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All Journal JURNAL GIZI INDONESIA Jurnal Ilmu Kedokteran (Journal of Medical Science) Majalah Kedokteran Bandung Medical Journal of Indonesia Jurnal Kesehatan Andalas Jurnal Penelitian Sains Jurnal Kesehatan Manarang Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun Journal of Midwifery Jurnal Respirologi Indonesia Majalah Kedokteran Andalas International Islamic Medical Journal Narra J Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Riset Ilmiah Jurnal Sains, Teknologi dan Kesehatan
Aisyah Elliyanti
1) Nuclear Medicine Division Of Radiology Department, Faculty Of Medicine, Universitas Andalas, Padang, Indonesia 2) Dr. M. Djamil Hospital, Padang, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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A comparative analysis between next-generation sequencing and conventional culture method to detect empyema-associated microorganisms: A systematic review Yovi, Indra; Syah, Nur A.; Anggraini, Dewi; Simanjuntak, Arya M.; Hanifah, Zulfa N.; Elliyanti, Aisyah
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.650

Abstract

Empyema poses a significant global health concern, yet identifying responsible bacteria remains elusive. Recent studies question the efficacy of conventional pleural fluid culture in accurately identifying empyema-causing bacteria. The aim of this study was to compare diagnostic capabilities of next-generation sequencing (NGS) with conventional pleural fluid culture in identifying empyema-causing bacteria. Five databases (Google Scholar, Science Direct, Cochrane, Research Gate, and PubMed) were used to search studies comparing conventional pleural fluid culture with NGS for identifying empyema-causing bacteria using keywords. Positive results identified through conventional pleural fluid culture and NGS were extracted. In addition, bacterial profiles identified by NGS were also documented. Joanna-Briggs Institute (JBI) critical appraisal tool was employed to assess quality of included studies. Descriptive analysis was employed to present outcome of interests. From five databases, three studies, with 354 patients, were included. Findings from three studies showed that NGS outperformed conventional pleural fluid culture in detecting empyema-causing bacteria even in culture-negative samples. Moreover, dominant bacterial profiles identified through NGS included Streptococcus pneumoniae, Staphylococcus aureus, and anaerobic bacteria. In conclusion, NGS outperforms conventional pleural fluid culture in detection empyema-causing bacteria, yet further studies with larger samples and broader bacterial profiles are needed to increase confidence and urgency in its adoption over conventional pleural fluid culture.
Transcriptomic analysis of profibrinolytic and fibrinolytic inhibitor genes in COVID-19 patients Febrianti, Ika K.; Putra, Andani E.; Raveinal, Raveinal; Elliyanti, Aisyah
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.843

Abstract

The immunopathogenesis of COVID-19 infection is initiated by the entry of the SARS-CoV-2 virus into the human body through droplets, entering the lungs and binding to the ACE-2 receptor. Activated macrophages stimulate an immune and inflammatory response, leading to the activation of the coagulation cascade, including profibrinolytic and fibrinolytic inhibitor processes. One of the proteins involved in profibrinolytic is encoded by the PLAUR gene, while fibrinolytic inhibitor proteins are encoded by the A2M and SERPINE1 genes. This research aims to assess the transcriptomic analysis of genetic expression data of profibrinolytic genes, fibrinolytic inhibitor genes and their correlation with serum D-dimer levels, which describe the clinical condition of coagulation in COVID-19 patients. This cross-sectional study included 25 patients each for mild and moderate-to-severe COVID-19 at Dr. M. Djamil Padang General Hospital, Padang, Indonesia. Inter-group gene expression comparisons will be analyzed using log2 folds change, and bivariate tests will be analyzed using correlation. The results show that the PLAUR gene has higher expression in moderate-to-severe compared to mild cases. Similarly, the SERPINE1 and A2M genes expressions are higher in moderate-to-severe compared to mild cases. Furthermore, there is a significant correlation between serum D-dimer levels and profibrinolytic factor (PLAUR gene) expression in COVID-19 patients. The correlation between serum D-dimer levels with fibrinolytic inhibitor factor (SERPINE1 and A2M genes) expression was found. These conclude that there is a significant difference in the expression of the profibrinolytic and fibrinolytic inhibitor genes between mild and moderate-to-severe cases in COVID-19, demonstrating COVID-19 infection affects coagulation activities.
Treatment Problems In Triple Negative Breast Cancer Fasril , Thira; Hilbertina, Noza; Elliyanti, Aisyah
Jurnal Medis Islam Internasional Vol 4 No 2 (2023): June
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v4i2.3951

