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All Journal JURNAL GIZI INDONESIA Jurnal Ilmu Kedokteran (Journal of Medical Science) Majalah Kedokteran Bandung Medical Journal of Indonesia Jurnal Kesehatan Andalas MEDISAINS Jurnal Penelitian Sains Jurnal Kesehatan Manarang Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun Journal of Midwifery Jurnal Respirologi Indonesia Majalah Kedokteran Andalas Andalas obstetrics and gynecology journal Jurnal Ners International Islamic Medical Journal Narra J Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Riset Ilmiah Jurnal Sains, Teknologi dan Kesehatan Media Penelitian dan Pengembangan Kesehatan
Aisyah Elliyanti
1) Nuclear Medicine Division Of Radiology Department, Faculty Of Medicine, Universitas Andalas, Padang, Indonesia 2) Dr. M. Djamil Hospital, Padang, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Potensi Terapeutik Tanaman Andalas (Morus macroura Miq.) sebagai Sumber Antioksidan dan Antiinflamasi : Narrative Review Wulandari, Wulandari; Siregar, Muhammad Abi Ghoffari; Rasya, Salsabila Faiha Wiendra; Husna, Annisaul; Elliyanti, Aisyah
Majalah Kedokteran Andalas Vol. 48 No. 4 (2025): MKA October 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v48.i4.p457-465.2025

Abstract

Latar Belakang: Tanaman Andalas (Morus macroura Miq.) merupakan salah satu tanaman asli Indonesia yang dianggap sebagai maskot Sumatera Barat. Tanaman herbal ini kaya akan senyawa bioaktif. Tujuan: Mengetahui potensi terapeutik dan preventif tanaman andalas sebagai sumber antioksidan dan antiinflamasi. Metode: Pendekatan narrative review, sumber literatur dari Pubmed, Google Scholar, dan Science Direct. Penulis menggunakan kata kunci Morus macroura Miq. atau andalas, potensi terapeutik, antioksidan, antiinflamasi. Kriteria inklusi berupa artikel sesuai dengan tema penelitian, artikel terindeks scopus, serta diterbitkan tahun 2019-2023. Kriteria eksklusi meliputi artikel yang tidak dapat diakses, tidak menjawab jenis review. Hasil: Tanaman andalas berpotensi sebagai antioksidan dengan cara mengurangi indeks stres oksidatif dan meningkatkan pertahanan antioksidan. Tanaman andalas juga berpotensi sebagai antiinflamasi dengan cara menurukan kadar biomarker peradangan dan meningkatkan ekspresi miRNA-223. Kesimpulan: Tanaman andalas berpotensi sebagai sumber antioksidan dan antiinflamasi serta agen terapeutik yang menjanjinkan dalam pengobatan penyakit terkait inflamasi dan stres oksidatif, seperti kolitis ulserativa, kanker, neurotoksisitas, dan lainnya yang memerlukan uji klinis lebih lanjut.
Bacterial Profile and Antimicrobial Resistance Patterns of Pleural Empyema in Pekanbaru Hospitals Yovi, Indra; Safari, Dodi; Syah, Nur Afrainin; Anggraini, Dewi; Hanifah, Zulfa Nur; Shapira, Vanesya Zahrani; Elliyanti, Aisyah
Jurnal Respirologi Indonesia Vol 44 No 1 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i1.590

