pengambilan sampel menggunakan metode accidental sampling dengan sampel terdiri dari 392 mahasiswa UNSIKA yang masuk ke dalam kriteria inklusi. Hasil analisis univariat mayoritas responden berpengetahuan baik, dipengaruhi efektivitas dan efisiensi produk dengan baik, memiliki ketersediaan informasi yang memadai, percaya terhadap produsen, dipengaruhi preferensi pemakaian, dan menggunakan obat dengan baik. Hasil analisis bivariat menggunakan metode chi square terdapat hubungan antara pengetahuan, kepercayaan terhadap produsen, dan preferensi pemakaian terhadap penggunaan obat kategori OTC dengan nilai signifikansi 0,001 (p <0,05) dan tidak terdapat hubungan antara efektivitas dan efisiensi produk serta ketersediaan informasi terhadap penggunaan obat kategori over the counter dengan nilai signifikansi berturut-turut sebesar 0,911 dan 0,973 (p > 0,05). Kata Kunci: OTC, penggunaan obat, swamedikasi, mahasiswa
Literature Review: Efektivitas dan Efek Samping PCSK9 Inhibitor (Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor) dengan Golongan Statin pada Pasien Penderita Kolesterol Affandhy, Adhwa'a Kaylla; Sudarjat, Hadi; Hilmi, Indah Laily; Shadrina, Jahra Almas; Dzannuba, Fadya Laila Dzannuba Laila
Jurnal Sehat Mandiri Vol 20 No 1 (2025): Jurnal Sehat Mandiri, Volume 20 Nomor 1 Juni 2025
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v20i1.1746

Abstract

Cholesterol is an essential molecule in the human body, but excessive levels can lead to various diseases, including hypercholesterolemia. The management of high cholesterol involves the use of statins and PCSK9 inhibitors. This study aims to compare the effectiveness and side effects of these two drug classes.This study is a literature review conducted from August to September using articles from the PubMed database with keywords related to PCSK9 inhibitors and statins. The data were analyzed through bibliometric analysis using VOSviewer software with keywords such as PCSK9 inhibitor, alirocumab, bococizumab, and evolocumab.The results showed that PCSK9 inhibitors could reduce LDL-C levels by 57-61% with a good safety profile, although side effects such as injection site reactions were observed. In comparison, statins reduced LDL-C levels by 18-55% and increased HDL-C levels by up to 15%, but their side effects included muscle disorders and liver function impairment. PCSK9 inhibitors provide an additional solution for patients who do not respond optimally to statins. Conclusion: PCSK9 inhibitors are effective in lowering LDL-C in patients who have difficulty achieving target levels with statin therapy alone.
Literatur Review: Efektivitas Konseling Farmasis Terhadap Kepatuhan Minum Obat pada Diabetes Melitus Tipe 2: Literature Review: Effectiveness of Pharmacist Counseling on Compliance with Taking Medication in Diabetes Mellitus Type 2 Nurdin, Fitri Oktaviani; Hilmi, Indah Laily; Sudarjat, Hadi; Yulianti Surasa, Triana Maudy
Jurnal Surya Medika (JSM) Vol. 11 No. 1 (2025): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v11i2.9723

Abstract

Diabetes Melitus (DM) tipe 2 merupakan penyakit metabolik kronis yang memerlukan pengobatan seumur hidup. Salah satu faktor yang memengaruhi keberhasilan terapi DM adalah tingkat kepatuhan pasien terhadap pengobatan. Ketidakpatuhan ini sering kali disebabkan oleh kurangnya pemahaman pasien tentang pentingnya pengobatan jangka panjang. Tujuan: mengevaluasi efektivitas konseling farmasis dalam meningkatkan kepatuhan penggunaan obat pada pasien diabetes mellitus tipe 2. Metode yang digunakan adalah narrative review terhadap artikel yang membahas dampak konseling terhadap kepatuhan pasien. Hasil: Analisis 10 artikel memperlihatkan konseling oleh farmasis secara signifikan meningkatkan kepatuhan pengobatan, menurunkan kadar gula darah, serta memperbaiki hasil klinis secara keseluruhan. Kesimpulan: konseling farmasis merupakan intervensi yang efektif dalam meningkatkan kepatuhan pengobatan dan kontrol glukosa darah, yang berpotensi meningkatkan kualitas hidup pasien diabetes.
Knowledge and Attitudes Related to Health Seeking Behavior of Communities in Developing Countries Towards Tuberculosis (TB) Disease Ramadhani, Rima Putri; Sophy Wulandari; Indah Laily Hilmi
Jurnal Kesehatan Cendikia Jenius Vol. 2 No. 3 (2025): Agustus
Publisher : CV. CENDIKIA JENIUS INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70920/jenius.v2i3.190