Abstract

Background: Breast cancer ranks second on the list of common diseases worldwide. It causes many deaths in the United States and Europe, second only to lung cancer. Triple-negative breast cancer (TNBC) does not express Estrogen Receptor (ER), Progesterone Receptor (PR), and Human Epithelial Receptor (HER2). It represents 24% of new cases of all breast cancer, and its incidence increases yearly. TNBC is a hormone-resistant breast cancer, so no current standard therapy exists. This article aims to explore regimen-resistant and troubleshooting treatment responses in TNBC cases. The method of writing this article is a literature review of studies using the keywords triple-negative breast cancer treatment and regimen, which are limited to only the most recent articles, 2012-2022, using search engines from PubMed, Science Direct, and Google Scholar. Results: There is no definitive therapy for the triple-negative breast cancer subtype, in which the TNBC type has no target receptor. Chemotherapy is the SOC of TNBC for early stage treatment. For late-stage and relapsed TNBC, however, chemotherapy is no longer the first choice. Currently there is no standard chemotherapy regimen that can be given to patients who experience relapse after chemotherapy because they will have a short response and lead to metastases. Some studies have shown that chemotherapy gives a better response, but the prognosis of TNBC remains poor. TNBC has different responses to therapy. TNBC showed a good response to combination chemotherapy along with pembrolizumab, capecitabine, olaparib, and radiotherapy, compared to chemotherapy by itself. Surgical therapy, such as Breast-Conserving Surgery (BCS), does not improve better prognosis in TNBC patients. Conclusions: Combining pembrolizumab, olaparib, capecitabine, and radiotherapy with chemotherapy increased survival rates compared to chemotherapy only.
Bacterial Profile and Antimicrobial Resistance Patterns of Pleural Empyema in Pekanbaru Hospitals Yovi, Indra; Safari, Dodi; Syah, Nur Afrainin; Anggraini, Dewi; Hanifah, Zulfa Nur; Shapira, Vanesya Zahrani; Elliyanti, Aisyah
Jurnal Respirologi Indonesia Vol 44, No 1 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i1.590

Abstract

Background: Empyema is a problem worldwide due to its high incidence, mortality, and morbidity rates. So, administering antibiotics is mandatory to treat the disease. It should be sensitive to the causal microorganisms and avoid resistant ones for treatment efficacy. This research aimed to determine bacterial profile and antimicrobial resistance, which can be fundamental foundations for clinical practices in the treatment of patients, especially in Pekanbaru.Methods: This was a cross-sectional study from medical records at Arifin Achmad and Eka Hospitals from January 1, 2015, to December 31, 2022, including culture and antibiotic resistance test results with samples from pleural fluid and antibiotic susceptibility test using VITEK 2.0.Results: A total of 197 pleural fluid specimens were obtained. Gram-negative bacteria were found to be the most prevalent at 79.7%, namely Klebsiella pneumoniae (18.5%), Escherichia coli (12.0%), and Pseudomonas aeruginosa (11.0%). Gram-positive bacteria were found at 12.2%, the most common being Staphylococcus aureus (6.1%) and Enterococcus faecalis (2.0%). Antibiotic sensitivity tests for Gram-negative bacteria showed that amikacin and tigecycline were the most sensitive, and Gram-positive bacteria showed the most sensitivity to linezolid, tigecycline, and vancomycin. The resistance of Klebsiella pneumoniae and Escherichia coli to cephalosporins was 18.5% and 75.0%, respectively. The resistance of Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa to carbapenems was 8.0%, 13.0%, and 53.0%, respectively.Conclusion: Gram-negative is the most common microorganism found in pleural empyema. The resistance of multiresistant bacteria to antibiotics is high and requires supervision to apply appropriate antibiotic administration based on local antimicrobial patterns and the need to strengthen antimicrobial stewardship programs. 
Analisis Ekspresi Protein c-Fos pada Cell Line Kanker Payudara Aisyah Elliyanti
Majalah Kedokteran Andalas Vol 46, No 12 (2024): Online Oktober 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i12.p1900-1911.2024

