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Characteristics of COVID-19 Patients in Haji Adam Malik General Hospital, Medan, North Sumatera Dyana Destylya; Bintang YM Sinaga; Parluhutan Siagian; Putri Chairani Eyanoer
Respiratory Science Vol. 2 No. 3 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i3.53

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Background: Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The increase in the number of COVID-19 cases was happening quite quickly and has spread between countries so that COVID-19 has become a pandemic in the world. This study aimed to determine the characteristics of COVID-19 patients at Haji Adam Malik General Hospital Medan. Method: This was a descriptive study. Data were taken from the medical records of 110 hospitalized patients with positive RT-PCR results for COVID-19 from December 2020 to April 2021. The inclusion criteria for the case samples were patients diagnosed with COVID-19 based on RT-PCR and the exclusion criteria were incomplete medical records. Characteristic analysis was carried out using the Kruskal Wallis test. Results: The most common comorbidities found in patients with severe COVID-19 were diabetes mellitus and HIV. The most common comorbidity found in moderate-level COVID-19 patients was pregnant women. The most common chest X-rays finding in severe and critical levels was bilateral infiltrates. Recovered patients were mostly obtained at moderate level, while deceased patients were mostly observed at critical levels. Conclusion: Characteristics of COVID-19 patients at Haji Adam Malik General Hospital were classified based on the degree of disease by age, lymphocyte value, N/L ratio, levels of CRP, D-dimer, procalcitonin, fibrinogen, ferritin, and comorbidities as well as the appearance of infiltrates in both lung fields.
Correlation between Genetic Polymorphism of CYP2A13 Genotype and Lung Cancer in Female Passive Smokers Nurul Ramadhani; Noni Novisari Soeroso; Setia Putra Tarigan; Putri Chairani Eyanoer; Hidayat Hidayat
Molecular and Cellular Biomedical Sciences Vol 6, No 2 (2022)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v6i2.246

Abstract

Background: Nicotine is metabolized to cotinine by cytochrome P450 enzyme, and this enzyme is involved in the activation of toxic and carcinogenic substances. The aim of this research was to assess the relationship between genetic polymorphism of CYP2A13 and lung cancer incidence in female passive smokers.Materials and methods: This research was a case-control study that involved 104 research subjects. Subjects were recruited through purposive sampling technique from 2 hospitals in Medan, North Sumatra, Indonesia. The case population consisted of female passive smokers with lung cancer and the control population consisted of female passive smokers without lung cancer. All research subjects underwent blood sampling for genomics DNA extraction and CYP2A13 genotyping by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Data was analyzed by conditional logistic regression by Epi Info 7.0 software.Results: Among 104 subjects, 26 (25%) individuals were heterozygous, 76 (73%) individuals were wild type, and 2 (2%) were mutant for the 257Cys allele. There was a significant correlation between CYP2A13 genotype and lung cancer incidence (p-value<0.05). Female passive smokers with CT genotype had 2.7 greater risk of developing lung cancer than those with CC genotype (wild type). The C allele had more frequency and 1.6 times higher risk of lung cancer compared to T allele with a wide confidence range (0.73–3.52).Conclusion: There was a significant correlation between CYP2A13 polymorphism and lung cancer incidence in female passive smokers.Keywords: polymorphism, CYP2A13, PCR-RFLP, female passive smoker, lung cancer
Association of CYP2A6 Genetic Polymorphism and Lung Cancer in Female Never Smokers R.A Henny Anggriani; Noni Novisari Soeroso; Setia Putra Tarigan; Putri Chairani Eyanoer; Hidayat Hidayat
Molecular and Cellular Biomedical Sciences Vol 6, No 2 (2022)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v6i2.232

Abstract

Background: The major significant factor that affected lung cancer development among female passive smokers is environmental tobacco smoke. Nicotine can be found in a never smoker population, such as a child whose father is a smoker. Lung carcinogenesis in never smoker populations is affected by nicotine metabolism by CYP2A6 gene, which encodes the main nicotine metabolizing-enzyme. The aim of this study was to assess the genetic polymorphism of CYP2A6 and its association with secondhand smokers among females who have suffered from lung cancer in North Sumatra population.Materials and methods: This study was a case-control study, composed of 53 case subjects and 46 control subjects that were involved through a purposive sampling technique from two hospitals in Medan. PCR-RFLP was used for the examination of CYP2A6 gene to determine the genotype. The data were analyzed with conditional logistic regression test using Epi Info 7.0 software.Results: The most common genotype of CYP2A6 detected in this study was *1B/*1B (40.4%), while *1B allele had the highest prevalence (55.5%). There was no significant association between CYP2A6 genotype (p-value=0.61) or alleles (p-value=0.25) and the incidence of lung cancer.Conclusion: There was no association between CYP2A6 polymorphism and the incidence of lung cancer in secondhand smoker females.Keywords: CYP2A6, PCR-RFLP, female secondhand smokers, lung cancer
HUBUNGAN ABNORMALITAS EKG DENGAN MORTALITAS PADA PASIEN STROKE HEMORAGIK Peter Peter; Joshua Asley; Alfansuri Kadri; Putri Chairani Eyanoer; Eddy Bangun; Felisia Felisia
Callosum Neurology Vol 4 No 1 (2021): Callosum Neurology Journal
Publisher : The Indonesia Neurological Association Branch of Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29342/cnj.v4i1.136

