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All Journal PHARMACON Pharmaciana: Jurnal Kefarmasian Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) Jurnal Pengabdian Al-Ikhlas BERNAS: Jurnal Pengabdian Kepada Masyarakat Health Media JUKESHUM: Jurnal Pengabdian Masyarakat Jurnal EduHealth Jurnal Farmasi Tinctura Journal Prima Health Science Multidisiplin Pengabdian Kepada Masyarakat (M-PKM) Jurnal Kesehatan dr. Soebandi Medical Sains : Jurnal Ilmiah Kefarmasian J-CEKI Indonesian Pharmacopeia Journal (IPJ)
Shinta Mayasari
Fakultas Ilmu Kesehatan Universitas Dr Soebandi, Jember, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Identification of Transcribing Errors in Prescriptions for Type 2 Diabetes Mellitus Patients at Clinic X, Jember Haris Agung; Shinta Mayasari; Fendy Prasetyawan
Indonesian Pharmacopeia Journal Vol. 2 No. 1 (2025): January 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i1.39

Abstract

Abstract Background: Clinical Pharmacy Services play an important role in health services in hospitals. Pharmaceutical service standards are direct and responsible services to patients related to pharmaceutical preparations with the aim of achieving definite results to improve the quality of life of patients. Medication error (ME) is an incident that causes or has an impact on inappropriate drug services or endangers patients when the drug is under the control of health workers or patients. Transcribing Error (TE) is an error in reading a prescription before entering the dispensing stage. TE includes changes to the drug name, drug formulation, route, dose, dosage regimen to prescription orders. According to the East Java Health Service in 2021, Diabetes Mellitus (DM) sufferers in East Java were 2.6 of the population aged 15 years and over. Health services for diabetes mellitus sufferers at first-level health facilities (FKTP) in 38 districts/cities throughout East Java reached 867,257 cases (93.3% of the estimated DM sufferers. Based on dataBasic Health Research, 2021cases of diabetes mellitus in Jember amounted to 1.4%. This study aims toIdentifying transcription errors in prescriptions for type 2 DM patients at clinic x, Jember district. This research uses research descriptive using observation method The data source taken from this study is data from outpatient prescriptions for type 2 Diabetes Mellitus for the period January - December 2022-2024 at clinic x Jember district. The population of this study was 37 medical prescriptions for outpatients with type 2 DM for the period January - December 2022-2024 at clinic x Jember. The sample in this study was prescription data for patients diagnosed with type 2 DM who met the inclusion and exclusion criteria with a total of 37 samples by total sampling. The results of this study were obtained. Data from the identification of transcription errors still contained errors. From the total sample taken, 37 prescriptions, the results of the identification of transcription errors still contained errors including no medical record number (89.2%) no patient age (45.9%) no dosage form (43.2%). While the parameters of patient name, drug name, dosage, duration of administration, route of administration, date of prescription request have been complete, there are no errors.From the discussion above, it can be concluded that the results of transcription error identification still contain errors. Keywords:Medication error, transcribing error, DM type 2
IN SILICO STUDY OF SOYBEAN (Glycine max L.) ISOFLAVONES FOR ANTI-BREAST CANCER THROUGH HER2 TARGETING Ayu Tri Agustin; Nadia Khairun Nisa; IGA Karnasih; Mohammad Rofik Usman; Shinta Mayasari
Indonesian Pharmacopeia Journal Vol. 2 No. 2 (2025): 31 July 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i2.45