Abstract

Tujuan: Untuk menganalisis ekspresi protein c-Fos pada cell line kanker payudara. Metode: Penelitian ini merupakan penelitian eksperimental murni menggunakan metode imunositofluoresens untuk melihat jumlah intensitas ekspresi protein c-Fos dengan sampel penelitian adalah cell line MCF-7 mewakili kanker payudara subtipe luminal A, cell line SKBR3 mewakili kanker payudara subtipe HER2+, dan cell line HaCat mewakili sel normal. Ekspresi protein c-Fos diinduksi dengan EGF 50 ng/mL, ATP 100µM dan gabungan ATP+EGF selama 45 menit. Perhitungan intensitas protein c-Fos menggunakan aplikasi imageJ. Hasil penelitian ekspresi c-Fos dianalisis menggunakan uji oneway anova  apabila p<0.05 dianggap berbeda secara signifikan. Hasil: Ekspresi protein c-Fos pada cell line yang diberi perlakuan ATP dan EGF meningkat dibandingkan kontrol. Peningkatan intensitas protein c-Fos terdapat pada ketiga jenis cell line. Tidak terdapat perbedaan bermakna pada ketiga jenis sel berdasarkan jenis induksi (p>0,05). Kesimpulan: Pemberian ATP, EGF dan kombinasi ATP+EGF meningkatkan intensitas protein c-Fos pada cell line kanker payudara tipe MCF-7 dan SKBR3.
Differences in non-high density lipoprotein levels, blood pressure and waist circumference between normal-weight obesity, lean, and obese women Angriani, Winda; Desmawati, Desmawati; Elliyanti, Aisyah
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 13, No 1 (2024): December
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.13.1.9-15

Abstract

Background: Normal Weight Obesity (NWO) is a condition characterized by an average Body Mass Index (BMI) with high body fat percentage (BFP≥30%), distinct from individuals with normal BMI and normal body fat (BFP <30%), known as Normal Weight Lean (NWL). NWO is associated with an increased risk of cardiovascular diseases, dyslipidemia, and central obesity. Objectives: Investigate differences in non-high-density lipoprotein (non-HDL) levels, blood pressure, and waist circumference among respondents with NWO, NWL, and obesity.Materials and Methods: The research adopts an observational design with a cross-sectional approach. The respondents, 96 adult women aged 30-45 from Padang City, were selected based on inclusion and exclusion criteria. Measurements included BMI, body fat using Bioelectrical Impedance Analysis (BIA), waist circumference, and blood pressure. Nutritional status determination was employed to differentiate between NWL, NWO, and obesity. Subsequently, blood samples were taken for non-HDL analysis. Analysis of customarily distributed data used one-way ANOVA and post-hoc Bonferroni, while non-normally distributed data were analyzed using Kruskal-Wallis and post-hoc Mann-Whitney.Results: The study revealed that 20 women (20.8%) were classified as having NWO. The study results indicate a significant difference in non-HDL levels among NWL, NWO, and obesity (p-value = 0.015). There were differences in non-HDL levels between NWO and NWL women, as well as between NWL women and those with obesity. Blood pressure analysis showed no significant difference in blood pressure among NWO, NWL, and obesity. There was a difference in waist circumference, with a significant difference between NWL and obesity (p-value <0.05) and NWO and obesity (p-value <0.05). However, there was no significant difference between NWO and NWL (p-value = 1.00).Conclusion: There were differences in non-HDL levels and waist circumference among NWO, NWL, and obese women, but no significant difference in blood pressure was observed among the three groups.Keywords: Normal weight obesity; non-HDL; blood pressure; Waist circumference
Frekuensi Karier Streptococcus pneumoniae pada Populasi Dewasa Suku Akit Provinsi Riau Rosdiana, Dani; Veronica, R. Merlinda; Harahap, Sari; Esha, Indi; Mardhatilah, Ashifa; Putri, Nabila; Safitri, Nuridha Audinia; Safari, Dodi; Sarassari, Rosantia; Ilmiawati, Cimi; Elliyanti, Aisyah
Jurnal Ilmu Kedokteran Vol 18, No 2 (2024): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v18i2.2024.137-143

Abstract

Stretococcus pneumoniae (S.pneumoniae) is a commonly colonized in healthy people that potentially to be transmitted directly to other individuals through droplets and as an invasive pathogen. The prevalence/ frequency of S. pneumoniae carriage in children is around 20-60%, while data of carriage’s frequency in adult population is still limited. Akit tribe is a tribe who lives in a group in the coastal rural area of Rupat Island. The high incidence of upper respiratory tract infection among Akit tribe and the location can be risk for S. pneumoniae carriage. Study aimed is to identify the frequency of carriage in the adult population of the Akit tribe. Nasopharyngeal swab was collected from healthy adults, then cultivated on agar media. Colonies suspected as S. pneumoniae then selected, then subjected to optochin test. S. pneumoniae confirmation were using automatic machine VITEK. We reported S. pneumoniae carriage rate was 7.8% (12 of 153 participants) among Akit tribe.
Exploring the promising therapeutic benefits of iodine and radioiodine in breast cancer cell lines Elliyanti, Aisyah; Hafizhah, Nurul; Salsabila, Dhianisa; Susilo, Veronica Y.; Setiyowati, Sri; Tofrizal, Alimuddin; Kurniawati, Yulia; Irrahmah, Miftah
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1078

