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The Potential of Iodine as A Treatment for Breast Cancer: A Narrative Review Ibrahim, Raihan Syah; Elliyanti, Aisyah
Jurnal Kesehatan Manarang Vol 9 No 3 (2023): December 2023
Publisher : Politeknik Kesehatan Kemenkes Mamuju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33490/jkm.v9i3.834

Abstract

Breast cancer is a cancer with the highest incidence of death in women in the world. Studies state that breast cancer can capture iodine molecules, making this substance a potential alternative therapy for further research and study. Opportunities for iodine as a treatment for breast cancer are supported by the fact that iodine is a molecular element widely available in nature, such as in food, plants, and oceans, so iodine is an easy substance to obtain. This article explores the potential of iodine as a treatment for breast cancer. The method used is a literature review study, in which literature is collected through the PubMed, Science Direct, and Google Scholar databases published from 2013-2022, and full text is available. The results of the review of the 10 articles obtained are the exposure of sources and intake of iodine, the physiological effects of iodine, and the effects of iodine on breast cancer cells. Iodine has the potential as a substance with anticancer activity through antiproliferative mechanisms, apoptosis, and immune system activation when given in sufficient quantities and at appropriate doses. The mechanism of iodine affecting breast cancer cells occurs through direct and indirect effects on the biological processes of cancer cells. These mechanisms occur molecularly in cancer cells by intermediary mitochondrial organelles and specific ligands in the cell. Iodine can also be combined with breast cancer chemotherapy, such as doxorubicin, which gives a good treatment response after chemotherapy. This is important to ensure sufficient daily intake of iodine for the body, especially in patients with breast cancer.
Potensi Terapeutik Tanaman Andalas (Morus macroura Miq.) sebagai Sumber Antioksidan dan Antiinflamasi : Narrative Review Wulandari, Wulandari; Siregar, Muhammad Abi Ghoffari; Rasya, Salsabila Faiha Wiendra; Husna, Annisaul; Elliyanti, Aisyah
Majalah Kedokteran Andalas Vol. 48 No. 4 (2025): MKA October 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v48.i4.p457-465.2025

Abstract

Latar Belakang: Tanaman Andalas (Morus macroura Miq.) merupakan salah satu tanaman asli Indonesia yang dianggap sebagai maskot Sumatera Barat. Tanaman herbal ini kaya akan senyawa bioaktif. Tujuan: Mengetahui potensi terapeutik dan preventif tanaman andalas sebagai sumber antioksidan dan antiinflamasi. Metode: Pendekatan narrative review, sumber literatur dari Pubmed, Google Scholar, dan Science Direct. Penulis menggunakan kata kunci Morus macroura Miq. atau andalas, potensi terapeutik, antioksidan, antiinflamasi. Kriteria inklusi berupa artikel sesuai dengan tema penelitian, artikel terindeks scopus, serta diterbitkan tahun 2019-2023. Kriteria eksklusi meliputi artikel yang tidak dapat diakses, tidak menjawab jenis review. Hasil: Tanaman andalas berpotensi sebagai antioksidan dengan cara mengurangi indeks stres oksidatif dan meningkatkan pertahanan antioksidan. Tanaman andalas juga berpotensi sebagai antiinflamasi dengan cara menurukan kadar biomarker peradangan dan meningkatkan ekspresi miRNA-223. Kesimpulan: Tanaman andalas berpotensi sebagai sumber antioksidan dan antiinflamasi serta agen terapeutik yang menjanjinkan dalam pengobatan penyakit terkait inflamasi dan stres oksidatif, seperti kolitis ulserativa, kanker, neurotoksisitas, dan lainnya yang memerlukan uji klinis lebih lanjut.
Bacterial Profile and Antimicrobial Resistance Patterns of Pleural Empyema in Pekanbaru Hospitals Yovi, Indra; Safari, Dodi; Syah, Nur Afrainin; Anggraini, Dewi; Hanifah, Zulfa Nur; Shapira, Vanesya Zahrani; Elliyanti, Aisyah
Jurnal Respirologi Indonesia Vol 44 No 1 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i1.590

