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Correlation of Hemostatic Parameter with Lung Tumor Marker in Non-Small Cell Lung Cancer Patient with Chemotherapy Ganda M. Leonard Samosir; Parluhutan Siagian; Putri Chairani Eyanoer
Jurnal Respirologi Indonesia Vol 38, No 1 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i1.137

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Backgrounds: There is a subclinical activation of coagulation and fibrinolysis system in patient with lung cancer. Alterations in hemostatic system are seen frequently in lung cancer correlated with the prognosis of disease. In oncology practice, the use of tumor markers may be helpful in the diagnosis and pathologic classification of tumors. Tumor marker may reflect both, stage of the disease and prognosis. Aim of this research is to asses the correlation of this parameters in patient non-small cell lung cancer with chemotherapy. Methods: This research is an analytic observational with a cross sectional design. The research was conducted at RSUP Haji Adam Malik, Medan from January 1, 2015 to May 31, 2016. Blood test examination was performed to measure the hemostatic parameter (PT, INR, APTT, TT, D-dimer) and serum tumor marker (CEA, Cifra21-1, NSE) of 41 non-small cell lung cancer patients before first cycle of chemotherapy and after fourth or sixth cycles of chemotherapy. Results: The study comprised 41 patients of non-small cell lung cancer (31 adenocarcinoma, 10 squamous cell carcinoma), There were 35 men (85,4%) and 3 women (14,6%) with mean age of 56,7 years. For all patients, we give a platinum based therapy as first line chemotherapy (gemsitabine and carboplatin regimen in 27 patients, paclitaxel and carboplatin in 10 patients, vinorelbine and carboplatin in 4 patients). There is no significant difference of hemostatic parameter and serum tumors marker values before chemotherapy againts after chemotherapy values. And there is a weak negative correlation of hemostatic parameter againts serum tumor marker on non-small cell lung cancer patients with chemotherapy. Conclusion: There is a weak negative correlation of hemostatic parameter againts serum tumor marker in non-small cell lung cancer patients with chemotherapy. (J Respir Indo 2018; 38(1): 33-38)
Hubungan merokok dengan gangguan pendengaran akibat bising pada pekerja pabrik kelapa sawit X Maesyara Adinda Sari; Adlin Adnan; Delfitri Munir; Putri Chairani Eyanoer
Oto Rhino Laryngologica Indonesiana Vol 47, No 2 (2017): Volume 47, No. 2 July - December 2017
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (306.364 KB) | DOI: 10.32637/orli.v47i2.218

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Latar belakang: Paparan bising dapat mengakibatkan kerusakan pada organ korti, dan menurunkan aliran darah koklea yang mengakibatkan hipoksia koklea. Merokok diketahui sebagai ototoksik langsung dan pemicu iskemia koklea. Kebiasaan merokok dan paparan bising secara sendiri ataupun secara bersama-sama dapat menyebabkan gangguan pendengaran. Tujuan: Mengetahui hubungan merokok terhadap kejadian gangguan pendengaran akibat bising (GPAB). Metode: Penelitian analitik dengan pendekatan potong lintang. Hasil: Dari 122 pekerja, didapati sebanyak 89,3% pekerja mengalami GPAB. Tuli ringan paling banyak ditemukan (68,8%). Didapatkan adanya hubungan yang signifikan antara tipe perokok dengan derajat beratnya GPAB (p=0,000). Kemungkinan pekerja yg merokok untuk mengalami GPAB 1,224 kali lebih besar dibandingkan dengan pekerja yang tidak merokok (PR=1,224, p=0,002, CI 95%=1,077–1,392). Kesimpulan: Terdapat hubungan yang signifikan antara kebiasaan merokok dengan kejadian GPAB.Kata kunci: Merokok, gangguan pendengaran, gangguan pendengaran akibat bising, bising lingkungan kerja ABSTRACT Introduction: Noise exposure can lead to the organ of corti damage, and decrease the blood flow to the cochlea resulting in cochlear hypoxia. Cigarette smoking could be ototoxic to cochlea, and could evoke cochlear ischemia. Cigarette smoking habit and noise exposure, each or together can cause hearing loss. Objective: To identify the correlation between cigarette smoking and noise induced hearing loss (NIHL). Method: Analytic with a cross-sectional study. Results: From the 122 workers, we found that the proportion of NIHL was 89.3%. Mild deafness was most common (68.8%). We found that there was a significant correlation between type of smokers and grade of hearing loss (p=0.000). Workers who smoked likely to undergo NIHL 1.224 times greater than nonsmokers (PR=1.224, p=0.002, CI 95%=1.077–1.392). Conclusion: There was a significant correlation between cigarette smoking habit and noise induced hearing loss.Keywords : Cigarette smoking, hearing loss, noise induced hearing loss, occupational noise exposure
The Effect of Two-Mile Jogging Training on Lung Function Values in TNI Soldier Kodam I/Bukit Barisan Rifda Hayati; Nuryunita Nainggolan; Amira Permatasari Tarigan; Putri Chairani Eyanoer
Respiratory Science Vol. 1 No. 1 (2020): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i1.8