Abstract

Iodine has an anti-proliferative effect on cancer cells; however, its effects have not been explored adequately. The aim of this study was to evaluate the therapeutic potential of iodine and radioiodine by assessing their effects on the viability of various breast cancer cell lines: MCF7, SKBR3, and MDA-MB231. The viability of cells was measured in treated cells exposed to six doses of iodine (5, 10, 20, 40, 60, 80 µM) and two doses of radioiodine (3.7×104 and 3.7×105 Bq). A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and modified clonogenic assays were used to assess cell viability. Exposure to 80 µM of iodine significantly reduced the viability of all cell types. The cells were then exposed to a 50% inhibitory concentration (IC50) dose. When the cells were exposed to the IC50 dose of iodine, the MCF7 cell viability was reduced by 42.6±0.14% (IC50 dose 12.88 µM), 40.2±0.08% for SKBR3 (IC50 dose 11.03 µM) and 47.0±0.02% for MDA-MB231 (IC50 dose 14.09 µM). All cells were also exposed to 3.7×104 Bq and 3.7×105 Bq radioiodine. Both doses significantly reduced the cell viability of MCF7 and SKBR3 cells compared to the unexposed control cells (all had p<0.05), while MDA-MB231 cell viability only reduced significantly after 3.7×105 Bq of radioiodine exposure compared to the unexposed control cells (p<0.05). This study highlighted that iodine had a toxic effect on breast cancer cells, and radioiodine enhanced the toxicity to breast cancer cells. The types of cancer cells and doses of iodine and radioiodine influenced the effect. These findings suggest that iodine and radioiodine hold promise as therapeutic agents for breast cancer, similar to their established use in thyroid disease treatment. However, further in vivo studies are important to provide more evidence.
Reproductive function after radioactive iodine treatment for differentiated thyroid carcinoma patients: a systematic review Elliyanti, Aisyah; Aziza, Zulva; Kurniawati, Yulia; Khambri, Daan; Amir, Arni; Katar, Yusticia
Medical Journal of Indonesia Vol. 34 No. 1 (2025): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257458

Abstract

BACKGROUND Thyroid cancer is one of the most prevalent cancers in the endocrine system, with a rapidly rising incidence over the past 3 decades. Treatment for patients with differentiated thyroid cancer (DTC) typically includes surgery, radioactive iodine (I-131) therapy, and levothyroxine (L-T4) suppressive therapy. This study aimed to explore the potential side effects of I-131 therapy on reproductive function in men and women with DTC. METHODS A literature search was performed using 4 databases (PubMed, ScienceDirect, BioMed Central, and Google Scholar), limited to English publications since 2013. Clinical trials and observational studies that evaluated I-131 in DTC, focused on reproductive-age patients, and included pre-therapy or during-therapy examinations, administered doses, and treatment frequencies of I-131 were selected. The Joanna Briggs Institute Critical Appraisal Checklist is used as a comprehensive evaluation tool, and the literature quality was categorized as high, moderate, and low. RESULTS The final 17 articles examined the effect of I-131, with 13 focusing on women's reproductive function and 4 on men's. Women who received I-131 therapy can lower anti-Mullerian hormone levels and disrupt menstrual cycles within the first year, and it does not affect subsequent pregnancies. For men, the therapy led to elevated levels of follicle-stimulating hormone and luteinizing hormone, along with changes in sperm quantity, morphology, and motility, which tend to normalize within a year post-therapy. CONCLUSIONS The reproductive side effects associated with I-131 therapy are generally transient, with most individuals experiencing a return to normal within 1 year following treatment.
PERSEPSI MAHASISWA TERHADAP PENERAPAN INTERPROFESSIONAL EDUCATION DALAM PROGRAM FOME II FAKULTAS KEDOKTERAN UNIVERSITAS ANDALAS 2021-2022 Rahman, Fikri; Yetti, Husna; Elliyanti, Aisyah
SINERGI : Jurnal Riset Ilmiah Vol. 2 No. 4 (2025): SINERGI : Jurnal Riset Ilmiah, April 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v2i4.1119

