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All Journal Journal of Biomedicine and Translational Research JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE The Indonesian Biomedical Journal Jurnal Keperawatan dan Fisioterapi (JKF) Jurnal Kesmas dan Gizi (JKG) JURNAL FARMASIMED (JFM) JURNAL MUTIARA NERS NURSING UPDATE JURNAL ILMIAH ILMU KEPERAWATAN PREPOTIF : Jurnal Kesehatan Masyarakat Excellent Midwifery Journal Jurnal Multidisiplin Madani (MUDIMA) Formosa Journal of Sustainable Research (FJSR) Indonesian Nursing Journal of Education and Clinic (Jurnal Pendidikan dan Praktik Keperawatan Indonesia) Jurnal Pengmas Kestra (JPK) Jurnal ABDIMAS MUTIARA Jurnal Indah Sains dan Klinis Tour Health Journal Medistra Medical Journal (MMJ) JURNAL TEKNOLOGI, KESEHATAN DAN ILMU SOSIAL
Karnirius Harefa
Institut Kesehatan Medistra Lubuk Pakam
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : JURNAL FARMASIMED (JFM)

 1 
ANTI-INFLAMMATORY ACTIVITY TEST OF LIME LEAF (CITRUS AURANTIIFOLIA) ETHANOL EXTRACT IN MALE MICE (MUS MUSCULUS) INDUCED CARRAGEENAN ON 2022 Purba, Novandi; Andriani Harianja, Bulan; Akbar, Khairil; Harefa, Karnirius
Jurnal FARMASIMED (JFM) Vol 5 No 1 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v5i1.1233

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol daun jeruk nipis (Citrus aurantiifolia) sebagai antiinflamasi. Metode yang digunakan adalah udema buatan telapak kaki mencit putih jantan dengan induksi karagenan 1%. Pengujian aktivitas antiinflamasi ekstrak etanol daun jeruk nipis menggunakan 25 hewan uji, dengan 5 kelompok perlakuan. Kelompok terdiri atas kontrol positif yang diberikan na.diklofenak dengan dosis 6,5 mg/kgBB, kontrol negatif yang diberi perlakuan CMC Na 0,5%, dan 3 kelompok ekstrak yang dimana kelopok ektrak dosis 100 mg/kgBB, kelompok ekstrak dosis 200 mg/kgBB, dan kelompok ekstrak dosis 300 mg/kgBB. persen radang pada kelima kelompok uji mengalami penurunan secara terus menerus mulai dari menit ke-60 sampai menit ke-360 setelah induksi karagenan. persen radang terbesar terjadi pada menit ke-120 pada suspensi Na.cmc dan diikuti oleh 100 mg/kgBB, 200 mg/kgBB, 300 mg/kgBB dan Na.diklofenak. nilai persen inhibisi radang terbesar dimiliki oleh kelompok Na.diklofenak dan diikuti oleh 300 mg/kgBB, 200 mg/kgBB dan 100 mg/kgBB. Hal ini berarti, persen hambatan yang baik terdapat pada EEDJN 300 mg/kgBB setelah Na.diklofenak, kemudian diikuti EEDJN 200 dan 100 mg/kgBB dan hal ini menunjukan bahwa kelompok Na.diklofenak, 100, 200 dan 300 mg/kgBB memiliki potensi sebagai agen antiinflamasi sedangkan kelompok Na.Cmc tidak.
ANTIDIABETIC ACTIVITY TEST OF ETHANOL EXTRACT BROCOLI (BRASSICA OLERACEA VAR. ITALICA) IN WHITE MALE RATS Purba, Novandi; Handayani, Diah Tri; Cahayani Zebua, Kristian; Harefa, Karnirius
Jurnal FARMASIMED (JFM) Vol 5 No 2 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v5i2.1587

