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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Proceeding International Conference on Global Resource Conservation ELINVO (Electronics, Informatics, and Vocational Education) Edu Sains: Jurnal Pendidikan Sains dan Matematika QUANTUM: Jurnal Inovasi Pendidikan Sains Journal of Geoscience, Engineering, Environment, and Technology Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Moral Kemasyarakatan Jurnal SOLMA Al-Madrasah: Jurnal Ilmiah Pendidikan Madrasah Ibtidaiyah Anterior Jurnal Pedagogik: Jurnal Pendidikan PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Bitnet: Jurnal Pendidikan Teknologi Informasi JURNAL PENDIDIKAN MIPA Bio-Inoved : Jurnal Biologi-Inovasi Pendidikan Bubungan Tinggi: Jurnal Pengabdian Masyarakat BioEksakta : Jurnal Ilmiah Biologi Unsoed Journal of Banua Science Education LEARNING : Jurnal Inovasi Penelitian Pendidikan dan Pembelajaran Jurnal Sylva Lestari Jurnal Keilmuan dan Keislaman Scientica: Jurnal Ilmiah Sains dan Teknologi JIM: Jurnal Ilmiah Mahasiswa Pendidikan Sejarah HJSE Kayuh Baimbai: Jurnal Pengabdian Masyarakat Konstruktivisme : Jurnal Pendidikan dan Pembelajaran LEADERIA : Jurnal Manajemen Pendidikan Islam International Journal of Universal Education Jurnal Perspektif Penelitian Pendidikan Tunas: Jurnal Pendidikan Guru Sekolah Dasar
Fathul Zannah
Universitas Muhammadiyah Palangkaraya
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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Exploration of the Potential of Local Plants of Melastoma malabatchricum Fruit for Food Fortification: Potential of Local Plants of M. malabatchricum Fruit for Food Fortification fathul zannah; Kamaliah; Pramudiyanti; Ayatusaadah; Nurul Hadayati
Journal of Tropical Life Science Vol. 12 No. 3 (2022)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.12.03.06

Abstract

Endurance can be increased by maintaining nutritional intake, one of which is by consuming local plants such as Melastoma malabatchricum  Fruit. This study aims to explore the nutritional content of Melastoma malabatchricum  fresh fruit, flour and processed products from the flour. This research was conducted at the Baristand Laboratory of the Banjar Baru Industrial Center, South Kalimantan. The results showed that flour and processed products from Melastoma malabatchricum  flour had higher nutritional content than fresh Melastoma malabatchricum  fruit. Nutritional content of Melastoma malabatchricum  flour are cal, ca, Fe, Water, Ash, Fat, Protein and Carbohydrate. These results indicate that Melastoma malabatchricum  has the potential to be developed as an ingredient for food fortification.
Computational Study of Flavonoid Compounds from Diplazium esculentum as Potential Anti-Acne Agents through Molecular Docking and ADMET Analysis Zannah, Fathul; Fajeriyati, Nurul
Journal of Tropical Life Science Vol. 16 No. 01 (2026)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.16.01.15

Abstract

Acne vulgaris is a common skin disorder influenced by multiple biological factors, including hormonal regulation, microbial activity, and inflammatory processes. The overactivation of androgen-regulated pathways contributes to excessive sebum production, which plays a central role in acne development. Although synthetic anti-acne drugs are widely used, their prolonged application may cause adverse effects, prompting growing interest in natural compounds as alternative therapeutic candidates. Diplazium esculentum, a medicinal fern traditionally used in Indonesia, has been reported to possess antibacterial activity; however, its molecular potential as an anti-acne agent remains insufficiently explored. This study aims to computationally investigate flavonoid compounds derived from Diplazium esculentum as potential anti-acne agents by evaluating their molecular interactions and pharmacokinetic properties. The research focuses on a molecular docking approach combined with pharmacokinetic and toxicity prediction to provide preliminary insights at the molecular level. Flavonoid compounds identified from liquid chromatography–mass spectrometry profiling, including apigenin, genistein, daidzein, and naringenin, were selected as ligands for computational analysis. Molecular docking simulations were performed to predict the interaction between these compounds and the androgen receptor, a key molecular target associated with hormone-regulated sebum production. In addition, pharmacokinetic and toxicity properties were evaluated using in silico absorption, distribution, metabolism, excretion, and toxicity prediction tools to assess drug-likeness and safety profiles. The results demonstrated that all evaluated flavonoids exhibited favorable binding interactions within the ligand-binding domain of the androgen receptor, with interaction patterns comparable to those of a reference compound. Pharmacokinetic predictions indicated acceptable absorption characteristics and low toxicity risk for the selected flavonoids. In conclusion, this computational study highlights the potential of flavonoid compounds from D. esculentum as promising natural candidates for anti-acne applications. The findings support the use of molecular docking and pharmacokinetic prediction as effective preliminary approaches for exploring drug potential and provide a scientific basis for further experimental validation.
Co-Authors A'yuni, Qurrota Abdurrahman, Shemsu Gupta Ade S Permadi Ade Salahudin Permadi Agung Riadin Ahmad Jauhari Ahmad Syarif Alpian Amelia Dwi Astuti Amisyah, Siti Aprilia, Agnes Arna Purtina Asep Solikhin Ayatusaadah Ayatusaadah Ayu Purnama, Sari Banjir Banjir, Banjir Beni Iskandar Betty Lukiati Binadari, Fairuz Andhira Chandra Anugrah Putra Dian Novian Didy Murjani Dwi Sari Usop, Dwi Sari Dwi Setyo Astuti Endang Wahyudi Erliantie, Erliantie Ervawaty Ervawaty Ervawaty, Ervawaty Esty Aryani Safithry Fajeriyati, Nurul Fazakkir Noor Gultom, Norita Gusti Nida Nurkhaliza Gusti Nida Nurkhaliza Hadi Suwono Haen Haen Hamsi Mansur Hariyatmi Hariyatmi Hidayat, Ahmad Iqbal Hunainah Hunainah Iin Nurbudiyani Imelda Indah Sari Dewi Iskandar, Beni Kamaliah Kurnia, Adib Ahmad Lanna Musna Sananta Luthfia Noorannisa Mahmud, Randy Saputra Mellawen Mohamad Nor Aufa Mohammad Nor Aufa Muh Azhari Muhammad Andi Setiawan Muhammad Luthfi Hidayat Muhammad Noor Fitriyanto Muhammad Qamaruddin Muqor Rama Hasanah Musarapah, Zidnatul Ni'mah, Nurun Noormaliah, Noormaliah Norliana, Tanrisa Nur Fajariah Nurul Hadayati Nurul Hikmah Kartini Patni, Patni Permadi, Ade Shalahuddin Prabawati, Ratna Pramudiyanti Prastyo, Dwi Putra, Candra Anugerah Rahmatullah Rahmatullah Rifqi Ansari Rita Rahmaniati Rohman, Rizky Habibur Rosdiani, Feny Rose, Een Sabela, Windari Saidah Sapari, Alpian Sari Dewi, Indah Selia, Selia Siska Hairiyanti Siska Siti Arnisyah Siti Nur Aisyah Sitorus, Mido Ester Sofyan Anif Sri Hayati, Sri Suci Nanda Suhendie, Denni Syahbana, Rezky Aulianur Syahrorini, Syamsudduha Syarif , Ahmad Syarif, Ahmad Syarif Tazkiyatunnafs Elhawwa Tukilah Tuti, Puji Indias Utomo, Eko Cahyo Wagiran Wagiran Warnida, Yenny Widyasari, Dinda Wndari Sabella Yaya, Erni Yudha Adrian, Yudha