Abstract

Background: Empyema is a problem worldwide due to its high incidence, mortality, and morbidity rates. So, administering antibiotics is mandatory to treat the disease. It should be sensitive to the causal microorganisms and avoid resistant ones for treatment efficacy. This research aimed to determine bacterial profile and antimicrobial resistance, which can be fundamental foundations for clinical practices in the treatment of patients, especially in Pekanbaru.Methods: This was a cross-sectional study from medical records at Arifin Achmad and Eka Hospitals from January 1, 2015, to December 31, 2022, including culture and antibiotic resistance test results with samples from pleural fluid and antibiotic susceptibility test using VITEK 2.0.Results: A total of 197 pleural fluid specimens were obtained. Gram-negative bacteria were found to be the most prevalent at 79.7%, namely Klebsiella pneumoniae (18.5%), Escherichia coli (12.0%), and Pseudomonas aeruginosa (11.0%). Gram-positive bacteria were found at 12.2%, the most common being Staphylococcus aureus (6.1%) and Enterococcus faecalis (2.0%). Antibiotic sensitivity tests for Gram-negative bacteria showed that amikacin and tigecycline were the most sensitive, and Gram-positive bacteria showed the most sensitivity to linezolid, tigecycline, and vancomycin. The resistance of Klebsiella pneumoniae and Escherichia coli to cephalosporins was 18.5% and 75.0%, respectively. The resistance of Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa to carbapenems was 8.0%, 13.0%, and 53.0%, respectively.Conclusion: Gram-negative is the most common microorganism found in pleural empyema. The resistance of multiresistant bacteria to antibiotics is high and requires supervision to apply appropriate antibiotic administration based on local antimicrobial patterns and the need to strengthen antimicrobial stewardship programs. 
Optimalisasi Terapi Radioaktif Yodium (RAI) pada Kanker Tiroid: Tinjauan Literatur Rasyada, Latifah Aulia; Fardela, Ramacos; Elliyanti, Aisyah
Jurnal Penelitian Sains Vol 27, No 3 (2025)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56064/jps.v27i3.1224

Abstract

Penelitian ini dilakukan untuk mengetahui peran penggunaan Yodium-131 dalam pengobatan kanker tiroid. Penelitian ini merupakan tinjauan literatur pada 10 artikel penelitian yang telah dipublikasikan dalam 10 tahun terakhir. Sumber informasi yang digunakan di ambil pada data publikasi Science Direct, Elsevier, Google Scholar, dan PubMed. Hasil dari beberapa penelitian menunjukkan bahwa radioaktif yodium (RAI) sangat berperan penting dalam pengobatan di bidang kedokteran nuklir terhadap pasien yang didiagnosis dengan tipe tiroid terdiferensiasi (DTC), papillary thyroid carcinoma (PTC), oncocytic carcinoma (OCA), dan follicular thyroid carcinoma (FTC). Dalam pengobatan RAI, diperlukan perhatian terhadap faktor risiko yang meliputi besar dosis yang diterima, fungsi kelenjar tiroid yang tersisa, dan aktivitas kumulatif yang diberikan sepanjang hidup pasien. Penerapan RAI yang benar dan tepat akan membantu pasien dalam pengobatan berbasis kedokteran nuklir, meningkatkan tingkat kelangsungan hidup pasien, serta meminimalkan risiko efek samping. Dengan demikian, pemahaman yang lebih baik tentang penerapan dan regulasi dosis RAI sangat penting untuk meningkatkan hasil pengobatan kanker tiroid.
Peran Mekanisme Apoptosis dan Autophagy Pada Ketuban Pecah Dini: Tinjauan Sistematis Studi Klinis dan Pre-Klinis Arvan Syahruddin; Aisyah Elliyanti; Donel Suheimi; Mohamad Reza
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.54125