Abstract

Latar Belakang: Stroke merupakan penyebab kematian terbanyak kedua di dunia setelah penyakit jantung. Di negara berkembang, stroke hemoragik mencakup 34% dari semua stroke, yang disebabkan oleh perdarahan intraserebral dan perdarahan subaraknoid. Kelainan EKG dapat ditemukan pada pasien stroke hemoragik  pada 72 jam pertama setelah kejadian. Penelitian ini bertujuan menilai hubungan abnormalitas EKG pada pasien stroke hemoragik yang mungkin berdampak pada peningkatan mortalitas, disertai pengaruh faktor usia, jenis kelamin, dan tekanan darah sistolik terhadap mortalitas pasien stroke hemoragik. Metode: Penelitian potong lintang retrospektif pada data rekam medis pasien stroke hemoragik di RS Haji Adam Malik, Medan periode 2017-2020, dengan teknik total sampling. Jumlah sampel yang masuk dalam kriteria inklusi sebanyak 157 sampel, yang kemudian di bagi berdasarkan karakteristik usia, jenis kelamin, tekanan darah sistolik, abnormalitas EKG, dan mortalitas. Hasil: Subjek penelitian yang meninggal dengan EKG abnormal berjumlah 45/77 (58,4%), sedangkan subjek yang meninggal dengan EKG normal sebanyak 32/77 (41,6%). Didapatkan hubungan bermakna antara abnormalitas EKG dan mortalitas pasien stroke hemoragik dengan odd ratio (OR) 3,281; 95% IK 1,698-6,341; p<0,001. Usia (OR 0,985; 95% IK 0,960-1,010; p=0,234), jenis kelamin (OR 0,794; 95% IK 0,424-1,487; p=0,472), dan tekanan darah sistolik (OR 0,993; 95% IK 0,984-1,002; p=0,135) tidak memiliki hubungan yang bermakna dengan mortalitas pasien stroke hemoragik. Simpulan: Pasien stroke hemoragik dengan kelainan EKG memiliki kemungkinan mortalitas lebih tinggi dibandingkan dengan pasien normal, sedangkan variasi usia, jenis kelamin, dan tekanan darah sistolik tidak memiliki hubungan signifikan dengan mortalitas pasien stroke hemoragik. Kata Kunci: EKG, Mortalitas, Stroke, Perdarahan Intrakranial
EDUKASI DAN SOSIALISASI PENCEGAHAN PENYEBARAN COVID-19 PADA SISWA DAN GURU SEKOLAH MENENGAH PERTAMA BERBASIS USAHA KESEHATAN SEKOLAH (UKS) DI KECAMATAN BINJAI KABUPATEN LANGKAT, PROVINSI SUMATERA UTARA, TAHUN 2020 Rina Amelia; Arlinda Sari Wahyuni; Yuki Yunanda; , Putri Chairani Eyanoer; Juliandi Harahap; Isti Ilmiati Fujiati
Prosiding Konferensi Nasional Pengabdian Kepada Masyarakat dan Corporate Social Responsibility (PKM-CSR) Vol 3 (2020): Peran Perguruan Tinggi dan Dunia Usaha Dalam Pemberdayaan Masyarakat Untuk Menyongsong
Publisher : Asosiasi Sinergi Pengabdi dan Pemberdaya Indonesia (ASPPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (81.842 KB) | DOI: 10.37695/pkmcsr.v3i0.1040

