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All Journal JURNAL PENELITIAN SAINTIKA JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Jurnal Hasil Penelitian Industri Jurnal Surya Medika Jurnal Biologi Tropis AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT PREPOTIF : Jurnal Kesehatan Masyarakat Science Midwifery Journal of Pharmaceutical and Health Research Indonesian Journal of Chemical Science and Technology Jurnal Kesehatan Tambusai Jurnal Farmanesia IKA BINA EN PABOLO : PENGABDIAN KEPADA MASYARAKAT Journal of Health and Medical Science International Journal of Health and Pharmaceutical (IJHP) Jurnal Farmasi Klinik dan Sains Cross-border Eduvest - Journal of Universal Studies Jurnal Pengabdian West Science FARMASAINKES PCJN Pharmaceutical and Clinical Journal of Nusantara Usada Nusantara: Jurnal Kesehatan Tradisional Jurnal Ilmu Kesehatan dan Gizi Journal of Pharmaceutical and Sciences. Medic Nutricia : Jurnal Ilmu Kesehatan Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Indonesian Journal of Science and Pharmacy Jurnal Bakti Nusantara
Anny Sartika Daulay
Universitas Muslim Nusantara Al Washliyah, Medan
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Kandungan Vitamin C dan Uji Aktivitas Antioksidan Teh Herbal Kombucha Daun Bidara (Ziziphus mauritiana Lam) Siagian , Anggi Yani; Yuniarti, Rafita; Daulay, Anny Sartika; Pulungan , Ainil Fithri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.880

Abstract

Background: Bidara leaves (Ziziphus mauritiana Lam.) have long been used in traditional medicine due to their bioactive compounds, such as flavonoids, tannins, and vitamin C. Fermenting bidara leaves into kombucha has the potential to enhance antioxidant activity through bioconversion processes carried out by starter microbes (Acetobacter xylinum and Saccharomyces cerevisiae). However, scientific data regarding the vitamin C profile and antioxidant activity of bidara leaf kombucha remain limited. Objective: This study aims to analyze the vitamin C content and antioxidant activity of bidara leaf herbal kombucha, as well as to characterize the quality of the simplisia based on the Indonesian National Standard (SNI) 4324:2014. Methods: This descriptive study involved: (1) preparation of bidara leaf simplisia, (2) 12-day kombucha fermentation, (3) phytochemical screening, (4) determination of vitamin C content using UV-Vis spectrophotometry (λ = 266 nm), and (5) antioxidant activity assay using the DPPH method (λ = 517 nm). Results: The bidara leaf simplisia met the SNI quality standards, with a moisture content of 5.33% and a total ash content of 6.73%. Phytochemical screening identified the presence of flavonoids, saponins, tannins, glycosides, steroids/triterpenoids, and alkaloids. The vitamin C content of the kombucha was 0.009 mg/g, while the IC₅₀ value for antioxidant activity was 621.2158 µg/mL, which falls into the weak category. Conclusion: Bidara leaf kombucha contains bioactive compounds and vitamin C, with weak antioxidant activity. Fermentation increases antioxidant activity compared to non-fermented bidara tea infusion (IC₅₀ = 1129.0069 µg/mL), although it remains lower than that of pure vitamin C (IC₅₀ = 3.0710 µg/mL).
Determination of Total Alkaloid Content of Raru (Cotylelobium lanceolatum Craib) Bark Extract Using UV-ViS Spectrophotometry Method andriani, cici; Daulay, Anny Sartika; Ridwanto, Ridwanto; Nasution, Haris Munandar
Indonesian Journal of Science and Pharmacy Vol. 1 No. 1 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i1.10