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Background: Military soldiers are army personnel who are required to have good physical endurance and optimal fitness, include. So, it's needed physical exercise, include to be able to improve lung function. One parameter that can reflect physical fitness are lung function and m VO2max. This study aims to determine whether there is a relationship between physical exercise in the form of 2-mile jogging with increased lung function and VO2max of military soldiers Kodam 1 Bukit Barisan Methods: This research is an experimental study carried out in February-April 2019 against the TNI soldiers of the Bukit Barisan Military District 1. The research subjects were divided into two groups, group 1 who underwent regular 2-mile jogging exercises 3-5 times a week with a duration of 25 minutes for 2 months, and group 2 who underwent non-routine jogging exercises (less than 3 times a week). Lung function was assessed by spirometry. Results: As many as 68 military soldiers were involved in this study which were divided into two groups, 38 people in the group 1 who routinely trained and 30 people in group 2 that did not routinely practice. Group 1 VEP1 values were higher than group 2 (p=0.03). No significant differences in terms of KVP, MVV and VO2max in both groups. Lung function of smokers were lower than non-smokers, but not statistically significant. Conclusion: There were significant differences in VEP1 values between military soldiers who routinely and did not routinely undergo 2-mile jogging exercises.
Accuracy Between CURB-65 Score and PSI in Determining The Prognosis of Community-Acquired Pneumonia Patients at H. Adam Malik General Hospital, Medan Fransisco Sentosa Pakpahan; Syamsul Bihar; Fajrinur Syarani; Putri Chairani Eyanoer
Respiratory Science Vol. 1 No. 3 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i3.25

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Background: Community-Acquired Pneumonia (CAP) is an important problem associated with morbidity and mortality. An accurate initial assessment is required before starting management of a CAP patient to determine the prognosis of the patient as early as possible. The CURB-65 score and PSI (Pneumonia Severity Index) are initial assessment scores that can be used. This study aimed to compare the accuracy between the CURB-65 score and the PSI in determining the prognosis in CAP patients at H. Adam Malik General Hospital Medan. Method: A descriptive study was conducted on 76 patients diagnosed with CAP. Each patient was assessed for their CURB-65 score, PSI class and mortality within 30 days of admission. Data were collected through patient medical records diagnosed CAP in 2018 and performed statistical analysis using 2x2 tables. Results: The CURB-65 ≥3 score showed accuracy (71.0%), sensitivity (53.8%), and specificity (89,2%). The CURB-65 ≥ 2 score showed accuracy (75.0%), sensitivity (82.1%), and specificity (67.6%).  Meanwhile, the Class IV-V PSI showed accuracy (77.6%), sensitivity (87.2%) and specificity (67.6%). Conclusion: The accuracy of the PSI is higher when compared to the CURB-65 score in determining the prognosis of CAP patients at H. Adam Malik General Hospital Medan. Although PSI is more accurate, CURB-65 is simpler, easier and less expensive to use
CT Guided TTNA and Core Biopsy in Suspected Lung Cancer, Review of Cases in Adam Malik General Hospital, Medan Hadi Suhendra; Fajrinur Syarani; Syamsul Bihar; Putri Chairani Eyanoer
Respiratory Science Vol. 2 No. 1 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i1.27

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ounds: The cytological and histopathological findings establish the type of lung cancer cells as the definitive diagnosis of lung cancer. This study aimed to determine the characteristics of lung cancer patients in terms of age, mean age, gender, staging, the proportion of lung cancer cells by cytologic examination of Transthoracic Needle Aspiration (TTNA) and histopathologic evaluation from CT-guided core biopsy. Method: This is a descriptive study involving 42 subjects diagnosed with lung cancer at H. Adam Malik Hospital Medan in 2016-2020 that met the inclusion criteria through consecutive sampling. Data was analysed using descriptive statistics for categorical variables. Results: Of 42 study subjects, the 60–71-year age group had the highest percentage of lung cancer (42.9%). Male (71.4%) was higher than female, the most common lung cancer staging was IVA (57.1%), and adenocarcinoma was found to be the most frequent type of lung cancer in both cytology (33.3%) and histopathology (31.0%). Conclusion: We concluded that core biopsy is superior in diagnosing lung cancer compared to TTNA.
Vitamin C Supplementation Improves Pulmonary Tuberculosis Patients' Sputum Conversion During Intensive Phase Category I Treatment in Medan Elok Ariyani Safitri; Parluhutan Siagian; Bintang Yinke Magdalena Sinaga; Putri Chairani Eyanoer
Respiratory Science Vol. 2 No. 2 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i2.30

