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All Journal Medula Wikrama Parahita : Jurnal Pengabdian Masyarakat Jurnal Ilmu Kedokteran dan Kesehatan JURNAL PENELITIAN PERAWAT PROFESIONAL Wellness And Healthy Magazine JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal teknologi Kesehatan Borneo Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Journal of Student Research Jurnal Kedokteran Ibnu Nafis Jurnal Kesehatan Metro Sai Wawai JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Sangging, Putu Ristyaning Ayu
Fakultas Kedokteran, Universitas Lampung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Pengaruh Pemberian Teh Hijau (Camellia sinensis) terhadap Gambaran Histopatologi Paru-Paru Tikus Putih (Rattus novergicus) Jantan Galur Sprague Dawley yang di Papar Uap Rokok Elektronik Ni Putu Sari Widiyani; susianti; Putu Ristyaning Ayu Sangging
Medula Vol 12 No 3 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i3.472

Abstract

E-cigarettes are easy to obtain and feel safer than conventional cigarettes, making smokers begin to change their habits in using conventional cigarettes. This trend has made e-cigarettes increasingly popular. Toxic contained in e-cigarettes causes an oxidative stress process that triggers an inflammatory response and causes respiratory problems. Green tea extract is believed to be an antioxidant to suppress the oxidative stress process. The study used a pure experimental design using 30 white rats of the Sprague Dawley strain. There was a change in histopathological damage in all samples where there was a significant difference in the control group, but not significant in the value of the vape control (K2) with treatment group 1 (50 mg/kgBW) p=0.163. E-cigarette consumption leads to an increase in circulating markers of oxidative stress. E-cigarette vapor induces an increase in cellular reactive oxygen species which in turn increases circulating inflammatory markers. Green tea polyphenols seek reactive oxygen species (ROS) by generating more stable phenolic radicals. The protective effect is attributed to the antioxidant capacity thereby reducing lung tissue damage. The conclusion is that there is an effect of giving green tea extract at a dose of 50 mg/kgBW but there is an effect of giving green tea extract at a dose of 100 mg/kgBW and 200 mg/kgBW on changes in the histopathological picture of the lungs of white rats (Ratus novergicus) Sprague dawley strain exposed to steam. electronic cigarette.
Potensi Ekstrak Kulit Batang Bakau Minyak (Rhizophora apiculata) Sebagai Larvasida Terhadap Larva Aedes Aegypti Dzakwan Cedri Ketierteu; Jhons Fatriyadi Suwandi; Putu Ristyaning Ayu Sangging; Hanna Mutiara
Medula Vol 12 No 4 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i4.577

Abstract

Dengue Hemorrhagic Fever (DHF) is a disease in humans which is transmitted by the Aedes aegypti mosquito as a vector which causes many cases of death. In Indonesia, the number of cases of dengue fever deaths will be 705 cases in 2021. Alternative natural insecticides are needed to avoid potential resistance to chemical insecticides. Rhizophora apiculata stem bark contains active compounds, namely saponins, flavonoids, alkaloids, and tannins which are larvicidal. The purpose of this study was to determine the larvicidal effectiveness of Rhizophora apiculata stem bark extract. This study used a laboratory experimental research design with a post test only control group design pattern. Divided into 6 groups, namely negative control, 0.045%, 0.09%, 0.18%, 0.36%, and positive control. Each group contained 25 larvae in 20 ml of Rhizophora apiculata stem bark extract solution with 4 repetitions. The data analysis used was univariate data analysis to find which concentration caused the highest death of Aedes aegypti larvae. From the research results, it was found that the average mortality of larvae from 4 repetitions at concentrations of 0.045%, 0.09%, 0.18%, and 0.36% were 68%, 97%, 99%, and 100% respectively.
The ROLE OF OBESITY IN BREAST CANCER METASTASIS Fadila Gustiani Daraz; Indri Windarti; Putu Ristyaning Ayu Sangging
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.562