Abstract

A person with tuberculosis may experience disease severity due to a lack of knowledge about tuberculosis, gender, place of residence, occupation, education level, and age. These factors influence knowledge and attitudes related to health-seeking behavior in communities of developing countries. The aim of this study is to explore knowledge, attitudes, and health-seeking behavior among people in developing countries.Methods: This study used an observational method with a literature review approach. The data sources used in this literature review were the PubMed and Scopus databases. Results: From the literature review, eight articles were identified and analyzed based on inclusion and exclusion criteria. The results showed that factors associated with knowledge and attitudes toward health-seeking behavior among people with tuberculosis in developing countries include lack of knowledge about the disease, gender, place of residence, age, education level, and occupation. Conclusion: Knowledge about tuberculosis significantly influences community attitudes and behavior in seeking appropriate healthcare services. Recommendation Future researchers should expand data coverage and provide education about TB to improve the accuracy and usefulness of the research.
Analysis of the Side Effects of Long-Term Proton Pump Inhibitor (PPI) Use in Patients with Gastroesophageal Reflux Disease (GERD) Nurhafidah, Zahra; Hilmi, Indah Laily; Sudarjat, Hadi
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i2.1628

Abstract

Background: Proton Pump Inhibitors (PPIs) are widely prescribed to manage gastrointestinal disorders, especially gastroesophageal reflux disease (GERD). However, long-term PPI use has been linked to serious side effects and potential complications. Objective: This study aims to analyze the side effects associated with prolonged PPI use in patients with GERD. Methods: A systematic review was conducted using Google Scholar and PubMed databases with relevant keywords. Article selection was carried out carefully based on inclusion and exclusion criteria to ensure the quality and relevance of the data. Additionally, a bibliometric analysis was performed to explore research trends related to the long-term use of PPIs. Results: The review found that prolonged PPI use is associated with various adverse effects, including an increased risk of dementia, progression of chronic kidney disease (CKD), gastric cancer, bone fractures, Frailty Syndrome, hypomagnesemia, iron deficiency, vitamin B12 deficiency, myocardial infarction, and esophageal cancer. The bibliometric analysis also indicated a growing trend of research focusing on the safety and complications of long-term PPI use. Conclusion: Long-term PPI therapy carries significant risks. Therefore, regular monitoring and appropriate discontinuation strategies are essential when using PPIs over extended periods to minimize potential harm.
Effectiveness of Clinical Pharmacy Interventions in Medication Adherence for Geriatric Patients: Literature Review Ilham, Febrian Dzikri; Hilmi, Indah Laily; Sudarjat, Hadi
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i2.1654

Abstract

Background: Medication adherence in geriatric patients is a major challenge as polypharmacy increases the risk of drug-related problems (DRPs). The role of clinical pharmacy is important in addressing these issues through evidence-based approaches. Objective: To review the effectiveness of various clinical pharmacy interventions in improving medication adherence in geriatric patients. Methods: This article used a systematic review of 13 literature selected from 934 articles based on inclusion criteria in the last 10 years, using PubMed and Google Scholar databases. The focus of the analysis included education, monitoring, and the use of tools such as pill cards and medication reminder charts. Results: Clinical pharmacy interventions, such as the use of Beers and STOPP/START criteria, counseling, and educational programs using tools, were shown to improve adherence in geriatric patients. Programs such as pill boxes increased adherence by 83.33%. However, some tools such as medication reminder charts had limited effectiveness. Conclusion: A collaborative approach, including patient and family education, monitoring, and clinical criteria-based therapy adjustments, is essential to improve medication adherence in geriatric patients, which directly improves their quality of life.
Studi Literatur: Analisis Pengetahuan dan Sikap Mahasiswa Farmasi dalam Pembuangan Limbah Obat dengan Perspektif Ekofarmakologi Putriyani, Shalum; Hilmi, Indah Laily; Ratnasari, Devi
Jurnal Sehat Mandiri Vol 20 No 1 (2025): Jurnal Sehat Mandiri, Volume 20 Nomor 1 Juni 2025
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v20i1.1638

Abstract

This literature study aims to evaluate pharmacy students' knowledge and attitudes regarding pharmaceutical waste disposal from an ecopharmacology perspective. Ecopharmacology is a branch of science that examines the environmental impact of drug residues, particularly how pharmaceutical compounds affect ecosystems after disposal. This perspective is important because unused or improperly discarded medications can contaminate water and soil, and disrupt ecological balance. The study employs a qualitative literature review method by analyzing articles from the PubMed and Scopus databases over the past ten years. The results show that although pharmacy students possess basic knowledge about the environmental risks of improper drug disposal, there remains a gap in practical application. Ecopharmacology education has proven to play a significant role in raising awareness and fostering environmentally responsible attitudes. Conclusion: Pharmacy students have basic knowledge about the environmental impact of drug disposal, but its implementation is still suboptimal.Recommendation: It is recommended to integrate ecopharmacology into the pharmacy curriculum and provide proper and easily accessible pharmaceutical waste disposal facilities.
Literature Review: Pengaruh Efek Samping Obat Anti Tuberkulosis (OAT) Terhadap Kepatuhan Minum Obat Pasien Tuberkulosis di Indonesia: Literature Review: The Influence of Side Effect of Anti-Tuberculosis Drugs (Oats) on Drug Compliance of Tuberculosis Patients in Indonesia Hermawan, Deri; Hilmi, Indah Laily; Sudarjat, Hadi
Jurnal Surya Medika (JSM) Vol. 11 No. 2 (2025): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v11i2.8554