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Background: Many factors influence the success of the acceleration of Acid-Fast Bacilli (AFB) sputum conversion in the treatment of the intensive phase of pulmonary tuberculosis (TB). One of these factors is the nutritional status or nutrition of pulmonary TB patients. Through a fenton reaction, Vitamin C is known to be able to sterilize Mycobacterium tuberculosis. This study aims to determine the effect of giving vitamin C on the conversion of AFB sputum in the intensive phase of pulmonary TB treatment. Method: This study was an inferential, quasi-experimental evaluation of the acceleration of AFB sputum conversion following vitamin C supplementation in patients with category I pulmonary TB. The study group was separated into two groups: 40 TB patients getting Anti Tuberculosis Treatment (ATT) with vitamin C, and 40 TB patients receiving ATT with placebo. Every two weeks, AFB sputum was examined, and vitamin C levels were measured before and after two months of therapy. Results: Conversion of AFB occurred sooner in the vitamin C group of pulmonary TB patients, with as many as 29 patients (72.5%) experiencing conversion of AFB sputum at the end of the second week of therapy, whereas there was no conversion in the placebo group. At the end of the fourth week, all patients (100%) given vitamin C showed AFB sputum conversion, whereas only eight patients (20%) in the placebo group had conversion at the end of the fourth week of treatment. Vitamin C levels increased significantly in the group of pulmonary tuberculosis patients who received vitamin C supplementation. Conclusion: Vitamin C supplementation in the treatment of pulmonary TB can accelerate the conversion of AFB sputum, which is statistically significant.
The Associations Between Severity Of Symptoms, D-Dimer and Incidence of ARDS In COVID-19 Herani Mutia Riandini; Fajrinur Syaran; Syamsul Bihar; Putri Chairani Eyanoer
Respiratory Science Vol. 2 No. 3 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i3.40

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Background: Severe acute respiratory injury caused by COVID-19 (ARDS) is a serious emerging complication. ARDS results from a cytokine storm that occurs in the second week of the disease course and acute-onset hypoxemia can be seen with bilateral infiltrates on chest radiograph. This study aimed to relate the severity of symptoms and D-dimer level to the incidence of ARDS in COVID-19 at H. Adam Malik Hospital as the referral center for COVID-19 in North Sumatra. Method: This was a descriptive study with a retrospective cohort design. The sample of this study was secondary data from medical records of positive RT-PCR COVID-19 patients from November 2020 to April 2021. The inclusion criteria were patients with moderate to critical COVID-19 cases with D-dimer examination taken from the first day of admission. Subjects were then followed up until discharge from the hospital to assess for ARDS episodes which were confirmed by the results of PaO2/FiO2 in arterial blood gases and bilateral infiltrations in chest X-Ray. The exclusion criteria were incomplete medical records. Results: The association between the severity of symptoms and the incidence of ARDS, 1 of which was found to be moderate, 19 cases were severe and 20 were critical. However, there was a statistically significant correlation between the severity of symptoms and the incidence of ARDS (P=0.0001). Conclusion: There was a significant correlation between the severity of symptoms and the D-dimer value on the incidence of ARDS.
Characteristics of COVID-19 Patients in Haji Adam Malik General Hospital, Medan, North Sumatera Dyana Destylya; Bintang YM Sinaga; Parluhutan Siagian; Putri Chairani Eyanoer
Respiratory Science Vol. 2 No. 3 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i3.53