Abstract

Breast cancer is the most common type of cancer in women worldwide. One of the factors that are believed to have a role in the development and growth of breast cancer is nutritional status which can be associated with the body mass index of adult patients. It is estimated that overweight and obesity are risk factors for the spread of breast cancer to distant metastases. Mechanism of spread through two ways, estrogen and leptin. Aromatase is an enzyme in estrogen biosynthesis that promotes tumor growth through its expression in breast adipose stromal cells. Meanwhile, leptin is produced by adipocytes. Adipocytes that experience hypertrophy and hyperplasia cause pathophysiological changes that affect the development of breast cancer. Various case studies show that a diet high in fat and calories is associated with breast cancer. The high risk of obesity for breast cancer metastases. This is important to be studied further because of the large number of cases of breast cancer both globally, in Indonesia and in Lampung. This review article is important to know the relationship between obesity and breast cancer metastases, as scientific information and knowledge, and can be used as material for dietary intervention in obese breast cancer patients.
Labyrinthitis: Comprehensive Literature Review Of Inner Part Ear Infection Rafi Gutra Aslam; Putu Ristyaning Ayu Sangging; Rani Himayani
Medula Vol 13 No 4.1 (2023): Medula - Edisi Spesial (Special Sense)
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i4.1.684

Abstract

Labyrinthitis (Internal otitis) is an inflammation process of the ear labyrinth located in the inner part of the ear. Labyrinthitis has distinctive symptoms that combine from hearing ability and balance disturbance that cause  sensorineural type deafness and vertigo. This paper uses the literature review method as a  chosen method that chooses from bibliographic that last 15 years ago to discuss comprehensively about labyrinthitis. Labyrinthitis  is a condition that generally happens in elder age because the disturbance of the vestibulocochlear system  that has similarity with other health problem such as Ménière disease, patient history and advance examination comprehensively needed to rule out labyrinthitis with another health related to balance and hearing  problem. Labyrinthitis prognosis is bonam if treatment occurs as soon as possible and there is no expansion found into another region adjacent to the ear structure that potentially cause severe complication. Despite of severe complication is rare in post-antibiotic era, complication  could still happen in few patient and become life threatening problem because of it’s site adjacent with brain anatomy structure, therefore treatment could  be given to the patient with this condition. Further research need to discuss about another therapy option that available to treat the Labyrinthitis from every classification such as viral, bacteria, autoimmune, immunodeficiency, ossificant, and even the recent one associated with COVID-19 pandemic.
Article Review: Congenital Nasolacrimal Duct Obstruction With Massage Therapy of The Lacrimal Sac Farraz Kanya Syahra; Rani Himayani; Putu Ristyaning Ayu Sangging
Medula Vol 13 No 5 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i5.693

Abstract

Nasolacrimal duct obstruction is a disorder that is often found in children at the early age of birth. In most cases, the obstruction lies distal to the nasolacrimal duct as a result of a patent Hasner's valve. Epidemiological studies report that the prevalence of congenital nasolacrimal duct obstruction ranges from 5% to 20% in early childhood. Clinical manifestations that can occur as a result of this obstruction are in the form of epiphora or tears that don't drain properly resulting in accumulation and overflow of tears. In addition, symptoms that arise can be erythema on the periorbital skin, upper and lower eyelids due to irritation originating from reflex rubbing due to teardrops and discharge with inadequate drainage. This case can be given conservative therapy in the form of massage of the lacrimal sac which has been proven in many studies with favorable results. This therapy can be given in the absence of further complications such as mucocele or dacryocystitis. Massage therapy used since 1923 is the Crigler Technique. There is a new technique devised by a pediatric ophthalmologist, Philip, who provides new information based on his experience. This writing uses the article review method using several sources obtained from journals and books. This paper aims to determine the understanding and conservative management of congenital nasolacrimal duct obstruction so that the obstruction will disappear and prevent further complications.
Hubungan antara Kejadian Tuberkulosis Ekstra Paru dengan Kadar Limfosit dan Monosit di RSUD Dr. H. Abdul Moeloek Provinsi Lampung periode Januari 2018-Desember 2019 Raihanah Nabilah; Putu Ristyaning Ayu Sangging; Anggraeni Janar Wulan
Medula Vol 13 No 5 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i5.745