Abstract

Agen infeksi yang menyebabkan Tuberkulosis (TB) masih menjadi salah satu masalah kesehatan terbesar di Indonesia adalah Mycobacterium tuberculosis. Faktor kunci dalam keberhasilan pengobatan tuberkulosis adalah komitmen pasien terhadap regimen terapi jangka panjang. Namun, kepatuhan pasien terhadap terapi sering kali sangat terhambat oleh adanya efek samping Obat Anti-Tuberkulosis (OAT). Tujuan penelitian ini untuk mengevaluasi dampak efek samping OAT terhadap kepatuhan pengobatan pada pasien tuberkulosis di Indonesia. Metode yang digunakan dalam pembuatan review artikel ini adalah literatur review dari sumber data sekunder Google Scholar dan Pubmed. Hasil penelitian ini menunjukkan efek samping Obat Anti-Tuberkulosis (OAT) yang paling sering terjadi adalah mual, muntah, nyeri sendi, gangguan pencernaan, dan perubahan warna pada urin berperan dalam kepatuhan minum obat pasien Tuberkulosis di Indonesia. Kesimpulan yang didapat, berdasarkan analisis terhadap 14 artikel, Semakin berat efek samping yang dialami, semakin rendah tingkat kepatuhan pasien terhadap pengobatan, sehingga diperlukan pemantauan terhadap pasien guna meningkatkan tingkat kepatuhan pengobatan Tuberkulosis di Indonesia.
Evaluasi Bukti dari Uji Klinis tentang Interaksi Antibiotik dan Antasida: Suatu Tinjauan Sistematis Literatur Al Qindy, Wildan Hidayah; Nurdin, Fitri Oktaviani; Khaerunisa, Aulia; Putri, Meisya Diffa Amalia; Hilmi, Indah Laily; Putri, Mukarromah Dita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1093

Abstract

Drug interactions between antibiotics and antacids represent an important clinical issue that can affect therapeutic efficacy and increase the risk of treatment failure. The concurrent use of these drug classes frequently occurs in clinical practice, particularly in patients receiving antibiotic therapy who also present with gastrointestinal complaints. This systematic literature review aims to evaluate the clinical trial evidence regarding antibiotic–antacid interactions, focusing on pharmacokinetic and pharmacodynamic mechanisms, clinical implications, and current research limitations. Relevant articles were identified through PubMed, Google Scholar, and other scientific databases using standardized keywords. Literature selection followed the PRISMA guidelines to ensure the quality and relevance of included studies. The analysis revealed that antacids and proton pump inhibitors (PPIs) can significantly reduce the bioavailability of antibiotics, especially fluoroquinolones and tetracyclines, through chelation with metal ions and by increasing gastric pH, thereby impairing drug absorption. Concomitant use of antibiotics and PPIs was also associated with a higher risk of Clostridioides difficile infection (CDI), particularly in elderly or comorbid patients. Conversely, newer acid-suppressing agents such as vonoprazan demonstrated good efficacy in Helicobacter pylori eradication regimens without compromising antibiotic activity. Despite these findings, most studies were retrospective, with limited sample sizes and specific populations. Therefore, large-scale prospective clinical trials are needed to strengthen the evidence base. A comprehensive understanding of antibiotic–antacid interactions is essential to support rational, safe, and effective prescribing practices in clinical settings.
DEVELOPMENT OF PLASMID-BASED FOR EXTERNAL CONTROL MATERIALS OF CYP2D6*10 (rs1065852) GENE PCR-BASED DETECTION Malau, Jekmal; Zahra, Aliya Azkia; Kasasiah, Ahsanal; Rahmasari, Ratika; Raekiansyah, Muhareva; Rohmah, Siti; Meilani, Nanda Diva; Septi, Annisa Frastica; Zahro, Aurora Fatimatuz; Annajla, Fathina; Hermosaningtyas, Anastasia Aliesa; Hilmi, Indah Laily
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 10 No. 2 (2023)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2023.2557

