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All Journal Jurnal Veteriner Indonesian Journal of Human Nutrition Jurnal Berkala Epidemiologi Jurnal Media Gizi Indonesia (MGI) Masyarakat, Kebudayaan dan Politik Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Preventia Health Notions Jurnal Ilmiah Universitas Batanghari Jambi Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Journal of Applied Food Technology Jurnal Kesehatan Prima Indonesian Journal of Medicine Journal of Maternal and Child Health Amerta Nutrition Darmabakti Cendekia: Journal of Community Service and Engagements Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Jurnal Aisyah : Jurnal Ilmu Kesehatan Abdimasku : Jurnal Pengabdian Masyarakat Jurnal Layanan Masyarakat (Journal of Public Service) Bakti Cendana: Jurnal Pengabdian Masyarakat Media Gizi Kesmas Journal SAGO Gizi dan Kesehatan Jurnal Kesehatan Tambusai Nutrisia Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Keperawatan Journal of Community Engagement in Health Strada Jurnal Ilmiah Kesehatan (SJIK)
Annis Catur Adi
Departemen Gizi Kesehatan Fakultas Kesehatan Masyarakat, Universitas Airlangga, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Jurnal Preventia

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PENGARUH GLUTAMIN & GLUKOSA UNHIDRAT PADA JUMLAH LIMFOSIT TIKUS MODEL KURANG ENERGI PROTEIN Septa Katmawanti; Bambang Wirdjadmaji; Annis Catur Adi
Preventia : The Indonesian Journal of Public Health Vol 1, No 1 (2016)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (338.859 KB) | DOI: 10.17977/um044v1i1p25-34