Abstract

One of the cancers with the most excellent death rates worldwide, including in Indonesia, is breast cancer. Elevated HER2 expression significantly contributes to breast cancer progression by stimulating cell proliferation. Targeted therapies such as trastuzumab have limitations due to potential side effects. This study aims to identify the possible role of soybean (Glycine max L.) isoflavone compounds in inhibiting HER2 using an in silico approach prediction of physicochemical properties, pharmacokinetics, and bioactivity through SwissADME and PASS Online. The Hex 8.0.0 docking tool and Biovia Discovery Studio 2019 looked into how molecules interact with each other in complicated ways. Our study revealed that physicochemically the compounds acetylgenistin, acetylglycitin, and acetyldaidzin met Lipinski's Rule of Five criteria (BM (< 500), Log P (< 5), HBD (< 5), HBA (< 10), and MR (40-130)), pharmacokinetically the compound acetylgenistin met the ADME parameters and bioactively all six compounds had anticancer activity (Pa > 0.2). Based on the results of molecular docking analysis, the six soy isoflavone compounds can interact and have low binding energy values. The binding energy values of malonylgenistin, acetylgenistin, and acetyldaidzin are the lowest and close to trastuzumab, at -286.6, -283.4, and -277.7kcal/mol, respectively. These findings suggest that soybean (Glycine max L.) isoflavone compounds have potential as anticancer drug candidates in inhibiting HER2.
The PROFILE OF ANTIBIOTIC USE IN PATIENTS WITH URINARY TRACT INFECTIONS AT ABDOER RAHEM GENERAL HOSPITAL, SITUBONDO Hafiz Achmad Hafiz Auni Iswanto; SHINTA MAYASARI; Sholihatil Hidayati; Nur Hasanah
Indonesian Pharmacopeia Journal Vol. 2 No. 2 (2025): 31 July 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i2.50

Abstract

Harmful bacteria multiply, causing urinary tract infections (UTIs). Patients with urinary tract infections often receive antibiotics and supportive care. This study aims to assess the pharmacological treatment of patients with urinary tract infections at RSUD Abdoer Rahem Situbondo. This study used a descriptive design by collecting data retrospectively. This study used a sample of thirty medical records taken using total sampling from May to August 2024. The findings are presented in the form of tables and percentages. The results showed that RSUD Abdoer Rahem Situbondo used urinary tract infection drugs, with 90% of the pharmaceuticals included in the antibiotic class, and cefixime was the most commonly used antibiotic at 27.27%. Ondansetron was the dominant additional treatment, accounting for 21.5% of the total use of additional drugs, followed by ranitidine and lansoprazole at 16.07% and omeprazole and ketorolac at 14.29%.
Literature Review: Pharmacological Activity and Characteristics of Red Onion (Allium cepa L.) Arista Wahyuningsih; Shinta Mayasari; Iski Weni Pebriarti; Sepbrilla Ananda Kusriadi
Indonesian Pharmacopeia Journal Vol. 2 No. 2 (2025): 31 July 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i2.54

Abstract

Shallot skin (Allium cepa L.) is a household waste that is still rarely utilized, even though it contains secondary metabolites such as flavonoids, anthocyanins, saponins, tannins, and other phenolic compounds that have pharmacological potential, especially as antioxidants and antibacterials. This study evaluates shallot skin's specific and non-specific pharmacognosy parameters through literature studies. Specific parameters include organoleptic, microscopic tests, and identifying active compound content using TLC, while non-specific parameters include water, ash, and contamination. The literature search method was done through Google Scholar, PubMed, and ScienceDirect, using the criteria of articles from 2015 to 2025. The study results indicate that flavonoid content, especially quercetin, contributes significantly to the antioxidant and anti-inflammatory effects. Shallot skin also shows effective antibacterial and antimicrobial activity against pathogenic strains such as Staphylococcus aureus, Escherichia coli, and Salmonella typhi. In addition, the mechanism of inhibition of α-amylase and α-glucosidase enzymes shows potential as an antidiabetic agent. Anticancer activity is supported by the active compounds' ability to induce apoptosis and inhibit cancer cell proliferation. With its abundant bioactive compound profile, shallot skin has the potential to be developed.
Antidiarrheal Effectiveness Test of Moringa Leaf Infusion (Moringaoleifera L.) on Male Mice (Mus musculus) Siti Saidah; Hartalina Mufidah; Shinta Mayasari
Indonesian Pharmacopeia Journal Vol. 2 No. 2 (2025): 31 July 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i2.57