Abstract

The raru plant (Cotylelobium  lanceolatum Craib) comes from the Dipterocarpaceae family. Raru bark is usually added to the wine to enhance the taste of the wine. raru bark has antidiabetic compounds as a lowering of sugar levels in the blood. The purpose of this study was to determine the alkaloids in the Raru plant (Cotylelobium   lanceolatum  Craib) and to determine the total alkaloid content found in the Raru plant (Cotylelobium  lanceolatum  Craib). The extraction method used is the maceration extraction method using methanol solvent with various concentrations which is then evaporated with a rotary evaporator. Whereas the quantitative test was carried out by means of the viscous extract obtained by adding 2 mL of Phosphate buffer with a pH of 4.7, 2 mL of bromocresol green (BCG), and measured at a wavelength of 272.705 nm. The yield of the extract from a concentration of 95% was 23.0779%, a concentration of 70% was 21.2144%, a concentration of 50% was 20.3274%. The correlation equation obtained from the caffeine curve is y = 0.0508X + 0.008 and the value of r = 0.999, and the levels of alkaloids with different extract concentrations. Actual alkaloid content in raru bark methanol extract 95% was 14.9094 ± 0.3697 mg/g, actual alkaloid content in raru bark methanol extract 70% was 10.0472 ± 0.4594 mg/g, actual alkaloid content in extract 50% raru bark methanol was 6.6260 ± 0.803.
Analysis of Sodium Benzoate Content in the Market Soft Beverages Using Uv-Vis Spectrophotometry Method Akbar, Windi Hari; Pulungan, Ainil Fithri; Ridwanto, Ridwanto; Daulay, Anny Sartika
Indonesian Journal of Science and Pharmacy Vol. 1 No. 1 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i1.15

Abstract

Sodium benzoate is one of the preservatives that are permitted to be used in food and beverages. Research has been carried out with the aim of knowing that carbonated drinks contain the preservative sodium benzoate, knowing the amount of sodium benzoate in soft drinks and to find out the levels of sodium benzoate in soft drinks fulfilling the maximum usage requirements according to BPOM RI Head Regulation No. 36 of 2013. This study used the uv-vis spectrophotometry method. To determine the preservative content of sodium benzoate, a qualitative test was first carried out on the sample using the color reaction method and esterification test. To determine the levels using a UV-Vis spectrophotometer at a wavelength of 269 nm with ethanol p.a as a solvent. The results of the qualitative test using the color reaction method showed that the three samples of soft drinks positively contained the preservative sodium benzoate. To validate this, an esterification test was carried out on the three samples and they produced the smell of Ambon bananas which proved that the three samples positively contained sodium benzoate. For the quantitative test using the Uv-Vis spectrophotometry method at a wavelength of 269 nm using ethanol p.a as a solvent. The results of the analysis showed that the preservative content of sodium benzoate which was calculated for each sample was for a soft drink sample a: 244.93 ± 19.9349 mg/kg. Soft drinks b: 65.3 ± 0 mg/kg, soft drinks. Soft drinks c: 78.6 ± 13.1291 mg/kg. Based on these results, it can be concluded that the levels of sodium benzoate in samples A, B, and C met the standard requirements for maximum usage limits, namely not more than 600 mg/kg.
Effect of Extraction Method on Yellow Wood Rendement and Phenolic Content (Arcangelisia flava (L.) Merr) UV-Vis Spectrophotometry Extract of Ethanol Sasnita, Merida; Daulay, Anny Sartika; Ridwanto, Ridwanto; Nasution, Haris Munandar
Indonesian Journal of Science and Pharmacy Vol. 1 No. 1 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i1.25

Abstract

Indonesia is a country rich in biodiversity. With the wealth of natural resources, there is very much that can be used from flora and fauna to treat various diseases, yellow wood is one of the plants that have medicinal properties and has not been widely studied, yellow wood is efficacious as antimicrobial, antioxidant, antihyperlipidemia, and anticancer. The objective of this study was to determine the class of chemical compounds found in simplicial and extracts of yellow wood plants and to determine the effect of extraction methods on the yield and phenolic levels of ethanol extracts of yellow wood plants. The stages of this research include processing plant materials, making maceration extracts and socletation of yellowwood plants, examination of characteristics, phytochemical screening and determination of total phenolic levels of ethanol extract 96% maceration and socleation of yellow wood (Arcangelisia flava (L.) Merr) by UV-Vis Spectrophotometry method. The highest yield research results are found in the maceration extract yield, this is because the maceration process time is shorter than the socleation process, so that the compound withdrawal process carried out by maceration is more optimal than the socleation method. In addition, the more solvent used, the more extracts produced. The determination of total phenolics is performed by determining the maximum wavelength of gallic acid using UV-Vis spectrophotometry methods. Yellowwood maceration ethanol extract has a total phenolic content of 22.0087 ± 0.8567 mg GAE/g and socleation extract has a total phenolic content of 18.2023 ± 0.1434 mg GAE/g.
Determination Of Total Alkaloid Content Of Yellow Wood (Arcangelisia flava (L.) Merr) Extract Based On Differences In Ethanol Concentration Using Uv-Vis Spectrophotometry Method Yuliana, Rika; Daulay, Anny Sartika; Ridwanto, Ridwanto; Rahman, Fathur
Indonesian Journal of Science and Pharmacy Vol. 1 No. 2 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i2.27