Abstract

Background: Empyema is a problem worldwide due to its high incidence, mortality, and morbidity rates. So, administering antibiotics is mandatory to treat the disease. It should be sensitive to the causal microorganisms and avoid resistant ones for treatment efficacy. This research aimed to determine bacterial profile and antimicrobial resistance, which can be fundamental foundations for clinical practices in the treatment of patients, especially in Pekanbaru.Methods: This was a cross-sectional study from medical records at Arifin Achmad and Eka Hospitals from January 1, 2015, to December 31, 2022, including culture and antibiotic resistance test results with samples from pleural fluid and antibiotic susceptibility test using VITEK 2.0.Results: A total of 197 pleural fluid specimens were obtained. Gram-negative bacteria were found to be the most prevalent at 79.7%, namely Klebsiella pneumoniae (18.5%), Escherichia coli (12.0%), and Pseudomonas aeruginosa (11.0%). Gram-positive bacteria were found at 12.2%, the most common being Staphylococcus aureus (6.1%) and Enterococcus faecalis (2.0%). Antibiotic sensitivity tests for Gram-negative bacteria showed that amikacin and tigecycline were the most sensitive, and Gram-positive bacteria showed the most sensitivity to linezolid, tigecycline, and vancomycin. The resistance of Klebsiella pneumoniae and Escherichia coli to cephalosporins was 18.5% and 75.0%, respectively. The resistance of Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa to carbapenems was 8.0%, 13.0%, and 53.0%, respectively.Conclusion: Gram-negative is the most common microorganism found in pleural empyema. The resistance of multiresistant bacteria to antibiotics is high and requires supervision to apply appropriate antibiotic administration based on local antimicrobial patterns and the need to strengthen antimicrobial stewardship programs. 
Optimalisasi Terapi Radioaktif Yodium (RAI) pada Kanker Tiroid: Tinjauan Literatur Rasyada, Latifah Aulia; Fardela, Ramacos; Elliyanti, Aisyah
Jurnal Penelitian Sains Vol 27, No 3 (2025)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56064/jps.v27i3.1224

Abstract

Penelitian ini dilakukan untuk mengetahui peran penggunaan Yodium-131 dalam pengobatan kanker tiroid. Penelitian ini merupakan tinjauan literatur pada 10 artikel penelitian yang telah dipublikasikan dalam 10 tahun terakhir. Sumber informasi yang digunakan di ambil pada data publikasi Science Direct, Elsevier, Google Scholar, dan PubMed. Hasil dari beberapa penelitian menunjukkan bahwa radioaktif yodium (RAI) sangat berperan penting dalam pengobatan di bidang kedokteran nuklir terhadap pasien yang didiagnosis dengan tipe tiroid terdiferensiasi (DTC), papillary thyroid carcinoma (PTC), oncocytic carcinoma (OCA), dan follicular thyroid carcinoma (FTC). Dalam pengobatan RAI, diperlukan perhatian terhadap faktor risiko yang meliputi besar dosis yang diterima, fungsi kelenjar tiroid yang tersisa, dan aktivitas kumulatif yang diberikan sepanjang hidup pasien. Penerapan RAI yang benar dan tepat akan membantu pasien dalam pengobatan berbasis kedokteran nuklir, meningkatkan tingkat kelangsungan hidup pasien, serta meminimalkan risiko efek samping. Dengan demikian, pemahaman yang lebih baik tentang penerapan dan regulasi dosis RAI sangat penting untuk meningkatkan hasil pengobatan kanker tiroid.
Peran Mekanisme Apoptosis dan Autophagy Pada Ketuban Pecah Dini: Tinjauan Sistematis Studi Klinis dan Pre-Klinis Arvan Syahruddin; Aisyah Elliyanti; Donel Suheimi; Mohamad Reza
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.54125

Abstract

Ketuban Pecah Dini (KPD) merupakan kondisi obstetri multifaktorial yang berkontribusi signifikan terhadap persalinan prematur dan morbiditas neonatal. Bukti terbaru menunjukkan bahwa disregulasi apoptosis dan autophagy berperan penting dalam melemahnya integritas membran ketuban. Tujuan tinjauan sistematis  ini bertujuan untuk menganalisis peran jalur apoptosis dan autophagy dalam patogenesis KPD berdasarkan temuan studi klinis dan pre-klinis. Metode tinjauan sistematis dilakukan  mengikuti pedoman PRISMA dengan pencarian pada database Google Scholar, PubMed, Taylor & Francis, dan Science Direct untuk publikasi tahun 2015–2025. Seleksi artikel menggunakan kriteria PICOS, dengan fokus pada faktor biomolekuler apoptosis dan autophagy pada KPD. Jenis studi dengan temuan: 9 studi klinis dan 6 pre-klinis. Jumlah sampel 254 dengan riwayat partus KPD dan 295 dengan riwayat partus normal. Hasil sebanyak 10 studi memenuhi kriteria inklusi. KPD ditandai oleh peningkatan mediator apoptosis seperti caspase-3, caspase-8, BAX, dan AIF, disertai penurunan BCL-2. Di sisi lain, terjadi penurunan ekspresi regulator autophagy utama seperti Beclin-1, ULK1, ATG5, dan ATG7, yang menunjukkan gangguan aliran autophagy protektif. Interaksi antara inflamasi, stres oksidatif, dan disfungsi metabolik memperkuat aktivasi apoptosis dan kegagalan autophagy. Kesimpulan disregulasi keseimbangan apoptosis dan autophagy berperan sentral dalam patogenesis KPD dan berpotensi menjadi target diagnostik serta terapeutik di masa mendatang.
The Role of Transforming Growth Factor Beta (TGF-β) in Pelvic Organ Prolapse : A Systematic Review Yulia Margaretta Sari; Bobby Indra Utama; Zelly Dia Rofinda; Elliyanti, Aisyah
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.58-69.2026