Abstract

Extra pulmonary tuberculosis (extra pulmonary TB) is a TB infection that attacks organs other than the lungs and is also a complication of TB. Adaptive immune response plays an important role in TB patients, one of which is the role of lymphocytes as antigen-antibody specificity and monocytes as phagocytosis of pathogens. The aim of this study was to determine the relationship between the incidence of extrapulmonary TB patients with lymphocyte and monocyte levels in RSUD dr. H. Abdul Moeloek Lampung Province. This research is a type of retrospective analytic observational study with a cross-sectional research design which was conducted in December 2020 levels in RSUD dr. H. Abdul Moeloek Lampung Province by looking at medical records for the period January 2018-December 2019. The sampling technique was consecutive sampling and calculated using the Slovin formula with a total sample of 103 patients. The analysis used is the chi square test. Central nervous system TB patients totaled 80 people who had lymphocytopenia 66 people (82.5%) and normal lymphocytes 14 people (17.5%), in TB lymphocytopenic patients there were 23 people who had lymphocytopenia 14 people (60.9%) and normal lymphocytes 9 people (39.1%). As for monocyte levels, there were 80 central nervous system TB patients with normal monocytes 50 people (62.5%) and monocytosis as many as 30 people (37.5%), in TB lymphadenitis patients there were 23 people with normal monocytes 12 people (52 .2%) and monocytosis in 11 people (47.8%). The results of the chi square test on lymphocyte levels with a value of p = 0.028 and monocyte levels with a value of p = 0.373, which means that there is a relationship between the incidence of extra pulmonary TB and lymphocyte levels and there is no relationship between the incidence of extra pulmonary TB and monocyte levels levels in RSUD dr. H. Abdul Moeloek Lampung Province.
Management of pterygium surgery: Limbal Conjunctival Autograft and Subconjunctival Amniotic Membrane Graft Reisyah Syahfira; Putu Ristyaning Ayu Sangging; Rani Himayani
Medula Vol 13 No 4.1 (2023): Medula - Edisi Spesial (Special Sense)
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i4.1.751

Abstract

Pterygium is one of the common ocular surface disorders. From two Greek words, the word "pterygium" has been derived: “pteryx” meaning wing and “pterygion” meaning fin. Usually, pterygium is asymptomatic apart from its appearance. Meanwhile, no special examination is needed to diagnose it, only a physical examination is needed using a slit lamp to diagnose this condition. A slit lamp for observing the eye using magnification and bright lighting. Medical treatment in modern times includes lubrication with artificial tear drops or decongestants to provide short-term comfort and a slight improvement in cosmetics. Topical NSAIDs, eye drop loteprednol, brings added comfort. Vasoconstrictive agents minimize redness and enhance the appearance and add antihistamines to the decongestant drops to help prevent the effect of histamine associated edema and itching. However, surgical treatment remains the preferred option. In patients with pterygium, the reasons for surgery are decreased vision due to visual axis encroachment, chronic pain, persistent inflammation, abnormal astigmatism, restrictive ocular motility, and cosmesis. Many surgical techniques have been used since past to present, though none is universally accepted because of variable recurrence rates. Some examples of surgery, namely the avulsion technique, Simple excision technique, The Bare Sclera Technique, Conjunctival Autograft, and Limbal Conjunctival Autotransplant (LCAT). However, combined between limbal conjunctival autograft with the adjunctive use of a prophylactic subconjunctival graft of the amniotic membrane can decrease the recurrence rate after surgery in an ethnically diverse population with a statistically higher risk for recurrence.
Diagnosis dan Tatalaksana Trikiasis Keziah Tirtawijaya; Putu Ristyaning Ayu Sangging; Rani Himayani
Medula Vol 13 No 4.1 (2023): Medula - Edisi Spesial (Special Sense)
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i4.1.674

