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Yustini Alioes
Fakultas Kedokteran Universitas Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Jurnal Sains, Teknologi dan Kesehatan

 1 
SYNERGISTIC COMBINATION OF JAVA PLUM (SYZYGIUMCUMINI(L.) SKEELS) LEAF EXTRACT AND VITAMIN C ON ASPARTATE AMINOTRANSFERASE AND ALANINE AMINOTRANSFERASE LEVELS IN LEAD ACETATE-INDUCED RAT Ikhsan, M; Rita, Rauza Sukma; Elmatris, Elmatris; Alioes, Yustini; Mahata, Liganda Endo; Almurdi, Almurdi
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 3 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, September 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i3.1708

Abstract

Lead (Pb) is a toxic metal that is used to trigger oxidative stress. Oxidative stress causes damage to organs, especially the liver increasing aspartate aminotransferase (AST) and alanine aminotransferase (ALT). This study aims to determine the synergistic effect of antioxidant as Java plum leaf extract and vitamin C together on lead-induced levels of AST and ALT in rats.This type of research is true experimental research with a randomized posttest-only-control group design. The study used 20 male white rats which were divided into 4 groups. The treatment was carried out for 30 days. The examination for AST and ALT levels using the Micro Lab 300 with the Sample Star method. Data analysis was performed by using One-way Anova and Post Hoc-Turkey HSD.In this study, The results were obtained in the form of a decrease in AST and ALT levels in rats that had been induced lead acetate 40 mg/KgBW by administration of Java plum leaf extract dose 75 mg/KgBW and vitamin C dose 35 mg/KgBW as well as the administration of Java plum leaf extract at a dose of 150 mg / KgBB and vitamin C dose of 75 mg / KgBB with significant influence at the lower dose (p=0,01).It can be concluded that administrating of Java plum leaf extract dose 75 mg/KgBB and vitamin C dose 35 mg/KgBB was effective to protect the liver based on the decrease of AST and ALT levels in rats that had been induced lead acetate dose 40 mg/KgBB
Co-Authors Adrial Adrial, Adrial Aida Fitriana Aliya, Lisana Shidiqqin Almurdi Almurdi amalia Kartika Amelia Amelia Amirah Zatil Izzah Ananda, Abi Awfa Rahman Andree, Azzahra Anggita Anggraini, Syahzalya Anggrainy, Fenty Annisa Pratiwi Asterina Asterina Asterina, Asterina Ayu Ratna Sari Azzati, Normaida Baizura Benni Raymond Catur Hadi Arief Dermawan Chindy Jhonel Putri Deddy Saputra Desmawati Desmawati Desmawati Desmawati Dessy Arisanty Desy Arisanti Desy Arisanti Dia Rofinda, Zelly Dia Dian Pertiwi Dinda Aprilia Dwi Yulia Efendi, Altio Efendi, Altio Efrida Efrida Elmatris , Elmatris Elmatris Sy Elmatris Syamsir Elmatris, Elmatris Elsi Wineri Endrinaldi Endrinaldi , Endrinaldi Eni Rahmi Eti Yerizel Eva Chundrayetti Eva Decroli F, Annisa Maida Fadil Oenzil Fadrian, Fadrian Faradila Faradila Fika Tri Anggraini Harsa Rusda Hasibuan, Imron Martua Hasnah Hasnah Hasnah, Hidayatul Hasnah, Widya Jummatul Hayyumahdania Reswan Hendra Permana Hirowati Ali Husnil Kadri Husnil Wardiyah Indah Febranambela Jovie Irwan Jamsari Jamsari Kartika, amalia Lili Irawati Lily Syukriani Lisma Yendri Lydia Susanti, Lydia M Ikhsan Mahata, Liganda Endo Mentari Artika Merisca Gayatri Ryosa Meska Amelia Putri Miftah Irrahmah Miftah Irramah Murniwati Murniwati Mutya Restu Ayu Nila Kasuma Nining Kurniawati Nurhayati Nurhayati Nursyafi, Fauzan Syarif Prasetio, Ade Prima Astuti Handayani Prima Julistia Pritasa Muthia Ulfa Putri Mira Magistri Putri Mulya Sari Putri, Biomechy Oktomalio Rahmatini . Raihan Afif Salam Ramadhan, Mario Arya Ramadhan, Mario Arya Rauza Sukma Rita Reza, Mohamad Rikarni Rikarni Rima Semiarty Risa Firka Rismawati Yaswir Roslaili Rasyid Rydwan Efendi Saptino Miro Saptino Miro, Saptino Selfi Renita Rusjdi Sheila Jihan Safira Sofina Rusdan Suci Erawati Surya Nelis Susi Susi Susila Sastri Tafdil, Zhafirah Khairunnisa Yenny Mayang Sari Yulia, Dwi Yusri Dianne Jurnalis Yusri, Elfira