Abstract

Introduction: Pelvic organ prolapse (POP) is a gynaecological disorder with a rising prevalence, significantly affecting quality of life. While the pathogenesis of POP is multifactorial, alterations in the extracellular matrix (ECM) have been implicated, particularly the role of transforming growth factor-beta (TGF-β) in ECM remodelling. However, the precise relationship between TGF-β and POP remains unclear. Methods: A systematic review was conducted following PRISMA guidelines. Relevant studies were identified from PubMed, Scopus, Web of Science, and the Cochrane Library. Inclusion criteria focused on studies investigating TGF-β expression in women with POP. Data extraction included study design, patient demographics, TGF-β detection methods, and key findings. Results: Analysis of nine studies revealed mixed findings. Four studies reported a significant reduction in TGF-β1 expression in POP patients, suggesting impaired ECM regulation via the TGF-β1/Smad3 pathway. Three studies found no significant differences in TGF-β levels between POP and control groups, while one study linked increased TGF-β1 levels to severe prolapse, possibly as a compensatory response. Variations in methodology, sample size, and patient characteristics contributed to inconsistencies across studies. Conclusion: Current evidence suggests that TGF-β1 plays a role in POP pathogenesis, with lower levels potentially weakening ECM integrity and higher levels in advanced cases reflecting a failed reparative response. Further research is needed to explore TGF-β interactions with other biomarkers and assess its potential as a therapeutic target.
Validity and reliability test of the knowledge level questionnaire of cancer patients undergoing radiotherapy Hanum, Fathiya Juwita; Machmud, Rizanda; Gondhowiardjo, Soehartati; Khambri, Daan; Harahap, Wirsma Arif; Elliyanti, Aisyah; Firdawati, Firdawati; Semiarty, Rima
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 1 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i1.3604

Abstract

Background: Radiotherapy is one of the main modalities in cancer treatment. The success of this therapy is strongly influenced by the knowledge of patients about the disease and radiotherapy. The researcher developed a questionnaire to measure the level of knowledge among cancer patients undergoing radiotherapy. Objective: This study aimed to assess the validity and reliability of a knowledge-level questionnaire for cancer patients receiving radiotherapy at Dr. M. Djamil General Hospital, Padang. Methods: This research employed a quantitative approach with a cross-sectional design. A total of 30 cancer patients undergoing radiotherapy were included as respondents using a consecutive sampling technique. The questionnaire instrument was developed by the researcher and consisted of 25 items covering five domains of knowledge: cancer, radiotherapy, side effects, self-care, and nutrition. Results: Validity testing was conducted using Pearson’s correlation analysis, while reliability was assessed using Cronbach’s Alpha. Out of the 25 items, 19 were statistically valid (p<0.05), with correlation coefficients (r) ranging from moderate to strong (0.470–0.745). The Cronbach’s Alpha value for the valid items was 0.904, indicating excellent reliability. Conclusion: The developed questionnaire was proven to be both valid and reliable for measuring the knowledge level of cancer patients undergoing radiotherapy. This instrument has the potential to be used in clinical practice and research to support more targeted educational interventions.
Transport index in lymphoscintigraphy for patients with lymphedema: a case report Kurniawati, Yulia; Elliyanti, Aisyah; Zahra, Rahmi
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i1.29636