Abstract

Ketuban Pecah Dini (KPD) merupakan kondisi obstetri multifaktorial yang berkontribusi signifikan terhadap persalinan prematur dan morbiditas neonatal. Bukti terbaru menunjukkan bahwa disregulasi apoptosis dan autophagy berperan penting dalam melemahnya integritas membran ketuban. Tujuan tinjauan sistematis  ini bertujuan untuk menganalisis peran jalur apoptosis dan autophagy dalam patogenesis KPD berdasarkan temuan studi klinis dan pre-klinis. Metode tinjauan sistematis dilakukan  mengikuti pedoman PRISMA dengan pencarian pada database Google Scholar, PubMed, Taylor & Francis, dan Science Direct untuk publikasi tahun 2015–2025. Seleksi artikel menggunakan kriteria PICOS, dengan fokus pada faktor biomolekuler apoptosis dan autophagy pada KPD. Jenis studi dengan temuan: 9 studi klinis dan 6 pre-klinis. Jumlah sampel 254 dengan riwayat partus KPD dan 295 dengan riwayat partus normal. Hasil sebanyak 10 studi memenuhi kriteria inklusi. KPD ditandai oleh peningkatan mediator apoptosis seperti caspase-3, caspase-8, BAX, dan AIF, disertai penurunan BCL-2. Di sisi lain, terjadi penurunan ekspresi regulator autophagy utama seperti Beclin-1, ULK1, ATG5, dan ATG7, yang menunjukkan gangguan aliran autophagy protektif. Interaksi antara inflamasi, stres oksidatif, dan disfungsi metabolik memperkuat aktivasi apoptosis dan kegagalan autophagy. Kesimpulan disregulasi keseimbangan apoptosis dan autophagy berperan sentral dalam patogenesis KPD dan berpotensi menjadi target diagnostik serta terapeutik di masa mendatang.
Validity and reliability test of the knowledge level questionnaire of cancer patients undergoing radiotherapy Hanum, Fathiya Juwita; Machmud, Rizanda; Gondhowiardjo, Soehartati; Khambri, Daan; Harahap, Wirsma Arif; Elliyanti, Aisyah; Firdawati, Firdawati; Semiarty, Rima
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 1 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i1.3604

Abstract

Background: Radiotherapy is one of the main modalities in cancer treatment. The success of this therapy is strongly influenced by the knowledge of patients about the disease and radiotherapy. The researcher developed a questionnaire to measure the level of knowledge among cancer patients undergoing radiotherapy. Objective: This study aimed to assess the validity and reliability of a knowledge-level questionnaire for cancer patients receiving radiotherapy at Dr. M. Djamil General Hospital, Padang. Methods: This research employed a quantitative approach with a cross-sectional design. A total of 30 cancer patients undergoing radiotherapy were included as respondents using a consecutive sampling technique. The questionnaire instrument was developed by the researcher and consisted of 25 items covering five domains of knowledge: cancer, radiotherapy, side effects, self-care, and nutrition. Results: Validity testing was conducted using Pearson’s correlation analysis, while reliability was assessed using Cronbach’s Alpha. Out of the 25 items, 19 were statistically valid (p<0.05), with correlation coefficients (r) ranging from moderate to strong (0.470–0.745). The Cronbach’s Alpha value for the valid items was 0.904, indicating excellent reliability. Conclusion: The developed questionnaire was proven to be both valid and reliable for measuring the knowledge level of cancer patients undergoing radiotherapy. This instrument has the potential to be used in clinical practice and research to support more targeted educational interventions.
Transport index in lymphoscintigraphy for patients with lymphedema: a case report Kurniawati, Yulia; Elliyanti, Aisyah; Zahra, Rahmi
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i1.29636

Abstract

Background: Lymphedema is an interstitial edema caused by impaired lymphatic drainage. Lymphoscintigraphy is a functional imaging modality used to evaluate lymphatic flow and diagnose lymphedema, with interpretation performed qualitatively and semi-quantitatively using the Transport Index (TI). Case Presentation: Four patients with progressive unilateral extremity swelling at RSUP M. Djamil Hospital underwent lymphoscintigraphy. Subcutaneous injections of 99mTc-albumin nanocolloid were administered into both extremities, followed by dynamic and delayed imaging up to three hours after injection. Two patients showed complete lymphatic obstruction with TI scores of 36, while contralateral extremities demonstrated normal lymphatic transport (TI 1.2). The remaining two patients showed delayed lymphatic drainage with TI scores of 10.2, whereas contralateral extremities demonstrated near-normal TI values (1.2–4.2). TI values <10 indicate normal lymphatic transport, whereas values ≥10 reflect lymphatic dysfunction. Conclusion: Qualitative and semi-quantitative analyses using the Transport Index provide consistent results in evaluating lymphatic dysfunction. Lymphoscintigraphy combined with TI scoring offers an objective and reproducible approach to improve diagnostic accuracy and support clinical decision-making, including treatment planning and disease monitoring.
Protective Effects of Short-Chain Fatty Acids on Gut Mucosa Nurwiyeni Nurwiyeni; Aisyah Ellyanti; N Hilbertina; Almurdi Almurdi
AJARCDE (Asian Journal of Applied Research for Community Development and Empowerment) Vol. 10 No. 2 (2026)
Publisher : Asia Pacific Network for Sustainable Agriculture, Food and Energy (SAFE-Network)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29165/ajarcde.v10i2.986