Abstract

Yellow wood with its secondary metabolites is one of the plants that has the potential as a traditional medicinal plant to treat various diseases, such as cancer. The chemical compounds contained in yellow wood are alkaloids, saponins, tannins, flavonoids, steroids/triterpenoids. The objective of this research was to determine the chemical compounds contained in ethanol extract and determine the total alkaloid value of yellow wood extract. This research method is an experimental method which includes processing plant materials, making ethanol extract concentrations of 50, 70 and 96%. Characterization examination, phytochemical screening and determination of total alkaloid levels of yellow wood extract by Uv-Vis spectrophotometry method. The results of phytochemical screening on yellow wood ethanol extract contain chemical compounds such as alkaloids, saponins, tannins, flavonoids, steroids/triterpenoids. Determination of total alkaloid levels is carried out by determining the maximum wavelength of caffeine, measuring the kaffein calibration curve and calculating total alkaloid levels using the Uv-Vis spectrophotometry method. Results The determination of total alkaloid levels in ethanol solvent extract concentration of 50% is 2.9649 ± 0.1767%, ethanol solvent extract with a concentration of 70% is 6.0180 ± 0.2469% and ethanol solvent extract with a concentration of 96% is 10.92001 ± 2.7803%.
Simultaneous Solubility Analysis of Paracetamol, Propyphenazone, and Caffeine Using Principal Component and Absorbance Ratio Regression Methods Rosaldi, Hikmah; Pulungan, Ainil Fithri; Ridwanto, Ridwanto; Daulay, Anny Sartika
Indonesian Journal of Science and Pharmacy Vol. 1 No. 2 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i2.39

Abstract

Medicines can cause changes in the physiology or psychology of an organism when consumed. In general, medicines consist of several mixtures of active ingredients such as paracetamol (PCT), propifenazone (PRO), and caffeine (KAF), which are often found in several types of branded medicines that are claimed to be able to cure or treat. This research aims to obtain a type of solvent that has the smallest photometric error value and can completely dissolve the active ingredient mixture of PCT, PRO, and KAF. In general, organic solvents such as ethanol and methanol are very often used to dissolve compounds that mix with each other, but these solvents cannot always dissolve other active substances. Therefore, researchers carried out an analysis of several types of solvents that could dissolve the three active ingredients. Solvents that can dissolve perfectly without any specification stage must go through a solvent optimization process. The types of solvents that will be tested are methanol, HCl 0.1N, phosphate buffer pH 7.2, and the ratio of phosphate buffer: methanol (DM) (DM 9:1 pH 7.4), (DM 7:3 pH 7.8), (DM 5:5 pH 8.3), (DM 3:7 pH 8.9), and (DM 1:9 pH 9.6). The results of this research show that the solvent that has the smallest photometric error value and can completely dissolve the three active substances is the DM 7:3 pH 7.8 solvent with a total percentage of 0.0846%, which is the smallest value compared to other solvents that have been optimized.
Characterization and Phytochemical Screening Of Tampala Bajakah Wood (Spatholobus littoralis Hassk) Extract With Methanol and Ethyl Acetate Solvents Alviana, Liya; Ridwanto, Ridwanto; Daulay, Anny Sartika; Rani, Zulmai
Indonesian Journal of Science and Pharmacy Vol. 1 No. 3 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i3.40