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The coronavirus pandemic (COVID-19) is designated as a Public Health Emergency that is troubling the world, much remains unknown about the virus that causes COVID-19, but in general, this virus is transmitted through direct contact with droplets from the respiratory tract of an infected person (which exits through coughs). And sneezes). People can also become infected by touching a surface contaminated with this virus and then touching their face (eg, eyes, nose, mouth). The school health program (SHP) is a health program implemented at the school level. The main activities of SHP are carried out through health education, health services, and fostering a healthy school environment with the primary target of students, educators, educators, and the school community. Efforts to maintain health can be started from the school environment, which emphasizes changing behavior. Therefore this SHP program is essential because it includes early health education. This community service aims to provide education and socialization to prevent the spread of the COVID-19 virus to teachers and students based on UKS at Amanah SMPS, Binjai District, Langkat Regency. Before being given education, assessing the COVID-19 prevention behavior that they have implemented is carried out using a valid questionnaire. Then proceed with educational activities. The educational method carried out was by lecturing and discussing the prevention of COVID-19 and simulating the proper use of masks, after which several participants were asked to practice it and witnessed by other participants. It is hoped that with this community, serving students and teachers will increase their understanding and be able to prevent COVID-19 both for themselves and prevention in the community.
The Effect of Long-Acting Beta-2 Agonist Monotherapy and Long-Acting Anticholinergic Monotherapy to Quality-of-Life in Group B Stable COPD Patients Tri Setia Negara Sinulingga; Pandiaman Pandia; Amira P. Tarigan; Putri Chairani Eyanoer
Jurnal Respirologi Indonesia Vol 42, No 4 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i4.370

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Background: Based on the 2019 Global Initiative for Chronic Obstructive Lung Disease (GOLD), treatment for group B stable COPD patients is a long-acting beta-2 agonist (LABA) or long-acting anticholinergic (LAMA). Some studies experienced that LAMA was better than LABA but the opposite was also found in several studies. COPD patients often experience a decline in physical activity which causes a decrease in quality of life. We aimed to compare the effect of LABA or LAMA on quality of life in group B stable COPD patients.Methods: This was a study with case series design conducted on 50 COPD patients divided into two groups. The first group consisted of patients who used LABA for at least 3 months. The second group used LAMA for at least 3 months. All subjects filled in the SGRQ. The calculation of SGRQ was carried out using Microsoft Excel Calculator SGRQ.Results: A total 41 men and 9 women were enrolled in this study. There was no significant difference between the use of indacaterol monotherapy and tiotropium monotherapy on the quality of life although tiotropium showed a better quality of life (76%) than indacaterol monotherapy (64%).Conclusion: There was no significant difference in the use of indacaterol and tiotropium on the quality of life although in this case tiotropium showed better results (P=0.538).
Characteristics of Albumin Levels and Liver Function in Patients With COVID-19 at H. Adam Malik Hospital, Medan Ghazali Akhmad Putranta; Fajrinur Syarani; Syamsul Bihar; Putri Chairani Eyanoer
Respiratory Science Vol. 3 No. 1 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v3i1.61

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Background: COVID-19 (Corona Virus Disease-2019) pandemic has a high mortality rate especially in Medan, Indonesia. Serum albumin and liver function tests are believed to be predictive biomarkers for prognosis in patients with infectious diseases, including COVID-19. This study aimed to investigate the association between the mortality events and severely ill COVID-19 patients' serum albumin and liver enzymes. Method: This is a cross-sectional study using secondary data from the medical records of H. Adam Malik Hospital patients with COVID-19 who were confirmed by RT-PCR from August to December 2020. All patients were analyzed for age, sex, hypoalbuminemia, increased liver enzymes and outcome using Chi-square tests (P<0.05). Results: The average age of severe COVID-19 patients at H. Adam Malik Hospital ranged from 41 to 60 years, with more women prevalence than men. Most of the patients had hypoalbuminemia (84.2%), an increase in AST (59.4)% and ALT (45.5%). There was no significant association between hypoalbuminemia and the disease outcome (P=0.12). There was a significant association between elevated liver enzymes and mortality in severely ill COVID-19 patients (P<0.001). Conclusion: We found that hypoalbuminemia is common in patients with severe COVID-19. However, we found that albumin levels had no association with the patients' mortality rate. Liver enzymes levels appear to be a predictive biomarker for outcomes in COVID-19 patients of H. Adam Malik Hospital. We found that higher ALT and AST levels were associated with significantly higher mortality.
Respiratory Emergency in Hospitalized patient with Intrathoracic Malignancy at H. Adam Malik General Hospital Elizabeth Napitupulu; Noni Novisari Soeroso; Setia Putra Tarigan; Putri Chairani Eyanoer
Jurnal Respirologi Indonesia Vol 42, No 1 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i1.12

