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Journal : Universa Medicina

Combination of three species of Zingiberaceae prevents doxorubicin-induced hepatotoxicity Heny Ekowati; Sarmoko Sarmoko; Retno Widiastuti
Universa Medicina Vol. 32 No. 1 (2013)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2013.v32.11 - 19

Abstract

BACKGROUND Doxorubicin as an anticancer drug has hepatotoxic side effects. Curcuma xanthorrhiza, Curcuma longa and Zingiber officinale are commonly used as herbals in Indonesia and around the world. Several compounds in these plants have antioxidant activities and are known to exhibit protection against doxorubicin-induced toxicities. This study aimed to observe the hepatoprotective effect of a combination of C. xanthorriza, C. longa, and Z. officinale extract on doxorubicin-induced hepatotoxicity in rats. METHODS A total of 28 Wistar male rats were divided into four groups: 1) control group (0.9% NaCl); 2) doxorubicin 5 mg/kg intraperitoneally (ip) four times in 14 days (days 1, 5, 9, 13); 3) doxorubicin + combination of C. xanthorriza, C. longa, and Z. officinale (temulawak, kunyit, and jahe merah, designated as Tekuja) 250 mg/kg/day orally for 14 days; and 4) doxorubicin + Tekuja extract 500 mg/kg/day orally for 14 days. Measurements of parameters based on liver histopathology and the parameters of serum alanine amino transferase (ALT) and aspartate amino tranferase (AST). RESULTS Doxorubicin caused significant elevation in serum ALT and AST enzymes after 14 days of treatment. Rats treated with doxorubicin + Tekuja extract 250 mg/kg/ day showed no histological changes, but had decreased levels of ALT and AST. CONCLUSION This study indicates that the combination of C. xanthorriza, C. longa, and Z. officinale has a protective effect in rats against liver damage induced by doxorubicin
Co-Authors . Anindyajati Abdul Karim, Dewi Damayanti Achmad Baihaqi Ulma Adam Hermawan Adinda Salsabila Aditya Fitriasari Aditya Fitriasari Afif Hariawan Pratama Agung Endro Nugroho Agustin, Lanita Alsadila, Kalista Anandar, Salsabila Fauziah Anindyajati Anindyajati Anjar Hermadi Saputro Aprilia, Vika arif ashari Asrada, Syahdan Bama Tangguh Galih Binar Asrining Dhiani Cahyadi, Dzaky Raihan Charisa Nabirawati Sitindaon Choironi, Nur Amalia Dalili Akhmad, Atika Dika Pramita Destiani Dirga Dirga Dirga Dito Aditya Sasongko Dwi Aulia Ramdini Dyaningtyas D. P. Putri Dyaningtyas Dewi P. Putri Dyaningtyas Dewi Putri Pamungkas Edy Meiyanto Edy Meiyanto Endah Puspitasari Erna Harfiani Fadlan, Arif Fadlan, Arif Fareza, Muhamad Salman Farhan Fauzan Fauziyya, Riri Fazila, Safia Febrian, Dicky Rizky Fischellya, Dafi Hakim, Ahmad Zammi Autadan Hanif Nasiatul Baroroh HENDRI WASITO Heny Ekowati Hidayaturahmah, Rizky Ihsanti Dwi Rahayu Ingeswari, Aulya Vidiana Irna Windari, Nurul Joko Setyono Joko Setyono Khozin, Muhamad Nur Kireine Kosma Ramadhani Maharani, Putu Audi Mas Mardi Santoso Maulana Malik Mayefis, Delladari Meiyanto, Edy Muhamad Salman Fareza Muhammad Iqbal Muhammad Salman Fareza Muhammad Yogi Saputra Mukaromah Khoirunnisa, Sudewi Mustikaningtyas, Ika Nabila, Novrilia Atika Nabila, Sofia Zahra Nadiah, Syaadatun Nisa Yulianti Suprahman Novrilia Atika Nabila Nugraha, Yudhi Nugraheni, Zjahra Vianita Nur Adliani Nur Amalia Choironi Nur Ismiyati Nur Ismiyati Oktariza, Yasinda Pamungkas P, Dyaningtyas Dewi Pane, Esteria Christina Pangestu, Maryo Adjie Purwanata, I Gede Raditya Putra, Okta Nama Rahayyu, Annisa Maulidia Ramadhan Triyandi Ratna Asmah Susidarti Refsya Azanti Putri Rehana, Rehana Retno Wahyuningrum Retno Widiastuti Rifki Febriansah Rifki Febriansah Rispriandari, Aulia Ayu Rooswita, Putri Amelia Safei, Imam Samudra, Genta Hafied Naga Sekar Cahyo Nurani Setiyabudi, Lulu Silvia Damayanti Siregar, Fajri Marindra Sukrasno Sukrasno Syahjoko Saputra, Iwan Tantri Liris Nareswari Tri Warsito Tri Warsito Tri Warsito Tria Putriani Triyadi Hendra Wijaya Tuti Sri Suhesti Uswatun Hasanah Vigo Atsil Nugraha Wenda Reka Pratama Wibowo, Muhammad Rizky Windari, Nurul Irna Winni Nur Auli Wisesa, Sindhu Yudhi Nugraha Yulianto, Akbar Zahra, Miralda Ziske Maritska Zusela, Titah