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All Journal Jurnal Entropi Sainstek AKADEMIKA Biology, Medicine, & Natural Product Chemistry Jurnal Penelitian Sains JURNAL PENDIDIKAN GLASSER Jurnal Pendidikan Kimia (JPKim) Indonesian Journal of Chemistry Indonesian Journal of Pure and Applied Chemistry Chemistry Indonesian Journal of Chemical Research Dalton : Jurnal Pendidikan Kimia dan Ilmu Kimia Jambura FIsh Processing Journal Jambura Journal of Educational Chemistry Jambura Journal of Chemistry Jurnal Riset Pendidikan Kimia (JRPK) Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Stannum : Jurnal Sains dan Terapan Kimia SPIN: Jurnal Kimia & Pendidikan Kimia Jurnal Kolaboratif Sains CHEDS: Journal of Chemistry, Education, and Science Pentagon: Jurnal Matematika dan Ilmu Pengetahuan Alam Damhil: Jurnal Pengabdian kepada Masyarakat Journal of Community Services on Multidisciplinary Sciences Jurnal Pendidikan Kimia, Fisika dan Biologi Konstanta : Jurnal Matematika dan Ilmu Pengelatuan Alam

Nurhayati Bialangi

Universitas Negeri Gorontalo

Author-ID : 3534105

Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Other

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ISOLASI DAN IDENTIFIKASI SENYAWA METABOLIT SEKUNDER EKSTRAK METANOL DAUN KELOR (Moringa oleifera Lamk.) Yuszda K. Salimi; Nurhayati Bialangi; Saiman Saiman
Akademika Vol 6, No 2 (2017): September
Publisher : LPPM Universitas Muhammadiyah Gorontalo

A study has been conducted on the isolation and identification of secondary metabolite compounds from methorol extract of kelor leaf (Moringa oleifera Lamk.). This study aims to isolate and identify secondary metabolite compounds from leaf kelur methanol extract. Moringa leaf was macerated with methanol and obtained a yield of 16.7% methanol extract. The extract of methanol separated by column chromatography yielded 272 fractions. The fraction was purified and analyzed by thin layer chromatography using eluent n-hexane: ethyl acetate (7: 3) and obtained stain spots with Rf (0.61) and (0.47). Phytochemical results of positive isolates on flavonoids test. The results of identification using UV-Vis spectrophotometry and infrared spectrophotometry is a flavonoid compound. The identification using UV-Vis spectrophotometry yields I absorbing bands at 250 nm wavelength. The absorption at 250 nm wavelength is suspected because of the non-bonding electron transition to the σ anti-bonding orbital (n → σ *) by an unconjugated ausochrome suspected to be a hydroxyl functional (OH) group. Identification using infrared (IR) spectrophotometry showed the presence of a bound OH function group, C = O, C = C aromatic, C-H aliphatic, C -O alcohol and = C-H aromatic. Telah dilakukan penelitian tentang isolasi dan identifikasi senyawa metabolit sekunder dari ekstrak metanol daun kelor (Moringa oleifera Lamk.). Penelitian ini bertujuan untuk mengisolasi dan mengidentifikasi senyawa metabolit sekunder dari ekstrak metanol daun kelor. Daun kelor dimaserasi dengan metanol dan diperoleh rendemen ekstrak metanol 16,7%. Ekstrak metanol dipisahkan dengan kromatografi kolom menghasilkan 272 fraksi. Fraksi dimurnikan dan dianalisis dengan kromatografi lapis tipis menggunakan eluen n-heksan:etil asetat (7:3) dan diperoleh bercak noda dengan Rf (0,61) dan (0,47). Hasil uji fitokimia isolat positif terhadap uji flavonoid. Hasil identifikasi mengunakan spektrofotometri UV-Vis dan spektrofotometri inframerah merupakan senyawa flavonoid. Identifikasi menggunakan spektrofotometri UV-Vis menghasilkan I pita yang menyerap pada panjang gelombang 250 nm. Serapan pada panjang gelombang 250 nm di duga karena adanya transisi elektron yang tidak berikatan ke orbital σ anti-ikatan (n→σ*) oleh suatu ausokrom yang tidak terkonjugasi yang diduga merupakan gugus fungsional hidroksil (OH). Identifikasi menggunakan spektrofotometri inframerah (IR) menunjukkan adanya gugus fungsi OH terikat, C=O, C=C aromatik, C-H alifatik, C−O alkohol dan =C-H aromatik.