Abstract

Diabetes is a chronic disease characterized by excessive blood glucose levels caused by absolute and relative insulin deficiency. The stages in this study were sampling, identification of samples/plants, simplification, simplification screening, and preparation of extracts by maceration. The method used in the diabetes activity test uses a glucometer to induce alloxan in rats at a dose of 150 mg/kg body weight. The test animals were 25 rats which were divided into 5 treatment groups namely CMC Na 0.5% (negative control), glibenclamide (positive control) 0.45 mg/kg body weight and EEB dose 200 mg/kg body weight, 400 mg/kg body weight and 600. mg/kg body weight. kg B.W. kg body weight as a test material given orally. Measurement of blood glucose values ??according to Allox and on days 3, 5, and 7 after administration of the test substance, namely EEB. The test results data were analyzed statistically using one-way ANOVA at a 95% confidence level followed by Tukey's post hoc test. The results of the phytochemical screening showed that EEB contains alkaloids, flavonoids, tannins, saponins, and glycosides. The results of the diabetes efficacy test showed that EEB doses of 200, 400, and 600 mg/kg BW had an anti-diabetic effect on male white rats. The EEB dose of 600 mg/kg is the most effective. Post hoc Tukey test results showed that EEB doses of 200 mg/kg, 400 mg/kg, and 600 mg/kg were not significantly different from the positive control glibenclamide 0.45 mg/kg (p>0.05) and 200,400 ug. and 600 mg/kg BW were significantly different from the negative control CMC Na 0.5% (p<0.05).
Purification of used Cooking Oil using a Combination of Activated Carbon and Bentonite Adsorbents Aritonang, Barita; Ritonga, Ahmad Hafizullah; Harefa, Karnirius; Wiratma, Dicky Yuswardi; Herlina
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2331

Abstract

The repeated use of cooking oil at high temperatures can significantly degrade its quality, as indicated by darkened color, unpleasant odor, elevated peroxide value (PV), and free fatty acid (FFA) levels. This deterioration can contribute to health risks such as obesity, high cholesterol, heart disease, and cancer. This study investigated the effectiveness of combined activated carbon and bentonite adsorbent in reducing peroxide value and free fatty acid levels in used cooking oil. The purification method involved an adsorption process using a combination of activated carbon derived from mangosteen peel waste and bentonite. The carbonization process was carried out at 600°C for 3 hours, followed by chemical activation with H?PO? at varying concentrations of 1M, 3M, and 5M. Bentonite was activated using 5M HCl. The results demonstrated that 5 grams of activated carbon from mangosteen peel, treated with 5M H?PO?, and bentonite activated with 5M HCl, were highly effective in lowering the peroxide value and free fatty acid levels in used cooking oil. Initially, the PV of the untreated used cooking oil was 16 meq O?/kg, reduced to 3.6 meq O?/kg after treatment with the combined adsorbents. Similarly, the FFA content decreased from 2.2% to 0.09%. Both peroxide value and free fatty acid levels met the standards set by SNI 3741:2013. In conclusion, using activated carbon and bentonite is an efficient method for purifying used cooking oil, as their strong adsorption capacity effectively reduces peroxide value and free fatty acid levels.
Reduction of BOD, COD, and TSS in Textile Wastewater Using Bentonite Activated Charcoal Adsorbent Aritonang, Barita; Ritonga, Ahmad Hafizullah; Harefa, Karnirius; H, Herlina
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2699

Abstract

Wastewater generated by the textile industry contains a variety of hazardous contaminants, including complex organic compounds, synthetic dyes, surfactants, heavy metals, and critical pollution indicators such as biochemical oxygen demand (BOD), chemical oxygen demand (COD), and total suspended solids (TSS). This study evaluates the efficacy of a dual-adsorbent system comprising hydrochloric acid-activated bentonite and phosphoric acid-activated carbon for the removal of BOD, COD, and TSS from textile effluents. The activation processes significantly altered the physicochemical properties of both adsorbents. The moisture content of activated carbon decreased from 18% to 3.10%, while ash content was reduced from 15% to 3.05%. The iodine number, indicative of adsorption capacity, increased from 650 mg/g to 810 mg/g. Additionally, the fixed carbon content improved from 55% to 80%. Surface characterization via Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) confirmed substantial structural modifications, which enhanced the adsorption performance of the materials. Application of the combined adsorbent system resulted in substantial pollutant removal efficiencies, with reductions of 70.23% in BOD, 70.11% in COD, and 74.88% in TSS. These findings demonstrate that acid-activated bentonite and phosphoric acid-treated activated carbon represent a promising and efficient adsorptive treatment strategy for the remediation of textile wastewater.
The Effect of a Combination of Activated Carbon and Bentonite on Reducing COD, BOD, and TSS Levels in Tofu Industry Wastewater Aritonang, Barita; Ritonga, Ahmad Hafizullah; Harefa, Karnirius; Dicky Yuswardi Wiratma; herlina, herlina
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/cbxjb379