Abstract

One of the plants that contains secondary metabolite compounds is Bajakah Tampala wood (Spatholobus littoralis Hassk). The aim of this research is to determine the chemical compounds contained in methanol and ethyl acetate extracts. The stages of this research include processing plant materials, making methanol and ethyl acetate extracts, characterization examinations, and phytochemical screening. Bajakah Tampala wood extract was made using the maceration method using methanol and ethyl acetate. The extract obtained was concentrated using a rotary evaporator. The characterization of Bajakah Tampala sawdust showed that the water content test was 2%, the water soluble juice content test was 7.1%, the ethanol soluble juice content test was 12.05%, the total ash content test was 3.65%. , and testing the ash content that is insoluble in acid was 0.1%. Meanwhile, the results of the phytochemical screening of Bajakah Tampala wood showed that it contained chemical compounds such as alkaloids, flavonoids, saponins, tannins, and steroids and triterpenoids.
Isolation of Chitosan from Lake Toba Freshwater Lobster Shells (Cherax quadricarinatus) Sinaga, Novita Yulianti; Ridwanto, Ridwanto; Daulay, Anny Sartika; Nasution, Haris Munandar
Indonesian Journal of Science and Pharmacy Vol. 1 No. 3 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i3.41

Abstract

Chitosan is an amine polysaccharide that is formed after chitin undergoes a deacetylation process. This compound has a significant role as a natural biopolymer which is polycationic. This research aims to make chitosan from freshwater lobster shells obtained from Lake Toba. The research method is experimental. Includes making chitosan from freshwater lobster shells. The process of making chitosan includes demineralization, deproteination and deacetylation stages. Chitosan was characterized by measuring water content, ash content, yield, solubility, and analysis using an FTIR spectrophotometer. Based on the results of research that has been carried out, it was found that the characteristics of chitosan have a yield value of 50.88%, water content 5.9%, ash content 0.67% and chitosan dissolves in glacial acetic acid. The results of the research show that chitosan has similar functional groups to standard chitosan and the degree of deacetylation is 80.25%. This research has met the chitosan standard (SNI 7949:2013) with a percentage of the degree of deacetylation of chitosan that meets the standard (>60%).
Antibacterial Activity Of Freshwater Lobster Shells (Cherax quadricarinatus) Against Escherichia coli Hafizha, Putri; Ridwanto, Ridwanto; Daulay, Anny Sartika; Nasution, Haris Munandar
Indonesian Journal of Science and Pharmacy Vol. 1 No. 3 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i3.42

Abstract

People still do not utilize freshwater lobster (Cherax quadricarinatus) shells optimally, even though the chitin compound contained in this waste can be modified into chitosan through chemical reactions. Chitosan obtained from freshwater lobster shells can be used as an antibacterial. This study aims to test the antibacterial activity of chitosan from freshwater lobster shell waste against Escherichia coli bacteria. Making chitosan is carried out through three processes, namely, demineralization, deproteination, and deacetylation stages. Then, characterization of the chitosan is carried out, which includes water content, ash content, yield, and solubility. The research results showed that the chitosan obtained in this study was 43.96%, and the degree of deacetylation value of freshwater lobster shell chitosan was 75.11%. Chitosan with a concentration of 0.3, 0.5, 0.7, and 0.9% provides an inhibition zone of 13.5, 15.9, 16.8, and 17.2 mm, respectively, against Escherichia coli. Thus, a concentration of 0.9% chitosan from freshwater lobster shells has better antibacterial activity and is categorized as having strong inhibitory power.
Edukasi Tujuh Langkah Mencuci Tangan Yang Benar Pada Anak TK Jundi Al Imami Namorambe Deli Serdang Dalimunnthe, Gabena Indrayani; Daulay, Anny Sartika; Syahputri, Hindri
Jurnal Bakti Nusantara Vol. 1 No. 1 (2023): Jurnal Bakti Nusantara
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/jbn.v1i1.22