Abstract

Reliable clinical diagnosis of Single Nucleotide Polymorphisms (SNPs) is necessary for personalizing tamoxifen medication according to CYP2D6*10 genetic variations. Our research aimed to create a recombinant plasmid for external control material with a molecular size of 3812 bp. The recombinant plasmid was achieved by cloning an 838 bp gene insert of CYP2D6*10 rs1065852 into a 2974 bp pJET1.2 plasmid into Escherichia coli DH10B and selection on ampicillin agar medium. Isolated E. coli recombinants provided the plasmid molecules for analysis. Bi-directional sequencing and Real-Time PCR confirmed the presence of wild-type and mutant rs1065852 DNA fragments in the plasmid, namely homozygote CC and TT. The conclusion is that we have successfully introduced a novel recombinant plasmid developed by cloning the SNP rs1065852, which carries the 100C>T mutation, using pJET 1.2/blunt system, which could significantly enhance the accuracy of clinical SNP diagnostics for personalized medicine in breast cancer treatment.
Co-Authors Adhwa'a Kaylla Aditia Putra Tama Adzkia, Muhammad Adit Affandhy, Adhwa'a Kaylla Ahsanal Kasasiah Aisha K. Nur Aisiyah, Adella Al Qindy, Wildan Hidayah Aliya Azkia Zahra Alya Nafis Alya, Rahma Ananda, Meisya Dwi Angga Prawira Kautsar Annajla, Fathina Annisa, Windy Aprida, Cantika Dewi Berliana Aryani, Ajeng Nita Audi Ichsani Ariwibowo Bunga Nur Annisa Cartas Cartas Cindhy Maulida Nurawaliah Devi Ratnasari Devi Ratnasari Deviana Farhani Dika Ramadhani Dinda Shafira Diniarti, Fuji Ayu Dytha Andri Deswati, Dytha Andri Dzannuba, Fadya Laila Dzannuba Laila Ellin Rachmawati Ellin Rachmawati Fatharani, Adelia Firli Reisya Subekti Fitri Otaviani Nurdin Fitriana, Nariyyah Fuji Ayu Diniarti Gun Gun Gumilar Gun Gun Gumilar Hajar Hartati Herdiana Verliani Herlaesa, Shofiatulfuadah Retnaningrum Hermawan, Deri Hermosaningtyas, Anastasia Aliesa Ibnu Mukti, Galih Ilham, Febrian Dzikri Ilmi, Yuniar Fathil Imel Ramelia Hudaya Ineke Rossa Caroline Irene Virda Sakina Irvan Yoga Pardistya Irwansyah, Silvana Lestari Ita Novianti Izzati, Maulia Jahra Almas Shadrina Jaja Muhammad Zakaria Jasmine Rahma Saputri Jekmal Malau Jekmal Malau Khaerunisa, Aulia Khuriyah . Lala Komala Sari Lely Sulfiani Saula Lestari, Sepiyani Ayu Maharani, Dhavina Mahardika Urbaningrum, Lestari Mally Ghinan Sholih Marisah Marisah Marsah Utami Maula, Kholida Atiyatul Meilani, Nanda Diva Mochammad Wahyudin Zarkasyi Muhammad Naufal Nurhadi Hidayat Muhareva Raekiansyah Muini, Chantiara FM Mukarromah Dita Putri Munir Alinu Mulki MUTIARA ISKANDAR, PUTRI Nadia Andriani Nailuvar, Regita Nico Nico Nisrina, Hasna Nurdin, Fitri Oktaviani Nurhafidah, Zahra Nurlaela Nurlaela Oktavianti, Alfina Piantara, Seia Piantara Prasetyo, Fajar Puteri Rahma Maharani Putra, Hasan Etanov Putri, Meisya Diffa Amalia Putri, Mukarromah Dita Putria, Devy Kasih Putriyani, Shalum Rachmawati, Ellin Rahmasari, Ratika Rahmi Indian Rahmi Indiani Rahmi Zubaedah Rahmi Zubaidah Ramadhani, Rima Putri Ratnasari, Devi Rizky Abdulah Salman Salman Salman Salman Salman Salman Salsabila, Isyana salsabilla, Diva rizqi Sekar Ayu Maharani Septi, Annisa Frastica Septiani, Dia Shadrina, Jahra Almas Sholih, Mally Ghinan Siti Komariah Siti Rohmah Sophy Wulandari Sophy Wulandari Sridevi Anggraini Sudarjat, Hadi Sulastri Sulastri Supryatno, Adi Triana Maudy Yulianti Surasa Tsani Arsy Mura Valensia, Rika Vina Luthfiana Hasna Wahyudin Wahyudin Wardani, Aulia Wildani Zakiyah Windari, Welly Wulandari, Sophy Wulandari, Yulia Eka Yuli Yuliani Yulianti Surasa, Triana Maudy Zahra Nurhafidah Zahra, Aliya Azkia Zahro, Aurora Fatimatuz