Isolasi Dan Identifikasi Senyawa Metabolit Sekunder Ekstrak Etil Asetat Daun Sambiloto Nurhayati Bialangi; Reski Rahmatia Idris; Akram La Kilo; Ahmad Kadir Kilo
Jambura Journal of Chemistry Vol 4, No 1 (2022): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v4i1.11957

Penelitian ini bertujuan untuk mengisolasi dan mengidentifikasi senyawa metabolit sekunder ekstrak etil asetat dari daun sambiloto. Isolasi tersebut dilakukan melalui tahap maserasi, fraksinasi, dan kromatografi. Identifikasi ekstrak tersebut dan isolatnya dilakukan dengan cara uji fitokimia, spektrofotometer-UV Vis, dan IR. Daun sambiloto kering sebanyak 633 gram dimaserasi dengan metanol selama 3×24 jam, dan diperoleh ekstrak kental metanol setelah melalui proses evaporasi. Ekstrak tersebut difraksinasi berturut-turut dengan n-heksana dan etil asetat untuk menghasilkan ekstrak kental etil asetat sebanyak 21,99 gram. Kemudian, ekstrak kental etil asetat dipisahkan dengan kromatografi kolom dan diuji kemurniannya dengan KLT dan diperoleh isolat murni yang berupa kristal putih dengan berat 126,3 mg. Hasil uji fitokimia ekstrak etil asetat menunjukkan bahwa daun sambiloto mengandung flavanoid dan triterpenoid. Sementara, isolat murni yang dihasilkan adalah senyawa triterpenoid. Hasil pengukuran spektrofotometer UV-Vis menunjukkan adanya 2 pita serapan pada panjang gelombang 278 dan 202, dan hasil pengukuran spektrofotometer IR adanya gugus fungsi O-H alkohol pada bilangan gelombang 3426.5 cm-1, C-H alifatik pada bilangan gelombang 2918.1 cm-1 dan 1463.3 cm-1, C=O pada bilangan gelombang 1640.6 cm-1, C=C alkena pada bilangan gelombang 1559.2 cm-1, C-H pada bilangan gelombang 802.5 cm-1 dan 886.4 cm-1, dan C-O alkohol pada bilangan gelombang 1099.6 cm-1 yang menandakan bahwa isolat merupakan suatu senyawa golongan triterpenoid

PENGARUH EKSTRAK BUAH MENGKUDU (MORINDA CITRIFOLIA) TERHADAP PERTUMBUHAN STAPHYLOCOCCUS AUREUS The Effect of Noni Fruit Extracts (Morinda Citrifolia) on Staphylococcus aureus growth RISNAYANTI R DJURAMANG; YULIANA RETNOWATI; NURHAYATI BIALANGI
JURNAL PENDIDIKAN GLASSER Vol 1, No 2 (2017)
Publisher : Fakultas Keguruan dan Ilmu Pendidikan Universitas Muhammadiyah Luwuk

This aim of study was to determine the effect of noni fruit extract on Staphylococcus aureus growth. Indicator is the Bacteria growth of diameter inhibitory zone formed. The study was conducted at the Laboratory of Microbiology, Departement of Biology, State University of Gorontalo. The research method was experimental which consisted of 12 treatments (15%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%) and 2 replicates, and quantitatively analyzed using non-parametric Kruskal Wallis Test. Based on the statistical results indicate that there is influence of noni fruit extract on the growth of Staphylococcus aureus at 15%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, and 50% concentrations, with a diameter of inhibition zone formed by each is 7,87mm, 7,75mm, 8,81mm, 9,62mm, 9mm, 10,44mm, 10,88mm, 12mm, 8,37mm and 12,13mm. This result is evidenced by the Kruskal Wallis 000 ≤ 0,05.Keyword: Growth, Staphylococcus aureus,Extraction, Noni, Inhibitory zones

Antimalarial activity and phitochemical analysis from Suruhan (Peperomia pellucida) extract Nurhayati Bialangi; Moh Adam Mustapa; Yuszda K Salimi; Ari Widiantoro; Boima Situmeang
Jurnal Pendidikan Kimia (JPKim) Vol 8, No 3 (2016): Desember
Publisher : Pascasarjana Universitas Negeri Medan

Abstract. Infectious and parasitic diseases is one of various disease that the most common. Based on data from the World Health Organization (WHO) in 2011, infectious and parasitic diseases become the third largest cause of death in the world. One of the plants that have potential as an antimalarial is suruhan (Peperomia pellucida). The purpose of this study is to test antimalarial activity against Plasmodium falciparum and analysis photochemistry consituen from extract suruhan. Antimalarial activity test using Desjardin method. Extraction was done by using maceration wuth methanol as a solvent and fractionation using partition methods. Results of phytochemical screening revealed the presence of alkaloids, flavonoid, steroid, saponins and triterpenoid test results antimalarial activity fraction of n-hexane, ethyl acetate and water show IC50 values are 12.80, 2.90 and 10.74 mg/ mL respectively.Keyword: Peperomia pellucida, suruhan, antimalarial