Abstract

Background: Lymphedema is an interstitial edema caused by impaired lymphatic drainage. Lymphoscintigraphy is a functional imaging modality used to evaluate lymphatic flow and diagnose lymphedema, with interpretation performed qualitatively and semi-quantitatively using the Transport Index (TI). Case Presentation: Four patients with progressive unilateral extremity swelling at RSUP M. Djamil Hospital underwent lymphoscintigraphy. Subcutaneous injections of 99mTc-albumin nanocolloid were administered into both extremities, followed by dynamic and delayed imaging up to three hours after injection. Two patients showed complete lymphatic obstruction with TI scores of 36, while contralateral extremities demonstrated normal lymphatic transport (TI 1.2). The remaining two patients showed delayed lymphatic drainage with TI scores of 10.2, whereas contralateral extremities demonstrated near-normal TI values (1.2–4.2). TI values <10 indicate normal lymphatic transport, whereas values ≥10 reflect lymphatic dysfunction. Conclusion: Qualitative and semi-quantitative analyses using the Transport Index provide consistent results in evaluating lymphatic dysfunction. Lymphoscintigraphy combined with TI scoring offers an objective and reproducible approach to improve diagnostic accuracy and support clinical decision-making, including treatment planning and disease monitoring.
Co-Authors Ade Sukma Afriwardi Afriwardi Andani Eka Putra Angriani, Winda Ariani, Novita Arina Widya Murni Arnelis Arnelis Arni Amir Arvan Syahruddin Ashal, Taufik Aswiyanti Asri Aziza, Zulva Bobby Indra Utama Cimi Ilmiawati, Cimi Daan Khambri Dani Rosdiana Desmawati Desmawati Dewi Anggraini Dewi Anggraini Dia Rofinda, Zelly Dia Dian Pertiwi Dian Pertiwi Donel Suheimi Ediwi, Nabila C. Elisabet, Adinda Elizabeth Bahar Elmatris Sy Eryati Darwin Esha, Indi Eti Yerizel Faiz Chalidzar Fasril , Thira Febrianti Ika Kurnia Febrianti, Ika K. Fika Anggraini Fika Anggraini Firdawati, Firdawati Fitri Wahyu Febriwani Genia, Dara Indah Hafizhah, Nurul Hanifah, Zulfa N. hanifah, zulfa nur Hanum, Fathiya Juwita Harahap, Sari Hendriati, Hendriati Herlambang Herlambang Husna Yetti Husna, Annisaul Husnil Wardiyah Ibrahim, Raihan Syah Ilmiati Ilmiati INDRA YOVI Intan, Shinta Ayu Irrahmah, Miftah Iskandar Iskandar Johan S. Masjhur, Johan S. Julizar Julizar Julizar Julizar Julizar Julizar Katrin Monika Lili Irawati Lili Irawati Lusikooy, Ronald E. Mardhatilah, Ashifa Meidrin Joni Miftah Irrahmah Miftah Irrahmah Miftah Irramah Mohamad Reza Mohamad Reza Monika, Katrin Muhammad Abi Ghoffari Siregar Netti Suharti, Netti Noormartany Nora Harminarti Noza Hilbertina, Noza Nur Afrainin Syah Nurhajjah, Sitti Nurrahma, Zuyyina ER. Putra, Andani E. Putri, Nabila Putri, Rahmi T. Raden Mohamad Herdian Bhakti Rahmad Syawqi Rahmad Syawqi Rahman, Fikri Rahmat Syawqi Rahmat Syawqi Raihan Syah Ibrahim Ramacos Fardela Rasya, Salsabila Faiha Wiendra Rasyada, Latifah Aulia RAVEINAL RAVEINAL Rima Semiarty Rina Gustia Rivai, Muhammad I. Rizanda Machmud S Setiyowati Sabar Hutabarat Safari, Dodi Safitri, Nuridha Audinia Salsabila, Dhianisa Sarassari, Rosantia Shapira, Vanesya Zahrani Simanjuntak, Arya M. Siregar, Fajri M. Siti Nurhajjah Soehartati Gondhowiardjo Sorayya A'dilah Putri Sri Setiyowati Suminta RS, Teresia Susilo, Veronica Y. Syah, Nur A. Syaiful Azmi Syamel, Muhammad Tenny Putri Wikayani, Tenny Putri Tofrizal, Alimuddin Tri Hanggono Achmad Veronica, R. Merlinda VY Susilo Wirsma Arif Harahap Wulandari Wulandari Yose Ramda Ilhami Yose Ramda Ilhsmi Yulia Iriani, Yulia Yulia Kurniawati Yulia Kurniawati Yulia Kurniawati Yulia Margaretta Sari Yulistini, Yulistini Yusticia Katar, Yusticia Zahra, Rahmi Zelly Dia Rofinda