Abstract

Trichiasis is a condition in which the eyelashes are in the wrong position, facing back and rubbing against the cornea or conjunctiva. In trichiasis the eyelash follicles are normal, but the direction of their growth is abnormal. Some of the eyelashes or all of the eyelashes at the eyelid margin may be involved. Trichiasis can be classified into major and minor. Trichiasis is an acquired condition, not a congenital condition. Trichiasis affects the lower eyelids, but in certain cases, such as chemical burns of both eyelids and trachoma, the upper eyelids are more affected. The cause of trichiasis is often idiopathic, but chronic eyelid inflammation or an infection such as trachoma, herpes simplex or zoster, can be the cause. Trichiasis often occurs with other diseases such as trachoma, cicatricial pemphigoid, and other eyelid trauma. Trichiasis is complicated by corneal erosion and corneal ulcers. Trichiasis can cause eye irritation. Treatment of trichiasis is divided into operative and non-operative management. Treatment of trichiasis depends on the number of eyelashes involved. Treatment of trichiasis can be in the form of using contact lenses, removing eyelashes, or surgery. This paper uses the article review method using sources such as journals and books. The purpose of this writing is to know the definition, diagnosis, and management of trichiasis. The diagnosis of trichiasis can be established by anamnesis and physical examination. The management of trichiasis depends on the symptoms in the anamnesis and physical examination.
Hubungan Glaukoma dengan Hipertensi Muhammad Arsy Kamal Faadhil; Putu Ristyaning Ayu Sangging; Rani Himayani
Medula Vol 13 No 4.1 (2023): Medula - Edisi Spesial (Special Sense)
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i4.1.675

Abstract

Glaucoma is a group of progressive optic neuropathy characterized by degeneration of retinal ganglion cells and resulting changes in the optic nerve head. Glaucoma can be classified into 2 broad categories: open-angle glaucoma and angle-closure glaucoma. In patients with open-angle glaucoma, there is increased resistance to aqueous outflow through the trabecular meshwork. Conversely, access to drainage pathways is usually obstructed in patients with angle-closure glaucoma. Intraocular pressure can cause mechanical stress and strain on the posterior structures of the eye, especially the lamina cribrosa and the surrounding tissues.Acute open angle glaucomacan manifest itself with pain radiating from the eye, visual disturbances, conjunctival hyperemia, and occasionally nausea and vomiting with a tense, rock-hard globe. This is an ophthalmological emergency that requires immediate treatment to prevent severe eye damage and blindness. In contrast, open-angle glaucoma is usually asymptomatic until it reaches an advanced stage. If there are visual field defects, they are usually not located in the same part of the fields of the two eyes and are therefore well compensated for by binocular vision. Thus, people with open-angle glaucoma generally report no symptoms and many are completely unaware that they have the condition.Several epidemiological studies have reported that an increase in systemic blood pressure is associated with a small increase in intraocular pressure. Individuals with hypertension have a risk of about 1.2 times higher for developing open-angle glaucoma than individuals without hypertension followed by other risk factors, namely age over 40 years, and use of antihypertensive drugs. Patients over 40 years of age, especially those with a history of hypertension, are advised to undergo an eye examination.
Buta Senja: Hubungannya Dengan Asupan Vitamin A di Indonesia Evan Christian Christian; Putu Ristyaning Ayu Sangging; Rani Himayani
Medula Vol 13 No 4.1 (2023): Medula - Edisi Spesial (Special Sense)
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i4.1.679