Abstract

Wastewater produced from tofu manufacturing typically contains substantial amounts of organic substances and suspended particles. The concentrations of Biochemical Oxygen Demand (BOD), Chemical Oxygen Demand (COD), and Total Suspended Solids (TSS) frequently surpass the permissible thresholds established in the Regulation of the Minister of Environment and Forestry (Permen LHK) No. P.16 of 2019. Such high levels of pollutants may degrade water quality and pose risks to both aquatic ecosystems and public health in nearby areas. This study investigates the efficiency of combining activated carbon and bentonite, in both raw and activated forms, for reducing BOD, COD, and TSS concentrations in wastewater originating from tofu industries. The BOD test was performed using a five-day incubation at 24 °C, COD was analysed via the closed reflux method, and TSS was quantified using the gravimetric approach. Adsorbent characteristics were examined in accordance with the Indonesian National Standard (SNI), supported by functional group analysis using Fourier Transform Infrared (FT-IR) spectroscopy and morphological observation with Scanning Electron Microscopy (SEM). The results demonstrated that activation enhanced pore development and improved the adsorption capability of both materials. The combined activated carbon and bentonite effectively decreased BOD from 3,600 mg/L to 140 mg/L, COD from 1,500 mg/L to 185 mg/L, and TSS from 320 mg/L to 270 mg/L. All treated parameters met the regulatory quality standards, indicating that the activated mixture of these adsorbents provides an efficient and environmentally sound method for treating tofu processing wastewater.
Co-Authors A.Dachi, Rahmat Abdi Lestari Sitepu Agnes Silvina Marbun Ahmad Hafizullah Ritonga Andriani Harianja, Bulan Aritonang, Barita Bahdin Nur Tanjung Bancin, Dewi R. Bintang, Siti Sarah Br Siagian, Khairunnisa Brahmana, Netti Etalia Br. Cahayani Zebua, Kristian Chatarina Umbul Wahyuni CHRESNANDO GINTING, JOE Christiani N Daely, Ruth Cut Nurjulianti Daniel Ginting Debi Meilani Desideria Yosepha Ginting Dian Christy Rahayu Dicky Yuswardi Wiratma Elisabeth Purba, Ivan Emi Juniarita Br. Barus Evawani Martalena Silitonga Evi Martina, Siska Fikrih Utama, Rezza Gandaria Purba, Anita Sri Ginting, Raynald Ignasius Ginting, Rosita Gultom, Rumondang Handayani, Diah Tri Harahap, Fitri Ramadani Harahap, Hasni Yaturramadhan Hariyati Wahyuni Hasibuan, Eva Kartika Herlina Herlina . Herlina H Herlina Herlina Hestina Hutajulu, Johansen Ihsan Ihsan Ika Nursaputri Irmayani Irmayani Jehaman, Isidorus Junita Karokaro, Tati Murni Kesaktian Manurung Ketaren, Otniel Khairil Akbar Lina br Tarigan, Frida Lukman Hakim Manik, Tumpak Rudi Aman Manurung, Tetty Grace Manurung Marbun, Agnes Silvina Marlindawani, Jenny Mestika Lumbantoruan Monika Helen Sinaga Myrnawati N.C Sitanggang, Margaretha Nababan, Donal Novita Br. Ginting Munthe Purba, Novandi Rahmad Gurusinga Rahmat Alyakin Dakhi Ramadani Sitepu Rinco Siregar Riri Safitri Ritonga, Tintin Insani Hartuti Rohana, Taruli Romi Syahputra Tarigan Roslianizar, Syarifah Rotua Sumihar Sitorus Rumapea, Fina Sagala, Erlina Bernadet Sari, Yuli Permata Siagian, Mindo Tua Siahaan, Marlinewati Sianturi, Theodora R. Silitonga, Evani Martalena SILITONGA, EVAWANI Simamora, Artha Sinabutar, Theresia Yuni Florensia Sinaga, Arman Bemby Siregar, Hesti Despita Sitorus, Binsar Sitorus, Mido Ester Sri Wulan, Sri Suharyanisa Syara, Arfah May Teja Kesuma Theresia Yuni Florensia Sinabutar Togatorop, Lamtiar Betty Ulina Purba, Sri Vierto Yosepha Ginting, Desideria Yulia Mehatte