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Background: Increased number of intrathoracic malignancy cases (Lung tumor, Mediastinum tumor, Secondary lung cancer and Chest wall tumor) contribute in increased complications of respiratory emergencies such as superior cava vein yyndrome (scvs), massive malignant pleura effusion (mpe), central airway obstruction (cao), massive hemoptysis, lung thromboembolism and pneumothorax. This study aims to look at the proportions, outcomes, and factors that influence respiratory emergency in intrathoracic malignancy cases.Methods: This was a retrospective case series of inpatient respiratory emergencies in patients intrathoracic malignancy at H. Adam Malik Central General Hospital - Medan from 1 May 2011 to 30 April 2016.Results: From 690 subjects intrathoracic malignancy, there were 137 (19.8%) patients with respiratory emergencies and mostly caused by lung tumors (83.9%). Massive MPE was is the most common emergency of 45 cases (6.5%) and massive haemoptysis of at least 4 cases (0.6%). The risk of death was higher in patients with respiratory emergencies. Mediastinum and location of tumor contribute in respiratory emergency appearance with respective OR of 3.9 and 1.5 (p value <0.005)Conclusions: Increased of mortality rate in patients with respiratory emergency and MPE massive is the most cases. Type of the malignancy and Right lung tumor contribute of respiratory emergency in intrathoracic malignancy cases.
Deciphering the Coagulation Factors in Pulmonary Embolism Incident-Based Thorax Enhanced Chest CT in COVID-19 Patient Wan Betty Pratiwi; Noni Novisari Soeroso; Setia Putra Tarigan; Muntasir Abdullah; Rosita Juwita Sembiring; Azizah Ghanie Icksan; Netty Delvrita Lubis; Putri Chairani Eyanoer
Jurnal Respirasi Vol. 9 No. 2 (2023): May 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.2.2023.93-100

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Introduction: Pulmonary embolism is associated with coagulopathy in COVID-19. It is one of the causes of death in COVID-19 cases and is often underdiagnosed in Indonesia because computed tomography-pulmonary angiography (CTPA) is not used as the gold standard. T Methods: This study used a prospective analytical design with a cross-sectional approach. The study participants were 45 COVID-19 patients admitted to Santa Elisabeth Hospital, Medan, from January to March 2021.  Patients were identified with moderate to severe degrees of COVID-19 and elevated D-dimer and subsequently instructed to undergo a thorax CT scan with IV contrast. The data was analyzed using dependent t-test statistical analysis. The p-value < 0.05 was noted as significant. Results: Moderate to severe coagulation factor values in COVID-19 patients with mean + SD PT, APTT, D-dimer, fibrinogen, and platelets were 14.11; 30.65; 1172.14; 423.56 and 215.822, respectively. In this study, 22 (48.9%) patients experienced a pulmonary embolism, while the other 23 (51.1%) did not. No significant correlation was found between all coagulation factors and embolism (p > 0.05). The mean + SD well score for pulmonary embolism was 0.23 + 0.57. Conclusion: Pulmonary embolism was detected in 22 patients (48.49%) with moderate to severe COVID-19 who developed hypercoagulation as indicated by the thorax CT scan with IV contrast. This case was quite common. In resource-constrained situations, a thorax CT scan with IV contrast may replace CTPA in diagnosing/detecting the presence of pulmonary embolism.
Inflammatory Markers of ARDS Events among Patients with Severe and Critical COVID-19 Infection at Adam Malik General Hospital, Medan, North Sumatera Eva Susanti Debora Hutabarat; Fajrinur Syarani; Syamsul Bihar; Putri Chairani Eyanoer
Respiratory Science Vol. 3 No. 3 (2023): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v3i3.78