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Background: Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The increase in the number of COVID-19 cases was happening quite quickly and has spread between countries so that COVID-19 has become a pandemic in the world. This study aimed to determine the characteristics of COVID-19 patients at Haji Adam Malik General Hospital Medan. Method: This was a descriptive study. Data were taken from the medical records of 110 hospitalized patients with positive RT-PCR results for COVID-19 from December 2020 to April 2021. The inclusion criteria for the case samples were patients diagnosed with COVID-19 based on RT-PCR and the exclusion criteria were incomplete medical records. Characteristic analysis was carried out using the Kruskal Wallis test. Results: The most common comorbidities found in patients with severe COVID-19 were diabetes mellitus and HIV. The most common comorbidity found in moderate-level COVID-19 patients was pregnant women. The most common chest X-rays finding in severe and critical levels was bilateral infiltrates. Recovered patients were mostly obtained at moderate level, while deceased patients were mostly observed at critical levels. Conclusion: Characteristics of COVID-19 patients at Haji Adam Malik General Hospital were classified based on the degree of disease by age, lymphocyte value, N/L ratio, levels of CRP, D-dimer, procalcitonin, fibrinogen, ferritin, and comorbidities as well as the appearance of infiltrates in both lung fields.
Correlation between Genetic Polymorphism of CYP2A13 Genotype and Lung Cancer in Female Passive Smokers Nurul Ramadhani; Noni Novisari Soeroso; Setia Putra Tarigan; Putri Chairani Eyanoer; Hidayat Hidayat
Molecular and Cellular Biomedical Sciences Vol 6, No 2 (2022)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v6i2.246

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Background: Nicotine is metabolized to cotinine by cytochrome P450 enzyme, and this enzyme is involved in the activation of toxic and carcinogenic substances. The aim of this research was to assess the relationship between genetic polymorphism of CYP2A13 and lung cancer incidence in female passive smokers.Materials and methods: This research was a case-control study that involved 104 research subjects. Subjects were recruited through purposive sampling technique from 2 hospitals in Medan, North Sumatra, Indonesia. The case population consisted of female passive smokers with lung cancer and the control population consisted of female passive smokers without lung cancer. All research subjects underwent blood sampling for genomics DNA extraction and CYP2A13 genotyping by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Data was analyzed by conditional logistic regression by Epi Info 7.0 software.Results: Among 104 subjects, 26 (25%) individuals were heterozygous, 76 (73%) individuals were wild type, and 2 (2%) were mutant for the 257Cys allele. There was a significant correlation between CYP2A13 genotype and lung cancer incidence (p-value<0.05). Female passive smokers with CT genotype had 2.7 greater risk of developing lung cancer than those with CC genotype (wild type). The C allele had more frequency and 1.6 times higher risk of lung cancer compared to T allele with a wide confidence range (0.73–3.52).Conclusion: There was a significant correlation between CYP2A13 polymorphism and lung cancer incidence in female passive smokers.Keywords: polymorphism, CYP2A13, PCR-RFLP, female passive smoker, lung cancer
Association of CYP2A6 Genetic Polymorphism and Lung Cancer in Female Never Smokers R.A Henny Anggriani; Noni Novisari Soeroso; Setia Putra Tarigan; Putri Chairani Eyanoer; Hidayat Hidayat
Molecular and Cellular Biomedical Sciences Vol 6, No 2 (2022)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v6i2.232