Abstract

Abstract: Protein-energy malnutrition condition causes lymphocytes number to decrease which then lead to body's cellular immune system disorders, the condition where patient is more vulnerable to infection. Number of lymphocytes in the body is dependent to some factors, some of them are anti-oxidant, amino acid glutamine and glucose. The aim of his research is to study the effect of L-glutamine and glucose unhidrate administration in rat model of protein-energy malnutrition to the increase of lymphocytes number in the blood. This is an experimental study with Completely Random Design. Sample is malnutrition induced with parched rice for 15 days (n=20). Then some samples are examined to figure out the lymphocytes number after the rate model experience lack of energy and protein. Sample is then divided into four treatment groups, they are: group with normal diet (control), normal diet + L-glutamine, normal diet + glucose unhidrate, and normal diet + L-glutamine + glucose unhidrate. Lymphocytes content is measured again after 10 days. The result of the study shows that number of lymphocytes increase significantly (P<0.05) in the four treatment groups after the intervention compared with number of lymphocytes in the malnutrition induced group. Statistical analysis of the four groups with L-glutamine and glucose unhidrate administered shows significant difference each other (p<0.05). These observations imply that the glutamin and gluocose unhidrat has an effect to the increase of lymphocytes number in the blood.Keywords: Protein-Energy Malnutrition (PEM), lymphocyte, l-glutamine, glucose unhidrateAbstrak: Kondisi KEP menyebabkan penurunan jumlah limfosit yang mengakibatkan gangguan sistem imun seluler tubuh, sehingga penderita menjadi lebih rentan terhadap infeksi. Jumlah sel limfosit pada tubuh dipengaruhi oleh beberapa faktor antara lain keberadaan antioksidan, asam amino glutamin dan glukosa. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian glutamin dan glukosa unhidrat pada tikus model KEP terhadap kenaikan jumlah limfosit darah. Studi ekperimental menggunakan metode Rancang Acak Lengkap. Sampel diinduksi malnutrisi dengan nasi aking (karak) selama15 hari (n=20). Kemudian subsampel diperiksa untuk mengetahui jumlah limfosit setelah tikus mengalami kekurangan energi dan protein. Sampel kemudian dibagi menjadi empat kelompok perlakuan, yaitu kelompok dengan diet normal (kontrol), diet normal + glutamin, diet normal + glukosa unhidrat, dan diet normal + glutamin + glukosa unhidrat. Kadar limfosit diukur kembali setelah 10 hari. Hasil penelitian ini menunjukkan bahwa setelah dilakukan intervensi terdapat kenaikan jumlah limfosit secara bermakna (P<0,05) pada keempat kelompok perlakuan dibandingkan dengan jumlah limfosit pada kelompok induksi malnutrisi. Analisis secara statistik pada keempat kelompok yang diberikan intervensi Glutamin dan glukosa unhidrat menunjukkan bahwa terdapat perbedaan yang bermakna satu sama lain (p<0,05).Kata kunci: Kekurangan Energi Protein (KEP), limfosit, glutamin, glukosa unhidrat
Co-Authors Abdurrahman Ali Adi Pranoto Adinda Nurul Istiqomah Adiningsih, Sri Afifah, Lyna Nur Aisyah Noer Auliyah Madani Pertiwi Al Himny Rusydy, Muhammad Al'aliyyu, Fikriyah Alfian Yusuf Ali Iqbal Tawakal Ali Iqbal Tawakal Ali Iqbal Tawakal Alristina, Arie Dwi Alzha Adila Harisina Amirah Adlia Amirah Adlia Andini Octaviana Putri Anggun Pinasti Ilahi Anisah, Mufidah Anna Smdyah Putri Anna Surgean Veterini Anni Syntya Annisa Lutfiah Annisa Rizky Malichati Annisa Rizky Maulidiana Arina Farmalabitta Annis Arina Mufida Ersanti Arina Mufida Ersanti Ariza, Nahya Rahmatul Asrul Bahar Atsarina Anindya Aulanni'am, Aulanni'am Aulanni’am Aulanni’am Aulia Ramadhani Aulia, Noni Angelina Tazky Bambang Wahjuprajitno Bambang Wirdjadmaji Bambang Wirdjadmaji, Bambang Brilliant Anjar Saputro Calvin Ramadhani Chatarina Umbul Wahyuni Cindhy Pamela Kesuma Claudia Ni Luh Merry Marzeline Damar Rasti Adhika Daniel Christanto Dea Amanda Caressa Deandra Ardya Regitasari Deandra Ardya Regitasari Dewi, Ratna Candra Diah Patria Nuringtyas Dian Puteri Andani Dini Andrias Andrias Dini Ririn Andrias Dominikus Raditya Atmaka Dyah Patria Nuringtyas Edinda Ayu Miranti Elya Sugianti Emyr Reisha Ishaura Endah Bardiati Enny Susanti Eny Qurniyawati Eva Flourentina Kusumawardani Eva Flourentina Kusumawardani Faradillah Rahmy Savitri Faradita Meilinda Wulan Sari Farah Rosyihana Fadhila Farapti Farapti Fariani Syahrul Fathrizqita Aghnia Raudhany Fathrizqita Aghnia Raudhany Febry Dian Permatasari Fifi Nirmala G Firdaus, Salwa Sausan Ghanynafi, Abdullah Hamzah Hamzah Hari Basuki Notobroto Haryana, Nila Reswari Hasanah, Dina Khomariyatul HENI RACHMAWATI Heni Rachmawati Hernita Riski Humaira, Arisya Iga Ayuni Fatmala Iga Ema Dini Ikeu Ekayanti Ikhtiar, Ilham Irfa Ekasanti Irwanto Irwanto Irwanto, Irwanto Isaura, Emyr Reisha Isyana, Deta Oryza Ivan Mahardika Yusuf Jayantini, Hikmah Ervina Junaida Astina Kamila Dwi Febrianti Kartini Kartini Lailata, Irina Lailatul Muniroh Lailia Wahyuliana Lathifah Ilmawati Laura Navika Yamani Lina Nurbaiti Lipu, Yanto Lisda Juniarsy Rahardjo Luki Mundiastuti M. G. Bagus Ani Putra Maharani, Shafira Mahmud Aditya Rifqi Mardiyono Yono Mawaddah, Tsalatsa Aulia Mei Lestari Ika Widyyati Meity Ardiana Melissa Ruslan Merryana Adriani Meyrina Putri Cahyariani Mohammad Fahmi Rasyidi Muamar Afdhal Mahendra Muda, Tasya Shafa Salsabila Mufida Ersanti, Arina Muhammad Atoillah Isfandiari Nabillah Eka Permatasari Nanik Handayani Nelly Setiawaty Nisa, Hisma Zauharotun Novira Dian Rachmadia Nur Mufida Wulan Sari Nuraidah, Lutfi Fajar Nurlaila, Amilenia Nuthathai Sutthiwong Oktaviani, Dhiyah Ariba Purwandini, Septiana Puspitasari, Prastiwi Novia Putra, M.G. Bagus Ani Putri Safrida Rahmawati Putri, Cahya Ramadhanti Rachmad Suhanda Rachmahnia Pratiwi Rahmawati, Siti Irma Rakhmalia Imeldawati Rakhman, Dinis Puspita Ramadhan, Ramadivan Bagus Rasyidi, Mohammad Fahmi Ratna Candra Dewi Rehatta, Nancy Margarita Reza Yuanita Ananta Riris Diana Rachmayanti Rita Ismawati Rita Ismawati Rizky Arifandy Amir Rizma Dwi Nastiti Rofiqoh, Fauzatur Romadhona, Salsabila S R Widya Areta Humaniora Justisia S.Pd. M Kes I Ketut Sudiana . Sakinah Aljuffrie Salisa, Wizara Salma Chalisha Salsabila Muda, Tasya Shafa Santi Martini Sarmanu, Sarmanu Septa Katmawanti, Septa Septyaningrum Putri Purwoto Shabhati, Berliandita Shafira Putri, Maurilla Shrimarti R Devi Sinaga, Niken Ayu Br Siti Nur Husnul Yusmiati Siti Rahayu Nadhiroh Siti Shofiya Novita Sari Siti Shofiya Novita Sari SOETJIPTO . Soetjipto Soetjipto SRI LESTARI Subijanto Marto Soedarmo Subijanto Marto Soedarmo Sukmadewi, Marcella Suryanto Suryanto Suryanto, Suryanto Syafrina Mareta Sari Thom, Fedora Ivena Timbuktu Harthana Tri Ratnaningsih Tri Ratnaningsih Tri Sulistijorini, Hinu Trias Mahmudiono Tsaqifah, Hafizotun Ulfatul Karomah Vetty Silvana Maulida Vidya Anggarini Rahmasari Vidya Anggarini Rahmasari Wening, Damar Maulidina Nur Widati Fatmaningrum Widijiati Widijiati Widjiati Widjiati Widodo Jatim P Widodo Jatim Pudjirahardjo Widyyati, Mei Lestari Ika Wijaya, Vania Alvabella Wizara Salisa Wizara Salisa Wizara Salisa Wizara Salisa Wizara Salisa Wizara Salisa Wizara Salisa Wizara Salisa Yama Dharma Putera Yasmin Muntaza Yeni Susanti Yulia Kurnia Sari Yusmiati, Siti Nur Husnul Yusuf, Alfian