Abstract

Background: Short-chain fatty acids (SCFAs) are key metabolites produced by microbial fibre fermentation and act as an epigenetic link between diet and gene expression. SCFA production is highly dependent on dietary fiber diversity to support a healthy microbial ecosystem. Through the gut-brain axis, SCFAs influence cognitive function by altering the brain's response to food signals and reducing systemic inflammation. Objective: This study aimed to determine the effects of short-chain fatty acids on the gastrointestinal mucosa and their relationships with diet, fibre, and the gut-brain axis. Methods: This study used a systematic review guided by PRISMA 2020 (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). The literature was searched across three databases: PubMed, EBSCO, and Scopus. The study selection process followed predetermined inclusion and exclusion criteria, and the results of included studies were systematically analyzed. Results: A total of 20 studies were analyzed. Most studies show that SCFAs can protect the gastrointestinal mucosa through a healthy microbiota balance and a proper diet, including a high-fiber diet.  Conclusion: A high-fibre diet can produce SCFAs that regulate metabolic/inflammatory genes, improve intestinal mucosal function, enhance glucagon-like peptide-1 (GLP-1) secretion, improve glycemic/appetite control, and reduce the brain's response to high-calorie foods. It also lowers high-sensitivity C-reactive protein (high-sensitivity C-reactive protein (high-sensitivity C-reactive protein (high-sensitivity C-reactive protein (high-sensitivity C-reactive protein (hs-CRP))))), improving stress, anxiety, and mental health. Contribution to Sustainable Development Goals (SDGs):SDG 3- Good Health and Well-BeingSDG 4:- Quality EducationSDG 12 – Responsible Consumption and Production
THE EFFECT OF A LOW-CALORIE BALANCED NUTRITION DIET BASED ON MINANG CUISINE IN OBESE PEOPLE Mirnawati Mirnawati; Nur Indrawati Lipoeto; Aisyah Elliyanti; Dewi Susanti febri
Jurnal Endurance Vol. 10 No. 1 (2025): Jurnal Endurance: Kajian Ilmiah Problema Kesehatan
Publisher : LLDIKTI Wilayah X

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22216/jen.v10i1.3208

Abstract

Obesity is a significant health issue worldwide and leads to various metabolic disorders. The primary method for addressing obesity is through dietary therapy. A commonly adopted diet for this purpose is a low-calorie, well-balanced eating plan. Minang cuisine offers traditional dishes that can provide healthy, balanced nutrition. This research assessed the eating habits of individuals with obesity. It explored the impact of a low-calorie, nutritionally balanced diet rooted in Minang cuisine on metabolic indicators (such as body weight, body mass index (BMI), body fat percentage, blood pressure, fasting blood sugar levels, and lipid profile levels) among obese individuals. The study utilized an experimental design with a pre-post clinical trial format. The dietary intervention lasted for 8 weeks, featuring a calorie deficit of 500–600 kcal from typical daily intake while maintaining balanced nutrition. Data from the research were analyzed using SPSS statistical software version 26. Interventions involving low-calorie and balanced nutrition derived from traditional Indonesian meals proved effective in decreasing weight, BMI, waist circumference, and body fat percentage in participants with obesity. However, the interventions did not show a significant impact on blood pressure, fasting blood glucose, or lipid profiles. This study demonstrates that Minang cuisine can be a nutritious and healthy option for combating obesity. Keywords: Obesity; dietary interventions; Minang cuisine; metabolic biomarkers; obesity.
Effects of Radiation on the Histology of the Tongue and Lip Mucosa in Rats : Preliminary Research Sagita Yudha; Aisyah Elliyanti; Eti Yerizel; Sukri Rahman
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 03 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) In Progress
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss03/696