Abstract

Night blindness is a disorder of the eyes where the eyes cannot function properly in low light or inadequate lighting conditions. This occurs due to dysfunction of the rod cells present in the retina of the eye. Rod cells play a crucial role in vision and are closely related to the availability of vitamin A in the body. Vitamin A is an essential micronutrient for the body and plays an active role in a person’s vision. Vitamin A works in conjunction with rhodopsin in the mechanism of vision. Vitamin A can produce rhodopsin and regulate vision mechanisms through several mechanisms, one of which is the conversion of the cis chain to trans. Vitamin A deficiency can disrupt a person’s vision. Research shows that there are still many children in the world and in Indoneisa who suffer from vitamin A deficiency. The WHO estimates that around 190 million children worldwide suffer from vitamin A deficiency. Studies in Central Java shows that Indonesia still experiences vitamin A deficiency, with about 60% of children having serum retinol levels below normal. Low serum retinol is indicator of a person’s vitamin A deficiency, The use of vitamin A supplements is important in preventing night blindness. Research shows that the use of additional vitamin A supplements can be done since infancy, by providing supplements to newly delivering mothers, so that the vitamin A supplements consumed by the mother can increase the retinol level in the colostrum of mother’s milk that will be consumed by the child.
Co-Authors Adinda Husna Cahyana Agung Ikhssani Agustyas Tjiptaningrum Ahmad Duta Al-Ihya Alghani, Sulthan Rafi Almaina Puteri Jasmine Almaina Amira Nabila Andi Nafisah Angelica Philia Christy Anggraeni Janar Wulan Annisarahma, Lyvia Aprilia, Intan Rahma Ardian Reza Putra Arfa Salma Firnandya Ari Irawan Ari Irawan Ari Wahyuni Aulia Nur Fitriatsani Aurora Awindya Nareswari Azizah Nur Rahmah Bagus Pratama Brigitta Shinta dewi Carissa Aprilia Y Cholyviona W.S Handhayani Citra Yuliyanda Pardilawati Cut Karel Dithia Daffa Fahreiza Daffa Fahreiza Devina Hardianto Devira Fitriani Kamal Devya Aulia Dian Isti Angraini Dilla Syahra Noor Fitri Dzakwan Cedri Ketierteu Ellysa Angguman Putri Evan Christian Christian Fadila Gustiani Daraz Fadilah Alwiyah Faiq Razaan Razaan Farid Hammadi Faridi Pani Farraz Kanya Syahra Fayza Syachrani Fityah Zabrina Hidayat Ganesha Rahman Hakim Ghina Salsabila Fenty PNR Gusnirwan, Alief Hanifah Qollama Astrid Hanna Mutiara Hendri Busman Herlambang, Geri Indra Imtinan Khoirunnisa Indah Kurnia Putri Waruwu Indah Salsabila Indri Windarti Intanri Kurniati Isabela Irene Pangestu Jhons Fatriyadi Suwandi Julianti, Dinul Aliya Kalih, Abigael Ludwina Kamila Nastiti Karima, Nisa Keziah Tirtawijaya Khairun Nisa Kurnia Fithrananda Kurniawaty, Evi Laja, Rana Salsabila Putri Lintang Lestari Cahya Sawitri Mafalda Marzon Maria Devi Melni Armadani Mentari Putri Maharani Mira Yustika Mochamad Fauzan Dava Muhamad Zaidan Algifari Muhammad Ammar Naufal Muhammad Arsy Kamal Faadhil Muhammad Maulana Muhammad Rizki Akbar, Muhammad Rizki Mukhbita, Khalila Alya Mukhlis Imanto, Mukhlis Nabila Alsa Sagia Nabila Shafira Nabila Yoli Rahmadani Nadhia Wihelga Nahrassyiah Rahma Putri Ni Putu Sari Widiyani Noval Ramadirta Nurul Fadhilah Az-zahro Nurul Utami Oktafany Oktafany Oktoba, Zulpakor Pardilawati, Citra Yulianda Pardilawati, Citra Yuliyanda Prasetyo, Muhammad Purwono Qoriba, Fathan RA Genta Syakira Hatta Rachel Agustin Inggrid Zefanya Rafi Gutra Aslam rahmawati, selvi Rahmi Zuraida Raihanah Nabilah Rani Himayani Rani Himayani Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Regita Dwi M Reisyah Syahfira Rifka Putri Dewi Rika Lisiswanti Risti Graharti Rizqiani Astrid Nasution Rudiyanto, Waluyo Salsabila Haqya Kusuma Salshabilla, Annisa Sembiring, Dustin Delano Pranata Setiorini, Anggi Shiddiq, Muhammad Nasrullah Nur Shinta Nareswari, Shinta Simanungkalit, Jesica Natalia Sinulingga, Anselmus Libreya Siti Shafira Elfreda Suharmanto Suryani Agustina Daulay Susianti Susianti Sutarto Sutarto Sutyarso Sutyarso Syahrani Alya Murfi Syalwa Meutia Syiva Ulhayah Tamaulina Br Sembiring Tiasti, Jania Tri Umiana Soleha Tsurayya Fathma Zahra Yashila Rahimah Zahra, Siti Aqila Zayatri Nurul Jannaty Zheva Aprillia Yozevi