Abstract

ABSTRACT Diarrhea is a digestive system disorder defined as having more than three bowel movements per day, characterized by changes in stool shape and consistency, as well as an increased water content in the stool compared to normal levels. Recent data from the 2022 Indonesia Nutrition Status Survey (SSGI) indicates that the prevalence of diarrhea stands at 10.2%, up from 9.8% in the 2021 SSGI results. Many people still view diarrhea as a minor illness, often leading to fatal outcomes in its management. Most synthetic anti-diarrheal medications can cause unwanted side effects, prompting the need for safer alternatives derived from natural sources. One such herbal plant, moringa leaves, is known to contain flavonoids with potential anti-diarrheal properties. This study aimed to evalute the optimal dosage 200, 400 and 800 mg/kgBW of Moringa oleifera L. Leaf infusion for its antidiarrheal efficacy in male Mus musculus exhibiting oleum ricini by induced diarrhea. This research uses a type of laboratory experimental study research using male white mice (Mus musculus) that have been induced by oleum ricini. The mice used were 20 and divided into 5 groups, namely: negative control group (CMC Na), positive control group (loperamid HCl), moringa leaf infusion treatment group with infusion doses of 200, 400 and 800 mg/KgBW. The parameters analyzed were frequency of diarrhea, stool consistency, stool weight and duration of diarrhea. The results of phytochemical screening of moringa leaf infusa show that moringa leaf infusa contains flavonoids, alkaloids and tannins. The results of the observation of the antidiarrheal effectiveness of moringa leaf infusa (Moringa oleifera L.) at the most optimal dose, namely the dose of 400mg/KgBW with the parameters of the average frequency of diarrhea 6.5 times with an average stool weight of 0.62 grams and the average duration of diarrhea is 95 minutes. The data obtained were analyzed by ANOVA at the 95% confidence level. Moringa leaf infusa (Moringa oleifera L.) has activity as antidiarrheal in male white mice (Mus musculus) induced by oleum ricini with the most effective dose is at a dose of 400 mg/KgBW.
Formulation And Physical Quality Test Of Handsanitizer Gel PreparationOf Katuk Leaf Extract(Sauropus androgynus L.) With Gelling Agent Variations Puteri Shinta; Shinta Mayasari; Aliyah Purwanti
Indonesian Pharmacopeia Journal Vol. 2 No. 2 (2025): 31 July 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i2.60