Abstract

Collaboration between health professionals was needed to improve health services. The collaboration can be applied to the education system through the Interprofessional Education (IPE) concept. The purpose of this study was to examine students’ perception of IPE in the Family Oriented Medical Education (FOME) II program. This research is a descriptive study with a cross-sectional design. The research samples were 162 Medical Faculty Universitas Andalas students who took part in the FOME II program in the 2021-2022 academic year. FOME II is a learning activities created by FK Unand with the aim of producing competent health workers with a family approach. There were 142 medical study program students and 20 undergraduate midwifery study program students. Study data was collected by using the Interdisciplinary Education Perception Scale (IEPS) questionnaire.  The vast majority of students(153 students,94.4%) had a good perception on IPE with the evidence of working together’s component having the highest percentage (90.7%) and needing to work together’s component had the lowest percentage (59.9%). Medical Study Program students have the highest percentage of the application of IPE perception (95.7%) while midwifery study program students have the lowest percentage of the application of IPE perception (85%).  Most of FK Unand students’ perceptions of IPE are in the good category. However, the aspect of the need to cooperate is still lacking so this needs to be considered and improved
Co-Authors Ade Sukma Afriwardi Afriwardi Andani Eka Putra Angriani, Winda Ariani, Novita Arina Widya Murni Arnelis Arnelis Arni Amir Ashal, Taufik Aswiyanti Asri Aziza, Zulva Cimi Ilmiawati, Cimi Daan Khambri Dani Rosdiana Desmawati Desmawati Dewi Anggraini Dewi Anggraini Dia Rofinda, Zelly Dia Dian Pertiwi Dian Pertiwi Ediwi, Nabila C. Elisabet, Adinda Elizabeth Bahar Elmatris Sy Eryati Darwin Esha, Indi Eti Yerizel Faiz Chalidzar Fasril , Thira Febrianti, Ika K. Febrianti, Ika Kurnia Fika Anggraini Fika Anggraini Fitri Wahyu Febriwani Genia, Dara Indah Hafizhah, Nurul Hanifah, Zulfa N. hanifah, zulfa nur Harahap, Sari Hendriati, Hendriati Herlambang Herlambang Husna Yetti Husna, Annisaul Husnil Wardiyah Ibrahim, Raihan Syah Ika Kurnia Febrianti Ilmiati Ilmiati INDRA YOVI Intan, Shinta Ayu Irrahmah, Miftah Iskandar Iskandar Johan S. Masjhur, Johan S. Julizar Julizar Julizar Julizar Julizar Julizar Katrin Monika Lili Irawati Lili Irawati Lusikooy, Ronald E. Mardhatilah, Ashifa Meidrin Joni Miftah Irrahmah Miftah Irrahmah Miftah Irramah Mohamad Reza Monika, Katrin Netti Suharti, Netti Noormartany Nora Harminarti Noza Hilbertina, Noza Nur Afrainin Syah Nurhajjah, Sitti Nurrahma, Zuyyina ER. Putra, Andani E. Putri, Nabila Putri, Rahmi T. Raden Mohamad Herdian Bhakti Rahmad Syawqi Rahmad Syawqi Rahman, Fikri Rahmat Syawqi Rahmat Syawqi Raihan Syah Ibrahim Ramacos Fardela Rasya, Salsabila Faiha Wiendra Rasyada, Latifah Aulia RAVEINAL RAVEINAL Rina Gustia Rivai, Muhammad I. S Setiyowati Sabar Hutabarat Safari, Dodi Safitri, Nuridha Audinia Salsabila, Dhianisa Sarassari, Rosantia Shapira, Vanesya Zahrani Simanjuntak, Arya M. Siregar, Fajri M. Siregar, Muhammad Abi Ghoffari Siti Nurhajjah Sorayya A'dilah Putri Sri Setiyowati Suminta RS, Teresia Susilo, Veronica Y. Syah, Nur A. Syaiful Azmi Syamel, Muhammad Tenny Putri Wikayani, Tenny Putri Tofrizal, Alimuddin Tri Hanggono Achmad Veronica, R. Merlinda VY Susilo Wulandari Wulandari Yose Ramda Ilhami Yose Ramda Ilhsmi Yulia Iriani, Yulia Yulia Kurniawati Yulia Kurniawati Yulistini, Yulistini Yusticia Katar, Yusticia Zelly Dia Rofinda