Triterpenoid compound from metanol extract of mangrove leaves (Sonneratia alba) and anti-cholesterol activity test Weny J.A Musa; Nurhayati Bialangi; Boima Situmeang; Saronom Silaban
Jurnal Pendidikan Kimia (JPKim) Vol 11, No 1 (2019): April
Publisher : Pascasarjana Universitas Negeri Medan

Mangrove plant (Sonneratia alba) is easily found in West and North Indonesia. Mangrove plant has the potential of being a herb medicine. Mangrove plant variously used in ethnomedicine to treat various deseases like wounds, diarrhea, and fever. In previously sutudy, leaf extract of mangrove plants reported have anti-cholesterol activity. This plant is widely used to treat various deseases like wounds, diarrhea, and fever. The purpose of this study was to isolate triterpenoid compound from the ethyl acetate fraction of mangrove leaves and anticholesterol activity test. Extraction was done by maceration method using methanol 96% as solvent. Isolation was carried out by column chromatography using a combination of n-hexane, ethyl acetate, and methanol solvents. The elucidation of the structure was determined by analysis of IR, 1H-NMR, 13C-NMR, 2D-NMR, and MS spectroscopies as well as by comparisons with the literature. Anticholesterol activity test was carried out in vitro. The results showed that triterpenoid compounds (lupeol) were able to reduce cholesterol from concentrations of 5, 10, 20, 40, 60, and 80 ppm are 13.7; 29.4; 49.0; 60,1; 70.2; and 77.0% respectively. Therefore, isolates compound (lupeol) have anti-cholesterol activity.Keywords:Anti-cholesterol; mangrove; triterpenes

Methanol extract from kesambi (Schleichera oleosa (L.) oken) stem bark as a natural antioxidant to increase crude palm oil (CPO) quality Weny J A Musa; Nurhayati Bialangi; Diky Kurniawan; M Amrin Sunardi; Ninik Triayu susparini; Sriwijayanti Sriwijayanti; Boima Situmeang
Jurnal Pendidikan Kimia (JPKim) Vol 13, No 3 (2021): December
Publisher : Pascasarjana Universitas Negeri Medan

The content of active compounds in methanol extract of kesambi stem bark (Scheleicera oleosa) is known to have good antioxidant activity. Methanol extract of kesambi stem bark contain flavonoid and fenolic compounds. The purpose of this study was to evaluate the methanol extract of kesambi in inhibiting the oxidation of crude palm oil (CPO). In this study, the extraction of kesambi stem bark was carried out with methanol solvent. Antioxidant activity test of methanol extract of kesambi using the DPPH method. The parameters observed were free fatty acids (FFA) values, acids value, and DOBI (Deterioration of Bleachability Index). The used concentration of natural antioxidant were 200; 400; 600; 800 and 1000 ppm. Based on the results of this study, the natural antioxidant of methanol extract of Kesambi stem bark (Schleichera oleosa) can reduce levels of free fatty acid numbers, acid value, and DOBI value. Actioxidant activity methanol extract of kesambi stem bark shown IC50 42.092 ppm. The lowest FFA levels and acid numbers were obtained from samples with addition of 1000 ppm natural antioxidants with free fatty acid (4.1%), acid value (7.7 mg KOH/g) while the DOBI value increased to 1.331. Furthermore, FFA value meets the CPO quality standard, according to SNI-01-2901-2006. Keywords: Crude palm oil, antioxidant, free fatty acid (FFA), acid value

Antibacterial activity and phytochemical screening of Kesambi (Sapindaceae) against Eschericia coli and Staphylococcus aureus Boima Situmeang; Agus Malik Ibrahim; Nurhayati Bialangi; Weny J.A Musa; Saronom Silaban
Jurnal Pendidikan Kimia (JPKim) Vol 11, No 1 (2019): April
Publisher : Pascasarjana Universitas Negeri Medan