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Background: The major significant factor that affected lung cancer development among female passive smokers is environmental tobacco smoke. Nicotine can be found in a never smoker population, such as a child whose father is a smoker. Lung carcinogenesis in never smoker populations is affected by nicotine metabolism by CYP2A6 gene, which encodes the main nicotine metabolizing-enzyme. The aim of this study was to assess the genetic polymorphism of CYP2A6 and its association with secondhand smokers among females who have suffered from lung cancer in North Sumatra population.Materials and methods: This study was a case-control study, composed of 53 case subjects and 46 control subjects that were involved through a purposive sampling technique from two hospitals in Medan. PCR-RFLP was used for the examination of CYP2A6 gene to determine the genotype. The data were analyzed with conditional logistic regression test using Epi Info 7.0 software.Results: The most common genotype of CYP2A6 detected in this study was *1B/*1B (40.4%), while *1B allele had the highest prevalence (55.5%). There was no significant association between CYP2A6 genotype (p-value=0.61) or alleles (p-value=0.25) and the incidence of lung cancer.Conclusion: There was no association between CYP2A6 polymorphism and the incidence of lung cancer in secondhand smoker females.Keywords: CYP2A6, PCR-RFLP, female secondhand smokers, lung cancer
Co-Authors -, Fadhlia Ade Rahmaini Adlin Adnan Agnes Juni Jelita Sitohang Agnes Laurensia Gea Alona, Ivana Alwi Thamrin Nasution Amaiappan, Jesvinder Andika Pradana Andika Pradana Andika Pradana Arlinda Sari Wahyuni Armon Rahimi Asnir, Rizalina Arwinati Athalia Famelinda Gracia Sinaga Atiyatul Amra, Aryani Azali, Chairul Nurdin Azizah Ghanie Icksan Bintang Yinke Magdalena Sinaga Bintang Yinke Magdalena Sinaga Bintang YM Sinaga Bintang YM Sinaga Budi Jefri Budi Wiweko Chairiza Muttaqien Dana Jauhara Layali David Albert Pardede Delfitri Munir Delfitri Munir Delores Elisabeth Sormin Destylya, Dyana Dina Octafrida Marpaung Dyana Destylya E. Tito Julianda Sinaga Eddy Bangun Elisabeth Elisabeth Elizabeth Napitupulu Elmeida Effendy Elok Ariyani Safitri Elva Susanty Elvita Rahmi Daulay Endy Juli Anto Endy Todo Sirait endyjulianto endyjulianto Eva Susanti Debora Hutabarat Evo Elidar Harahap Fachrezi, Muhammad Alfian FAHDI, FIRDAUS Fajrinur Syahrani Fajrinur Syahrani Fajrinur Syaran Fajrinur Syarani Fajrinur Syarani Fajrinur Syarani Faradila, Devita Farhat, Farhat Faried, Mukhamad Febiyanti, Mica Felisia Felisia Firdaus, Ruby Fransisco Sentosa Pakpahan Fujiati, Isti Ilmiati Ganda M. Leonard Samosir Ghazali Akhmad Putranta Ginting, Franciscus Hadi Suhendra Hafizhalaila Ammar Hakim, Enggrek Pelita Halawa, Pisces Alfred Dorifman Hamdi, Tasrif Harahap, Juliandi Haryuna, Tengku Siti Hajar Hasibuan, Mangain Hemma Yulfi Hendri Wijaya, Hendri Henny Maisara Sipahutar Herani Mutia Riandini Hidayat Hidayat Hulu, Dirga Agustina Hutagalung, Angeline Kory Ihsan, Mhd. Joshua Asley Juli Anto, Endy Juliandi Harahap Kadri, Alfansuri Kartini harahap Kembaren, Tambar kenvin rusli Kiking Ritarwan Listyoko, Aditya Sri Lubis, Muhammad Allif Syafrin Lubis, Netty Delvrita Maesyara Adinda Sari Maulidina Hsb, Putri Sari Mirna Risna Lovinanda Lubis Muhammad Ichwan Muhammad Zainul A Muntasir Abdullah Nababan, Windika Nasution, Duma Ratna Sari Nathasia Simanjuntak Netty Delvrita Lubis Netty Delvrita Lubis Noni Novisari Soeroso Noni Novisari Soeroso Noni Novisari Soeroso Nurdiansah, Firman Nurul Citta Banu Putri Nurul Ramadhani Nuryunita Nainggolan Octavia, Nur Afni Heryanti Pandia, Pandiaman Pandiaman Pandia Pandiaman Pandia Panjaitan, Alfred Johnatan Pardede, Sujahn Anto Parluhutan Siagian Parluhutan Siagian Parluhutan Siagian Pase, M Aron Pendiaman Pandia Perangin-angin, Gwanita Nawariantina Peter Peter Pratama, Mhd. Rizki Pratiwi, Ade Dwi Putri Maria Regina R.A Henny Anggriani Ramadhani, Adini Arifah Rambe, Andrina Yunita Murni Restuti Hidayani Saragih Ribawanto, Muhammad Rafif Rifda Hayati Rina Amelia Rina Yunita Ririe Fachrina Malisie Risqin, Muhammad Anas Fatah Rosita Juwita Sembiring Rusda, Muhammad Salsabila, Anisa Samodra, Yoseph Leonardo Sarah, Dewi Maya Sekali, Oktaviani Karo Selvy Wulandari Siahaan, Jekson Martiar Sikumbang, Rahmat Hidayat Simanjuntak, Novita Hasiani Simanullang, Putri Andriani Sinaga, Bintang Yinke Magdalena Sinaga, Joshua Princeman Sinaga, Sudirman Parningotan Sirait, Asima Rodiarta Siregar, Nondang Purnama Syamsul Bihar Syamsul Bihar Syamsul Bihar Syarani, Fajrinur Tampubolon, Johana Bonafide Tampubolon, Jonaha Bonafide Tarigan, Amira Permatasari Tarigan, Setia Putra Tri Setia Negara Sinulingga Urip Harahap Vera, Yeni Wahyuni, Arlinda Sari Wan Betty Pratiwi Yahwardiah Siregar Yessi Andriani Zainal Yunanda, Yuki Zainuddin Amir Zakirah, Sarah Chairani