Abstract

Background: Diarrhea is one of the diseases caused by bacterial microorganism infections. Data obtained in 2023 showed that diarrhea cases increased to 27,385 diarrhea patients. Along with the times, people prefer instant and practical products as waterless hand sanitizers known as hand sanitizers. One of the important factors in the formulation of hand sanitizer gel preparations is the gelling agent to see the effect on the physical quality of the preparation. Objective: This study aims to formulate a hand sanitizer gel preparation of katuk leaf extract and evaluate its physical quality test with variations of the gelling agents Carbopol, CMC-Na, and HPMC. Method: This type of research is experimental research in the laboratory. This study uses katuk leaf extract as the active ingredient. Katuk leaf extract is obtained by maceration method with 96% ethanol solvent. The variations of gelling agents used in this study are carbopol, CMC-Na, and HPMC. The resulting handssanitizer gel preparations were tested for organoleptic, homogeneity, pH, dispersability and viscosity, respectively. Results: Katuk leaf extract can be formulated as a gel preparation of hand sanitizer of katuk leaf extract. The preparation of katuk leaf extract hand sanitizer gel with HPMC gelling agent has a thick texture, green, homogeneous gel form, pH 7,530.06, dispersion capacity of 4.75 cm0.69, and viscosity of 2.933251.66. Preparations with carbopol gelling agent have a gel form, have a thick texture, green color, homogeneous, pH 6,770.25, dispersion test 5.28 cm0.27, and viscosity of 3.033404.14. Preparations with CMC-Na gelling agent have a gel form, thick texture, green color, homogeneous, pH 6,970.06, dispersion test 5.17 cm0.03, and viscosity of 2.867251.66. Conclusion: Katuk leaf extract can be formulated as a gel preparation of hand sanitizer of katuk leaf extract. The evaluation of physical quality tests with variations of gelling agents that meet the standards of gel handssanitizer is from the gelling agent carbopol and CMC-Na, while HPMC does not meet the standards in terms of dispersion test.
Co-Authors Afnan Septi Mulyani Afnan Septy Mulyani Afrizal Maulidan Rachmawan Agustin, Ayu Tri Ahmad Khoirul Azwar Alfarisi, Hilmi Pratama Alfi Nur Ramadhani Alfira Rosaliana Aliyah Purwanti Alvia Putri Priyono, Rosyidatul Amalia Wardatul Firdaus Ambari, Yani Anas, Mohammad Nizar Andi Dwi Sandi Hariyono Anggie Noviana Putri Anggitasari, Wima Anggraeni, Linda Suci Anggraeni, Lutvi Arista Wahyu Ningsih Arista Wahyuningsih Atmanegara, Stivani Yanti Aulavia Hidayaturrobbani Aulia, Andira Aura Denaneer Mulya Aura Denaneer Mulya Avrillana Dewangi Gea Ayunda Diarso Ayu Angger Putri M. Soleh Ayu Dwi Wardani Ayu Tri Agustin Bekti Kusuma Primadani Damayanti, Mita Eka Damayanti, Selvi Danny Dwi F Danny Dwi Firmansyah Darrojah, Urfi Narva’u Dea Agita Anggraini DEWI RAHMAWATI Dewi, Novi Rosita Dina Trianggaluh Fauziah Dinayah, Syafinatud Dinda Febri Puspitasari Dinda Febri Puspitasari Dwi Koko Pratoko Dyan Wigati Elisa wardatul awaliya Fadli Muhammad F Fadli Muhammad Fathoni Fadli Muhammad Fathony Fahrur Rozi Shodiqi Fendy Prasetyawan Fitria, Ayu Florentinus Dika Octa Riswanto Hafiz Achmad Hafiz Auni Iswanto Haris Agung Hartalina Mufidah Hasanah, Adinda Shofiatul Hasiseh Hasiseh Heri Setyo Budi Hidayati, Sholihatil IGA Karnasih Indah Suciati Iski Weni Pebriarti Iski Weni Pebriarti Ismanti, Septie Putri Kanaya Dewayanti Khrisna Agung C Khrisna Agung Cendekiawan lindawati setyaningrum Maheswari, Anindya Dinarya Martina, Ina Michael Nicoin DC Michael Nicoin DC Mohammad Rofik Usman Mohammad Rofiq Usman Muhammad Alvin Yovansya Mu’affan, Achmad Adha Nabila, Talitha Vanian Nadia Khairun Nisa nafisah isnawati Nanda Pradwitha Fariansiska Novyananda Salmasfattah Nur Hasanah Nurul Fathona Pangesti, Yuli Pebriarti, Iski Weni Permatasari, Shafira Restu Pramesti, Lita Aulia Puteri Shinta Putra, Zulkarnain Permana Putri Ramadani Putri Ramadhani Putri, Masitah Nurwidiya Qurrotul Aini Rahmadania Affelia Dianto Ramadhan Bagus Cahyono Ramadhan, Muhammad Ridho Ratna Amelia Ratna Amelia Ressi, Monica Risqi Wahyudi rofiqoh rofiqoh savitri, Lisa Sepbrilla Ananda Kusriadi Sholihatil Hidayati Siti Aisyah Siti Hotima Siti Hotimah Siti Nur Maulita Siti Saidah Soleh, Ayu angger Putri M. Stevi R izky Anandha Susanti, Dhina Ayu Swastika, Melur Tri Taniya Tri Oktavia Ningrum Tuhfatul Hilmits T Tuhfatul Hilmits Tsania Ulum, Miftahol Wanda Tri Agustin Wardani, Ali Ridho Wardhani, Firdha Aprillia Wima Anggitasari Yola Kristina Cendani Yuneka Saristiana Zulkarnain Permana