Abstract

The tongue and lip mucosa, as tissues with high cell proliferation rates, are highly susceptible to injury caused by ionizing radiation. This study aimed to evaluate histological changes in the tongue and lip mucosa of rats after exposure to ionizing radiation at various doses. Nine rats were used, each consisting of three rats, divided into a negative control group (K) and three treatment groups receiving radiation doses of 13 Gy (30 seconds of radiation), 15 Gy (66 seconds of radiation), and 17 Gy (110 seconds of radiation). Samples of tongue and lip mucosa tissue were harvested after 7 days and processed for histological examination using Hematoxylin and Eosin (HE) staining at 100x objective magnification. The results of this preliminary study showed that radiation at 13 Gy caused epithelial erosion, loss of filiform papillae, subepithelial bullae formation, and acute inflammatory cell infiltration on the tongue. At 15 Gy, more extensive ulceration with subepithelial edema was observed. At 17 Gy, total epithelial loss with massive subepithelial edema and vascular dilatation occurs. This preliminary study concludes that the tongue mucosa exhibits greater radiation sensitivity than the lip mucosa, with a dose-dependent progression of damage ranging from erosion to total epithelial loss.  
Co-Authors Achmad Hussein Kartamihardja Ade Sukma Afriwardi Afriwardi Almurdi Almurdi Andani Eka Putra Angriani, Winda Ariani, Novita Arina Widya Murni Arnelis Arnelis Arni Amir Arvan Syahruddin Ashal, Taufik Aswiyanti Asri Aziza, Zulva Bobby Indra Utama Cimi Ilmiawati, Cimi Daan Khambri Daan Khambri Dani Rosdiana Desmawati Desmawati Dewi Anggraini Dewi Anggraini Dewi Susanti febri Dia Rofinda, Zelly Dia Dian Pertiwi Dian Pertiwi Donel Suheimi Ediwi, Nabila C. Elisabet, Adinda Elizabeth Bahar Elizabeth Bahar Elmatris Sy Eryati Darwin Eryati Darwin Esha, Indi Eti Yerizel Faiz Chalidzar Fasril , Thira Febrianti Ika Kurnia Febrianti, Ika K. Fika Anggraini Fika Anggraini Firdawati Firdawati Fitri Wahyu Febriwani Genia, Dara Indah Hafizhah, Nurul Hanifah, Zulfa N. hanifah, zulfa nur Hanum, Fathiya Juwita Harahap, Sari Hendriati, Hendriati Herlambang Herlambang Herlambang Husna Yetti Husna, Annisaul Husnil Wardiyah Ibrahim, Raihan Syah Ilmiati Ilmiati INDRA YOVI Intan, Shinta Ayu Irrahmah, Miftah Iskandar Iskandar Jihan Atiqah Johan S. Masjhur, Johan S. Joni, Meidrin Julizar Julizar Julizar Julizar Julizar Julizar Katrin Monika Lili Irawati Lili Irawati Lusikooy, Ronald E. Malinda Meinapuri Mardhatilah, Ashifa Meidrin Joni Miftah Irrahmah Miftah Irrahmah Miftah Irramah Mirnawati Mirnawati Mohamad Reza Mohamad Reza Monika, Katrin Muhammad Abi Ghoffari Siregar N Hilbertina Netti Suharti, Netti Noormartany Nora Harminarti Noza Hilbertina, Noza Nur Afrainin Syah Nur Indrawati Lipoeto Nurhajjah, Sitti Nurrahma, Zuyyina ER. Nurwiyeni Nurwiyeni Putra, Andani E. Putri, Nabila Putri, Rahmi T. Raden Mohamad Herdian Bhakti Rahmad Syawqi Rahmad Syawqi Rahman, Fikri Rahmat Syawqi Rahmat Syawqi Raihan Syah Ibrahim Ramacos Fardela Rasya, Salsabila Faiha Wiendra Rasyada, Latifah Aulia RAVEINAL RAVEINAL Rima Semiarty Rina Gustia Rivai, Muhammad I. Rizanda Machmud S Setiyowati Sabar Hutabarat Safari, Dodi Safitri, Nuridha Audinia Sagita Yudha Sagita Yudha Salsabila, Dhianisa Sarassari, Rosantia Shapira, Vanesya Zahrani Simanjuntak, Arya M. Siregar, Fajri M. Siti Nurhajjah Soehartati Gondhowiardjo Sorayya A'dilah Putri Sri Setiyowati Sukri Rahman Suminta RS, Teresia Susilo, Veronica Y. Syah, Nur A. Syaiful Azmi Syamel, Muhammad Tenny Putri Wikayani, Tenny Putri Tofrizal, Alimuddin Tri Hanggono Achmad Veronica, R. Merlinda VY Susilo Wirsma Arif Harahap Wulandari Wulandari Yose Ramda Ilhami Yose Ramda Ilhsmi Yulia Iriani, Yulia Yulia Kurniawati Yulia Kurniawati Yulia Kurniawati Yulia Margaretta Sari Yulistini, Yulistini Yusticia Katar, Yusticia Zahra, Rahmi Zelly Dia Rofinda