Kesambi plant (Schleichera oleosa) is a medicinal plant belongs to family Sapindaceae, commonly found in tropical and subtropical regions of the world. In Indonesia, kesambi plants can be found in Java and Bali island. The purpose of this study is to extraction and antibacterial activity test of steam bark extract of kesambi against Escherichia coli and Staphylococcus aureus. Extraction was done by maceration method using n-hexane, ethyl acetate and methanol. Antibacerial test using Kirby bauer method by measure inhibition zone. Phytochemical screening shown that n-hexane extract contain triterpenes and steroid compounds. Ethyl acetate extract contain triterpenes, flavonoid, steroid, and fenolic compounds. Methanol extract contain flavonoid, fenolic and triterpenes compounds. Inhibition zone of n-hexane, ethyl acetate and methanol extracts against E. coli and S. aureus at concentration of 5000 µg/mL showed 4.4; 7.9; 4.6 mm and 4.7; 8.9; 4.5 respectively, while amoxicillin and ciprofloxacin as positive control at concentration of 100 µg/mL showed 6.9 and 7.1 mm respectively. Kesambi extract have potential as antibacterial against E. coli and S. aureus.Keywords:Kesambi; antibacterial; Eschericia coli; Staphylococus aureus

Analysis Of Protein And Bioactivity Of Nike Fish (Awaous melanocephalus) Extract As Antioxidant Yayurulia Hadju; Yuszda K Salimi; Nurhayati Bialangi; Netty Ino Ischak
Jambura Fish Processing Journal Vol 4, No 2 (2022): VOLUME 4 NOMOR 2, JULY 2022
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jfpj.v4i2.15254

This study aims to determine the protein content and activity of nike fish (Awaous melanocephalus) extract as an antioxidant. Nike fish (amphidromous goby larva) is an endemic fish of Gorontalo which is consumed as food and contains minerals, fats, carbohydrates, amino acids, and high protein. Nike fish extract uses a buffer with several components such as water, Tris HCl 0.1 M pH 8.3, NaCl 2 M, CaCl 0.01 M, 2-Mercaptoethanol 1%, and Triton X-100 0.5%. Based on qualitative analysis, Nike fish protein extract was positive through biuret, ninhydrin, xantoproteate, and Pb sulfide tests. Judging from the quantitative analysis, nike fish extract using the biuret method using UV VIS and TVB-N spectrophotometers obtained 47.60% and 0.098%, respectively. The antioxidant activity of nike fish extract using the DPPH method (1,1-diphenyl-2-pycryhydrazyl) was 20.29 mg AEAC/g (Ascorbic acid Equivalent Antioxidant Capacity). IC50 (Inhibitory Concentration) is 520 ppm at low levels but has potential as an antioxidant.

Aktivitas Antioksidan Senyawa Metabolit Sekunder Ekstrak Metanol Daun Ketapang (Terminalia catappa L.) Yuszda K Salimi; Jumarni Kamarudin; Netty Ino Ischak; Nurhayati Bialangi
Jambura Journal of Chemistry Vol 4, No 2 (2022): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v4i2.11618

Daun ketapang (Terminalia catappa L.) merupakan tumbuhan pesisir pantai yang memiliki kandungan senyawa metabolit sekunder yaitu flavonoid, alkaloid, steroid, saponin dan tanin yang berpotensi sebagai antioksidan. Penelitian ini bertujuan untuk mengisolasi senyawa metabolit sekunder daun Terminalia catappa L. dan menguji aktivitas antioksidannya. Metode penelitian eksperimen laboratorium kuantitatif dan kualitatif meliputi ekstraksi, isolasi dan identifikasi senyawa metabolit sekunder menggunakan spektrofotometer FTIR, penetapan total kadar flavonoid dengan spektrofotometer UV-Vis, dan uji aktivitas antioksidan menggunakan metode DPPH. Hasil uji fitokimia ekstrak metanol mengandung senyawa flavonoid, steroid, saponin, tanin dan isolat menunjukkan hasil positif senyawa flavonoid. Hasil identifikasi menunjukkan keberadaan gugus fungsi flavonoid dengan adanya pita serapan seperti O-H, C-H aromatik, C-H alifatik, C=O aromatik, C=C aromatik dan C-O alkohol. Hasil pengukuran total kadar flavonoid sebesar 114,65 mgQE/g. Nilai aktivitas antioksidan ekstrak metanol sebesar 460,37 mg AEAC (Ascorbic Acid Equivalent Antioxidant Capacity) /g dan isolat diperoleh sebesar 19,62 mg AEAC/g.