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Background: COVID-19 can cause fatal outcomes, especially acute respiratory distress syndrome (ARDS). It manifests as organ dysfunction during COVID-19's hyperinflammatory phase, which is associated with a high mortality rate. Data on the clinical characteristics and inflammation markers of patients with severe and critical degrees of COVID-19 with ARDS events are limited. Method: This study is carried out at the Haji Adam Malik General Hospital in Medan. We grouped 204 medical records from February to July 2022 of hospitalized patients with severe and critical COVID-19 cases into two groups, ARDS and non-ARDS. Characteristics of demographic and laboratory inflammatory markers upon admission between each group were collected. After collecting data and serving as categorical data in the frequency distribution table by SPSS ver 25.0. Results: We identified 116 patients (56.9%) who had ARDS event upon hospital admission. ARDS event are most commonly found in the elderly group and the median age of ARDS group patients was 59.5 years higher than the non-ARDS group. Male patients were more likely to have ARDS than female patients. Compared with the non-ARDS group, ARDS group patients had lymphocytopenia, neutrophilia, increased neutrophil-to-lymphocyte ratio (NLR), Procalcitonin and C-Reactive Protein levels. Conclusion: Lymphocytopenia, neutrophilia, increased NLR, procalcitonin and CRP levels upon admission revealed that they were higher in ARDS patients compared to non-ARDS patients. It is critical to identify high-risk groups, such as male sex, the elderly, those with comorbidities, and patients with impaired inflammatory markers to prevent severe complications from COVID-19.
Co-Authors -, Fadhlia Ade Rahmaini Adlin Adnan Alona, Ivana Alwi Thamrin Nasution Amaiappan, Jesvinder Andika Pradana Andika Pradana Andika Pradana Arieta, Lydia Arlinda Sari Wahyuni Armon Rahimi Asnir, Rizalina Arwinati Azali, Chairul Nurdin Azizah Ghanie Icksan Bintang Yinke Magdalena Sinaga Bintang Yinke Magdalena Sinaga Bintang YM Sinaga Bintang YM Sinaga Budi Jefri Budi Wiweko Chairiza Muttaqien Dana Jauhara Layali Delfitri Munir Delfitri Munir Delores Elisabeth Sormin Destylya, Dyana Dyana Destylya Eddy Bangun Elisabeth Elisabeth Elizabeth Napitupulu Elmeida Effendy Elok Ariyani Safitri Elva Susanty Elvita Rahmi Daulay Endy Juli Anto Endy Todo Sirait endyjulianto endyjulianto Eva Susanti Debora Hutabarat Evo Elidar Harahap Fachrezi, Muhammad Alfian FAHDI, FIRDAUS Fajrinur Syahrani Fajrinur Syahrani Fajrinur Syaran Fajrinur Syarani Fajrinur Syarani Fajrinur Syarani Faradila, Devita Farhat, Farhat Faried, Mukhamad Febiyanti, Mica Felisia Felisia Firdaus, Ruby Fransisco Sentosa Pakpahan Fujiati, Isti Ilmiati Ganda M. Leonard Samosir Ghazali Akhmad Putranta Ginting, Franciscus Hadi Suhendra Hafizhalaila Ammar Hakim, Enggrek Pelita Hamdi, Tasrif Harahap, Juliandi Haryuna, Tengku Siti Hajar Hasibuan, Mangain Hemma Yulfi Hendri Wijaya, Hendri Henny Maisara Sipahutar Herani Mutia Riandini Hidayat Hidayat Ihsan, Mhd. Joshua Asley Juli Anto, Endy Juliandi Harahap Kadri, Alfansuri Kartini harahap Kembaren, Tambar kenvin rusli Kiking Ritarwan Listyoko, Aditya Sri Lubis, Muhammad Allif Syafrin Lubis, Netty Delvrita Maesyara Adinda Sari Maulidina Hsb, Putri Sari Muhammad Ichwan Muhammad Zainul A Muntasir Abdullah Nababan, Windika Nasution, Duma Ratna Sari Netty Delvrita Lubis Netty Delvrita Lubis Noni Novisari Soeroso Noni Novisari Soeroso Noni Novisari Soeroso Nurdiansah, Firman Nurul Citta Banu Putri Nurul Ramadhani Nuryunita Nainggolan Octavia, Nur Afni Heryanti Pandia, Pandiaman Pandiaman Pandia Pandiaman Pandia Panjaitan, Alfred Johnatan Pardede, Sujahn Anto Parluhutan Siagian Parluhutan Siagian Parluhutan Siagian Pase, M Aron Pendiaman Pandia Perangin-angin, Gwanita Nawariantina Peter Peter Pratama, Mhd. Rizki Pratiwi, Ade Dwi R.A Henny Anggriani Ramadhani, Adini Arifah Rambe, Andrina Yunita Murni Restuti Hidayani Saragih Ribawanto, Muhammad Rafif Rifda Hayati Rina Amelia Rina Yunita Ririe Fachrina Malisie Risqin, Muhammad Anas Fatah Rosita Juwita Sembiring Salsabila, Anisa Samodra, Yoseph Leonardo Sarah, Dewi Maya Sekali, Oktaviani Karo Selvy Wulandari Siahaan, Jekson Martiar Sikumbang, Rahmat Hidayat Sinaga, Bintang Yinke Magdalena Sinaga, Joshua Princeman Sinaga, Sudirman Parningotan Sirait, Asima Rodiarta Siregar, Nondang Purnama Syamsul Bihar Syamsul Bihar Syamsul Bihar Syarani, Fajrinur Tarigan, Amira Permatasari Tarigan, Setia Putra Tri Setia Negara Sinulingga Vera, Yeni Wahyuni, Arlinda Sari Wan Betty Pratiwi Yahwardiah Siregar Yessi Andriani Zainal Yunanda, Yuki Zainuddin Amir Zakirah, Sarah Chairani