Abstract

Mencuci tangan adalah salah satu kebiasaan kebersihan yang penting untuk diajarkan sejak dini kepada anak-anak. Anak-anak usia TK (Taman Kanak-Kanak) adalah kelompok yang rentan terhadap penyakit karena sistem kekebalan tubuh mereka masih dalam tahap perkembangan. Oleh karena itu, mengajarkan mereka langkah-langkah yang benar dalam mencuci tangan akan membantu mencegah penyebaran penyakit dan menjaga kesehatan mereka. tulisan ini akan membahas mengenai edukasi 7 langkah mencuci tangan yang tepat dan efektif pada anak-anak TK. Pentingnya memberikan pembelajaran kepada anak usia dini tentang cara mencuci tangan dengan metode yang benar yaitu melalui tujuh langkah yang tepat. Edukasi ini bertujuan untuk membentuk kebiasaan sehat, mencegah penyakit, dan memberikan pemahaman kepada anak-anak mengenai praktik kebersihan yang esensial sejak usia dini.
Co-Authors Afrizani, Afrizani Akbar, Windi Hari Ali Djamhuri Alviana, Liya Anugrah, Bayu Asep Trizaldi Asparyzha, Rhyzha Azri, Atika Cici Andriani D. Elysa Putri Mambang Daeng Elysa Putri Mambang Daeng Elysa Putri Mambang Dahnia Ayu Fitria Dalimunnthe, Gabena Indrayani Dalimunthe, Gabena Indriyani Dikki Miswanda Dina Agustia Parlin Dina Suciati Saragih Dinda Sari Utami Eli Handayani Elma Natasya Fadillah, Nike Falah Rambe, Raudhotul Fathur Rahman Fathur Rahman Fatur Rahman fatur Rahman, fatur Fithri Pulungan, Ainil Fitri Mulyani, Fitri FRANSISKA, EVA Gabena Indrayani Dalimunthe H., Fathur Rahman Habibie, Dian Hafizha, Putri Harahap, Siti Salimah Haris Munandar Nasution Haris Munandar Nst Hasanah, Qori Hasrul Abdi Hasibuan Hastri Kholifah Helni Maulida Hindri Syahputri Ihsan Fadhilah Imelda Natasia Br S Meliala Indah Triutami Harahap Irfan Ahmad Dasuki Nasution Lastri Afni Leni Handayani Leni Handayani Lubis, Minda Sari Lulu Ilma Khoirun Nissa M Rayhan Ulmi M. Naufal Rifqi M. Pandapotan Nasution M. Pandapotan Nasution Makhfirah Manik, Umi Chairani Mardhatillah, Wulan Maya Syafira Mayang Sari Ritonga Melati Yulia Kusumastuti Merani Phaustina Lumban Gaol Miranza, Nona Muhammad Amin Nasution Muhammad Hizbullah Muhammad Wahyudi Munthe, Ariska Nabilla, Alfira nasution, Alfina Tri Utami Nasution, Kartika Zsaskia Nasution, Nur Sahadah Nia Novranda Pertiwi Nomi Noviani Nomi Noviani Nur Ainun Nur Hanifah Nur'ain Harahap Nurul Salsa Abya Ritonga Nurul Shaleha Pasaribu, Mesi Wilia Afrima Pasaribu, Mesi Willia Afrima Pulungan, Ainil Fitri Putri Intan Sari Putri Theresia Harianja Rahayu Rahayu Rahmadani Rahmadani Rahmah, Ruhiya Rahmi Ayusasmita Gultom Retno Sekarini Rezky , Deswita Ina Ridwanto Ridwanto Ridwanto Rika Yuliana, Rika Risma Fauziah Pasaribu Rizki, Rahmad Rosaldi, Hikmah Rossa, Aliffa Safrida Safrida Sagita Marina Simatupang Sandika, M Teguh Sarmadansyah Sarmadansyah Sasnita, Merida Sekarini, Retno Selfiani Selfiani Shakila Salwa Shilvia, Fatin Siagian , Anggi Yani Sinaga, Novita Yulianti Siti Rahmasari Sri Murni Sri Wahyuni Supiyani Supiyani Supiyani, Supiyani Syahfitri , Adelya Syahputra, Ricky Andi Syalsabila Putri Syarifah Nadia Tamara Army Tuzzahra, Safira Ulmi, M Rayhan Winda Kesuma Yayuk Putri Rahayu Yayuk Putri Rahayu Yulia Nanda Putri Yuniarti , Rafita Yuniarti, Rafita Ziza Putri Aisyia Fauzi Zulmai Rani