Evaluation of the Antiplasmodial Properties of Andrographis paniculata (Burm.f.) and Peperomia pellucida (L.) Kunth Nurhayati Bialangi; Mohamad Adam Mustapa; Yuszda Salimi; Weny Musa; Ari Widiyantoro; Agus Malik Ibrahim; Boima Situmeang; Julinton Sianturi
Indonesian Journal of Chemistry Vol 23, No 1 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.74481

Plasmodium species are the infectious agents that are responsible for malaria, a disease that claims the lives of approximately 400,000 people annually. The fact that drug resistance against malaria is on the rise suggests that new antimalarial compounds need to be discovered. It is well known that medicinal plants present the best opportunity for the identification of novel antimalaria chemicals. Both the Andrographis paniculata (Burm.f.) and Peperomia pellucida (L. Kunth) species have been tested for their antiplasmodial ability against the Plasmodium falciparum strain. The P. pellucida (L. Kunth) species has also been subjected to in vitro and in vivo biological research. P. pellucida was used to isolate the steroid known as 3-hydroxy-24-ethyl-5,22-cholestadiene (1) and the triterpenoid known as 3-hydroxy-9-lanosta-7,24E-dien-26-oic acid (2). Both compounds were then tested for their activity in vitro. In the mice model, triterpenoid 2 had a substantial chemo-suppressive impact.

Co-Authors Agus Malik Ibrahim Agus Malik Ibrahim Ahmad Fajar Muzakir Ahmad Kadir Kilo Ahmad, Halid S. Akram La Kilo Anggraini Dj Usman Ari Widiantoro Ari Widiyantoro Arviani Arviani Arviani Arviani, Arviani Astin Lukum Boima Ramses Situmeang Boima Situmeang Boima Situmeang Botutihe, Deasy N. Deasy Natalia Botutihe Diky Kurniawan Djalil, Jhodi Pratama Djalil, Moh. Rifaldi Dzulhijar Eka Puspita Sari Erga Kurniawati Erni Mohamad Faradin, Faradin Fauziah, Eka Donna giu, fitri ani Hadji, Fitri Halalutu, Hamdan Halalutu, Hamdan Haleda, Padria Haris Munandar Hendri Iyabu Hidayatullah, Ryan Holisha Widiyanto Ibrahim, Agus Malik Ibrahim, Agus Malik Ishak Isa Isna Lailatusholihah Jafar La Kilo Jinanti, Nazwa Julhim S Tangio Julhim S Tangio Julhim S. Tangio Juliandoz Julinton Sianturi Jumarni Kamarudin Kupang, Sri Revayana La Alio La Alio La Ode Aman Lailatusholihah, Isna Lailatussholihah, Isna Laliyo, Lukman Lintang Panji Setyoko Lintong, Kristin Lisdawati N. Umar Lukman A. R. Laliyo M Amrin Sunardi Mangara Sihaloho Mardjan Paputungan Marsya Divya Olii Masrid Pikoli Meli A. Rasid Miftahul Nur Moh Adam Mustapa Mohamad Adam Mustapa Muhridja, Melisa Mulyadi, Agus Musa, Weni J.A Musa, Weny J.A. Mustafid, Afif Hidayatul Najmah, Najmah Nani Yulianti Netty Ino Ischak Ngabito, Putri Amalia Nilda Apriyati Tengo Ninik Triayu Susparini, Ninik Triayu Nita Suleman Nona Wingti Posangi Nur Rafida Akub Nur Riska Apriana Nur, Dian Nurfadilah M. Kasim Nurkhaliq, Nurkhaliq Nurlaela Abd. Kadir Ode, Nur Mei Yulianty Olii, Marsya Divya Pakaya, Agustina H. Paputungan, Fadilah Alawiya Parulian, Boima Ramses Perry Zakaria R Tulie, Wina Zulviana Ramadhan, Muhammad Bagus Reski Rahmatia Idris Rifki Brahmono Idrus Risnayanti R Juramang Rustam I. Husain Sahami, Ulin Saiman Saiman Samosir, Andeston Sumandoli Saronom Silaban Setiyandani, Kurnia Indah Setyoko, Lintang Panji Situmeang, Boima Sri Wijayanti Sriwijayanti Sriwijayanti Sriwijayanti, Sriwijayanti Stasya Anggriani Talib Suleman Duengo Sumarlin Soleman Susparini, Ninik Triayu Susvira, Dian Thayban, Thayban Wenny J A Musa Weny J.A Musa Weny J.A Musa Weny JA Musa Weny Musa Widiyanto, Holisha Widy Susanti Abdulkadir Wiwin Rewini Kunusa Wiwiyani, Wiwiyani Yayurulia Hadju Yuliana Retnowati Yusuf, Risciana Yuszda K Salimi Yuszda K. Salimi Yuzda K Salimi

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